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Breast Ductal Carcinoma In Situ, Intermediate Grade

MedGen UID:
272759
Concept ID:
C1334206
Neoplastic Process
Synonyms: DCIS Grade 2; Ductal Intraepithelial Neoplasia, Grade 2; Intermediate Grade Ductal Breast Carcinoma In Situ; Intermediate-Grade DCIS; Intermediate-Grade Ductal Carcinoma In Situ of Breast

Definition

Breast ductal carcinoma in situ characterized by the presence of monomorphic neoplastic cells that form cribriform, micropapillary, or solid patterns. Intraluminal necrosis is present in some ducts. Ducts that contain neoplastic cells with occasional nucleoli and coarse chromatin may also be present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Ductal Carcinoma In Situ, Intermediate Grade

Professional guidelines

PubMed

Mills MN, Russo NW, Nanda RH, Wilson JP, Altoos TA, Caldwell DL, Stout LL, Dube S, Blumencranz PW, Allen KG, Diaz R
Brachytherapy 2021 Mar-Apr;20(2):345-352. Epub 2020 Dec 11 doi: 10.1016/j.brachy.2020.11.002. PMID: 33317964
Benson JR, Jatoi I, Toi M
Lancet Oncol 2016 Oct;17(10):e442-e451. doi: 10.1016/S1470-2045(16)30367-9. PMID: 27733270
Irvine T, Fentiman IS
Expert Rev Anticancer Ther 2007 Feb;7(2):135-45. doi: 10.1586/14737140.7.2.135. PMID: 17288525

Recent clinical studies

Etiology

McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Diagnosis

Vdovenko AA
Ann Diagn Pathol 2020 Dec;49:151605. Epub 2020 Sep 6 doi: 10.1016/j.anndiagpath.2020.151605. PMID: 32920473
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Dereere E, Papadimitriou K, Tjalma W, Altintas S
Minerva Chir 2015 Aug;70(4):231-9. Epub 2015 Apr 28 PMID: 25916193
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article
Bonnett M, Wallis T, Rossmann M, Pernick NL, Carolin KA, Segel M, Bouwman D, Visscher D
Mod Pathol 2002 Feb;15(2):95-101. doi: 10.1038/modpathol.3880497. PMID: 11850537

Therapy

McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Cambeiro M, Martinez-Regueira F, Rodriguez-Spiteri N, Olartecoechea B, Insausti LP, Elizalde A, Gastearena MI, Gallego JS, Santisteban M, Aramendía JM, Aristu JJ, Moreno LA, Moreno-Jiménez M, Valtueña G, Martínez-Monge R
Brachytherapy 2016 Jul-Aug;15(4):485-494. Epub 2016 Apr 26 doi: 10.1016/j.brachy.2016.03.001. PMID: 27129410
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article
Dereere E, Papadimitriou K, Tjalma W, Altintas S
Minerva Chir 2015 Aug;70(4):231-9. Epub 2015 Apr 28 PMID: 25916193
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Prognosis

Yu Y, Lajkosz K, Finelli A, Fleshner N, van der Kwast TH, Downes MR
Mod Pathol 2022 Nov;35(11):1695-1701. Epub 2022 Jun 8 doi: 10.1038/s41379-022-01111-w. PMID: 35676330
Vdovenko AA
Ann Diagn Pathol 2020 Dec;49:151605. Epub 2020 Sep 6 doi: 10.1016/j.anndiagpath.2020.151605. PMID: 32920473
Visscher DW, Yasir S
Endocr Pathol 2017 Jun;28(2):121-127. doi: 10.1007/s12022-017-9477-4. PMID: 28389994
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article
Dereere E, Papadimitriou K, Tjalma W, Altintas S
Minerva Chir 2015 Aug;70(4):231-9. Epub 2015 Apr 28 PMID: 25916193

Clinical prediction guides

McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Vdovenko AA
Ann Diagn Pathol 2020 Dec;49:151605. Epub 2020 Sep 6 doi: 10.1016/j.anndiagpath.2020.151605. PMID: 32920473
Alghamdi SA, Krishnamurthy K, Garces Narvaez SA, Algashaamy KJ, Aoun J, Reis IM, Recine MA, Jorda M, Poppiti RJ, Gomez-Fernandez CR
Am J Clin Pathol 2020 Feb 8;153(3):360-367. doi: 10.1093/ajcp/aqz179. PMID: 31769792
Dereere E, Papadimitriou K, Tjalma W, Altintas S
Minerva Chir 2015 Aug;70(4):231-9. Epub 2015 Apr 28 PMID: 25916193
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article

Recent systematic reviews

El Hage Chehade H, Headon H, Wazir U, Abtar H, Kasem A, Mokbel K
Am J Surg 2017 Jan;213(1):171-180. Epub 2016 Sep 6 doi: 10.1016/j.amjsurg.2016.04.019. PMID: 27773373

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