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Intraepithelial Melanocytic Hyperplasia

MedGen UID:
272772
•Concept ID:
C1334256
•
Pathologic Function
Synonym: Benign Acquired Melanosis

Definition

A hyperplasia of the intraepithelial melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntraepithelial Melanocytic Hyperplasia

Recent clinical studies

Etiology

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Atypical cells on reflectance confocal microscopy may not represent melanoma: A case of axillary pigmented extramammary Paget disease.
Chuchvara N, Reilly C, Haroon A, Wassef C, Maghari A, Rao B
J Cutan Pathol 2020 Dec;47(12):1170-1174. Epub 2020 Sep 7 doi: 10.1111/cup.13804. PMID: 32643790
Conjunctival Primary Acquired Melanosis: Is It Time for a New Terminology?
Jakobiec FA
Am J Ophthalmol 2016 Feb;162:3-19.e1. Epub 2015 Nov 10 doi: 10.1016/j.ajo.2015.11.003. PMID: 26556007
Primary mucosal melanoma of the sinonasal tract: a clinicopathologic and immunohistochemical study of thirty-two cases.
Mochel MC, Duncan LM, Piris A, Kraft S
Head Neck Pathol 2015 Jun;9(2):236-43. Epub 2014 Oct 8 doi: 10.1007/s12105-014-0570-4. PMID: 25292260Free PMC Article
Malignant melanoma of the conjunctiva.
Jeffrey IJ, Lucas DR, McEwan C, Lee WR
Histopathology 1986 Apr;10(4):363-78. doi: 10.1111/j.1365-2559.1986.tb02490.x. PMID: 3710441

Diagnosis

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Assessment of Melanocyte Density in Anorectal Mucosa for the Evaluation of Surgical Margins in Primary Anorectal Melanoma.
Tse JY, Chan MP, Zukerberg LR, Nazarian RM
Am J Clin Pathol 2016 May;145(5):626-34. doi: 10.1093/ajcp/aqw047. PMID: 27247367
Conjunctival Primary Acquired Melanosis: Is It Time for a New Terminology?
Jakobiec FA
Am J Ophthalmol 2016 Feb;162:3-19.e1. Epub 2015 Nov 10 doi: 10.1016/j.ajo.2015.11.003. PMID: 26556007
Lipofuscin pigmentation (so-called "melanosis") of the prostate.
Brennick JB, O'Connell JX, Dickersin GR, Pilch BZ, Young RH
Am J Surg Pathol 1994 May;18(5):446-54. doi: 10.1097/00000478-199405000-00003. PMID: 7513501
Ideas in pathology. Malignant melanoma in situ: the evolution of a concept.
Dubow BE, Ackerman AB
Mod Pathol 1990 Nov;3(6):734-44. PMID: 2263599

Therapy

Depigmented genital extramammary Paget's disease: a possible histogenetic link to Toker's clear cells and clear cell papulosis.
Chen YH, Wong TW, Lee JY
J Cutan Pathol 2001 Feb;28(2):105-8. doi: 10.1034/j.1600-0560.2001.280208.x. PMID: 11168760

Prognosis

Conjunctival Melanocytic Lesions.
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Primary mucosal melanoma of the sinonasal tract: a clinicopathologic and immunohistochemical study of thirty-two cases.
Mochel MC, Duncan LM, Piris A, Kraft S
Head Neck Pathol 2015 Jun;9(2):236-43. Epub 2014 Oct 8 doi: 10.1007/s12105-014-0570-4. PMID: 25292260Free PMC Article
Pigmented squamous intraepithelial neoplasia of the esophagus.
Ishida M, Mochizuki Y, Iwai M, Yoshida K, Kagotani A, Okabe H
Int J Clin Exp Pathol 2013;6(9):1868-73. Epub 2013 Aug 15 PMID: 24040452Free PMC Article
Pigmented Paget disease--a diagnostic pitfall mimicking melanoma.
Petersson F, Ivan D, Kazakov DV, Michal M, Prieto VG
Am J Dermatopathol 2009 May;31(3):223-6. doi: 10.1097/DAD.0b013e3181930dc6. PMID: 19384061
Malignant melanoma of the conjunctiva.
Jeffrey IJ, Lucas DR, McEwan C, Lee WR
Histopathology 1986 Apr;10(4):363-78. doi: 10.1111/j.1365-2559.1986.tb02490.x. PMID: 3710441

Clinical prediction guides

Pigmented squamous intraepithelial neoplasia of the esophagus.
Ishida M, Mochizuki Y, Iwai M, Yoshida K, Kagotani A, Okabe H
Int J Clin Exp Pathol 2013;6(9):1868-73. Epub 2013 Aug 15 PMID: 24040452Free PMC Article
Pigmented Paget disease--a diagnostic pitfall mimicking melanoma.
Petersson F, Ivan D, Kazakov DV, Michal M, Prieto VG
Am J Dermatopathol 2009 May;31(3):223-6. doi: 10.1097/DAD.0b013e3181930dc6. PMID: 19384061
Depigmented genital extramammary Paget's disease: a possible histogenetic link to Toker's clear cells and clear cell papulosis.
Chen YH, Wong TW, Lee JY
J Cutan Pathol 2001 Feb;28(2):105-8. doi: 10.1034/j.1600-0560.2001.280208.x. PMID: 11168760

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