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Ovarian biphasic or triphasic teratoma

MedGen UID:: 274086
•Concept ID:: C1518691
•: Neoplastic Process

Synonyms:	Ovarian Biphasic or Triphasic Teratoma; ovarian biphasic or triphasic teratoma

Monarch Initiative:	MONDO:0003821

Definition

A germ cell tumor that arises from the ovary and is composed of tissues that originate from two or three of the following germ layers, endoderm, ectoderm, or mesoderm. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOvarian biphasic or triphasic teratoma

Genital neoplasm
- Gonadal neoplasm
  - Germ cell neoplasia
    - Teratoma
      - Gonadal teratoma
        Ovarian teratoma
        Ovarian biphasic or triphasic teratoma
        Grade 1 Ovarian Teratoma
        Immature ovarian teratoma
        Childhood immature teratoma of ovary
        Malignant Ovarian Teratoma
        Mature ovarian teratoma
        Childhood mature teratoma of the ovary
        Ovarian dermoid cyst
        Ovarian fetiform teratoma
        Ovarian solid teratoma
        Ovarian cystic teratoma

Professional guidelines

PubMed

SOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia.

Chapel DB, Hirsch MS
Am J Surg Pathol 2022 Feb 1;46(2):213-219. doi: 10.1097/PAS.0000000000001792. PMID: 34411029

Biphasic Rapamycin Effects in Lymphoma and Carcinoma Treatment.

Liu Y, Pandeswara S, Dao V, Padrón Á, Drerup JM, Lao S, Liu A, Hurez V, Curiel TJ
Cancer Res 2017 Jan 15;77(2):520-531. Epub 2016 Oct 13 doi: 10.1158/0008-5472.CAN-16-1140. PMID: 27737881 Free PMC Article

Differential diagnosis of ovarian tumors based primarily on their patterns and cell types.

Young RH, Scully RE
Semin Diagn Pathol 2001 Aug;18(3):161-235. PMID: 11554665

See all (7)

Recent clinical studies

Etiology

In vitro maturation (IVM) of human immature oocytes: is it still relevant?

Das M, Son WY
Reprod Biol Endocrinol 2023 Nov 22;21(1):110. doi: 10.1186/s12958-023-01162-x. PMID: 37993914 Free PMC Article

Histopathological and immunohistochemical features of 14 peritoneal mesotheliomas with clinical outcomes and recent updates.

Karmarkar S, Rekhi B, Deodhar KK, Menon S
J Cancer Res Ther 2022 Oct-Dec;18(6):1683-1691. doi: 10.4103/jcrt.JCRT_1292_20. PMID: 36412430

Immunogenomic landscape of gynecologic carcinosarcoma.

Gotoh O, Kiyotani K, Chiba T, Sugiyama Y, Takazawa Y, Nemoto K, Kato K, Tanaka N, Nomura H, Hasegawa K, Fujiwara K, Takamatsu S, Matsumura N, Noda T, Mori S
Gynecol Oncol 2021 Feb;160(2):547-556. Epub 2020 Dec 6 doi: 10.1016/j.ygyno.2020.11.030. PMID: 33298310

Antidepressants and breast and ovarian cancer risk: a review of the literature and researchers' financial associations with industry.

Cosgrove L, Shi L, Creasey DE, Anaya-McKivergan M, Myers JA, Huybrechts KF
PLoS One 2011 Apr 6;6(4):e18210. doi: 10.1371/journal.pone.0018210. PMID: 21494667 Free PMC Article

Amenorrhea during the reproductive years--is it safe?

Schachter M, Shoham Z
Fertil Steril 1994 Jul;62(1):1-16. doi: 10.1016/s0015-0282(16)56808-3. PMID: 8005272

See all (60)

Diagnosis

Histopathological and immunohistochemical features of 14 peritoneal mesotheliomas with clinical outcomes and recent updates.

Karmarkar S, Rekhi B, Deodhar KK, Menon S
J Cancer Res Ther 2022 Oct-Dec;18(6):1683-1691. doi: 10.4103/jcrt.JCRT_1292_20. PMID: 36412430

Quantitative biophysical metrics for rapid evaluation of ovarian cancer metastatic potential.

Mukherjee A, Zhang H, Ladner K, Brown M, Urbanski J, Grieco JP, Kapania RK, Lou E, Behkam B, Schmelz EM, Nain AS
Mol Biol Cell 2022 May 15;33(6):ar55. Epub 2022 Jan 5 doi: 10.1091/mbc.E21-08-0419. PMID: 34985924 Free PMC Article

Mixed epithelial and stromal tumors of the kidney: an overview.

Mohanty SK, Parwani AV
Arch Pathol Lab Med 2009 Sep;133(9):1483-6. doi: 10.5858/133.9.1483. PMID: 19722760

Differential diagnosis of ovarian tumors based primarily on their patterns and cell types.

Young RH, Scully RE
Semin Diagn Pathol 2001 Aug;18(3):161-235. PMID: 11554665

Amenorrhea during the reproductive years--is it safe?

Schachter M, Shoham Z
Fertil Steril 1994 Jul;62(1):1-16. doi: 10.1016/s0015-0282(16)56808-3. PMID: 8005272

See all (99)

Therapy

Genomic and Molecular Characteristics of Ovarian Carcinosarcoma.

Ramphal K, Hadfield MJ, Bandera CM, Hart J, Dizon DS
Am J Clin Oncol 2023 Dec 1;46(12):572-576. Epub 2023 Oct 17 doi: 10.1097/COC.0000000000001056. PMID: 37986208

Inhibition of RANKL and Sema4D improves residual ridge resorption in mice.

Hisamoto M, Kimura S, Iwata K, Iwanaga T, Yokoyama A
Sci Rep 2022 Mar 8;12(1):4094. doi: 10.1038/s41598-022-08016-3. PMID: 35260755 Free PMC Article

Can Cannabidiol Affect the Efficacy of Chemotherapy and Epigenetic Treatments in Cancer?

Griffiths C, Aikins J, Warshal D, Ostrovsky O
Biomolecules 2021 May 20;11(5) doi: 10.3390/biom11050766. PMID: 34065479 Free PMC Article

Antidepressants and breast and ovarian cancer risk: a review of the literature and researchers' financial associations with industry.

Cosgrove L, Shi L, Creasey DE, Anaya-McKivergan M, Myers JA, Huybrechts KF
PLoS One 2011 Apr 6;6(4):e18210. doi: 10.1371/journal.pone.0018210. PMID: 21494667 Free PMC Article

Combined oral contraceptives: acceptability and effective use.

Kubba A, Guillebaud J
Br Med Bull 1993 Jan;49(1):140-57. doi: 10.1093/oxfordjournals.bmb.a072593. PMID: 8324604

See all (65)

Prognosis

Genomic and Molecular Characteristics of Ovarian Carcinosarcoma.

Ramphal K, Hadfield MJ, Bandera CM, Hart J, Dizon DS
Am J Clin Oncol 2023 Dec 1;46(12):572-576. Epub 2023 Oct 17 doi: 10.1097/COC.0000000000001056. PMID: 37986208

Quantitative biophysical metrics for rapid evaluation of ovarian cancer metastatic potential.

Immunogenomic landscape of gynecologic carcinosarcoma.

Novel targeted therapies in ovarian and uterine carcinosarcomas.

Han C, Altwerger G, Menderes G, Haines K, Feinberg J, Lopez S, Manzano A, Varughese J, Santin AD
Discov Med 2018 Jun;25(140):309-319. PMID: 30021104

The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer.

Yang G, Xiao X, Rosen DG, Cheng X, Wu X, Chang B, Liu G, Xue F, Mercado-Uribe I, Chiao P, Du X, Liu J
Clin Cancer Res 2011 Apr 15;17(8):2181-94. Epub 2011 Feb 21 doi: 10.1158/1078-0432.CCR-10-3265. PMID: 21339307 Free PMC Article

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Clinical prediction guides

BAP1 and Claudin-4, But Not MTAP, Reliably Distinguish Borderline and Low-grade Serous Ovarian Tumors From Peritoneal Mesothelioma.

Devins KM, Zukerberg L, Watkins JC, Hung YP, Oliva E
Int J Gynecol Pathol 2023 Mar 1;42(2):159-166. Epub 2022 May 20 doi: 10.1097/PGP.0000000000000877. PMID: 35512220

A Mechanism for Ovulation Number Control.

Shilo M, Mayo A, Alon U
Front Endocrinol (Lausanne) 2022;13:816967. Epub 2022 Jul 14 doi: 10.3389/fendo.2022.816967. PMID: 35909517 Free PMC Article

Quantitative biophysical metrics for rapid evaluation of ovarian cancer metastatic potential.

The two-step process of ovarian follicular growth and maturation in mammals can be compared to a fruit ripening where quality depends on the second step.

Sirard MA
Biol Reprod 2022 Feb 22;106(2):230-234. doi: 10.1093/biolre/ioab236. PMID: 34939644

The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer.

See all (82)