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Gain of Chromosome 8

MedGen UID:
273367
•Concept ID:
C1517422
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that refers to the allelic gain of all or part of chromosome 8. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 8

Professional guidelines

PubMed

Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
Lai D, Wetherill L, Bertelsen S, Carey CE, Kamarajan C, Kapoor M, Meyers JL, Anokhin AP, Bennett DA, Bucholz KK, Chang KK, De Jager PL, Dick DM, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI Jr, Raj T, Schuckit M, Scott DM, Taylor RE, Tischfield J, Hariri AR, Edenberg HJ, Agrawal A, Bogdan R, Porjesz B, Goate AM, Foroud T
Genes Brain Behav 2019 Jul;18(6):e12579. Epub 2019 Jun 4 doi: 10.1111/gbb.12579. PMID: 31090166Free PMC Article
Application of a novel score test for genetic association incorporating gene-gene interaction suggests functionality for prostate cancer susceptibility regions.
Ciampa J, Yeager M, Jacobs K, Thun MJ, Gapstur S, Albanes D, Virtamo J, Weinstein SJ, Giovannucci E, Willett WC, Cancel-Tassin G, Cussenot O, Valeri A, Hunter D, Hoover R, Thomas G, Chanock S, Holmes C, Chatterjee N
Hum Hered 2011;72(3):182-93. Epub 2011 Nov 11 doi: 10.1159/000331222. PMID: 22086326Free PMC Article
Hidden chromosome 8 abnormalities detected by FISH in adult primary myelodysplastic syndromes.
Panani AD, Pappa V
In Vivo 2005 Nov-Dec;19(6):979-81. PMID: 16277010

Recent clinical studies

Etiology

DNA rare copy number alterations in Reinke's Edema.
Móz LES, Martins RHG, Lapa RML, Villacis RAR, Dos Reis PP, Rogatto SR
Braz J Otorhinolaryngol 2023 Mar-Apr;89(2):279-284. Epub 2022 Sep 22 doi: 10.1016/j.bjorl.2022.09.002. PMID: 36243603Free PMC Article
Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic.
Matuskova V, Hornackova P, Uhmannova R, Zlamalikova L, Liskova K, Uher M, Vlkova E
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Dec;164(4):401-409. Epub 2019 Sep 23 doi: 10.5507/bp.2019.037. PMID: 31544901
Genetic landscape of uveal melanoma.
Rodrigues MJ, Stern MH
J Fr Ophtalmol 2015 Jun;38(6):522-5. Epub 2015 May 11 doi: 10.1016/j.jfo.2015.04.004. PMID: 25976133
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas.
Seo AN, Yang JM, Kim H, Jheon S, Kim K, Lee CT, Jin Y, Yun S, Chung JH, Paik JH
Br J Cancer 2014 May 27;110(11):2688-99. Epub 2014 May 8 doi: 10.1038/bjc.2014.218. PMID: 24809777Free PMC Article
Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma.
Lu Y, Ryan SL, Elliott DJ, Bignell GR, Futreal PA, Ellison DW, Bailey S, Clifford SC
PLoS One 2009 Jul 7;4(7):e6159. doi: 10.1371/journal.pone.0006159. PMID: 19584924Free PMC Article

Diagnosis

Assessment of Y chromosome copy number alterations in non-neoplastic and neoplastic leukocytes of male dogs.
Mochizuki H, Estrada AJ, Boggess M
Vet J 2024 Apr;304:106088. Epub 2024 Feb 25 doi: 10.1016/j.tvjl.2024.106088. PMID: 38412887
Complex/cryptic EWSR1::FLI1/ERG Gene Fusions and 1q Jumping Translocation in Pediatric Ewing Sarcomas.
Zou YS, Morsberger L, Hardy M, Ghabrial J, Stinnett V, Murry JB, Long P, Kim A, Pratilas CA, Llosa NJ, Ladle BH, Lemberg KM, Levin AS, Morris CD, Haley L, Gocke CD, Gross JM
Genes (Basel) 2023 May 24;14(6) doi: 10.3390/genes14061139. PMID: 37372318Free PMC Article
Strong Expression and Amplification of IGF1R in Pleuropulmonary Blastomas.
Vokuhl C, de Leon-Escapini L, Leuschner I
Pediatr Dev Pathol 2017 Nov-Dec;20(6):475-481. Epub 2017 Apr 6 doi: 10.1177/1093526617700945. PMID: 28382840
Amplification of chromosome 8q21-qter associated with the acquired paclitaxel resistance of nasopharyngeal carcinoma cells.
Li W, You Y, Zhang X, Song Y, Xiang H, Peng X, Qin J, Tan G
Int J Clin Exp Pathol 2015;8(10):12346-56. Epub 2015 Oct 1 PMID: 26722421Free PMC Article
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas.
Seo AN, Yang JM, Kim H, Jheon S, Kim K, Lee CT, Jin Y, Yun S, Chung JH, Paik JH
Br J Cancer 2014 May 27;110(11):2688-99. Epub 2014 May 8 doi: 10.1038/bjc.2014.218. PMID: 24809777Free PMC Article

Therapy

Biomarkers of outcome to weekly paclitaxel in epithelial ovarian cancer.
Madariaga A, Garg S, Bruce JP, Thiryayi S, Mandilaras V, Rath P, Oza AM, Dhani NC, Cescon DW, Lee YC, Chen E, Wang L, Clarke B, Lheureux S
Gynecol Oncol 2020 Nov;159(2):539-545. Epub 2020 Sep 8 doi: 10.1016/j.ygyno.2020.08.032. PMID: 32912664
Therapy reduction in patients with Down syndrome and myeloid leukemia: the international ML-DS 2006 trial.
Uffmann M, Rasche M, Zimmermann M, von Neuhoff C, Creutzig U, Dworzak M, Scheffers L, Hasle H, Zwaan CM, Reinhardt D, Klusmann JH
Blood 2017 Jun 22;129(25):3314-3321. Epub 2017 Apr 11 doi: 10.1182/blood-2017-01-765057. PMID: 28400376
Genomic change of chromosome 8 predicts the response to taxane-based neoadjuvant chemotherapy in node-positive breast cancer.
Han S, Park K, Shin E, Kim HJ, Kim JY, Kim JY, Gwak G
Oncol Rep 2010 Jul;24(1):121-8. PMID: 20514452
MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer.
Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, Reiss M, Au JL, Haffty BG, Kang Y
Cancer Cell 2009 Jan 6;15(1):9-20. doi: 10.1016/j.ccr.2008.11.013. PMID: 19111877Free PMC Article
Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma.
Lindberg E, Persson A, Øra I, Mertens F, Englund E, Gisselsson D
Neuropathology 2007 Dec;27(6):556-60. doi: 10.1111/j.1440-1789.2007.00810.x. PMID: 18021376

Prognosis

Complex/cryptic EWSR1::FLI1/ERG Gene Fusions and 1q Jumping Translocation in Pediatric Ewing Sarcomas.
Zou YS, Morsberger L, Hardy M, Ghabrial J, Stinnett V, Murry JB, Long P, Kim A, Pratilas CA, Llosa NJ, Ladle BH, Lemberg KM, Levin AS, Morris CD, Haley L, Gocke CD, Gross JM
Genes (Basel) 2023 May 24;14(6) doi: 10.3390/genes14061139. PMID: 37372318Free PMC Article
Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology.
Larsson AT, Bhatia H, Calizo A, Pollard K, Zhang X, Conniff E, Tibbitts JF, Rono E, Cummins K, Osum SH, Williams KB, Crampton AL, Jubenville T, Schefer D, Yang K, Lyu Y, Pino JC, Bade J, Gross JM, Lisok A, Dehner CA, Chrisinger JSA, He K, Gosline SJC, Pratilas CA, Largaespada DA, Wood DK, Hirbe AC
Neuro Oncol 2023 Nov 2;25(11):2044-2057. doi: 10.1093/neuonc/noad097. PMID: 37246765Free PMC Article
Uveal melanoma - testing of abnormalities of chromosome 3 and 8 in the Czech Republic.
Matuskova V, Hornackova P, Uhmannova R, Zlamalikova L, Liskova K, Uher M, Vlkova E
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Dec;164(4):401-409. Epub 2019 Sep 23 doi: 10.5507/bp.2019.037. PMID: 31544901
Genetic landscape of uveal melanoma.
Rodrigues MJ, Stern MH
J Fr Ophtalmol 2015 Jun;38(6):522-5. Epub 2015 May 11 doi: 10.1016/j.jfo.2015.04.004. PMID: 25976133
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas.
Seo AN, Yang JM, Kim H, Jheon S, Kim K, Lee CT, Jin Y, Yun S, Chung JH, Paik JH
Br J Cancer 2014 May 27;110(11):2688-99. Epub 2014 May 8 doi: 10.1038/bjc.2014.218. PMID: 24809777Free PMC Article

Clinical prediction guides

Assessment of Y chromosome copy number alterations in non-neoplastic and neoplastic leukocytes of male dogs.
Mochizuki H, Estrada AJ, Boggess M
Vet J 2024 Apr;304:106088. Epub 2024 Feb 25 doi: 10.1016/j.tvjl.2024.106088. PMID: 38412887
Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology.
Larsson AT, Bhatia H, Calizo A, Pollard K, Zhang X, Conniff E, Tibbitts JF, Rono E, Cummins K, Osum SH, Williams KB, Crampton AL, Jubenville T, Schefer D, Yang K, Lyu Y, Pino JC, Bade J, Gross JM, Lisok A, Dehner CA, Chrisinger JSA, He K, Gosline SJC, Pratilas CA, Largaespada DA, Wood DK, Hirbe AC
Neuro Oncol 2023 Nov 2;25(11):2044-2057. doi: 10.1093/neuonc/noad097. PMID: 37246765Free PMC Article
Prognostication of uveal melanoma is simple and highly predictive using The Cancer Genome Atlas (TCGA) classification: A review.
Shields CL, Dalvin LA, Vichitvejpaisal P, Mazloumi M, Ganguly A, Shields JA
Indian J Ophthalmol 2019 Dec;67(12):1959-1963. doi: 10.4103/ijo.IJO_1589_19. PMID: 31755428Free PMC Article
Amplification of chromosome 8q21-qter associated with the acquired paclitaxel resistance of nasopharyngeal carcinoma cells.
Li W, You Y, Zhang X, Song Y, Xiang H, Peng X, Qin J, Tan G
Int J Clin Exp Pathol 2015;8(10):12346-56. Epub 2015 Oct 1 PMID: 26722421Free PMC Article
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas.
Seo AN, Yang JM, Kim H, Jheon S, Kim K, Lee CT, Jin Y, Yun S, Chung JH, Paik JH
Br J Cancer 2014 May 27;110(11):2688-99. Epub 2014 May 8 doi: 10.1038/bjc.2014.218. PMID: 24809777Free PMC Article

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