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ERBB2 Protein Overexpression

MedGen UID:
273698
•Concept ID:
C1515560
•
Cell or Molecular Dysfunction
Synonyms: HER2 Protein Overexpression; Proto-Oncogene Neu Protein Overexpression; Receptor Tyrosine-Protein Kinase erbB-2 Protein Overexpression; Tyrosine Kinase-Type Cell Surface Receptor HER2 Protein Overexpression

Definition

A molecular abnormality indicating the presence of an abnormally high level of the receptor tyrosine-protein kinase erbB-2 protein. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVERBB2 Protein Overexpression

Professional guidelines

PubMed

Diagnosis and Treatment of ERBB2-Positive Metastatic Colorectal Cancer: A Review.
Strickler JH, Yoshino T, Graham RP, Siena S, Bekaii-Saab T
JAMA Oncol 2022 May 1;8(5):760-769. doi: 10.1001/jamaoncol.2021.8196. PMID: 35238866
Trastuzumab in the Treatment of Breast Cancer.
Maximiano S, Magalhães P, Guerreiro MP, Morgado M
BioDrugs 2016 Apr;30(2):75-86. doi: 10.1007/s40259-016-0162-9. PMID: 26892619
Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013.
Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel members
Ann Oncol 2013 Sep;24(9):2206-23. Epub 2013 Aug 4 doi: 10.1093/annonc/mdt303. PMID: 23917950Free PMC Article

Recent clinical studies

Etiology

Anti-metastasis activity of black rice anthocyanins against breast cancer: analyses using an ErbB2 positive breast cancer cell line and tumoral xenograft model.
Luo LP, Han B, Yu XP, Chen XY, Zhou J, Chen W, Zhu YF, Peng XL, Zou Q, Li SY
Asian Pac J Cancer Prev 2014;15(15):6219-25. doi: 10.7314/apjcp.2014.15.15.6219. PMID: 25124601
ERBB2 amplification is superior to protein expression status in predicting patient outcome in serous ovarian carcinoma.
Lassus H, Leminen A, Vayrynen A, Cheng G, Gustafsson JA, Isola J, Butzow R
Gynecol Oncol 2004 Jan;92(1):31-9. doi: 10.1016/j.ygyno.2003.10.010. PMID: 14751135

Diagnosis

The Prognostic Effect of HER2 Gene Amplification in High-Grade Endometrial Carcinomas and its Correlation with Protein Overexpression.
Bozkurt KK, Çiriş İM, Başpınar Ş, Çetin B, Erdemoğlu E, Bircan S, Ertunç O
Int J Surg Pathol 2023 Jun;31(4):365-374. Epub 2022 May 25 doi: 10.1177/10668969221102529. PMID: 35611517
ERBB2 amplification is superior to protein expression status in predicting patient outcome in serous ovarian carcinoma.
Lassus H, Leminen A, Vayrynen A, Cheng G, Gustafsson JA, Isola J, Butzow R
Gynecol Oncol 2004 Jan;92(1):31-9. doi: 10.1016/j.ygyno.2003.10.010. PMID: 14751135
Identification and validation of an ERBB2 gene expression signature in breast cancers.
Bertucci F, Borie N, Ginestier C, Groulet A, Charafe-Jauffret E, Adélaïde J, Geneix J, Bachelart L, Finetti P, Koki A, Hermitte F, Hassoun J, Debono S, Viens P, Fert V, Jacquemier J, Birnbaum D
Oncogene 2004 Apr 1;23(14):2564-75. doi: 10.1038/sj.onc.1207361. PMID: 14743203

Therapy

Identification and validation of an ERBB2 gene expression signature in breast cancers.
Bertucci F, Borie N, Ginestier C, Groulet A, Charafe-Jauffret E, Adélaïde J, Geneix J, Bachelart L, Finetti P, Koki A, Hermitte F, Hassoun J, Debono S, Viens P, Fert V, Jacquemier J, Birnbaum D
Oncogene 2004 Apr 1;23(14):2564-75. doi: 10.1038/sj.onc.1207361. PMID: 14743203

Prognosis

The Prognostic Effect of HER2 Gene Amplification in High-Grade Endometrial Carcinomas and its Correlation with Protein Overexpression.
Bozkurt KK, Çiriş İM, Başpınar Ş, Çetin B, Erdemoğlu E, Bircan S, Ertunç O
Int J Surg Pathol 2023 Jun;31(4):365-374. Epub 2022 May 25 doi: 10.1177/10668969221102529. PMID: 35611517
Evaluation of ERBB2 gene status and chromosome 17 anomalies in male breast cancer.
Fonseca RR, Tomás AR, André S, Soares J
Am J Surg Pathol 2006 Oct;30(10):1292-8. doi: 10.1097/01.pas.0000213354.72638.bd. PMID: 17001161
ERBB2 amplification is superior to protein expression status in predicting patient outcome in serous ovarian carcinoma.
Lassus H, Leminen A, Vayrynen A, Cheng G, Gustafsson JA, Isola J, Butzow R
Gynecol Oncol 2004 Jan;92(1):31-9. doi: 10.1016/j.ygyno.2003.10.010. PMID: 14751135
Identification and validation of an ERBB2 gene expression signature in breast cancers.
Bertucci F, Borie N, Ginestier C, Groulet A, Charafe-Jauffret E, Adélaïde J, Geneix J, Bachelart L, Finetti P, Koki A, Hermitte F, Hassoun J, Debono S, Viens P, Fert V, Jacquemier J, Birnbaum D
Oncogene 2004 Apr 1;23(14):2564-75. doi: 10.1038/sj.onc.1207361. PMID: 14743203
Quantification of ERBB2 protein expression in breast cancer: three levels of expression defined by their clinico-pathological correlations.
Cuny M, Simony-Lafontaine J, Rouanet P, Grenier J, Valles H, Lavaill R, Louason G, Causse A, Lequeux N, Thierry C
Oncol Res 1994;6(4-5):169-76. PMID: 7841539

Clinical prediction guides

The Prognostic Effect of HER2 Gene Amplification in High-Grade Endometrial Carcinomas and its Correlation with Protein Overexpression.
Bozkurt KK, Çiriş İM, Başpınar Ş, Çetin B, Erdemoğlu E, Bircan S, Ertunç O
Int J Surg Pathol 2023 Jun;31(4):365-374. Epub 2022 May 25 doi: 10.1177/10668969221102529. PMID: 35611517
Evaluation of ERBB2 gene status and chromosome 17 anomalies in male breast cancer.
Fonseca RR, Tomás AR, André S, Soares J
Am J Surg Pathol 2006 Oct;30(10):1292-8. doi: 10.1097/01.pas.0000213354.72638.bd. PMID: 17001161
ERBB2 amplification is superior to protein expression status in predicting patient outcome in serous ovarian carcinoma.
Lassus H, Leminen A, Vayrynen A, Cheng G, Gustafsson JA, Isola J, Butzow R
Gynecol Oncol 2004 Jan;92(1):31-9. doi: 10.1016/j.ygyno.2003.10.010. PMID: 14751135
Identification and validation of an ERBB2 gene expression signature in breast cancers.
Bertucci F, Borie N, Ginestier C, Groulet A, Charafe-Jauffret E, Adélaïde J, Geneix J, Bachelart L, Finetti P, Koki A, Hermitte F, Hassoun J, Debono S, Viens P, Fert V, Jacquemier J, Birnbaum D
Oncogene 2004 Apr 1;23(14):2564-75. doi: 10.1038/sj.onc.1207361. PMID: 14743203
Quantification of ERBB2 protein expression in breast cancer: three levels of expression defined by their clinico-pathological correlations.
Cuny M, Simony-Lafontaine J, Rouanet P, Grenier J, Valles H, Lavaill R, Louason G, Causse A, Lequeux N, Thierry C
Oncol Res 1994;6(4-5):169-76. PMID: 7841539

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