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Prostate Acinar Adenocarcinoma, Atrophic Variant

MedGen UID:
273772
•Concept ID:
C1515862
•
Neoplastic Process
Synonym: Acinar Prostate Adenocarcinoma, Atrophic Variant

Definition

An unusual variant of acinar prostate adenocarcinoma characterized by the presence of neoplastic small atrophic glands that contain malignant cells with scant cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate Acinar Adenocarcinoma, Atrophic Variant

Professional guidelines

PubMed

Pseudohyperplastic prostate carcinoma: histologic patterns and differential diagnosis.
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154

Recent clinical studies

Etiology

Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Histological variants of prostatic carcinoma and their significance.
Humphrey PA
Histopathology 2012 Jan;60(1):59-74. doi: 10.1111/j.1365-2559.2011.04039.x. PMID: 22212078

Diagnosis

Histological patterns, subtypes and aspects of prostate cancer: different aspects, different outcomes.
Wasinger G, Oszwald A, Shariat SF, Compérat E
Curr Opin Urol 2022 Nov 1;32(6):643-648. Epub 2022 Sep 8 doi: 10.1097/MOU.0000000000001038. PMID: 36081403
Atrophic and Microcystic Limited Prostatic Adenocarcinomas.
Arista-Nasr J, Martinez-Benitez B, Mendez-Cano V, Albores-Saavedra J
Int J Surg Pathol 2020 Sep;28(6):584-589. Epub 2020 Mar 31 doi: 10.1177/1066896920911087. PMID: 32233699
False-Negative Histopathologic Diagnosis of Prostatic Adenocarcinoma.
Yang C, Humphrey PA
Arch Pathol Lab Med 2020 Mar;144(3):326-334. Epub 2019 Nov 15 doi: 10.5858/arpa.2019-0456-RA. PMID: 31729886
Variants of acinar adenocarcinoma of the prostate mimicking benign conditions.
Humphrey PA
Mod Pathol 2018 Jan;31(S1):S64-70. doi: 10.1038/modpathol.2017.137. PMID: 29297496
Pseudohyperplastic prostate carcinoma: histologic patterns and differential diagnosis.
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154

Prognosis

Histological patterns, subtypes and aspects of prostate cancer: different aspects, different outcomes.
Wasinger G, Oszwald A, Shariat SF, Compérat E
Curr Opin Urol 2022 Nov 1;32(6):643-648. Epub 2022 Sep 8 doi: 10.1097/MOU.0000000000001038. PMID: 36081403
Variants of acinar adenocarcinoma of the prostate mimicking benign conditions.
Humphrey PA
Mod Pathol 2018 Jan;31(S1):S64-70. doi: 10.1038/modpathol.2017.137. PMID: 29297496
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Aberrant expression of p63 in adenocarcinoma of the prostate: a radical prostatectomy study.
Giannico GA, Ross HM, Lotan T, Epstein JI
Am J Surg Pathol 2013 Sep;37(9):1401-6. doi: 10.1097/PAS.0b013e31828d5c32. PMID: 23774168
Small-acinar patterns in the prostate gland with emphasis on atypical adenomatous hyperplasia and small-acinar carcinoma.
Srigley JR
Semin Diagn Pathol 1988 Aug;5(3):254-72. PMID: 2459751

Clinical prediction guides

Variants of acinar adenocarcinoma of the prostate mimicking benign conditions.
Humphrey PA
Mod Pathol 2018 Jan;31(S1):S64-70. doi: 10.1038/modpathol.2017.137. PMID: 29297496
Pseudohyperplastic prostate carcinoma: histologic patterns and differential diagnosis.
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Aberrant expression of p63 in adenocarcinoma of the prostate: a radical prostatectomy study.
Giannico GA, Ross HM, Lotan T, Epstein JI
Am J Surg Pathol 2013 Sep;37(9):1401-6. doi: 10.1097/PAS.0b013e31828d5c32. PMID: 23774168

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