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Grade 1 Colorectal Adenocarcinoma

MedGen UID:: 272682
•Concept ID:: C1333867
•: Neoplastic Process

Synonyms:

Grade I Colorectal Adenocarcinoma; Low Grade Colorectal Adenocarcinoma; Well Differentiated Colorectal Adenocarcinoma

Definition

A colorectal adenocarcinoma characterized by the presence of a malignant cellular infiltrate with more than 95% glandular formation. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGrade 1 Colorectal Adenocarcinoma

Disease
- Neoplasm
  - Epithelial neoplasm
    - Carcinoma
      - Adenocarcinoma
        Adenocarcinoma of the large intestine
        Grade 1 Colorectal Adenocarcinoma
        Grade 1 Colon Adenocarcinoma
        Grade 1 Rectal Adenocarcinoma

Professional guidelines

PubMed

SAGES/AHPBA guidelines for the use of microwave and radiofrequency liver ablation for the surgical treatment of hepatocellular carcinoma or colorectal liver metastases less than 5 cm.

Ceppa EP, Collings AT, Abdalla M, Onkendi E, Nelson DW, Ozair A, Miraflor E, Rahman F, Whiteside J, Shah MM, Ayloo S, Dirks R, Kumar SS, Ansari MT, Sucandy I, Ali K, Douglas S, Polanco PM, Vreeland TJ, Buell J, Abou-Setta AM, Awad Z, Kwon CH, Martinie JB, Sbrana F, Pryor A, Slater BJ, Richardson W, Jeyarajah R, Alseidi A
Surg Endosc 2023 Dec;37(12):8991-9000. Epub 2023 Nov 13 doi: 10.1007/s00464-023-10468-1. PMID: 37957297

Rationale of Treatment for Peritoneal Metastasis.

Yonemura Y, Ishibashi H, Mizumoto A, Fujita T, Liu Y, Wakama S, Sako S, Takao N, Kitai T, Katayama K, Kamada Y, Taniguchi K, Fujimoto D
Gan To Kagaku Ryoho 2022 Dec;49(13):1723-1726. PMID: 36732979

Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.

Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861 Free PMC Article

See all (61)

Recent clinical studies

Etiology

Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial.

Xu L, Su X, He Z, Zhang C, Lu J, Zhang G, Sun Y, Du X, Chi P, Wang Z, Zhong M, Wu A, Zhu A, Li F, Xu J, Kang L, Suo J, Deng H, Ye Y, Ding K, Xu T, Zhang Z, Zheng M, Xiao Y; RELARC Study Group
Lancet Oncol 2021 Mar;22(3):391-401. Epub 2021 Feb 12 doi: 10.1016/S1470-2045(20)30685-9. PMID: 33587893

Histologic Evaluation of Malignant Polyps and Low-Stage Colorectal Carcinoma.

Hagen CE, Farooq A
Arch Pathol Lab Med 2019 Dec;143(12):1450-1454. Epub 2019 Sep 11 doi: 10.5858/arpa.2019-0291-RA. PMID: 31509454

Clinicopathological and genetic differences between low-grade and high-grade colorectal mucinous adenocarcinomas.

Yoshioka Y, Togashi Y, Chikugo T, Kogita A, Taguri M, Terashima M, Mizukami T, Hayashi H, Sakai K, de Velasco MA, Tomida S, Fujita Y, Tokoro T, Ito A, Okuno K, Nishio K
Cancer 2015 Dec 15;121(24):4359-68. Epub 2015 Oct 21 doi: 10.1002/cncr.29676. PMID: 26488212

Estrogen and colorectal cancer incidence and mortality.

Lavasani S, Chlebowski RT, Prentice RL, Kato I, Wactawski-Wende J, Johnson KC, Young A, Rodabough R, Hubbell FA, Mahinbakht A, Simon MS
Cancer 2015 Sep 15;121(18):3261-71. Epub 2015 Jun 2 doi: 10.1002/cncr.29464. PMID: 26036212

Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.

de Gramont A, Figer A, Seymour M, Homerin M, Hmissi A, Cassidy J, Boni C, Cortes-Funes H, Cervantes A, Freyer G, Papamichael D, Le Bail N, Louvet C, Hendler D, de Braud F, Wilson C, Morvan F, Bonetti A
J Clin Oncol 2000 Aug;18(16):2938-47. doi: 10.1200/JCO.2000.18.16.2938. PMID: 10944126

See all (1024)

Diagnosis

Appendiceal adenocarcinoma: Current concepts & challenges.

Bell PD
Semin Diagn Pathol 2024 Sep;41(5):213-221. Epub 2024 Aug 16 doi: 10.1053/j.semdp.2024.08.005. PMID: 39214725

Assessment of Textbook Outcome in Laparoscopic and Open Liver Surgery.

Görgec B, Benedetti Cacciaguerra A, Lanari J, Russolillo N, Cipriani F, Aghayan D, Zimmitti G, Efanov M, Alseidi A, Mocchegiani F, Giuliante F, Ruzzenente A, Rotellar F, Fuks D, D'Hondt M, Vivarelli M, Edwin B, Aldrighetti LA, Ferrero A, Cillo U, Besselink MG, Abu Hilal M
JAMA Surg 2021 Aug 1;156(8):e212064. Epub 2021 Aug 11 doi: 10.1001/jamasurg.2021.2064. PMID: 34076671 Free PMC Article

Programmed death ligand-1 (PD-L1) as a predictive marker for immunotherapy in solid tumours: a guide to immunohistochemistry implementation and interpretation.

Paver EC, Cooper WA, Colebatch AJ, Ferguson PM, Hill SK, Lum T, Shin JS, O'Toole S, Anderson L, Scolyer RA, Gupta R
Pathology 2021 Feb;53(2):141-156. Epub 2020 Dec 30 doi: 10.1016/j.pathol.2020.10.007. PMID: 33388161

Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial.

Bahadoer RR, Dijkstra EA, van Etten B, Marijnen CAM, Putter H, Kranenbarg EM, Roodvoets AGH, Nagtegaal ID, Beets-Tan RGH, Blomqvist LK, Fokstuen T, Ten Tije AJ, Capdevila J, Hendriks MP, Edhemovic I, Cervantes A, Nilsson PJ, Glimelius B, van de Velde CJH, Hospers GAP; RAPIDO collaborative investigators
Lancet Oncol 2021 Jan;22(1):29-42. Epub 2020 Dec 7 doi: 10.1016/S1470-2045(20)30555-6. PMID: 33301740

Assessment of Hepatic Arterial Infusion of Floxuridine in Combination With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial.

Cercek A, Boerner T, Tan BR, Chou JF, Gönen M, Boucher TM, Hauser HF, Do RKG, Lowery MA, Harding JJ, Varghese AM, Reidy-Lagunes D, Saltz L, Schultz N, Kingham TP, D'Angelica MI, DeMatteo RP, Drebin JA, Allen PJ, Balachandran VP, Lim KH, Sanchez-Vega F, Vachharajani N, Majella Doyle MB, Fields RC, Hawkins WG, Strasberg SM, Chapman WC, Diaz LA Jr, Kemeny NE, Jarnagin WR
JAMA Oncol 2020 Jan 1;6(1):60-67. doi: 10.1001/jamaoncol.2019.3718. PMID: 31670750 Free PMC Article

See all (589)

Therapy

Organ Preservation and Survival by Clinical Response Grade in Patients With Rectal Cancer Treated With Total Neoadjuvant Therapy: A Secondary Analysis of the OPRA Randomized Clinical Trial.

Thompson HM, Omer DM, Lin S, Kim JK, Yuval JB, Verheij FS, Qin LX, Gollub MJ, Wu AJ, Lee M, Patil S, Hezel AF, Marcet JE, Cataldo PA, Polite BN, Herzig DO, Liska D, Oommen S, Friel CM, Ternent CA, Coveler AL, Hunt SR, Garcia-Aguilar J; OPRA Consortium
JAMA Netw Open 2024 Jan 2;7(1):e2350903. doi: 10.1001/jamanetworkopen.2023.50903. PMID: 38194231 Free PMC Article

Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study.

Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, Meyers JP, Desnoyers RJ, McCune JS, Pedersen K, Barzi A, Chiorean EG, Sloan J, Lacouture ME, Lenz HJ, Grothey A
Lancet Oncol 2019 Aug;20(8):1070-1082. Epub 2019 Jun 28 doi: 10.1016/S1470-2045(19)30272-4. PMID: 31262657 Free PMC Article

Modified XELIRI (capecitabine plus irinotecan) versus FOLFIRI (leucovorin, fluorouracil, and irinotecan), both either with or without bevacizumab, as second-line therapy for metastatic colorectal cancer (AXEPT): a multicentre, open-label, randomised, non-inferiority, phase 3 trial.

Xu RH, Muro K, Morita S, Iwasa S, Han SW, Wang W, Kotaka M, Nakamura M, Ahn JB, Deng YH, Kato T, Cho SH, Ba Y, Matsuoka H, Lee KW, Zhang T, Yamada Y, Sakamoto J, Park YS, Kim TW
Lancet Oncol 2018 May;19(5):660-671. Epub 2018 Mar 16 doi: 10.1016/S1470-2045(18)30140-2. PMID: 29555258

Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE Study.

Hochster HS, Hart LL, Ramanathan RK, Childs BH, Hainsworth JD, Cohn AL, Wong L, Fehrenbacher L, Abubakr Y, Saif MW, Schwartzberg L, Hedrick E
J Clin Oncol 2008 Jul 20;26(21):3523-9. doi: 10.1200/JCO.2007.15.4138. PMID: 18640933

See all (640)

Prognosis

Appendiceal adenocarcinoma: Current concepts & challenges.

Bell PD
Semin Diagn Pathol 2024 Sep;41(5):213-221. Epub 2024 Aug 16 doi: 10.1053/j.semdp.2024.08.005. PMID: 39214725

Histologic Evaluation of Malignant Polyps and Low-Stage Colorectal Carcinoma.

Hagen CE, Farooq A
Arch Pathol Lab Med 2019 Dec;143(12):1450-1454. Epub 2019 Sep 11 doi: 10.5858/arpa.2019-0291-RA. PMID: 31509454

Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study.

Fuchs CS, Marshall J, Mitchell E, Wierzbicki R, Ganju V, Jeffery M, Schulz J, Richards D, Soufi-Mahjoubi R, Wang B, Barrueco J
J Clin Oncol 2007 Oct 20;25(30):4779-86. doi: 10.1200/JCO.2007.11.3357. PMID: 17947725

Reporting colorectal cancer.

Quirke P, Morris E
Histopathology 2007 Jan;50(1):103-12. doi: 10.1111/j.1365-2559.2006.02543.x. PMID: 17204025

See all (939)

Clinical prediction guides

Cervical Adenocarcinoma: A Still Under-investigated Malignancy.

Pistolesi S, Fanelli GN, Giudice F, Garbini F, Naccarato AG, Cosio S, Caretto M, Gadducci A
Anticancer Res 2023 Jan;43(1):53-58. doi: 10.21873/anticanres.16133. PMID: 36585201

Chemotherapy versus chemoradiotherapy after surgery and preoperative chemotherapy for resectable gastric cancer (CRITICS): an international, open-label, randomised phase 3 trial.

Cats A, Jansen EPM, van Grieken NCT, Sikorska K, Lind P, Nordsmark M, Meershoek-Klein Kranenbarg E, Boot H, Trip AK, Swellengrebel HAM, van Laarhoven HWM, Putter H, van Sandick JW, van Berge Henegouwen MI, Hartgrink HH, van Tinteren H, van de Velde CJH, Verheij M; CRITICS investigators
Lancet Oncol 2018 May;19(5):616-628. Epub 2018 Apr 9 doi: 10.1016/S1470-2045(18)30132-3. PMID: 29650363

Patterns and outcomes of colorectal cancer in adolescents and young adults.

Teng A, Lee DY, Cai J, Patel SS, Bilchik AJ, Goldfarb MR
J Surg Res 2016 Sep;205(1):19-27. Epub 2016 May 26 doi: 10.1016/j.jss.2016.05.036. PMID: 27620994

Estrogen and colorectal cancer incidence and mortality.

Reporting colorectal cancer.

Quirke P, Morris E
Histopathology 2007 Jan;50(1):103-12. doi: 10.1111/j.1365-2559.2006.02543.x. PMID: 17204025

See all (780)

Recent systematic reviews

Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.

Silva A, Cerqueira MC, Rosa B, Sobral C, Pinto-Ribeiro F, Costa MF, Baltazar F, Afonso J
Int J Mol Sci 2023 Mar 7;24(6) doi: 10.3390/ijms24065141. PMID: 36982217 Free PMC Article

Colorectal cancer risk of flat low-grade dysplasia in inflammatory bowel disease: a systematic review and proportion meta-analysis.

Lauricella S, Fabris S, Sylla P
Surg Endosc 2023 Jan;37(1):48-61. Epub 2022 Aug 3 doi: 10.1007/s00464-022-09462-w. PMID: 35920906

Annexin A2 and cancer: A systematic review.

Christensen MV, Høgdall CK, Jochumsen KM, Høgdall EVS
Int J Oncol 2018 Jan;52(1):5-18. Epub 2017 Nov 8 doi: 10.3892/ijo.2017.4197. PMID: 29115416

Adiposity and cancer at major anatomical sites: umbrella review of the literature.

Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Martin-Hirsch P, Tsilidis KK
BMJ 2017 Feb 28;356:j477. doi: 10.1136/bmj.j477. PMID: 28246088 Free PMC Article

Systematic review and meta-analysis of published trials comparing the effectiveness of transanal endoscopic microsurgery and radical resection in the management of early rectal cancer.

Sajid MS, Farag S, Leung P, Sains P, Miles WF, Baig MK
Colorectal Dis 2014 Jan;16(1):2-14. doi: 10.1111/codi.12474. PMID: 24330432

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