U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Giant hemangioma

MedGen UID:
272670
•Concept ID:
C1333817
•
Neoplastic Process
Synonym: Giant hemangiomas
 
Monarch Initiative: MONDO:0003643

Definition

A cavernous hemangioma characterized by the presence of hylanized vascular channels and is often associated with the presence of calcifications, fibrosis, and hemorrhage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant hemangioma

Professional guidelines

PubMed

Management of giant liver hemangiomas: an update.
Hoekstra LT, Bieze M, Erdogan D, Roelofs JJ, Beuers UH, van Gulik TM
Expert Rev Gastroenterol Hepatol 2013 Mar;7(3):263-8. doi: 10.1586/egh.13.10. PMID: 23445235
Management of hemangioma of the liver: surgical therapy or observation?
Yedibela S, Alibek S, Müller V, Aydin U, Langheinrich M, Lohmüller C, Hohenberger W, Perrakis A
World J Surg 2013 Jun;37(6):1303-12. doi: 10.1007/s00268-013-1904-1. PMID: 23354918
Diagnosis and management of disseminated intravascular coagulation: the role of heparin therapy.
Feinstein DI
Blood 1982 Aug;60(2):284-7. PMID: 7046845

Recent clinical studies

Etiology

Liver Transplantation for Giant Hemangioma Complicated by Kasabach-Merritt Syndrome: A Case Report and Literature Review.
Zhao Y, Legan CE
Am J Case Rep 2022 May 23;23:e936042. doi: 10.12659/AJCR.936042. PMID: 35796001Free PMC Article
Characteristics and operative treatment of extremely giant liver hemangioma >20 cm.
Liu X, Yang Z, Tan H, Liu L, Xu L, Sun Y, Si S, Huang J, Zhou W
Surgery 2017 Jun;161(6):1514-1524. Epub 2017 Jan 23 doi: 10.1016/j.surg.2016.12.015. PMID: 28126252
Management of Giant Hepatic Hemangioma in Atypical Localization; Report of a Case and Literature Review.
Stankiewicz R, Kobryń K, Patkowski W, Krawczyk M
Pol Przegl Chir 2015 Mar;87(3):139-42. doi: 10.1515/pjs-2015-0034. PMID: 26146110
Tumor size is not a criterion for resection during the management of giant hemangioma of the liver.
Dong J, Zhang M, Chen JQ, Ma F, Wang HH, Lv Y
Eur J Gastroenterol Hepatol 2015 Jun;27(6):686-91. doi: 10.1097/MEG.0000000000000344. PMID: 25923944
Benign tumors and pseudotumors of the liver.
Ishak KG
Appl Pathol 1988;6(2):82-104. PMID: 3291906

Diagnosis

A giant head and neck hemangioma of the fetus: A case report.
Wang X, Zhang H, Zhang M, Guo Y
Medicine (Baltimore) 2023 Nov 24;102(47):e35855. doi: 10.1097/MD.0000000000035855. PMID: 38013270Free PMC Article
Late third trimester diagnosis of congenital giant hemangioma complicated by the Kasabach-Merritt phenomen: a case report and literature review.
Fantasia I, Polsinelli V, Ambrosii S, Tabacco S, Stanislao V, Ludovisi M, Dotta A, Conforti A, D'Alfonso A, Di Fabio S, Guido M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2274803. Epub 2023 Oct 31 doi: 10.1080/14767058.2023.2274803. PMID: 37908053
Management of Giant Hepatic Hemangioma in Atypical Localization; Report of a Case and Literature Review.
Stankiewicz R, Kobryń K, Patkowski W, Krawczyk M
Pol Przegl Chir 2015 Mar;87(3):139-42. doi: 10.1515/pjs-2015-0034. PMID: 26146110
Management of giant liver hemangiomas: an update.
Hoekstra LT, Bieze M, Erdogan D, Roelofs JJ, Beuers UH, van Gulik TM
Expert Rev Gastroenterol Hepatol 2013 Mar;7(3):263-8. doi: 10.1586/egh.13.10. PMID: 23445235
Benign tumors and pseudotumors of the liver.
Ishak KG
Appl Pathol 1988;6(2):82-104. PMID: 3291906

Therapy

Liver Transplantation for Giant Hemangioma Complicated by Kasabach-Merritt Syndrome: A Case Report and Literature Review.
Zhao Y, Legan CE
Am J Case Rep 2022 May 23;23:e936042. doi: 10.12659/AJCR.936042. PMID: 35796001Free PMC Article
Surgical Management of Giant Hepatic Hemangioma: Single Center's Experience with 144 Patients.
Abdel Wahab M, El Nakeeb A, Ali MA, Mahdy Y, Shehta A, Abdulrazek M, El Desoky M, Abdel Wahab R
J Gastrointest Surg 2018 May;22(5):849-858. Epub 2018 Feb 27 doi: 10.1007/s11605-018-3696-y. PMID: 29488123
Characteristics and operative treatment of extremely giant liver hemangioma >20 cm.
Liu X, Yang Z, Tan H, Liu L, Xu L, Sun Y, Si S, Huang J, Zhou W
Surgery 2017 Jun;161(6):1514-1524. Epub 2017 Jan 23 doi: 10.1016/j.surg.2016.12.015. PMID: 28126252
Tumor size is not a criterion for resection during the management of giant hemangioma of the liver.
Dong J, Zhang M, Chen JQ, Ma F, Wang HH, Lv Y
Eur J Gastroenterol Hepatol 2015 Jun;27(6):686-91. doi: 10.1097/MEG.0000000000000344. PMID: 25923944
Diagnosis and management of disseminated intravascular coagulation: the role of heparin therapy.
Feinstein DI
Blood 1982 Aug;60(2):284-7. PMID: 7046845

Prognosis

A giant head and neck hemangioma of the fetus: A case report.
Wang X, Zhang H, Zhang M, Guo Y
Medicine (Baltimore) 2023 Nov 24;102(47):e35855. doi: 10.1097/MD.0000000000035855. PMID: 38013270Free PMC Article
Unusual presentation of a case of fetal hepatic mass: a case report.
Liu D, Yu J, Yang Y, Ouyang M, Zhang M, Zeng S, Xu G
BMC Pregnancy Childbirth 2023 Apr 26;23(1):290. doi: 10.1186/s12884-023-05626-1. PMID: 37101255Free PMC Article
Characteristics and operative treatment of extremely giant liver hemangioma >20 cm.
Liu X, Yang Z, Tan H, Liu L, Xu L, Sun Y, Si S, Huang J, Zhou W
Surgery 2017 Jun;161(6):1514-1524. Epub 2017 Jan 23 doi: 10.1016/j.surg.2016.12.015. PMID: 28126252
Tumor size is not a criterion for resection during the management of giant hemangioma of the liver.
Dong J, Zhang M, Chen JQ, Ma F, Wang HH, Lv Y
Eur J Gastroenterol Hepatol 2015 Jun;27(6):686-91. doi: 10.1097/MEG.0000000000000344. PMID: 25923944
Management of hemangioma of the liver: surgical therapy or observation?
Yedibela S, Alibek S, Müller V, Aydin U, Langheinrich M, Lohmüller C, Hohenberger W, Perrakis A
World J Surg 2013 Jun;37(6):1303-12. doi: 10.1007/s00268-013-1904-1. PMID: 23354918

Clinical prediction guides

Late third trimester diagnosis of congenital giant hemangioma complicated by the Kasabach-Merritt phenomen: a case report and literature review.
Fantasia I, Polsinelli V, Ambrosii S, Tabacco S, Stanislao V, Ludovisi M, Dotta A, Conforti A, D'Alfonso A, Di Fabio S, Guido M
J Matern Fetal Neonatal Med 2023 Dec;36(2):2274803. Epub 2023 Oct 31 doi: 10.1080/14767058.2023.2274803. PMID: 37908053
Efficacy and factors affecting the choice of enucleation and liver resection for giant hemangioma: a retrospective propensity score-matched study.
Ju M, Xu F, Zhao W, Dai C
BMC Surg 2020 Nov 7;20(1):271. doi: 10.1186/s12893-020-00935-0. PMID: 33160352Free PMC Article
Giant mesenteric hemangioma of cavernous and venous mixed type: a rare case report.
Yang GZ, Li J, Jin H
BMC Surg 2013 Oct 30;13:50. doi: 10.1186/1471-2482-13-50. PMID: 24168418Free PMC Article
Management of giant liver hemangiomas: an update.
Hoekstra LT, Bieze M, Erdogan D, Roelofs JJ, Beuers UH, van Gulik TM
Expert Rev Gastroenterol Hepatol 2013 Mar;7(3):263-8. doi: 10.1586/egh.13.10. PMID: 23445235
Management of hemangioma of the liver: surgical therapy or observation?
Yedibela S, Alibek S, Müller V, Aydin U, Langheinrich M, Lohmüller C, Hohenberger W, Perrakis A
World J Surg 2013 Jun;37(6):1303-12. doi: 10.1007/s00268-013-1904-1. PMID: 23354918

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...