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Intermediate cell type choroid melanoma

MedGen UID:
272760
•Concept ID:
C1334208
•
Neoplastic Process
Synonyms: Choroid Intermediate Cell Type Melanoma; Intermediate Cell Type Choroid Melanoma; intermediate cell type choroid melanoma; intermediate cell type uveal melanoma of optic choroid; mixed cell melanoma of choroid; optic choroid intermediate cell type uveal melanoma
 
Monarch Initiative: MONDO:0004065

Definition

Choroid melanoma characterized by the presence of intermediate cells which are similar to but smaller than epithelioid cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntermediate cell type choroid melanoma

Recent clinical studies

Etiology

Adding the Cancer Genome Atlas Chromosome Classes to American Joint Committee on Cancer System Offers More Precise Prognostication in Uveal Melanoma.
Gelmi MC, Bas Z, Malkani K, Ganguly A, Shields CL, Jager MJ
Ophthalmology 2022 Apr;129(4):431-437. Epub 2021 Nov 16 doi: 10.1016/j.ophtha.2021.11.018. PMID: 34793831
Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma.
Cassoux N, Rodrigues MJ, Plancher C, Asselain B, Levy-Gabriel C, Lumbroso-Le Rouic L, Piperno-Neumann S, Dendale R, Sastre X, Desjardins L, Couturier J
Br J Ophthalmol 2014 Jun;98(6):769-74. Epub 2013 Oct 29 doi: 10.1136/bjophthalmol-2013-303867. PMID: 24169649Free PMC Article
Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category.
Augsburger JJ, Corrêa ZM, Schneider S, Yassin RS, Robinson-Smith T, Ehya H, Trichopoulos N
Trans Am Ophthalmol Soc 2002;100:225-32; discussion 232-4. PMID: 12545696Free PMC Article
Nucleolar organiser regions in iris melanocytic tumours: an accurate predictor?
Deuble K, McCartney A
Eye (Lond) 1990;4 ( Pt 5):743-50. doi: 10.1038/eye.1990.106. PMID: 1704315

Diagnosis

Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma.
Cassoux N, Rodrigues MJ, Plancher C, Asselain B, Levy-Gabriel C, Lumbroso-Le Rouic L, Piperno-Neumann S, Dendale R, Sastre X, Desjardins L, Couturier J
Br J Ophthalmol 2014 Jun;98(6):769-74. Epub 2013 Oct 29 doi: 10.1136/bjophthalmol-2013-303867. PMID: 24169649Free PMC Article
Microcirculation and tumor-infiltrating macrophages in choroidal and ciliary body melanoma and corresponding metastases.
Toivonen P, Mäkitie T, Kujala E, Kivelä T
Invest Ophthalmol Vis Sci 2004 Jan;45(1):1-6. doi: 10.1167/iovs.03-0622. PMID: 14691146
Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category.
Augsburger JJ, Corrêa ZM, Schneider S, Yassin RS, Robinson-Smith T, Ehya H, Trichopoulos N
Trans Am Ophthalmol Soc 2002;100:225-32; discussion 232-4. PMID: 12545696Free PMC Article
Choroidal schwannoma: immunohistochemical and electron-microscopic study.
Matsuo T, Notohara K
Ophthalmologica 2000;214(2):156-60. doi: 10.1159/000027488. PMID: 10720924
Nucleolar organiser regions in iris melanocytic tumours: an accurate predictor?
Deuble K, McCartney A
Eye (Lond) 1990;4 ( Pt 5):743-50. doi: 10.1038/eye.1990.106. PMID: 1704315

Therapy

Audiovestibular disorders as autoimmune reaction in patients with melanoma.
Barozzi S, Ginocchio D, Socci M, Alpini D, Cesarani A
Med Hypotheses 2015 Sep;85(3):336-8. Epub 2015 Jun 19 doi: 10.1016/j.mehy.2015.06.009. PMID: 26115944

Prognosis

Audiovestibular disorders as autoimmune reaction in patients with melanoma.
Barozzi S, Ginocchio D, Socci M, Alpini D, Cesarani A
Med Hypotheses 2015 Sep;85(3):336-8. Epub 2015 Jun 19 doi: 10.1016/j.mehy.2015.06.009. PMID: 26115944
Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma.
Cassoux N, Rodrigues MJ, Plancher C, Asselain B, Levy-Gabriel C, Lumbroso-Le Rouic L, Piperno-Neumann S, Dendale R, Sastre X, Desjardins L, Couturier J
Br J Ophthalmol 2014 Jun;98(6):769-74. Epub 2013 Oct 29 doi: 10.1136/bjophthalmol-2013-303867. PMID: 24169649Free PMC Article
Microcirculation and tumor-infiltrating macrophages in choroidal and ciliary body melanoma and corresponding metastases.
Toivonen P, Mäkitie T, Kujala E, Kivelä T
Invest Ophthalmol Vis Sci 2004 Jan;45(1):1-6. doi: 10.1167/iovs.03-0622. PMID: 14691146
Biologic determinants of uveal melanoma metastatic phenotype: role of intermediate filaments as predictive markers.
Hendrix MJ, Seftor EA, Seftor RE, Gardner LM, Boldt HC, Meyer M, Pe'er J, Folberg R
Lab Invest 1998 Feb;78(2):153-63. PMID: 9484713
Microcirculation architecture of melanocytic nevi and malignant melanomas of the ciliary body and choroid. A comparative histopathologic and ultrastructural study.
Rummelt V, Folberg R, Rummelt C, Gruman LM, Hwang T, Woolson RF, Yi H, Naumann GO
Ophthalmology 1994 Apr;101(4):718-27. doi: 10.1016/s0161-6420(94)31273-5. PMID: 8152768

Clinical prediction guides

Adding the Cancer Genome Atlas Chromosome Classes to American Joint Committee on Cancer System Offers More Precise Prognostication in Uveal Melanoma.
Gelmi MC, Bas Z, Malkani K, Ganguly A, Shields CL, Jager MJ
Ophthalmology 2022 Apr;129(4):431-437. Epub 2021 Nov 16 doi: 10.1016/j.ophtha.2021.11.018. PMID: 34793831
Microcirculation and tumor-infiltrating macrophages in choroidal and ciliary body melanoma and corresponding metastases.
Toivonen P, Mäkitie T, Kujala E, Kivelä T
Invest Ophthalmol Vis Sci 2004 Jan;45(1):1-6. doi: 10.1167/iovs.03-0622. PMID: 14691146
Effects of transpupillary thermotherapy on immunological parameters and apoptosis in a case of primary uveal melanoma.
Schurmans LR, Blom DJ, De Waard-Siebinga I, Keunen JE, Prause JU, Jager MJ
Melanoma Res 1999 Jun;9(3):297-302. doi: 10.1097/00008390-199906000-00012. PMID: 10465586
Structure, development and function of cytoskeletal elements in non-neuronal cells of the human eye.
Kivelä T, Uusitalo M
Prog Retin Eye Res 1998 Jul;17(3):385-428. doi: 10.1016/s1350-9462(98)00001-9. PMID: 9695798
Biologic determinants of uveal melanoma metastatic phenotype: role of intermediate filaments as predictive markers.
Hendrix MJ, Seftor EA, Seftor RE, Gardner LM, Boldt HC, Meyer M, Pe'er J, Folberg R
Lab Invest 1998 Feb;78(2):153-63. PMID: 9484713

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