U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grade 1 Invasive Breast Carcinoma

MedGen UID:
272673
•Concept ID:
C1333832
•
Neoplastic Process
Synonyms: Favorable Infiltrating Breast Carcinoma; Grade 1 Infiltrating Breast Carcinoma; Low Combined Histologic Grade Infiltrating Breast Carcinoma; Well Differentiated Infiltrating Breast Carcinoma; Well Differentiated Invasive Breast Carcinoma

Definition

A well differentiated invasive breast carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 1 Invasive Breast Carcinoma

Professional guidelines

PubMed

Universal Genetic Testing for Newly Diagnosed Invasive Breast Cancer.
Rezoug Z, Totten SP, Szlachtycz D, Atayan A, Mohler K, Albert S, Feng L, Lemieux Anglin B, Shen Z, Jimenez D, Hamel N, Meti N, Esfahani K, Boileau JF, Prakash I, Basik M, Meterissian S, Tremblay F, Fleiszer D, Anderson D, Chong G, Wong SM, Foulkes WD
JAMA Netw Open 2024 Sep 3;7(9):e2431427. doi: 10.1001/jamanetworkopen.2024.31427. PMID: 39226054Free PMC Article
European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Therapeutic potential of [(177)Lu]Lu-DOTAGA-FAPi dimers in metastatic breast cancer patients with limited treatment options: efficacy and safety assessment.
Yadav MP, Ballal S, Martin M, Roesch F, Satapathy S, Moon ES, Tripathi M, Gogia A, Bal C
Eur J Nucl Med Mol Imaging 2024 Feb;51(3):805-819. Epub 2023 Nov 7 doi: 10.1007/s00259-023-06482-z. PMID: 37932560

Recent clinical studies

Etiology

Tumor budding in breast carcinoma: A systematic review and meta-analysis.
Buch A, Khan U, Rathod H, Jain K, Dwivedi A, Rajesh A
J Cancer Res Ther 2023 Oct 1;19(7):1697-1713. Epub 2023 Apr 25 doi: 10.4103/jcrt.jcrt_188_22. PMID: 38376268
Grading of invasive breast carcinoma: the way forward.
van Dooijeweert C, van Diest PJ, Ellis IO
Virchows Arch 2022 Jan;480(1):33-43. Epub 2021 Jul 1 doi: 10.1007/s00428-021-03141-2. PMID: 34196797Free PMC Article
The histopathological and molecular features of breast carcinoma with tumour budding-a systematic review and meta-analysis.
Lloyd AJ, Ryan ÉJ, Boland MR, Elwahab SA, Malone C, Sweeney KJ, Barry KM, McLaughlin R, Kerin MJ, Lowery AJ
Breast Cancer Res Treat 2020 Oct;183(3):503-514. Epub 2020 Jul 24 doi: 10.1007/s10549-020-05810-3. PMID: 32710280
Grading Ductal Carcinoma In Situ (DCIS) of the Breast - What's Wrong with It?
Cserni G, Sejben A
Pathol Oncol Res 2020 Apr;26(2):665-671. Epub 2019 Nov 27 doi: 10.1007/s12253-019-00760-8. PMID: 31776839Free PMC Article
Invasive lobular breast cancer and its variants: how special are they for systemic therapy decisions?
Guiu S, Wolfer A, Jacot W, Fumoleau P, Romieu G, Bonnetain F, Fiche M
Crit Rev Oncol Hematol 2014 Dec;92(3):235-57. Epub 2014 Jul 30 doi: 10.1016/j.critrevonc.2014.07.003. PMID: 25129506

Diagnosis

Measuring Invasive Breast Carcinoma on Core Biopsy-Is It Necessary?
Liang Y, Oza T, Corben A, Zeizafoun N, Alexander M, Jaffer S
Arch Pathol Lab Med 2021 Nov 1;145(11):1432-1437. doi: 10.5858/arpa.2020-0287-OA. PMID: 33503224
Microglandular Adenosis and Associated Invasive Carcinoma.
Kravtsov O, Jorns JM
Arch Pathol Lab Med 2020 Jan;144(1):42-46. Epub 2019 May 22 doi: 10.5858/arpa.2019-0049-RA. PMID: 31116044
Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics.
McCart Reed AE, Kutasovic JR, Lakhani SR, Simpson PT
Breast Cancer Res 2015 Jan 30;17(1):12. doi: 10.1186/s13058-015-0519-x. PMID: 25849106Free PMC Article
Invasive lobular breast cancer and its variants: how special are they for systemic therapy decisions?
Guiu S, Wolfer A, Jacot W, Fumoleau P, Romieu G, Bonnetain F, Fiche M
Crit Rev Oncol Hematol 2014 Dec;92(3):235-57. Epub 2014 Jul 30 doi: 10.1016/j.critrevonc.2014.07.003. PMID: 25129506
Lobular breast carcinoma and its variants.
Rakha EA, Ellis IO
Semin Diagn Pathol 2010 Feb;27(1):49-61. doi: 10.1053/j.semdp.2009.12.009. PMID: 20306830

Therapy

Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial.
Vicini FA, Cecchini RS, White JR, Arthur DW, Julian TB, Rabinovitch RA, Kuske RR, Ganz PA, Parda DS, Scheier MF, Winter KA, Paik S, Kuerer HM, Vallow LA, Pierce LJ, Mamounas EP, McCormick B, Costantino JP, Bear HD, Germain I, Gustafson G, Grossheim L, Petersen IA, Hudes RS, Curran WJ Jr, Bryant JL, Wolmark N
Lancet 2019 Dec 14;394(10215):2155-2164. Epub 2019 Dec 5 doi: 10.1016/S0140-6736(19)32514-0. PMID: 31813636Free PMC Article
Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial.
Coles CE, Griffin CL, Kirby AM, Titley J, Agrawal RK, Alhasso A, Bhattacharya IS, Brunt AM, Ciurlionis L, Chan C, Donovan EM, Emson MA, Harnett AN, Haviland JS, Hopwood P, Jefford ML, Kaggwa R, Sawyer EJ, Syndikus I, Tsang YM, Wheatley DA, Wilcox M, Yarnold JR, Bliss JM; IMPORT Trialists
Lancet 2017 Sep 9;390(10099):1048-1060. Epub 2017 Aug 2 doi: 10.1016/S0140-6736(17)31145-5. PMID: 28779963Free PMC Article
Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trials.
Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, Ochs-Balcom HM, Thomson CA, Caan BJ, Tinker LF, Urrutia RP, Knudtson J, Anderson GL
JAMA Oncol 2015 Aug;1(5):611-21. doi: 10.1001/jamaoncol.2015.1546. PMID: 26182172Free PMC Article
Breast-conserving surgery with or without irradiation in women aged 65 years or older with early breast cancer (PRIME II): a randomised controlled trial.
Kunkler IH, Williams LJ, Jack WJ, Cameron DA, Dixon JM; PRIME II investigators
Lancet Oncol 2015 Mar;16(3):266-73. Epub 2015 Jan 28 doi: 10.1016/S1470-2045(14)71221-5. PMID: 25637340
Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Correa C, McGale P, Taylor C, Wang Y, Clarke M, Davies C, Peto R, Bijker N, Solin L, Darby S
J Natl Cancer Inst Monogr 2010;2010(41):162-77. doi: 10.1093/jncimonographs/lgq039. PMID: 20956824Free PMC Article

Prognosis

Measuring Invasive Breast Carcinoma on Core Biopsy-Is It Necessary?
Liang Y, Oza T, Corben A, Zeizafoun N, Alexander M, Jaffer S
Arch Pathol Lab Med 2021 Nov 1;145(11):1432-1437. doi: 10.5858/arpa.2020-0287-OA. PMID: 33503224
Roles and correlation of FOXA1 and ZIC1 in breast cancer.
Zhang YW, Ma J, Shi CT, Han W, Gao XJ, Zhou MH, Ding HZ, Wang HN
Curr Probl Cancer 2020 Oct;44(5):100559. Epub 2020 Feb 21 doi: 10.1016/j.currproblcancer.2020.100559. PMID: 32115254
Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418
Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article
Primary systemic chemotherapy of invasive lobular carcinoma of the breast.
Katz A, Saad ED, Porter P, Pusztai L
Lancet Oncol 2007 Jan;8(1):55-62. doi: 10.1016/S1470-2045(06)71011-7. PMID: 17196511

Clinical prediction guides

Measuring Invasive Breast Carcinoma on Core Biopsy-Is It Necessary?
Liang Y, Oza T, Corben A, Zeizafoun N, Alexander M, Jaffer S
Arch Pathol Lab Med 2021 Nov 1;145(11):1432-1437. doi: 10.5858/arpa.2020-0287-OA. PMID: 33503224
Microglandular adenosis of the breast: a deceptive and still mysterious benign lesion.
Foschini MP, Eusebi V
Hum Pathol 2018 Dec;82:1-9. Epub 2018 Jun 24 doi: 10.1016/j.humpath.2018.06.025. PMID: 29949742
Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis.
Liu YL, Choi C, Lee SM, Zhong X, Hibshoosh H, Kalinsky K, Connolly EP
Clin Breast Cancer 2018 Apr;18(2):114-120. Epub 2017 Jun 23 doi: 10.1016/j.clbc.2017.06.006. PMID: 28720418
Invasive lobular breast cancer and its variants: how special are they for systemic therapy decisions?
Guiu S, Wolfer A, Jacot W, Fumoleau P, Romieu G, Bonnetain F, Fiche M
Crit Rev Oncol Hematol 2014 Dec;92(3):235-57. Epub 2014 Jul 30 doi: 10.1016/j.critrevonc.2014.07.003. PMID: 25129506
Prognostic and predictive factors revisited.
Hayes DF
Breast 2005 Dec;14(6):493-9. Epub 2005 Oct 18 doi: 10.1016/j.breast.2005.08.023. PMID: 16239111

Recent systematic reviews

Tumor budding in breast carcinoma: A systematic review and meta-analysis.
Buch A, Khan U, Rathod H, Jain K, Dwivedi A, Rajesh A
J Cancer Res Ther 2023 Oct 1;19(7):1697-1713. Epub 2023 Apr 25 doi: 10.4103/jcrt.jcrt_188_22. PMID: 38376268
Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk.
Glechner A, Wagner G, Mitus JW, Teufer B, Klerings I, Böck N, Grillich L, Berzaczy D, Helbich TH, Gartlehner G
Cochrane Database Syst Rev 2023 Mar 31;3(3):CD009632. doi: 10.1002/14651858.CD009632.pub3. PMID: 36999589Free PMC Article
Partial breast irradiation versus whole breast radiotherapy for early breast cancer.
Hickey BE, Lehman M
Cochrane Database Syst Rev 2021 Aug 30;8(8):CD007077. doi: 10.1002/14651858.CD007077.pub4. PMID: 34459500Free PMC Article
The histopathological and molecular features of breast carcinoma with tumour budding-a systematic review and meta-analysis.
Lloyd AJ, Ryan ÉJ, Boland MR, Elwahab SA, Malone C, Sweeney KJ, Barry KM, McLaughlin R, Kerin MJ, Lowery AJ
Breast Cancer Res Treat 2020 Oct;183(3):503-514. Epub 2020 Jul 24 doi: 10.1007/s10549-020-05810-3. PMID: 32710280
Breast cancer in elderly women and altered clinico-pathological characteristics: a systematic review.
Lodi M, Scheer L, Reix N, Heitz D, Carin AJ, Thiébaut N, Neuberger K, Tomasetto C, Mathelin C
Breast Cancer Res Treat 2017 Dec;166(3):657-668. Epub 2017 Aug 12 doi: 10.1007/s10549-017-4448-5. PMID: 28803352

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...