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Hepatitis B Virus-Related Hepatocellular Carcinoma

MedGen UID:
272708
•Concept ID:
C1333977
•
Neoplastic Process
Synonym: Hepatitis B Virus Related Hepatocellular Carcinoma

Definition

A hepatocellular carcinoma that develops following hepatitis B virus exposure and injury of the liver parenchyma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatitis B Virus-Related Hepatocellular Carcinoma

Professional guidelines

PubMed

Cost-effectiveness of antiviral treatment after resection in hepatitis B virus-related hepatocellular carcinoma patients with compensated cirrhosis.
Xie L, Yin J, Xia R, Zhuang G
Hepatology 2018 Oct;68(4):1476-1486. Epub 2018 May 14 doi: 10.1002/hep.29922. PMID: 29633304
Nomogram for Preoperative Estimation of Microvascular Invasion Risk in Hepatitis B Virus-Related Hepatocellular Carcinoma Within the Milan Criteria.
Lei Z, Li J, Wu D, Xia Y, Wang Q, Si A, Wang K, Wan X, Lau WY, Wu M, Shen F
JAMA Surg 2016 Apr;151(4):356-63. doi: 10.1001/jamasurg.2015.4257. PMID: 26579636
Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma.
Kubo S, Takemura S, Tanaka S, Shinkawa H, Nishioka T, Nozawa A, Kinoshita M, Hamano G, Ito T, Urata Y
World J Gastroenterol 2015 Jul 21;21(27):8249-55. doi: 10.3748/wjg.v21.i27.8249. PMID: 26217076Free PMC Article

Recent clinical studies

Etiology

Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.
Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713098. PMID: 37685904Free PMC Article
Prediction model of hepatitis B virus-related hepatocellular carcinoma in patients receiving antiviral therapy.
Kim BK, Ahn SH
J Formos Med Assoc 2023 Dec;122(12):1238-1246. Epub 2023 Jun 15 doi: 10.1016/j.jfma.2023.05.029. PMID: 37330305
Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu H, Han CL, Tian BW, Ding ZN, Yang YF, Ma YL, Yang CC, Meng GX, Xue JS, Wang DX, Dong ZR, Chen ZQ, Hong JG, Li T
Expert Rev Gastroenterol Hepatol 2023 Jan-Jun;17(6):623-633. Epub 2023 May 9 doi: 10.1080/17474124.2023.2212161. PMID: 37148261
Peripheral immune characteristics of hepatitis B virus-related hepatocellular carcinoma.
Sun R, Li J, Lin X, Yang Y, Liu B, Lan T, Xiao S, Deng A, Yin Z, Xu Y, Xiang Z, Wu B
Front Immunol 2023;14:1079495. Epub 2023 Apr 3 doi: 10.3389/fimmu.2023.1079495. PMID: 37077908Free PMC Article
Hepatitis B virus-related hepatocellular carcinoma: primary, secondary, and tertiary prevention.
Giacomin A, Cazzagon N, Sergio A, Vanin V, Farinati F
Eur J Cancer Prev 2011 Sep;20(5):381-8. doi: 10.1097/CEJ.0b013e328346399b. PMID: 21540746

Diagnosis

Prediction model of hepatitis B virus-related hepatocellular carcinoma in patients receiving antiviral therapy.
Kim BK, Ahn SH
J Formos Med Assoc 2023 Dec;122(12):1238-1246. Epub 2023 Jun 15 doi: 10.1016/j.jfma.2023.05.029. PMID: 37330305
Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu H, Han CL, Tian BW, Ding ZN, Yang YF, Ma YL, Yang CC, Meng GX, Xue JS, Wang DX, Dong ZR, Chen ZQ, Hong JG, Li T
Expert Rev Gastroenterol Hepatol 2023 Jan-Jun;17(6):623-633. Epub 2023 May 9 doi: 10.1080/17474124.2023.2212161. PMID: 37148261
Peripheral immune characteristics of hepatitis B virus-related hepatocellular carcinoma.
Sun R, Li J, Lin X, Yang Y, Liu B, Lan T, Xiao S, Deng A, Yin Z, Xu Y, Xiang Z, Wu B
Front Immunol 2023;14:1079495. Epub 2023 Apr 3 doi: 10.3389/fimmu.2023.1079495. PMID: 37077908Free PMC Article
Pragmatic tools for the prediction and potential early diagnosis of hepatitis B virus-related hepatocellular carcinoma?
Merle P
Clin Res Hepatol Gastroenterol 2021 Sep;45(5):101722. Epub 2021 Jun 16 doi: 10.1016/j.clinre.2021.101722. PMID: 34146725
Antiviral therapies for hepatitis B virus-related hepatocellular carcinoma.
Zhang YQ, Guo JS
World J Gastroenterol 2015 Apr 7;21(13):3860-6. doi: 10.3748/wjg.v21.i13.3860. PMID: 25852270Free PMC Article

Therapy

Prediction model of hepatitis B virus-related hepatocellular carcinoma in patients receiving antiviral therapy.
Kim BK, Ahn SH
J Formos Med Assoc 2023 Dec;122(12):1238-1246. Epub 2023 Jun 15 doi: 10.1016/j.jfma.2023.05.029. PMID: 37330305
Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu H, Han CL, Tian BW, Ding ZN, Yang YF, Ma YL, Yang CC, Meng GX, Xue JS, Wang DX, Dong ZR, Chen ZQ, Hong JG, Li T
Expert Rev Gastroenterol Hepatol 2023 Jan-Jun;17(6):623-633. Epub 2023 May 9 doi: 10.1080/17474124.2023.2212161. PMID: 37148261
Antiviral therapies for hepatitis B virus-related hepatocellular carcinoma.
Zhang YQ, Guo JS
World J Gastroenterol 2015 Apr 7;21(13):3860-6. doi: 10.3748/wjg.v21.i13.3860. PMID: 25852270Free PMC Article
Anti-viral therapy to reduce recurrence and improve survival in hepatitis B virus-related hepatocellular carcinoma.
Ishikawa T
World J Gastroenterol 2013 Dec 21;19(47):8861-6. doi: 10.3748/wjg.v19.i47.8861. PMID: 24379608Free PMC Article
Hepatitis B virus-related hepatocellular carcinoma: primary, secondary, and tertiary prevention.
Giacomin A, Cazzagon N, Sergio A, Vanin V, Farinati F
Eur J Cancer Prev 2011 Sep;20(5):381-8. doi: 10.1097/CEJ.0b013e328346399b. PMID: 21540746

Prognosis

Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.
Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713098. PMID: 37685904Free PMC Article
Prediction model of hepatitis B virus-related hepatocellular carcinoma in patients receiving antiviral therapy.
Kim BK, Ahn SH
J Formos Med Assoc 2023 Dec;122(12):1238-1246. Epub 2023 Jun 15 doi: 10.1016/j.jfma.2023.05.029. PMID: 37330305
Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu H, Han CL, Tian BW, Ding ZN, Yang YF, Ma YL, Yang CC, Meng GX, Xue JS, Wang DX, Dong ZR, Chen ZQ, Hong JG, Li T
Expert Rev Gastroenterol Hepatol 2023 Jan-Jun;17(6):623-633. Epub 2023 May 9 doi: 10.1080/17474124.2023.2212161. PMID: 37148261
Entecavir versus tenofovir on prognosis of hepatitis B virus-related hepatocellular carcinoma after curative hepatectomy.
Kao WY, Tan EC, Lee HL, Huang YH, Huo TI, Chang CC, Chiou JF, Hou MC, Wu JC, Su CW
Aliment Pharmacol Ther 2023 Jun;57(11):1299-1312. Epub 2023 Mar 13 doi: 10.1111/apt.17438. PMID: 36914943
Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma.
Han YF, Zhao J, Ma LY, Yin JH, Chang WJ, Zhang HW, Cao GW
World J Gastroenterol 2011 Oct 14;17(38):4258-70. doi: 10.3748/wjg.v17.i38.4258. PMID: 22090781Free PMC Article

Clinical prediction guides

Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells.
Todorova VK, Byrum SD, Mackintosh SG, Jamshidi-Parsian A, Gies AJ, Washam CL, Jenkins SV, Spiva T, Bowman E, Reyna NS, Griffin RJ, Makhoul I
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713098. PMID: 37685904Free PMC Article
Neoadjuvant intensity modulated radiotherapy for a single and small (≤5 cm) hepatitis B virus-related hepatocellular carcinoma predicted to have high risks of microvascular invasion: a randomized clinical trial.
Wei X, Jiang Y, Feng S, Lu C, Huo L, Zhou B, Meng Y, Lau WY, Zheng Y, Cheng S
Int J Surg 2023 Oct 1;109(10):3052-3060. doi: 10.1097/JS9.0000000000000574. PMID: 37352528Free PMC Article
Prediction model of hepatitis B virus-related hepatocellular carcinoma in patients receiving antiviral therapy.
Kim BK, Ahn SH
J Formos Med Assoc 2023 Dec;122(12):1238-1246. Epub 2023 Jun 15 doi: 10.1016/j.jfma.2023.05.029. PMID: 37330305
Entecavir versus tenofovir on prognosis of hepatitis B virus-related hepatocellular carcinoma after curative hepatectomy.
Kao WY, Tan EC, Lee HL, Huang YH, Huo TI, Chang CC, Chiou JF, Hou MC, Wu JC, Su CW
Aliment Pharmacol Ther 2023 Jun;57(11):1299-1312. Epub 2023 Mar 13 doi: 10.1111/apt.17438. PMID: 36914943
Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma.
Han YF, Zhao J, Ma LY, Yin JH, Chang WJ, Zhang HW, Cao GW
World J Gastroenterol 2011 Oct 14;17(38):4258-70. doi: 10.3748/wjg.v17.i38.4258. PMID: 22090781Free PMC Article

Recent systematic reviews

Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis.
Liu H, Han CL, Tian BW, Ding ZN, Yang YF, Ma YL, Yang CC, Meng GX, Xue JS, Wang DX, Dong ZR, Chen ZQ, Hong JG, Li T
Expert Rev Gastroenterol Hepatol 2023 Jan-Jun;17(6):623-633. Epub 2023 May 9 doi: 10.1080/17474124.2023.2212161. PMID: 37148261
Preoperative antiviral therapy and microvascular invasion in hepatitis B virus-related hepatocellular carcinoma: A meta-analysis.
Wang Z, Duan Y, Zhang J, Lv Y, Wu S, Cheng M, Bhagavathula AS, Aldhaleei WA, Clark C, Huo Z
Eur J Pharmacol 2020 Sep 15;883:173382. Epub 2020 Jul 18 doi: 10.1016/j.ejphar.2020.173382. PMID: 32693099
Effect of adjuvant interferon therapy on hepatitis B virus-related hepatocellular carcinoma: a systematic review.
Yang S, Lin Q, Lin W, Hu W, Wang G
World J Surg Oncol 2016 Jun 9;14(1):159. doi: 10.1186/s12957-016-0912-7. PMID: 27282382Free PMC Article
Efficacy of antiviral therapy with nucleotide/nucleoside analogs after curative treatment for patients with hepatitis B virus-related hepatocellular carcinoma: A systematic review and meta-analysis.
Xia BW, Zhang YC, Wang J, Ding FH, He XD
Clin Res Hepatol Gastroenterol 2015 Sep;39(4):458-68. Epub 2015 Jan 28 doi: 10.1016/j.clinre.2014.12.003. PMID: 25650304
Nucleot(s)ide analogues for hepatitis B virus-related hepatocellular carcinoma after curative treatment: a systematic review and meta-analysis.
Sun P, Dong X, Cheng X, Hu Q, Zheng Q
PLoS One 2014;9(7):e102761. Epub 2014 Jul 24 doi: 10.1371/journal.pone.0102761. PMID: 25058587Free PMC Article

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