U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cancer Cell Growth

MedGen UID:
273061
•Concept ID:
C1516170
•
Neoplastic Process

Definition

The unregulated growth of cancer cells insofar as growth control and contact inhibition. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCancer Cell Growth

Professional guidelines

PubMed

Emerging Role of Cancer-Associated Fibroblasts in Progression and Treatment of Hepatocellular Carcinoma.
Akkız H
Int J Mol Sci 2023 Feb 15;24(4) doi: 10.3390/ijms24043941. PMID: 36835352Free PMC Article
Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia.
Niu Y, Lin Z, Wan A, Sun L, Yan S, Liang H, Zhan S, Chen D, Bu X, Liu P, Chen C, He W, Lu X, Wan G
Hepatology 2021 Sep;74(3):1461-1479. doi: 10.1002/hep.31846. PMID: 33813748Free PMC Article
Repurposing quinacrine for treatment-refractory cancer.
Oien DB, Pathoulas CL, Ray U, Thirusangu P, Kalogera E, Shridhar V
Semin Cancer Biol 2021 Jan;68:21-30. Epub 2019 Sep 25 doi: 10.1016/j.semcancer.2019.09.021. PMID: 31562955

Recent clinical studies

Etiology

Regulatory B cells in cancer.
Michaud D, Steward CR, Mirlekar B, Pylayeva-Gupta Y
Immunol Rev 2021 Jan;299(1):74-92. Epub 2020 Dec 23 doi: 10.1111/imr.12939. PMID: 33368346Free PMC Article
Methionine Restriction and Cancer Biology.
Wanders D, Hobson K, Ji X
Nutrients 2020 Mar 3;12(3) doi: 10.3390/nu12030684. PMID: 32138282Free PMC Article
Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer.
Snaebjornsson MT, Janaki-Raman S, Schulze A
Cell Metab 2020 Jan 7;31(1):62-76. Epub 2019 Dec 5 doi: 10.1016/j.cmet.2019.11.010. PMID: 31813823
Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin.
Tsepaeva OV, Nemtarev AV, Abdullin TI, Grigor'eva LR, Kuznetsova EV, Akhmadishina RA, Ziganshina LE, Cong HH, Mironov VF
J Nat Prod 2017 Aug 25;80(8):2232-2239. Epub 2017 Aug 7 doi: 10.1021/acs.jnatprod.7b00105. PMID: 28782948
Targeting Nur77 translocation.
Zhang XK
Expert Opin Ther Targets 2007 Jan;11(1):69-79. doi: 10.1517/14728222.11.1.69. PMID: 17150035

Diagnosis

Multifaceted role of branched-chain amino acid metabolism in cancer.
Peng H, Wang Y, Luo W
Oncogene 2020 Oct;39(44):6747-6756. Epub 2020 Sep 25 doi: 10.1038/s41388-020-01480-z. PMID: 32978521Free PMC Article
2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents.
Pajak B, Siwiak E, Sołtyka M, Priebe A, Zieliński R, Fokt I, Ziemniak M, Jaśkiewicz A, Borowski R, Domoradzki T, Priebe W
Int J Mol Sci 2019 Dec 29;21(1) doi: 10.3390/ijms21010234. PMID: 31905745Free PMC Article
Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
Fedoriw A, Rajapurkar SR, O'Brien S, Gerhart SV, Mitchell LH, Adams ND, Rioux N, Lingaraj T, Ribich SA, Pappalardi MB, Shah N, Laraio J, Liu Y, Butticello M, Carpenter CL, Creasy C, Korenchuk S, McCabe MT, McHugh CF, Nagarajan R, Wagner C, Zappacosta F, Annan R, Concha NO, Thomas RA, Hart TK, Smith JJ, Copeland RA, Moyer MP, Campbell J, Stickland K, Mills J, Jacques-O'Hagan S, Allain C, Johnston D, Raimondi A, Porter Scott M, Waters N, Swinger K, Boriack-Sjodin A, Riera T, Shapiro G, Chesworth R, Prinjha RK, Kruger RG, Barbash O, Mohammad HP
Cancer Cell 2019 Jul 8;36(1):100-114.e25. Epub 2019 Jun 27 doi: 10.1016/j.ccell.2019.05.014. PMID: 31257072
TRPM2 in Cancer.
Miller BA
Cell Calcium 2019 Jun;80:8-17. Epub 2019 Mar 6 doi: 10.1016/j.ceca.2019.03.002. PMID: 30925291Free PMC Article
An Orthotopic Mouse Model of Spontaneous Breast Cancer Metastasis.
Paschall AV, Liu K
J Vis Exp 2016 Aug 14;(114) doi: 10.3791/54040. PMID: 27584043Free PMC Article

Therapy

Ozone Therapy for Breast Cancer: An Integrative Literature Review.
Li Y, Pu R
Integr Cancer Ther 2024 Jan-Dec;23:15347354241226667. doi: 10.1177/15347354241226667. PMID: 38258533Free PMC Article
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics.
Kanai Y
Pharmacol Ther 2022 Feb;230:107964. Epub 2021 Aug 12 doi: 10.1016/j.pharmthera.2021.107964. PMID: 34390745
The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress-Mediated Apoptosis in Pancreatic Cancer.
Samanta S, Yang S, Debnath B, Xue D, Kuang Y, Ramkumar K, Lee AS, Ljungman M, Neamati N
Cancer Res 2021 Apr 1;81(7):1883-1895. Epub 2021 Feb 2 doi: 10.1158/0008-5472.CAN-20-1540. PMID: 33531374Free PMC Article
Methionine Restriction and Cancer Biology.
Wanders D, Hobson K, Ji X
Nutrients 2020 Mar 3;12(3) doi: 10.3390/nu12030684. PMID: 32138282Free PMC Article
The P2X7 Receptor in Infection and Inflammation.
Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S
Immunity 2017 Jul 18;47(1):15-31. doi: 10.1016/j.immuni.2017.06.020. PMID: 28723547

Prognosis

UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis.
Gan Y, Deng J, Hao Q, Huang Y, Han T, Xu JG, Zhao M, Yao L, Xu Y, Xiong J, Lu H, Wang C, Chen J, Zhou X
Redox Biol 2023 Jun;62:102705. Epub 2023 Apr 17 doi: 10.1016/j.redox.2023.102705. PMID: 37087976Free PMC Article
Metabolic reprogramming in cholangiocarcinoma.
Raggi C, Taddei ML, Rae C, Braconi C, Marra F
J Hepatol 2022 Sep;77(3):849-864. Epub 2022 May 18 doi: 10.1016/j.jhep.2022.04.038. PMID: 35594992
Immune Modulatory Properties of Collagen in Cancer.
Rømer AMA, Thorseth ML, Madsen DH
Front Immunol 2021;12:791453. Epub 2021 Dec 8 doi: 10.3389/fimmu.2021.791453. PMID: 34956223Free PMC Article
Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis.
Hu T, Liu H, Liang Z, Wang F, Zhou C, Zheng X, Zhang Y, Song Y, Hu J, He X, Xiao J, King RJ, Wu X, Lan P
Theranostics 2020;10(9):4056-4072. Epub 2020 Mar 4 doi: 10.7150/thno.40860. PMID: 32226539Free PMC Article
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.
Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E, Massagué J
Cell 2017 Mar 9;168(6):1101-1113.e13. doi: 10.1016/j.cell.2017.02.025. PMID: 28283064Free PMC Article

Clinical prediction guides

The function of LncRNA-ATB in cancer.
Anbiyaiee A, Ramazii M, Bajestani SS, Meybodi SM, Keivan M, Khoshnam SE, Farzaneh M
Clin Transl Oncol 2023 Jan;25(1):1-9. Epub 2022 May 21 doi: 10.1007/s12094-022-02848-1. PMID: 35597865
Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin.
Tang Z, Jiang W, Mao M, Zhao J, Chen J, Cheng N
Clin Transl Med 2021 Apr;11(4):e390. doi: 10.1002/ctm2.390. PMID: 33931967Free PMC Article
The role of ubiquitination and deubiquitination in cancer metabolism.
Sun T, Liu Z, Yang Q
Mol Cancer 2020 Oct 1;19(1):146. doi: 10.1186/s12943-020-01262-x. PMID: 33004065Free PMC Article
Genistein: Its Role in Breast Cancer Growth and Metastasis.
Mukund V
Curr Drug Metab 2020;21(1):6-10. doi: 10.2174/1389200221666200120121919. PMID: 31987018
Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.
Li Z, Zhang H
Cell Mol Life Sci 2016 Jan;73(2):377-92. Epub 2015 Oct 23 doi: 10.1007/s00018-015-2070-4. PMID: 26499846Free PMC Article

Recent systematic reviews

MicroRNAs role in telomere length maintenance and telomerase activity in tumor cells.
Bortoletto S, Nunes-Souza E, Marchi R, Ruthes MO, Okano LM, Tofolo MV, Centa A, Fonseca AS, Rosolen D, Cavalli LR
J Mol Med (Berl) 2024 Sep;102(9):1089-1100. Epub 2024 Jul 23 doi: 10.1007/s00109-024-02467-z. PMID: 39042290
Molecular Mechanism of Tocotrienol-Mediated Anticancer Properties: A Systematic Review of the Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response.
Pang KL, Mai CW, Chin KY
Nutrients 2023 Apr 12;15(8) doi: 10.3390/nu15081854. PMID: 37111076Free PMC Article
Phytochemicals in Inhibition of Prostate Cancer: Evidence from Molecular Mechanisms Studies.
Hao Q, Wu Y, Vadgama JV, Wang P
Biomolecules 2022 Sep 16;12(9) doi: 10.3390/biom12091306. PMID: 36139145Free PMC Article
Adipocytokines and disease progression in endometrial cancer: a systematic review.
Ray I, Meira LB, Michael A, Ellis PE
Cancer Metastasis Rev 2022 Mar;41(1):211-242. Epub 2021 Dec 24 doi: 10.1007/s10555-021-10002-6. PMID: 34951691Free PMC Article
The serological responses to acute exercise in humans reduce cancer cell growth in vitro: A systematic review and meta-analysis.
Orange ST, Jordan AR, Saxton JM
Physiol Rep 2020 Nov;8(22):e14635. doi: 10.14814/phy2.14635. PMID: 33207085Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...