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Gain of Chromosome 1

MedGen UID:
273356
•Concept ID:
C1517379
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 1

Professional guidelines

PubMed

Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
Lai D, Wetherill L, Bertelsen S, Carey CE, Kamarajan C, Kapoor M, Meyers JL, Anokhin AP, Bennett DA, Bucholz KK, Chang KK, De Jager PL, Dick DM, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI Jr, Raj T, Schuckit M, Scott DM, Taylor RE, Tischfield J, Hariri AR, Edenberg HJ, Agrawal A, Bogdan R, Porjesz B, Goate AM, Foroud T
Genes Brain Behav 2019 Jul;18(6):e12579. Epub 2019 Jun 4 doi: 10.1111/gbb.12579. PMID: 31090166Free PMC Article
Baseline characteristics, chromosomal alterations, and treatment affecting prognosis of deletion 17p in newly diagnosed myeloma.
Merz M, Hielscher T, Seckinger A, Hose D, Mai EK, Raab MS, Goldschmidt H, Jauch A, Hillengass J
Am J Hematol 2016 Nov;91(11):E473-E477. Epub 2016 Sep 3 doi: 10.1002/ajh.24533. PMID: 27508939
Evaluation of genetic heterogeneity in neuroblastoma.
Tajiri T, Shono K, Tanaka S, Suita S
Surgery 2002 Jan;131(1 Suppl):S283-7. doi: 10.1067/msy.2002.119964. PMID: 11821825

Recent clinical studies

Etiology

Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article
Pathogenesis, clinical characteristics and personalized managements of multiple myeloma with chromosome 1 abnormalities.
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
Concomitant deletion of the short arm (del(1p13.3)) and amplification or gain (1q21) of chromosome 1 by fluorescence in situ hybridization are associated with a poor clinical outcome in multiple myeloma.
Mohan M, Gong Z, Ashby TC, Al Hadidi S, Thanendrarajan S, Schinke C, Alapat D, Shaughnessy JD Jr, Zhan F, van Rhee F, Sawyer JR, Tian E, Zangari M
Cancer 2023 Aug 15;129(16):2491-2498. Epub 2023 Jun 6 doi: 10.1002/cncr.34895. PMID: 37282609
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
PCSK9: a key modulator of cardiovascular health.
Seidah NG, Awan Z, Chrétien M, Mbikay M
Circ Res 2014 Mar 14;114(6):1022-36. doi: 10.1161/CIRCRESAHA.114.301621. PMID: 24625727

Diagnosis

Pathogenesis, clinical characteristics and personalized managements of multiple myeloma with chromosome 1 abnormalities.
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
Prognostic significance of acquired 1q22 gain in multiple myeloma.
Audil HY, Cook JM, Greipp PT, Kapoor P, Baughn LB, Dispenzieri A, Gertz MA, Buadi FK, Lacy MQ, Dingli D, Fonder AL, Hayman SR, Hobbs MA, Muchtar E, Siddiqui M, Gonsalves WI, Hwa YL, Leung N, Lin Y, Kourelis TV, Warsame R, Kyle RA, Ketterling RP, Rajkumar SV, Kumar SK
Am J Hematol 2022 Jan 1;97(1):52-59. Epub 2021 Nov 3 doi: 10.1002/ajh.26391. PMID: 34710241
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
Evaluation of chromosome 1q gain in intracranial ependymomas.
Rajeshwari M, Sharma MC, Kakkar A, Nambirajan A, Suri V, Sarkar C, Singh M, Saran RK, Gupta RK
J Neurooncol 2016 Apr;127(2):271-8. Epub 2016 Jan 2 doi: 10.1007/s11060-015-2047-z. PMID: 26725097
Cytogenetics of melanoma and nonmelanoma skin cancer.
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365

Therapy

Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article
Filanesib plus bortezomib and dexamethasone in relapsed/refractory t(11;14) and 1q21 gain multiple myeloma.
Pan D, Kaufman JL, Htut M, Agrawal M, Mazumder A, Cornell RF, Zonder JA, Fay JW, Modiano MR, Moshier EL, Rush SA, Tunquist BJ, Chari A
Cancer Med 2022 Jan;11(2):358-370. Epub 2021 Dec 17 doi: 10.1002/cam4.4451. PMID: 34921527Free PMC Article
Prognostic significance of acquired 1q22 gain in multiple myeloma.
Audil HY, Cook JM, Greipp PT, Kapoor P, Baughn LB, Dispenzieri A, Gertz MA, Buadi FK, Lacy MQ, Dingli D, Fonder AL, Hayman SR, Hobbs MA, Muchtar E, Siddiqui M, Gonsalves WI, Hwa YL, Leung N, Lin Y, Kourelis TV, Warsame R, Kyle RA, Ketterling RP, Rajkumar SV, Kumar SK
Am J Hematol 2022 Jan 1;97(1):52-59. Epub 2021 Nov 3 doi: 10.1002/ajh.26391. PMID: 34710241
PCSK9: a key modulator of cardiovascular health.
Seidah NG, Awan Z, Chrétien M, Mbikay M
Circ Res 2014 Mar 14;114(6):1022-36. doi: 10.1161/CIRCRESAHA.114.301621. PMID: 24625727
Gain of 1q is a marker of poor prognosis in Wilms' tumors.
Segers H, van den Heuvel-Eibrink MM, Williams RD, van Tinteren H, Vujanic G, Pieters R, Pritchard-Jones K, Bown N; Children's Cancer and Leukaemia Group and the UK Cancer Cytogenetics Group
Genes Chromosomes Cancer 2013 Nov;52(11):1065-74. Epub 2013 Sep 4 doi: 10.1002/gcc.22101. PMID: 24038759

Prognosis

Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article
Pathogenesis, clinical characteristics and personalized managements of multiple myeloma with chromosome 1 abnormalities.
Zhou P, Li W, Zuo S, Ma R, Yuan X, Zhu Z
Leuk Lymphoma 2023 Jul-Aug;64(8):1373-1388. Epub 2023 Jun 10 doi: 10.1080/10428194.2023.2216325. PMID: 37300424
Concomitant deletion of the short arm (del(1p13.3)) and amplification or gain (1q21) of chromosome 1 by fluorescence in situ hybridization are associated with a poor clinical outcome in multiple myeloma.
Mohan M, Gong Z, Ashby TC, Al Hadidi S, Thanendrarajan S, Schinke C, Alapat D, Shaughnessy JD Jr, Zhan F, van Rhee F, Sawyer JR, Tian E, Zangari M
Cancer 2023 Aug 15;129(16):2491-2498. Epub 2023 Jun 6 doi: 10.1002/cncr.34895. PMID: 37282609
The oligodendroglial histological features are not independently predictive of patient prognosis in lower-grade gliomas.
Pareira ES, Shibuya M, Ohara K, Nakagawa Y, Kanazawa T, Kamamoto D, Kato Y, Arai E, Aimono E, Yoshida K, Nishihara H, Kanai Y, Sasaki H
Brain Tumor Pathol 2022 Apr;39(2):79-87. Epub 2022 Mar 15 doi: 10.1007/s10014-022-00426-5. PMID: 35292862
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article

Clinical prediction guides

Concomitant deletion of the short arm (del(1p13.3)) and amplification or gain (1q21) of chromosome 1 by fluorescence in situ hybridization are associated with a poor clinical outcome in multiple myeloma.
Mohan M, Gong Z, Ashby TC, Al Hadidi S, Thanendrarajan S, Schinke C, Alapat D, Shaughnessy JD Jr, Zhan F, van Rhee F, Sawyer JR, Tian E, Zangari M
Cancer 2023 Aug 15;129(16):2491-2498. Epub 2023 Jun 6 doi: 10.1002/cncr.34895. PMID: 37282609
The oligodendroglial histological features are not independently predictive of patient prognosis in lower-grade gliomas.
Pareira ES, Shibuya M, Ohara K, Nakagawa Y, Kanazawa T, Kamamoto D, Kato Y, Arai E, Aimono E, Yoshida K, Nishihara H, Kanai Y, Sasaki H
Brain Tumor Pathol 2022 Apr;39(2):79-87. Epub 2022 Mar 15 doi: 10.1007/s10014-022-00426-5. PMID: 35292862
Chromosome 1q21 abnormalities in multiple myeloma.
Schmidt TM, Fonseca R, Usmani SZ
Blood Cancer J 2021 Apr 29;11(4):83. doi: 10.1038/s41408-021-00474-8. PMID: 33927196Free PMC Article
Gain of 1q is a marker of poor prognosis in Wilms' tumors.
Segers H, van den Heuvel-Eibrink MM, Williams RD, van Tinteren H, Vujanic G, Pieters R, Pritchard-Jones K, Bown N; Children's Cancer and Leukaemia Group and the UK Cancer Cytogenetics Group
Genes Chromosomes Cancer 2013 Nov;52(11):1065-74. Epub 2013 Sep 4 doi: 10.1002/gcc.22101. PMID: 24038759
Genomic profile of 320 uveal melanoma cases: chromosome 8p-loss and metastatic outcome.
Ewens KG, Kanetsky PA, Richards-Yutz J, Al-Dahmash S, De Luca MC, Bianciotto CG, Shields CL, Ganguly A
Invest Ophthalmol Vis Sci 2013 Aug 23;54(8):5721-9. doi: 10.1167/iovs.13-12195. PMID: 23821189

Recent systematic reviews

Alterations in chromosome 1q in multiple myeloma randomized clinical trials: a systematic review.
Neupane K, Fortuna GG, Dahal R, Schmidt T, Fonseca R, Chakraborty R, Koehn KA, Mohan M, Mian H, Costa LJ, Sborov D, Mohyuddin GR
Blood Cancer J 2024 Jan 25;14(1):20. doi: 10.1038/s41408-024-00985-0. PMID: 38272897Free PMC Article

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