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Human papillomavirus-related squamous cell carcinoma

MedGen UID:
272726
•Concept ID:
C1334057
•
Neoplastic Process
Synonyms: HPV-Related Squamous Cell Carcinoma; HPV-related squamous cell carcinoma; Human Papilloma Virus Related Squamous Cell Carcinoma; human papilloma virus related squamous cell carcinoma; Human Papilloma Virus-Related Squamous Cell Carcinoma; human papilloma virus-related squamous cell carcinoma; Human Papillomavirus-Related Squamous Cell Carcinoma; human papillomavirus-related squamous cell carcinoma
 
Monarch Initiative: MONDO:0020657

Definition

A squamous cell carcinoma associated with the presence of human papillomavirus infection. [from NCI]

Professional guidelines

PubMed

De-Escalation Treatment for Human Papillomavirus-Related Oropharyngeal Cancer: Questions for Practical Consideration.
Chen AM
Oncology (Williston Park) 2023 Jul 21;37(7):281-287. doi: 10.46883/2023.25921000. PMID: 37499250
Transoral Robotic Surgery and De-escalation of Cancer Treatment.
Wahle B, Zevallos J
Otolaryngol Clin North Am 2020 Dec;53(6):981-994. Epub 2020 Sep 8 doi: 10.1016/j.otc.2020.07.009. PMID: 32917423Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360

Recent clinical studies

Etiology

Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656
Risk and Rate of Occult Contralateral Nodal Disease in Surgically Treated Patients With Human Papillomavirus-Related Squamous Cell Carcinoma of the Base of the Tongue.
Last AS, Pipkorn P, Chen S, Kallogjeri D, Zenga J, Rich JT, Paniello R, Zevallos J, Chernock R, Adkins D, Oppelt P, Gay H, Daly M, Thorstad W, Jackson RS
JAMA Otolaryngol Head Neck Surg 2020 Jan 1;146(1):50-56. doi: 10.1001/jamaoto.2019.3277. PMID: 31697348Free PMC Article
Human papillomavirus-related squamous cell carcinoma of the anal canal with papillary features.
Leon ME, Shamekh R, Coppola D
World J Gastroenterol 2015 Feb 21;21(7):2210-3. doi: 10.3748/wjg.v21.i7.2210. PMID: 25717259Free PMC Article
Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans.
Chernock RD, Zhang Q, El-Mofty SK, Thorstad WL, Lewis JS Jr
Arch Otolaryngol Head Neck Surg 2011 Feb;137(2):163-9. doi: 10.1001/archoto.2010.246. PMID: 21339403Free PMC Article
Detection of human papillomavirus-related squamous cell carcinoma cytologically and by in situ hybridization in fine-needle aspiration biopsies of cervical metastasis: a tool for identifying the site of an occult head and neck primary.
Zhang MQ, El-Mofty SK, Dávila RM
Cancer 2008 Apr 25;114(2):118-23. doi: 10.1002/cncr.23348. PMID: 18300234

Diagnosis

Monitoring Patients With Inflammatory Bowel Disease at High Risk of Anal Cancer.
Cairns CA, Cross RK, Khambaty M, Bafford AC
Am J Gastroenterol 2024 Jan 1;119(1):81-86. Epub 2023 Sep 18 doi: 10.14309/ajg.0000000000002503. PMID: 37721307
Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656
High-risk human papillomaviruses in two different primary tumors in the same patient.
de Oliveira Mota MT, Bonilha JL, Rosa BM, de Arruda JG, Soares FA, Vassallo J, Calmon MF, Rahal P
Int J Urol 2013 Oct;20(10):1046-8. Epub 2013 Jan 28 doi: 10.1111/iju.12096. PMID: 23350731
Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans.
Chernock RD, Zhang Q, El-Mofty SK, Thorstad WL, Lewis JS Jr
Arch Otolaryngol Head Neck Surg 2011 Feb;137(2):163-9. doi: 10.1001/archoto.2010.246. PMID: 21339403Free PMC Article
Detection of human papillomavirus-related squamous cell carcinoma cytologically and by in situ hybridization in fine-needle aspiration biopsies of cervical metastasis: a tool for identifying the site of an occult head and neck primary.
Zhang MQ, El-Mofty SK, Dávila RM
Cancer 2008 Apr 25;114(2):118-23. doi: 10.1002/cncr.23348. PMID: 18300234

Therapy

Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656

Prognosis

Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656
Detection of human papillomavirus-related squamous cell carcinoma cytologically and by in situ hybridization in fine-needle aspiration biopsies of cervical metastasis: a tool for identifying the site of an occult head and neck primary.
Zhang MQ, El-Mofty SK, Dávila RM
Cancer 2008 Apr 25;114(2):118-23. doi: 10.1002/cncr.23348. PMID: 18300234
Lower prevalence but favorable survival for human papillomavirus-related squamous cell carcinoma of tonsil in Taiwan.
Chien CY, Su CY, Fang FM, Huang HY, Chuang HC, Chen CM, Huang CC
Oral Oncol 2008 Feb;44(2):174-9. Epub 2007 Apr 5 doi: 10.1016/j.oraloncology.2007.01.018. PMID: 17418614

Clinical prediction guides

Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656
Human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and African Americans.
Chernock RD, Zhang Q, El-Mofty SK, Thorstad WL, Lewis JS Jr
Arch Otolaryngol Head Neck Surg 2011 Feb;137(2):163-9. doi: 10.1001/archoto.2010.246. PMID: 21339403Free PMC Article
Detection of human papillomavirus-related squamous cell carcinoma cytologically and by in situ hybridization in fine-needle aspiration biopsies of cervical metastasis: a tool for identifying the site of an occult head and neck primary.
Zhang MQ, El-Mofty SK, Dávila RM
Cancer 2008 Apr 25;114(2):118-23. doi: 10.1002/cncr.23348. PMID: 18300234

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