U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hereditary Female Breast Carcinoma

MedGen UID:
272712
•Concept ID:
C1333986
•
Neoplastic Process
Synonym: Familial Female Breast Carcinoma

Definition

Breast carcinoma that has developed in female relatives of patients with history of breast carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHereditary Female Breast Carcinoma

Professional guidelines

PubMed

Clinical practice guidelines for BRCA1 and BRCA2 genetic testing.
Pujol P, Barberis M, Beer P, Friedman E, Piulats JM, Capoluongo ED, Garcia Foncillas J, Ray-Coquard I, Penault-Llorca F, Foulkes WD, Turnbull C, Hanson H, Narod S, Arun BK, Aapro MS, Mandel JL, Normanno N, Lambrechts D, Vergote I, Anahory M, Baertschi B, Baudry K, Bignon YJ, Bollet M, Corsini C, Cussenot O, De la Motte Rouge T, Duboys de Labarre M, Duchamp F, Duriez C, Fizazi K, Galibert V, Gladieff L, Gligorov J, Hammel P, Imbert-Bouteille M, Jacot W, Kogut-Kubiak T, Lamy PJ, Nambot S, Neuzillet Y, Olschwang S, Rebillard X, Rey JM, Rideau C, Spano JP, Thomas F, Treilleux I, Vandromme M, Vendrell J, Vintraud M, Zarca D, Hughes KS, Alés Martínez JE
Eur J Cancer 2021 Mar;146:30-47. Epub 2021 Feb 10 doi: 10.1016/j.ejca.2020.12.023. PMID: 33578357
Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis.
Yoshida R
Breast Cancer 2021 Nov;28(6):1167-1180. Epub 2020 Aug 29 doi: 10.1007/s12282-020-01148-2. PMID: 32862296Free PMC Article
Diagnosis and Management of Endometrial Cancer.
Braun MM, Overbeek-Wager EA, Grumbo RJ
Am Fam Physician 2016 Mar 15;93(6):468-74. PMID: 26977831

Recent clinical studies

Etiology

Functions of Breast Cancer Predisposition Genes: Implications for Clinical Management.
Yoshimura A, Imoto I, Iwata H
Int J Mol Sci 2022 Jul 5;23(13) doi: 10.3390/ijms23137481. PMID: 35806485Free PMC Article
Young Women With Breast Cancer: Treatment, Care, and Nursing Implications.
Corey B, Smania MA, Spotts H, Andersen M
Clin J Oncol Nurs 2020 Apr 1;24(2):139-147. doi: 10.1188/20.CJON.139-147. PMID: 32196004
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Contrast-enhanced MRI for breast cancer screening.
Mann RM, Kuhl CK, Moy L
J Magn Reson Imaging 2019 Aug;50(2):377-390. Epub 2019 Jan 18 doi: 10.1002/jmri.26654. PMID: 30659696Free PMC Article
Genetics of breast cancer: a topic in evolution.
Shiovitz S, Korde LA
Ann Oncol 2015 Jul;26(7):1291-9. Epub 2015 Jan 20 doi: 10.1093/annonc/mdv022. PMID: 25605744Free PMC Article

Diagnosis

Hereditary Diffuse Gastric Cancer.
Decourtye-Espiard L, Guilford P
Gastroenterology 2023 Apr;164(5):719-735. Epub 2023 Feb 4 doi: 10.1053/j.gastro.2023.01.038. PMID: 36740198
Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Health and Racial Disparity in Breast Cancer.
Yedjou CG, Sims JN, Miele L, Noubissi F, Lowe L, Fonseca DD, Alo RA, Payton M, Tchounwou PB
Adv Exp Med Biol 2019;1152:31-49. doi: 10.1007/978-3-030-20301-6_3. PMID: 31456178Free PMC Article
Molecular Testing in Breast Cancer.
Litton JK, Burstein HJ, Turner NC
Am Soc Clin Oncol Educ Book 2019 Jan;39:e1-e7. Epub 2019 May 17 doi: 10.1200/EDBK_237715. PMID: 31099622
Contrast-enhanced MRI for breast cancer screening.
Mann RM, Kuhl CK, Moy L
J Magn Reson Imaging 2019 Aug;50(2):377-390. Epub 2019 Jan 18 doi: 10.1002/jmri.26654. PMID: 30659696Free PMC Article

Therapy

Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer.
Tutt ANJ, Garber JE, Kaufman B, Viale G, Fumagalli D, Rastogi P, Gelber RD, de Azambuja E, Fielding A, Balmaña J, Domchek SM, Gelmon KA, Hollingsworth SJ, Korde LA, Linderholm B, Bandos H, Senkus E, Suga JM, Shao Z, Pippas AW, Nowecki Z, Huzarski T, Ganz PA, Lucas PC, Baker N, Loibl S, McConnell R, Piccart M, Schmutzler R, Steger GG, Costantino JP, Arahmani A, Wolmark N, McFadden E, Karantza V, Lakhani SR, Yothers G, Campbell C, Geyer CE Jr; OlympiA Clinical Trial Steering Committee and Investigators
N Engl J Med 2021 Jun 24;384(25):2394-2405. Epub 2021 Jun 3 doi: 10.1056/NEJMoa2105215. PMID: 34081848Free PMC Article
Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications.
Zeng X, Liu C, Yao J, Wan H, Wan G, Li Y, Chen N
Pharmacol Res 2021 Jan;163:105320. Epub 2020 Dec 1 doi: 10.1016/j.phrs.2020.105320. PMID: 33271295
SEOM clinical guidelines in hereditary breast and ovarian cancer (2019).
González-Santiago S, Ramón Y Cajal T, Aguirre E, Alés-Martínez JE, Andrés R, Balmaña J, Graña B, Herrero A, Llort G, González-Del-Alba A; SEOM Hereditary Cancer Working Group
Clin Transl Oncol 2020 Feb;22(2):193-200. Epub 2019 Dec 30 doi: 10.1007/s12094-019-02262-0. PMID: 31889241
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Breastfeeding and maternal and infant health outcomes in developed countries.
Ip S, Chung M, Raman G, Chew P, Magula N, DeVine D, Trikalinos T, Lau J
Evid Rep Technol Assess (Full Rep) 2007 Apr;(153):1-186. PMID: 17764214Free PMC Article

Prognosis

Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications.
Zeng X, Liu C, Yao J, Wan H, Wan G, Li Y, Chen N
Pharmacol Res 2021 Jan;163:105320. Epub 2020 Dec 1 doi: 10.1016/j.phrs.2020.105320. PMID: 33271295
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies.
Lee A, Moon BI, Kim TH
Ann Lab Med 2020 Mar;40(2):114-121. doi: 10.3343/alm.2020.40.2.114. PMID: 31650727Free PMC Article
Molecular Testing in Breast Cancer.
Litton JK, Burstein HJ, Turner NC
Am Soc Clin Oncol Educ Book 2019 Jan;39:e1-e7. Epub 2019 May 17 doi: 10.1200/EDBK_237715. PMID: 31099622
Contrast-enhanced MRI for breast cancer screening.
Mann RM, Kuhl CK, Moy L
J Magn Reson Imaging 2019 Aug;50(2):377-390. Epub 2019 Jan 18 doi: 10.1002/jmri.26654. PMID: 30659696Free PMC Article

Clinical prediction guides

Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.
Bellcross CA
Obstet Gynecol Clin North Am 2022 Mar;49(1):117-147. doi: 10.1016/j.ogc.2021.11.005. PMID: 35168766
Overview of hereditary breast and ovarian cancer (HBOC) guidelines across Europe.
Marmolejo DH, Wong MYZ, Bajalica-Lagercrantz S, Tischkowitz M, Balmaña J; extended ERN-GENTURIS Thematic Group 3
Eur J Med Genet 2021 Dec;64(12):104350. Epub 2021 Oct 1 doi: 10.1016/j.ejmg.2021.104350. PMID: 34606975
Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications.
Zeng X, Liu C, Yao J, Wan H, Wan G, Li Y, Chen N
Pharmacol Res 2021 Jan;163:105320. Epub 2020 Dec 1 doi: 10.1016/j.phrs.2020.105320. PMID: 33271295
Molecular Testing in Breast Cancer.
Litton JK, Burstein HJ, Turner NC
Am Soc Clin Oncol Educ Book 2019 Jan;39:e1-e7. Epub 2019 May 17 doi: 10.1200/EDBK_237715. PMID: 31099622
Contrast-enhanced MRI for breast cancer screening.
Mann RM, Kuhl CK, Moy L
J Magn Reson Imaging 2019 Aug;50(2):377-390. Epub 2019 Jan 18 doi: 10.1002/jmri.26654. PMID: 30659696Free PMC Article

Recent systematic reviews

BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.
Lee YC, Lee YL, Li CY
Medicina (Kaunas) 2021 Aug 30;57(9) doi: 10.3390/medicina57090905. PMID: 34577828Free PMC Article
Hormone replacement therapy in BRCA mutation carriers and risk of ovarian, endometrial, and breast cancer: a systematic review.
Huber D, Seitz S, Kast K, Emons G, Ortmann O
J Cancer Res Clin Oncol 2021 Jul;147(7):2035-2045. Epub 2021 Apr 22 doi: 10.1007/s00432-021-03629-z. PMID: 33885953Free PMC Article
A new paradigm of genetic testing for hereditary breast/ovarian cancers.
Kwong A, Chen JW, Shin VY
Hong Kong Med J 2016 Apr;22(2):171-7. Epub 2016 Mar 14 doi: 10.12809/hkmj154634. PMID: 26980575
BRCA1 and BRCA2 germline mutation spectrum in hereditary breast/ovarian cancer families from Maghrebian countries.
Cherbal F, Bakour R, Adane S, Boualga K
Breast Dis 2012;34(1):1-8. doi: 10.3233/BD-130348. PMID: 23697973
Survivorship considerations in adults with hereditary breast and ovarian cancer syndrome: state of the science.
Crotser CB, Boehmke M
J Cancer Surviv 2009 Mar;3(1):21-42. Epub 2009 Jan 23 doi: 10.1007/s11764-008-0077-7. PMID: 19165605

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...