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Cervical Mixed Epithelial and Mesenchymal Neoplasm

MedGen UID:
273909
•Concept ID:
C1516420
•
Neoplastic Process

Definition

A benign or malignant neoplasm that arises from the cervix and is characterized by the presence of epithelial and mesenchymal elements. This category includes adenofibroma, adenomyoma, adenosarcoma, and carcinosarcoma. [from NCI]

Recent clinical studies

Etiology

Primordial Odontogenic Tumor; Archival Review of 19380 Cases in a 55-Year Retrospective Study.
Ranjbar M, Moradzadeh Khiavi M, Ghazi M, Derakhshan S
Asian Pac J Cancer Prev 2023 Aug 1;24(8):2845-2853. doi: 10.31557/APJCP.2023.24.8.2845. PMID: 37642073Free PMC Article
Frequency of Odontogenic Tumors: A Single Center Study of 1089 Cases in Japan and Literature Review.
Kokubun K, Yamamoto K, Nakajima K, Akashi Y, Chujo T, Takano M, Katakura A, Matsuzaka K
Head Neck Pathol 2022 Jun;16(2):494-502. Epub 2021 Oct 30 doi: 10.1007/s12105-021-01390-w. PMID: 34716904Free PMC Article
Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
Targeted Next-Generation Sequencing and Allele-Specific Quantitative PCR of Laser Capture Microdissected Samples Uncover Molecular Differences in Mixed Odontogenic Tumors.
Coura BP, Bernardes VF, de Sousa SF, Diniz MG, Moreira RG, de Andrade BAB, Romañach MJ, Pontes HAR, Gomez RS, Odell EW, Gomes CC
J Mol Diagn 2020 Dec;22(12):1393-1399. Epub 2020 Sep 20 doi: 10.1016/j.jmoldx.2020.08.005. PMID: 32966885
A case-control analysis of survival outcomes in sinonasal carcinosarcoma.
Patel TD, Vázquez A, Plitt MA, Baredes S, Eloy JA
Am J Otolaryngol 2015 Mar-Apr;36(2):200-4. Epub 2014 Oct 31 doi: 10.1016/j.amjoto.2014.10.031. PMID: 25465656

Diagnosis

Primordial Odontogenic Tumor; Archival Review of 19380 Cases in a 55-Year Retrospective Study.
Ranjbar M, Moradzadeh Khiavi M, Ghazi M, Derakhshan S
Asian Pac J Cancer Prev 2023 Aug 1;24(8):2845-2853. doi: 10.31557/APJCP.2023.24.8.2845. PMID: 37642073Free PMC Article
Frequency of Odontogenic Tumors: A Single Center Study of 1089 Cases in Japan and Literature Review.
Kokubun K, Yamamoto K, Nakajima K, Akashi Y, Chujo T, Takano M, Katakura A, Matsuzaka K
Head Neck Pathol 2022 Jun;16(2):494-502. Epub 2021 Oct 30 doi: 10.1007/s12105-021-01390-w. PMID: 34716904Free PMC Article
SALL-4 and Beta-Catenin Expression in Sinonasal Teratocarcinosarcoma.
Compton ML, Lewis JS Jr, Faquin WC, Cipriani NA, Shi Q, Ely KA
Head Neck Pathol 2022 Mar;16(1):229-235. Epub 2021 Jun 9 doi: 10.1007/s12105-021-01343-3. PMID: 34106411Free PMC Article
Immunohistochemical and genetic characteristics of HPV-associated endocervical carcinoma with an invasive stratified mucin-producing carcinoma (ISMC) component.
Park E, Kim YT, Kim S, Nam EJ, Cho NH
Mod Pathol 2021 Sep;34(9):1738-1749. Epub 2021 Jun 8 doi: 10.1038/s41379-021-00829-3. PMID: 34103667
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics.
Ding RB, Chen P, Rajendran BK, Lyu X, Wang H, Bao J, Zeng J, Hao W, Sun H, Wong AH, Valecha MV, Yang EJ, Su SM, Choi TK, Liu S, Chan KI, Yang LL, Wu J, Miao K, Chen Q, Shim JS, Xu X, Deng CX
Nat Commun 2021 May 24;12(1):3046. doi: 10.1038/s41467-021-23379-3. PMID: 34031426Free PMC Article

Therapy

RETRACTED: Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Guo SS, Liu R, Wen YF, Liu LT, Yuan L, Li YX, Li Y, Hao WW, Peng JY, Chen DN, Tang QN, Sun XS, Guo L, Mo HY, Qian CN, Zeng MS, Bei JX, Sun SY, Chen QY, Tang LQ, Mai HQ
Cancer Lett 2020 Jan 1;468:27-40. Epub 2019 Oct 8 doi: 10.1016/j.canlet.2019.10.008. PMID: 31604115
Metastasizing uterine mullerian adenosarcoma in a young female: Diagnostic enigma.
Patnayak R, Rukmangadha N, Architha P, Reddy GS, Lakshmi AY, Kannan T, Jena A
Indian J Pathol Microbiol 2018 Jul-Sep;61(3):440-442. doi: 10.4103/IJPM.IJPM_1_18. PMID: 30004077
Colony-forming assay of human salivary gland tumors. Applications for chemosensitivity and histogenetic studies.
Johns ME, Mills SE, Thompson KK
Arch Otolaryngol 1983 Nov;109(11):709-14. doi: 10.1001/archotol.1983.00800250003001. PMID: 6314953

Prognosis

Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancers.
Zhang C, Ren X, Zhang W, He L, Qi L, Chen R, Tu C, Li Z
Bioengineered 2020 Dec;11(1):1112-1123. doi: 10.1080/21655979.2020.1831361. PMID: 33124951Free PMC Article
RETRACTED: Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Guo SS, Liu R, Wen YF, Liu LT, Yuan L, Li YX, Li Y, Hao WW, Peng JY, Chen DN, Tang QN, Sun XS, Guo L, Mo HY, Qian CN, Zeng MS, Bei JX, Sun SY, Chen QY, Tang LQ, Mai HQ
Cancer Lett 2020 Jan 1;468:27-40. Epub 2019 Oct 8 doi: 10.1016/j.canlet.2019.10.008. PMID: 31604115
Molecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival.
Schliekelman MJ, Taguchi A, Zhu J, Dai X, Rodriguez J, Celiktas M, Zhang Q, Chin A, Wong CH, Wang H, McFerrin L, Selamat SA, Yang C, Kroh EM, Garg KS, Behrens C, Gazdar AF, Laird-Offringa IA, Tewari M, Wistuba II, Thiery JP, Hanash SM
Cancer Res 2015 May 1;75(9):1789-800. Epub 2015 Mar 5 doi: 10.1158/0008-5472.CAN-14-2535. PMID: 25744723Free PMC Article
A case-control analysis of survival outcomes in sinonasal carcinosarcoma.
Patel TD, Vázquez A, Plitt MA, Baredes S, Eloy JA
Am J Otolaryngol 2015 Mar-Apr;36(2):200-4. Epub 2014 Oct 31 doi: 10.1016/j.amjoto.2014.10.031. PMID: 25465656

Clinical prediction guides

Changes of immune microenvironment in head and neck squamous cell carcinoma in 3D-4-culture compared to 2D-4-culture.
Xiao J, Song Y, Gao R, You M, Deng C, Tan G, Li W
J Transl Med 2023 Oct 31;21(1):771. doi: 10.1186/s12967-023-04650-1. PMID: 37907991Free PMC Article
Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study.
Mühlenbrock MV, Navarrete-Rey P, Kovoor E, Guzman-Rojas R, Troncoso F, Miranda-Mendoza I
J Gynecol Obstet Hum Reprod 2021 Sep;50(7):101992. Epub 2020 Nov 17 doi: 10.1016/j.jogoh.2020.101992. PMID: 33217603
Targeted Next-Generation Sequencing and Allele-Specific Quantitative PCR of Laser Capture Microdissected Samples Uncover Molecular Differences in Mixed Odontogenic Tumors.
Coura BP, Bernardes VF, de Sousa SF, Diniz MG, Moreira RG, de Andrade BAB, Romañach MJ, Pontes HAR, Gomez RS, Odell EW, Gomes CC
J Mol Diagn 2020 Dec;22(12):1393-1399. Epub 2020 Sep 20 doi: 10.1016/j.jmoldx.2020.08.005. PMID: 32966885
Dental Germ Tumor: An Unusual, Cystic, Mixed Epithelial-Mesenchymal Odontogenic Tumor.
Passador-Santos F, Martelli SJ, Gomes P, Teixeira LN, Soares AB, Gomez RS, de Araújo VC
Head Neck Pathol 2020 Dec;14(4):1149-1153. Epub 2020 Feb 5 doi: 10.1007/s12105-020-01136-0. PMID: 32026295Free PMC Article
Molecular portraits of epithelial, mesenchymal, and hybrid States in lung adenocarcinoma and their relevance to survival.
Schliekelman MJ, Taguchi A, Zhu J, Dai X, Rodriguez J, Celiktas M, Zhang Q, Chin A, Wong CH, Wang H, McFerrin L, Selamat SA, Yang C, Kroh EM, Garg KS, Behrens C, Gazdar AF, Laird-Offringa IA, Tewari M, Wistuba II, Thiery JP, Hanash SM
Cancer Res 2015 May 1;75(9):1789-800. Epub 2015 Mar 5 doi: 10.1158/0008-5472.CAN-14-2535. PMID: 25744723Free PMC Article

Recent systematic reviews

Prevalence of BRAF p.V600E and Detection Methods in Benign Mixed and Malignant Odontogenic Tumors: A Systematic Review.
Severino-Lazo RJG, de Vasconcelos Carvalho M, Campello CP, Moraes SLD, do Egito Vasconcelos BC, Pellizzer EP
Head Neck Pathol 2023 Dec;17(4):1000-1010. Epub 2023 Dec 6 doi: 10.1007/s12105-023-01601-6. PMID: 38057461Free PMC Article

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