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Ionizing Radiation-Related Malignant Neoplasm

MedGen UID:
272777
•Concept ID:
C1334285
•
Neoplastic Process

Definition

A malignant neoplasm arising in an anatomic site exposed to ionizing radiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIonizing Radiation-Related Malignant Neoplasm

Professional guidelines

PubMed

LNT and cancer risk assessment: Its flawed foundations part 1: Radiation and leukemia: Where LNT began.
Calabrese EJ
Environ Res 2021 Jun;197:111025. Epub 2021 Mar 18 doi: 10.1016/j.envres.2021.111025. PMID: 33744270
The Muller-Neel dispute and the fate of cancer risk assessment.
Calabrese EJ
Environ Res 2020 Nov;190:109961. Epub 2020 Jul 23 doi: 10.1016/j.envres.2020.109961. PMID: 32810676
Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases.
Frey B, Rückert M, Deloch L, Rühle PF, Derer A, Fietkau R, Gaipl US
Immunol Rev 2017 Nov;280(1):231-248. doi: 10.1111/imr.12572. PMID: 29027224

Recent clinical studies

Etiology

Human Radiosensitivity and Radiosusceptibility: What Are the Differences?
El-Nachef L, Al-Choboq J, Restier-Verlet J, Granzotto A, Berthel E, Sonzogni L, Ferlazzo ML, Bouchet A, Leblond P, Combemale P, Pinson S, Bourguignon M, Foray N
Int J Mol Sci 2021 Jul 2;22(13) doi: 10.3390/ijms22137158. PMID: 34281212Free PMC Article
The downfall of the linear non-threshold model.
Suárez Fernández JP
Rev Esp Med Nucl Imagen Mol (Engl Ed) 2020 Sep-Oct;39(5):303-315. Epub 2020 Jul 18 doi: 10.1016/j.remn.2020.05.006. PMID: 32693978
Glaucomagenesis following ionizing radiation exposure.
Hamada N, Azizova TV, Little MP
Mutat Res Rev Mutat Res 2019 Jan-Mar;779:36-44. Epub 2019 Jan 8 doi: 10.1016/j.mrrev.2019.01.001. PMID: 31097150Free PMC Article
Potential Radiation-Related Effects on Radiologists.
Parikh JR, Geise RA, Bluth EI, Bender CE, Sze G, Jones AK; Human Resources Commission of the American College of Radiology
AJR Am J Roentgenol 2017 Mar;208(3):595-602. Epub 2016 Dec 22 doi: 10.2214/AJR.16.17212. PMID: 28004978
Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study.
Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de González A
Lancet 2012 Aug 4;380(9840):499-505. Epub 2012 Jun 7 doi: 10.1016/S0140-6736(12)60815-0. PMID: 22681860Free PMC Article

Diagnosis

Radiation-induced meningiomas.
Benjamin C, Shah JK, Kondziolka D
Handb Clin Neurol 2020;169:273-284. doi: 10.1016/B978-0-12-804280-9.00018-4. PMID: 32553295
Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands.
Meulepas JM, Ronckers CM, Smets AMJB, Nievelstein RAJ, Gradowska P, Lee C, Jahnen A, van Straten M, de Wit MY, Zonnenberg B, Klein WM, Merks JH, Visser O, van Leeuwen FE, Hauptmann M
J Natl Cancer Inst 2019 Mar 1;111(3):256-263. doi: 10.1093/jnci/djy104. PMID: 30020493Free PMC Article
30 years of the Chernobyl accident. Molecular genetic mechanisms of carcinogenesis of thyroid gland.
Tronko ND, Pushkarev VM
Tsitol Genet 2016 Nov-Dec;50(6):15-22. PMID: 30484597
Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study.
Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de González A
Lancet 2012 Aug 4;380(9840):499-505. Epub 2012 Jun 7 doi: 10.1016/S0140-6736(12)60815-0. PMID: 22681860Free PMC Article
Radiation-induced meningioma.
Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S
Neurosurg Focus 2008;24(5):E7. doi: 10.3171/FOC/2008/24/5/E7. PMID: 18447746

Therapy

Glaucomagenesis following ionizing radiation exposure.
Hamada N, Azizova TV, Little MP
Mutat Res Rev Mutat Res 2019 Jan-Mar;779:36-44. Epub 2019 Jan 8 doi: 10.1016/j.mrrev.2019.01.001. PMID: 31097150Free PMC Article
Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands.
Meulepas JM, Ronckers CM, Smets AMJB, Nievelstein RAJ, Gradowska P, Lee C, Jahnen A, van Straten M, de Wit MY, Zonnenberg B, Klein WM, Merks JH, Visser O, van Leeuwen FE, Hauptmann M
J Natl Cancer Inst 2019 Mar 1;111(3):256-263. doi: 10.1093/jnci/djy104. PMID: 30020493Free PMC Article
30 years of the Chernobyl accident. Molecular genetic mechanisms of carcinogenesis of thyroid gland.
Tronko ND, Pushkarev VM
Tsitol Genet 2016 Nov-Dec;50(6):15-22. PMID: 30484597
Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study.
Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de González A
Lancet 2012 Aug 4;380(9840):499-505. Epub 2012 Jun 7 doi: 10.1016/S0140-6736(12)60815-0. PMID: 22681860Free PMC Article
Radiation-induced meningioma.
Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S
Neurosurg Focus 2008;24(5):E7. doi: 10.3171/FOC/2008/24/5/E7. PMID: 18447746

Prognosis

Towards a New Concept of Low Dose.
Mothersill C, Rusin A, Seymour C
Health Phys 2019 Sep;117(3):330-336. doi: 10.1097/HP.0000000000001074. PMID: 31349357
Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands.
Meulepas JM, Ronckers CM, Smets AMJB, Nievelstein RAJ, Gradowska P, Lee C, Jahnen A, van Straten M, de Wit MY, Zonnenberg B, Klein WM, Merks JH, Visser O, van Leeuwen FE, Hauptmann M
J Natl Cancer Inst 2019 Mar 1;111(3):256-263. doi: 10.1093/jnci/djy104. PMID: 30020493Free PMC Article
Radiation-Induced Gliomas.
Aherne NJ, Murphy BM
Crit Rev Oncog 2018;23(1-2):113-118. doi: 10.1615/CritRevOncog.2018025740. PMID: 29953370
Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases.
Frey B, Rückert M, Deloch L, Rühle PF, Derer A, Fietkau R, Gaipl US
Immunol Rev 2017 Nov;280(1):231-248. doi: 10.1111/imr.12572. PMID: 29027224
Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study.
Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, Kim KP, Howe NL, Ronckers CM, Rajaraman P, Sir Craft AW, Parker L, Berrington de González A
Lancet 2012 Aug 4;380(9840):499-505. Epub 2012 Jun 7 doi: 10.1016/S0140-6736(12)60815-0. PMID: 22681860Free PMC Article

Clinical prediction guides

Human Radiosensitivity and Radiosusceptibility: What Are the Differences?
El-Nachef L, Al-Choboq J, Restier-Verlet J, Granzotto A, Berthel E, Sonzogni L, Ferlazzo ML, Bouchet A, Leblond P, Combemale P, Pinson S, Bourguignon M, Foray N
Int J Mol Sci 2021 Jul 2;22(13) doi: 10.3390/ijms22137158. PMID: 34281212Free PMC Article
Ionizing Radiation-Induced Epigenetic Modifications and Their Relevance to Radiation Protection.
Belli M, Tabocchini MA
Int J Mol Sci 2020 Aug 20;21(17) doi: 10.3390/ijms21175993. PMID: 32825382Free PMC Article
Towards a New Concept of Low Dose.
Mothersill C, Rusin A, Seymour C
Health Phys 2019 Sep;117(3):330-336. doi: 10.1097/HP.0000000000001074. PMID: 31349357
Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands.
Meulepas JM, Ronckers CM, Smets AMJB, Nievelstein RAJ, Gradowska P, Lee C, Jahnen A, van Straten M, de Wit MY, Zonnenberg B, Klein WM, Merks JH, Visser O, van Leeuwen FE, Hauptmann M
J Natl Cancer Inst 2019 Mar 1;111(3):256-263. doi: 10.1093/jnci/djy104. PMID: 30020493Free PMC Article
Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases.
Frey B, Rückert M, Deloch L, Rühle PF, Derer A, Fietkau R, Gaipl US
Immunol Rev 2017 Nov;280(1):231-248. doi: 10.1111/imr.12572. PMID: 29027224

Recent systematic reviews

Early life ionizing radiation exposure and cancer risks: systematic review and meta-analysis.
Abalo KD, Rage E, Leuraud K, Richardson DB, Le Pointe HD, Laurier D, Bernier MO
Pediatr Radiol 2021 Jan;51(1):45-56. Epub 2020 Sep 10 doi: 10.1007/s00247-020-04803-0. PMID: 32910229
Epidemiological Studies of Low-Dose Ionizing Radiation and Cancer: Summary Bias Assessment and Meta-Analysis.
Hauptmann M, Daniels RD, Cardis E, Cullings HM, Kendall G, Laurier D, Linet MS, Little MP, Lubin JH, Preston DL, Richardson DB, Stram DO, Thierry-Chef I, Schubauer-Berigan MK, Gilbert ES, Berrington de Gonzalez A
J Natl Cancer Inst Monogr 2020 Jul 1;2020(56):188-200. doi: 10.1093/jncimonographs/lgaa010. PMID: 32657347Free PMC Article
Prevention from radiation damage by natural products.
Fischer N, Seo EJ, Efferth T
Phytomedicine 2018 Aug 1;47:192-200. Epub 2017 Nov 13 doi: 10.1016/j.phymed.2017.11.005. PMID: 30166104
Comparative analyses of studies of childhood leukemia and magnetic fields, radon and gamma radiation.
Kheifets L, Swanson J, Yuan Y, Kusters C, Vergara X
J Radiol Prot 2017 Jun 26;37(2):459-491. Epub 2017 Jun 6 doi: 10.1088/1361-6498/aa5fc7. PMID: 28586320
Ionizing radiation and the risk of brain and central nervous system tumors: a systematic review.
Braganza MZ, Kitahara CM, Berrington de González A, Inskip PD, Johnson KJ, Rajaraman P
Neuro Oncol 2012 Nov;14(11):1316-24. Epub 2012 Sep 5 doi: 10.1093/neuonc/nos208. PMID: 22952197Free PMC Article

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