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Hepatic angiomyolipoma

MedGen UID:
272705
•Concept ID:
C1333962
•
Neoplastic Process
Synonyms: Angiomyolipoma of liver; Hepatic Angiomyolipoma; hepatic angiomyolipoma; Liver Angiomyolipoma; liver angiomyolipoma; Liver PEComa; liver PEComa
SNOMED CT: Angiomyolipoma of liver (1196904007)
 
Monarch Initiative: MONDO:0002605

Definition

An angiomyolipoma arising from the liver. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatic angiomyolipoma

Professional guidelines

PubMed

Hepatic angiomyolipoma: an international multicenter analysis on diagnosis, management and outcome.
Klompenhouwer AJ, Dwarkasing RS, Doukas M, Pellegrino S, Vilgrain V, Paradis V, Soubrane O, Beane JD, Geller DA, Nalesnik MA, Tripke V, Lang H, Schmelzle M, Pratschke J, Schöning W, Beal E, Sun S, Pawlik TM, de Man RA, Ijzermans JNM
HPB (Oxford) 2020 Apr;22(4):622-629. Epub 2019 Oct 13 doi: 10.1016/j.hpb.2019.09.004. PMID: 31619346
Management of hepatic angiomyolipoma: A systematic review.
Klompenhouwer AJ, Verver D, Janki S, Bramer WM, Doukas M, Dwarkasing RS, de Man RA, IJzermans JNM
Liver Int 2017 Sep;37(9):1272-1280. Epub 2017 Mar 6 doi: 10.1111/liv.13381. PMID: 28177188
Diagnosis and treatment of hepatic angiomyolipoma.
Ding GH, Liu Y, Wu MC, Yang GS, Yang JM, Cong WM
J Surg Oncol 2011 Jun;103(8):807-12. Epub 2011 Jan 31 doi: 10.1002/jso.21814. PMID: 21283992

Recent clinical studies

Etiology

Clinical characteristics and outcomes of patients with hepatic angiomyolipoma: A literature review.
Calame P, Tyrode G, Weil Verhoeven D, Félix S, Klompenhouwer AJ, Di Martino V, Delabrousse E, Thévenot T
World J Gastroenterol 2021 May 21;27(19):2299-2311. doi: 10.3748/wjg.v27.i19.2299. PMID: 34040323Free PMC Article
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis.
Yan Z, Grenert JP, Joseph NM, Ren C, Chen X, Shafizadeh N, Kakar S
Histopathology 2018 Jul;73(1):101-108. Epub 2018 Apr 19 doi: 10.1111/his.13509. PMID: 29512829Free PMC Article
Management of hepatic angiomyolipoma: A systematic review.
Klompenhouwer AJ, Verver D, Janki S, Bramer WM, Doukas M, Dwarkasing RS, de Man RA, IJzermans JNM
Liver Int 2017 Sep;37(9):1272-1280. Epub 2017 Mar 6 doi: 10.1111/liv.13381. PMID: 28177188
Rare benign tumors of the liver: still rare?
Bertino G, Ardiri A, Demma S, GiuseppeCalvagno S, Toro A, Basile E, Campagna D, Ferraro G, Frazzetto E, Proiti M, Malaguarnera G, Bertino N, Malaguarnera M, Malaguarnera M, Amaradio MD, Pricoco G, Di Carlo I
J Gastrointest Cancer 2014 Jun;45(2):202-17. doi: 10.1007/s12029-014-9580-4. PMID: 24510731Free PMC Article
Hepatic angiomyolipoma: clinical, imaging and pathological features in 178 cases.
Yang X, Li A, Wu M
Med Oncol 2013 Mar;30(1):416. Epub 2013 Jan 6 doi: 10.1007/s12032-012-0416-4. PMID: 23292871

Diagnosis

Clinical characteristics and outcomes of patients with hepatic angiomyolipoma: A literature review.
Calame P, Tyrode G, Weil Verhoeven D, Félix S, Klompenhouwer AJ, Di Martino V, Delabrousse E, Thévenot T
World J Gastroenterol 2021 May 21;27(19):2299-2311. doi: 10.3748/wjg.v27.i19.2299. PMID: 34040323Free PMC Article
Hepatic angiomyolipoma: an international multicenter analysis on diagnosis, management and outcome.
Klompenhouwer AJ, Dwarkasing RS, Doukas M, Pellegrino S, Vilgrain V, Paradis V, Soubrane O, Beane JD, Geller DA, Nalesnik MA, Tripke V, Lang H, Schmelzle M, Pratschke J, Schöning W, Beal E, Sun S, Pawlik TM, de Man RA, Ijzermans JNM
HPB (Oxford) 2020 Apr;22(4):622-629. Epub 2019 Oct 13 doi: 10.1016/j.hpb.2019.09.004. PMID: 31619346
Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis.
Yan Z, Grenert JP, Joseph NM, Ren C, Chen X, Shafizadeh N, Kakar S
Histopathology 2018 Jul;73(1):101-108. Epub 2018 Apr 19 doi: 10.1111/his.13509. PMID: 29512829Free PMC Article
Management of hepatic angiomyolipoma: A systematic review.
Klompenhouwer AJ, Verver D, Janki S, Bramer WM, Doukas M, Dwarkasing RS, de Man RA, IJzermans JNM
Liver Int 2017 Sep;37(9):1272-1280. Epub 2017 Mar 6 doi: 10.1111/liv.13381. PMID: 28177188
Hepatic angiomyolipoma.
Petrolla AA, Xin W
Arch Pathol Lab Med 2008 Oct;132(10):1679-82. doi: 10.5858/2008-132-1679-HA. PMID: 18834230

Therapy

The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients.
Ding H, Wei H, Liu H, Chen Y, Xue X, Weng H
Ann Hepatol 2017 Sep-Oct;16(5):759-764. doi: 10.5604/01.3001.0010.2769. PMID: 28809731
Management of hepatic angiomyolipoma: A systematic review.
Klompenhouwer AJ, Verver D, Janki S, Bramer WM, Doukas M, Dwarkasing RS, de Man RA, IJzermans JNM
Liver Int 2017 Sep;37(9):1272-1280. Epub 2017 Mar 6 doi: 10.1111/liv.13381. PMID: 28177188
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge.
Lee SJ, Kim SY, Kim KW, Kim JH, Kim HJ, Lee MG, Yu ES
AJR Am J Roentgenol 2016 Sep;207(3):562-70. Epub 2016 Jun 1 doi: 10.2214/AJR.15.15602. PMID: 27248975
Computed tomographic features of lymphangioleiomyomatosis: evaluation in 138 patients.
Tobino K, Johkoh T, Fujimoto K, Sakai F, Arakawa H, Kurihara M, Kumasaka T, Koike K, Takahashi K, Seyama K
Eur J Radiol 2015 Mar;84(3):534-541. Epub 2014 Dec 19 doi: 10.1016/j.ejrad.2014.12.008. PMID: 25544557
Giant hepatic angiomyolipoma associated with disseminated intravascular coagulation.
Ukai K, Fuji A, Nishiwaki J, Yamada T, Hotta N, Kobayashi Y, Kondo C, Miyajima K, Takada T, Kinoshita Y, Hanai S
Intern Med 1997 Mar;36(3):186-90. doi: 10.2169/internalmedicine.36.186. PMID: 9144010

Prognosis

Clinical characteristics and outcomes of patients with hepatic angiomyolipoma: A literature review.
Calame P, Tyrode G, Weil Verhoeven D, Félix S, Klompenhouwer AJ, Di Martino V, Delabrousse E, Thévenot T
World J Gastroenterol 2021 May 21;27(19):2299-2311. doi: 10.3748/wjg.v27.i19.2299. PMID: 34040323Free PMC Article
Hepatic Angiomyolipoma: Clinical Features and Imaging Findings of Quantitative Contrast-Enhanced Ultrasound Perfusion Analysis and Magnetic Resonance Imaging.
Huang Z, Zhou P, Li S, Li K
J Ultrasound Med 2020 Nov;39(11):2111-2122. Epub 2020 May 8 doi: 10.1002/jum.15316. PMID: 32383807
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients.
Ding H, Wei H, Liu H, Chen Y, Xue X, Weng H
Ann Hepatol 2017 Sep-Oct;16(5):759-764. doi: 10.5604/01.3001.0010.2769. PMID: 28809731
Rare benign tumors of the liver: still rare?
Bertino G, Ardiri A, Demma S, GiuseppeCalvagno S, Toro A, Basile E, Campagna D, Ferraro G, Frazzetto E, Proiti M, Malaguarnera G, Bertino N, Malaguarnera M, Malaguarnera M, Amaradio MD, Pricoco G, Di Carlo I
J Gastrointest Cancer 2014 Jun;45(2):202-17. doi: 10.1007/s12029-014-9580-4. PMID: 24510731Free PMC Article
Hepatic angiomyolipoma: report of 8 cases and review of literature.
Xu L, Shao Y, Zhang H, Wang H
Asian J Surg 2002 Jan;25(1):82-6; discussion 87-8. PMID: 17585451

Clinical prediction guides

Differentiation between hepatic angiomyolipoma and hepatocellular carcinoma in individuals who are not at-risk for hepatocellular carcinoma.
Park S, Kim MJ, Han K, Park JH, Han DH, Park YN, Kim J, Rhee H
Eur J Radiol 2023 Sep;166:110957. Epub 2023 Jul 6 doi: 10.1016/j.ejrad.2023.110957. PMID: 37451136
Hepatic Angiomyolipoma: Clinical Features and Imaging Findings of Quantitative Contrast-Enhanced Ultrasound Perfusion Analysis and Magnetic Resonance Imaging.
Huang Z, Zhou P, Li S, Li K
J Ultrasound Med 2020 Nov;39(11):2111-2122. Epub 2020 May 8 doi: 10.1002/jum.15316. PMID: 32383807
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients.
Ding H, Wei H, Liu H, Chen Y, Xue X, Weng H
Ann Hepatol 2017 Sep-Oct;16(5):759-764. doi: 10.5604/01.3001.0010.2769. PMID: 28809731
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases.
Wang CP, Li HY, Wang H, Guo XD, Liu CC, Liu SH, Gao XD, Qu JH, Liu Z, Chang XJ, Lu YY, Zeng Z, Lou M, Yang YP
Medicine (Baltimore) 2014 Dec;93(28):e194. doi: 10.1097/MD.0000000000000194. PMID: 25526436Free PMC Article
Hepatic angiomyolipoma: a clinical experience in diagnosis and treatment.
Zeng JP, Dong JH, Zhang WZ, Wang J, Pang XP
Dig Dis Sci 2010 Nov;55(11):3235-40. Epub 2010 Feb 18 doi: 10.1007/s10620-010-1144-2. PMID: 20165978

Recent systematic reviews

Management of hepatic angiomyolipoma: A systematic review.
Klompenhouwer AJ, Verver D, Janki S, Bramer WM, Doukas M, Dwarkasing RS, de Man RA, IJzermans JNM
Liver Int 2017 Sep;37(9):1272-1280. Epub 2017 Mar 6 doi: 10.1111/liv.13381. PMID: 28177188

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