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Cancer Cell Growth

MedGen UID:
273061
•Concept ID:
C1516170
•
Neoplastic Process

Definition

The unregulated growth of cancer cells insofar as growth control and contact inhibition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCancer Cell Growth

Professional guidelines

PubMed

Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia.
Niu Y, Lin Z, Wan A, Sun L, Yan S, Liang H, Zhan S, Chen D, Bu X, Liu P, Chen C, He W, Lu X, Wan G
Hepatology 2021 Sep;74(3):1461-1479. doi: 10.1002/hep.31846. PMID: 33813748Free PMC Article
Repurposing quinacrine for treatment-refractory cancer.
Oien DB, Pathoulas CL, Ray U, Thirusangu P, Kalogera E, Shridhar V
Semin Cancer Biol 2021 Jan;68:21-30. Epub 2019 Sep 25 doi: 10.1016/j.semcancer.2019.09.021. PMID: 31562955
Role of Phytosterols in Cancer Prevention and Treatment.
Ramprasath VR, Awad AB
J AOAC Int 2015 May-Jun;98(3):735-738. doi: 10.5740/jaoacint.SGERamprasath. PMID: 26086253

Recent clinical studies

Etiology

A novel Cuproptosis-related LncRNA signature to predict prognosis in hepatocellular carcinoma.
Zhang G, Sun J, Zhang X
Sci Rep 2022 Jul 5;12(1):11325. doi: 10.1038/s41598-022-15251-1. PMID: 35790864Free PMC Article
Regulatory B cells in cancer.
Michaud D, Steward CR, Mirlekar B, Pylayeva-Gupta Y
Immunol Rev 2021 Jan;299(1):74-92. Epub 2020 Dec 23 doi: 10.1111/imr.12939. PMID: 33368346Free PMC Article
Methionine Restriction and Cancer Biology.
Wanders D, Hobson K, Ji X
Nutrients 2020 Mar 3;12(3) doi: 10.3390/nu12030684. PMID: 32138282Free PMC Article
Genistein: Its Role in Breast Cancer Growth and Metastasis.
Mukund V
Curr Drug Metab 2020;21(1):6-10. doi: 10.2174/1389200221666200120121919. PMID: 31987018
Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer.
Snaebjornsson MT, Janaki-Raman S, Schulze A
Cell Metab 2020 Jan 7;31(1):62-76. Epub 2019 Dec 5 doi: 10.1016/j.cmet.2019.11.010. PMID: 31813823

Diagnosis

Ferroptosis Inducers Are a Novel Therapeutic Approach for Advanced Prostate Cancer.
Ghoochani A, Hsu EC, Aslan M, Rice MA, Nguyen HM, Brooks JD, Corey E, Paulmurugan R, Stoyanova T
Cancer Res 2021 Mar 15;81(6):1583-1594. Epub 2021 Jan 22 doi: 10.1158/0008-5472.CAN-20-3477. PMID: 33483372Free PMC Article
Multifaceted role of branched-chain amino acid metabolism in cancer.
Peng H, Wang Y, Luo W
Oncogene 2020 Oct;39(44):6747-6756. Epub 2020 Sep 25 doi: 10.1038/s41388-020-01480-z. PMID: 32978521Free PMC Article
2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents.
Pajak B, Siwiak E, Sołtyka M, Priebe A, Zieliński R, Fokt I, Ziemniak M, Jaśkiewicz A, Borowski R, Domoradzki T, Priebe W
Int J Mol Sci 2019 Dec 29;21(1) doi: 10.3390/ijms21010234. PMID: 31905745Free PMC Article
TRPM2 in Cancer.
Miller BA
Cell Calcium 2019 Jun;80:8-17. Epub 2019 Mar 6 doi: 10.1016/j.ceca.2019.03.002. PMID: 30925291Free PMC Article
An Orthotopic Mouse Model of Spontaneous Breast Cancer Metastasis.
Paschall AV, Liu K
J Vis Exp 2016 Aug 14;(114) doi: 10.3791/54040. PMID: 27584043Free PMC Article

Therapy

Therapeutics Targeting p53-MDM2 Interaction to Induce Cancer Cell Death.
Koo N, Sharma AK, Narayan S
Int J Mol Sci 2022 Apr 30;23(9) doi: 10.3390/ijms23095005. PMID: 35563397Free PMC Article
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics.
Kanai Y
Pharmacol Ther 2022 Feb;230:107964. Epub 2021 Aug 12 doi: 10.1016/j.pharmthera.2021.107964. PMID: 34390745
Methionine Restriction and Cancer Biology.
Wanders D, Hobson K, Ji X
Nutrients 2020 Mar 3;12(3) doi: 10.3390/nu12030684. PMID: 32138282Free PMC Article
Everolimus inhibits breast cancer cell growth through PI3K/AKT/mTOR signaling pathway.
Du L, Li X, Zhen L, Chen W, Mu L, Zhang Y, Song A
Mol Med Rep 2018 May;17(5):7163-7169. Epub 2018 Mar 16 doi: 10.3892/mmr.2018.8769. PMID: 29568883Free PMC Article
The P2X7 Receptor in Infection and Inflammation.
Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S
Immunity 2017 Jul 18;47(1):15-31. doi: 10.1016/j.immuni.2017.06.020. PMID: 28723547

Prognosis

A novel Cuproptosis-related LncRNA signature to predict prognosis in hepatocellular carcinoma.
Zhang G, Sun J, Zhang X
Sci Rep 2022 Jul 5;12(1):11325. doi: 10.1038/s41598-022-15251-1. PMID: 35790864Free PMC Article
Metabolic reprogramming in cholangiocarcinoma.
Raggi C, Taddei ML, Rae C, Braconi C, Marra F
J Hepatol 2022 Sep;77(3):849-864. Epub 2022 May 18 doi: 10.1016/j.jhep.2022.04.038. PMID: 35594992
Immune Modulatory Properties of Collagen in Cancer.
Rømer AMA, Thorseth ML, Madsen DH
Front Immunol 2021;12:791453. Epub 2021 Dec 8 doi: 10.3389/fimmu.2021.791453. PMID: 34956223Free PMC Article
Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis.
Hu T, Liu H, Liang Z, Wang F, Zhou C, Zheng X, Zhang Y, Song Y, Hu J, He X, Xiao J, King RJ, Wu X, Lan P
Theranostics 2020;10(9):4056-4072. Epub 2020 Mar 4 doi: 10.7150/thno.40860. PMID: 32226539Free PMC Article
Lapatinib.
Voigtlaender M, Schneider-Merck T, Trepel M
Recent Results Cancer Res 2018;211:19-44. doi: 10.1007/978-3-319-91442-8_2. PMID: 30069757

Clinical prediction guides

A novel Cuproptosis-related LncRNA signature to predict prognosis in hepatocellular carcinoma.
Zhang G, Sun J, Zhang X
Sci Rep 2022 Jul 5;12(1):11325. doi: 10.1038/s41598-022-15251-1. PMID: 35790864Free PMC Article
The role of ubiquitination and deubiquitination in cancer metabolism.
Sun T, Liu Z, Yang Q
Mol Cancer 2020 Oct 1;19(1):146. doi: 10.1186/s12943-020-01262-x. PMID: 33004065Free PMC Article
Genistein: Its Role in Breast Cancer Growth and Metastasis.
Mukund V
Curr Drug Metab 2020;21(1):6-10. doi: 10.2174/1389200221666200120121919. PMID: 31987018
Everolimus inhibits breast cancer cell growth through PI3K/AKT/mTOR signaling pathway.
Du L, Li X, Zhen L, Chen W, Mu L, Zhang Y, Song A
Mol Med Rep 2018 May;17(5):7163-7169. Epub 2018 Mar 16 doi: 10.3892/mmr.2018.8769. PMID: 29568883Free PMC Article
Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.
Li Z, Zhang H
Cell Mol Life Sci 2016 Jan;73(2):377-92. Epub 2015 Oct 23 doi: 10.1007/s00018-015-2070-4. PMID: 26499846

Recent systematic reviews

Molecular Mechanism of Tocotrienol-Mediated Anticancer Properties: A Systematic Review of the Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response.
Pang KL, Mai CW, Chin KY
Nutrients 2023 Apr 12;15(8) doi: 10.3390/nu15081854. PMID: 37111076Free PMC Article
Phytochemicals in Inhibition of Prostate Cancer: Evidence from Molecular Mechanisms Studies.
Hao Q, Wu Y, Vadgama JV, Wang P
Biomolecules 2022 Sep 16;12(9) doi: 10.3390/biom12091306. PMID: 36139145Free PMC Article
Adipocytokines and disease progression in endometrial cancer: a systematic review.
Ray I, Meira LB, Michael A, Ellis PE
Cancer Metastasis Rev 2022 Mar;41(1):211-242. Epub 2021 Dec 24 doi: 10.1007/s10555-021-10002-6. PMID: 34951691Free PMC Article
The serological responses to acute exercise in humans reduce cancer cell growth in vitro: A systematic review and meta-analysis.
Orange ST, Jordan AR, Saxton JM
Physiol Rep 2020 Nov;8(22):e14635. doi: 10.14814/phy2.14635. PMID: 33207085Free PMC Article
The role of perineural invasion in predicting survival in patients with primary operable colorectal cancer: A systematic review.
van Wyk HC, Going J, Horgan P, McMillan DC
Crit Rev Oncol Hematol 2017 Apr;112:11-20. Epub 2017 Feb 7 doi: 10.1016/j.critrevonc.2017.02.005. PMID: 28325252

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