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Gain of Chromosome 1

MedGen UID:
273356
•Concept ID:
C1517379
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 1

Professional guidelines

PubMed

Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
Lai D, Wetherill L, Bertelsen S, Carey CE, Kamarajan C, Kapoor M, Meyers JL, Anokhin AP, Bennett DA, Bucholz KK, Chang KK, De Jager PL, Dick DM, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI Jr, Raj T, Schuckit M, Scott DM, Taylor RE, Tischfield J, Hariri AR, Edenberg HJ, Agrawal A, Bogdan R, Porjesz B, Goate AM, Foroud T
Genes Brain Behav 2019 Jul;18(6):e12579. Epub 2019 Jun 4 doi: 10.1111/gbb.12579. PMID: 31090166Free PMC Article
Baseline characteristics, chromosomal alterations, and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma.
Merz M, Hielscher T, Seckinger A, Hose D, Mai EK, Raab MS, Goldschmidt H, Jauch A, Hillengass J
Am J Hematol 2016 Nov;91(11):E473-E477. Epub 2016 Sep 3 doi: 10.1002/ajh.24533. PMID: 27508939
Microdissection genotyping analysis of the effect of intraarterial cytoreductive chemotherapy in the treatment of lacrimal gland adenoid cystic carcinoma.
Tse DT, Finkelstein SD, Benedetto P, Dubovy S, Schiffman J, Feuer WJ
Am J Ophthalmol 2006 Jan;141(1):54-61. doi: 10.1016/j.ajo.2005.09.002. PMID: 16386976

Recent clinical studies

Etiology

Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells.
D'Agostino M, Rota-Scalabrini D, Belotti A, Bertamini L, Arigoni M, De Sabbata G, Pietrantuono G, Pascarella A, Tosi P, Pisani F, Pescosta N, Ruggeri M, Rogers J, Olivero M, Garzia M, Galieni P, Annibali O, Monaco F, Liberati AM, Palmieri S, Stefanoni P, Zamagni E, Bruno B, Calogero RA, Boccadoro M, Musto P, Gay F
Blood Cancer J 2024 Jun 7;14(1):94. doi: 10.1038/s41408-024-01075-x. PMID: 38849344Free PMC Article
Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article
Pathogenesis, clinical characteristics and personalized managements of multiple myeloma with chromosome 1 abnormalities.
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
PCSK9: a key modulator of cardiovascular health.
Seidah NG, Awan Z, Chrétien M, Mbikay M
Circ Res 2014 Mar 14;114(6):1022-36. doi: 10.1161/CIRCRESAHA.114.301621. PMID: 24625727

Diagnosis

Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells.
D'Agostino M, Rota-Scalabrini D, Belotti A, Bertamini L, Arigoni M, De Sabbata G, Pietrantuono G, Pascarella A, Tosi P, Pisani F, Pescosta N, Ruggeri M, Rogers J, Olivero M, Garzia M, Galieni P, Annibali O, Monaco F, Liberati AM, Palmieri S, Stefanoni P, Zamagni E, Bruno B, Calogero RA, Boccadoro M, Musto P, Gay F
Blood Cancer J 2024 Jun 7;14(1):94. doi: 10.1038/s41408-024-01075-x. PMID: 38849344Free PMC Article
Pathogenesis, clinical characteristics and personalized managements of multiple myeloma with chromosome 1 abnormalities.
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
Evaluation of chromosome 1q gain in intracranial ependymomas.
Rajeshwari M, Sharma MC, Kakkar A, Nambirajan A, Suri V, Sarkar C, Singh M, Saran RK, Gupta RK
J Neurooncol 2016 Apr;127(2):271-8. Epub 2016 Jan 2 doi: 10.1007/s11060-015-2047-z. PMID: 26725097
Cytogenetics of melanoma and nonmelanoma skin cancer.
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365

Therapy

Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells.
D'Agostino M, Rota-Scalabrini D, Belotti A, Bertamini L, Arigoni M, De Sabbata G, Pietrantuono G, Pascarella A, Tosi P, Pisani F, Pescosta N, Ruggeri M, Rogers J, Olivero M, Garzia M, Galieni P, Annibali O, Monaco F, Liberati AM, Palmieri S, Stefanoni P, Zamagni E, Bruno B, Calogero RA, Boccadoro M, Musto P, Gay F
Blood Cancer J 2024 Jun 7;14(1):94. doi: 10.1038/s41408-024-01075-x. PMID: 38849344Free PMC Article
Efficacy of daratumumab in newly diagnosed multiple myeloma patients with 1q21 gain.
Iriuchishima H, Saito A, Mihara M, Terasaki Y, Matsumoto A, Isoda A, Furukawa Y, Matsumoto M
Int J Hematol 2024 Jul;120(1):71-79. Epub 2024 Mar 29 doi: 10.1007/s12185-024-03760-w. PMID: 38551778
Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article
Filanesib plus bortezomib and dexamethasone in relapsed/refractory t(11;14) and 1q21 gain multiple myeloma.
Pan D, Kaufman JL, Htut M, Agrawal M, Mazumder A, Cornell RF, Zonder JA, Fay JW, Modiano MR, Moshier EL, Rush SA, Tunquist BJ, Chari A
Cancer Med 2022 Jan;11(2):358-370. Epub 2021 Dec 17 doi: 10.1002/cam4.4451. PMID: 34921527Free PMC Article
PCSK9: a key modulator of cardiovascular health.
Seidah NG, Awan Z, Chrétien M, Mbikay M
Circ Res 2014 Mar 14;114(6):1022-36. doi: 10.1161/CIRCRESAHA.114.301621. PMID: 24625727

Prognosis

Proteogenomic characterization of skull-base chordoma.
Zhang Q, Xu Z, Han R, Wang Y, Ye Z, Zhu J, Cai Y, Zhang F, Zhao J, Yao B, Qin Z, Qiao N, Huang R, Feng J, Wang Y, Rui W, He F, Zhao Y, Ding C
Nat Commun 2024 Sep 27;15(1):8338. doi: 10.1038/s41467-024-52285-7. PMID: 39333076Free PMC Article
Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells.
D'Agostino M, Rota-Scalabrini D, Belotti A, Bertamini L, Arigoni M, De Sabbata G, Pietrantuono G, Pascarella A, Tosi P, Pisani F, Pescosta N, Ruggeri M, Rogers J, Olivero M, Garzia M, Galieni P, Annibali O, Monaco F, Liberati AM, Palmieri S, Stefanoni P, Zamagni E, Bruno B, Calogero RA, Boccadoro M, Musto P, Gay F
Blood Cancer J 2024 Jun 7;14(1):94. doi: 10.1038/s41408-024-01075-x. PMID: 38849344Free PMC Article
Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article
Pathogenesis, clinical characteristics and personalized managements of multiple myeloma with chromosome 1 abnormalities.
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article

Clinical prediction guides

Proteogenomic characterization of skull-base chordoma.
Zhang Q, Xu Z, Han R, Wang Y, Ye Z, Zhu J, Cai Y, Zhang F, Zhao J, Yao B, Qin Z, Qiao N, Huang R, Feng J, Wang Y, Rui W, He F, Zhao Y, Ding C
Nat Commun 2024 Sep 27;15(1):8338. doi: 10.1038/s41467-024-52285-7. PMID: 39333076Free PMC Article
Additional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells.
D'Agostino M, Rota-Scalabrini D, Belotti A, Bertamini L, Arigoni M, De Sabbata G, Pietrantuono G, Pascarella A, Tosi P, Pisani F, Pescosta N, Ruggeri M, Rogers J, Olivero M, Garzia M, Galieni P, Annibali O, Monaco F, Liberati AM, Palmieri S, Stefanoni P, Zamagni E, Bruno B, Calogero RA, Boccadoro M, Musto P, Gay F
Blood Cancer J 2024 Jun 7;14(1):94. doi: 10.1038/s41408-024-01075-x. PMID: 38849344Free PMC Article
Fluorescence in situ hybridization reveals the evolutionary biology of minor clone of gain/amp(1q) in multiple myeloma.
Cui J, Liu Y, Lv R, Yan W, Xu J, Li L, Du C, Yu T, Zhang S, Deng S, Sui W, Hao M, Yi S, Zou D, Qiu L, Xu Y, An G
Leukemia 2024 Jun;38(6):1299-1306. Epub 2024 Apr 12 doi: 10.1038/s41375-024-02237-3. PMID: 38609496Free PMC Article
Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics.
Johann PD, Altendorf L, Efremova EM, Holsten T, Steinbügl M, Nemes K, Eckhardt A, Kresbach C, Bockmayr M, Koch A, Haberler C, Antonelli M, DeSisto J, Schuhmann MU, Hauser P, Siebert R, Bens S, Kool M, Green AL, Hasselblatt M, Frühwald MC, Schüller U
Acta Neuropathol 2023 Sep;146(3):527-541. Epub 2023 Jul 14 doi: 10.1007/s00401-023-02608-7. PMID: 37450044Free PMC Article
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article

Recent systematic reviews

Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article

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