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Positive Regulation of Oxidative Stress Process

MedGen UID:
274098
•Concept ID:
C1518761
•
Cell or Molecular Dysfunction
Synonym: Oxidative Stress Induction

Definition

Oxidative Stress Induction involves initiation of activities that induce a disturbance in the pro-oxidant/antioxidant balance, leading to disruption of cell function by superoxide and other free radicals through damage to DNA bases, protein oxidation products, and lipid peroxidation products. Not synonymous with hypoxia or hyperoxia, oxidative stress promotes a range of degenerative disorders. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPositive Regulation of Oxidative Stress Process

Professional guidelines

PubMed

Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications.
Anderson G, Maes M
Curr Top Med Chem 2020;20(7):524-539. doi: 10.2174/1568026620666200131094445. PMID: 32003689
Targeting the Canonical WNT/β-Catenin Pathway in Cancer Treatment Using Non-Steroidal Anti-Inflammatory Drugs.
Vallée A, Lecarpentier Y, Vallée JN
Cells 2019 Jul 15;8(7) doi: 10.3390/cells8070726. PMID: 31311204Free PMC Article
Glucocorticosteroids as antioxidants in treatment of asthma and COPD. New application for an old medication?
Sadowska AM, Klebe B, Germonpré P, De Backer WA
Steroids 2007 Jan;72(1):1-6. Epub 2006 Dec 4 doi: 10.1016/j.steroids.2006.10.007. PMID: 17145070

Recent clinical studies

Etiology

Food, Nutrition, Physical Activity and Microbiota: Which Impact on Lung Cancer?
Nigro E, Perrotta F, Scialò F, D'Agnano V, Mallardo M, Bianco A, Daniele A
Int J Environ Res Public Health 2021 Mar 1;18(5) doi: 10.3390/ijerph18052399. PMID: 33804536Free PMC Article
Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy.
Hu J, Li Y, Li H, Shi F, Xie L, Zhao L, Tang M, Luo X, Jia W, Fan J, Zhou J, Gao Q, Qiu S, Wu W, Zhang X, Liao W, Bode AM, Cao Y
Theranostics 2020;10(26):11921-11937. Epub 2020 Oct 25 doi: 10.7150/thno.46006. PMID: 33204320Free PMC Article
Mitochondria as a Source and a Target for Uremic Toxins.
Popkov VA, Silachev DN, Zalevsky AO, Zorov DB, Plotnikov EY
Int J Mol Sci 2019 Jun 25;20(12) doi: 10.3390/ijms20123094. PMID: 31242575Free PMC Article
Vitamin C, Aging and Alzheimer's Disease.
Monacelli F, Acquarone E, Giannotti C, Borghi R, Nencioni A
Nutrients 2017 Jun 27;9(7) doi: 10.3390/nu9070670. PMID: 28654021Free PMC Article
Genetic mouse models of brain ageing and Alzheimer's disease.
Bilkei-Gorzo A
Pharmacol Ther 2014 May;142(2):244-57. Epub 2013 Dec 19 doi: 10.1016/j.pharmthera.2013.12.009. PMID: 24362083

Diagnosis

Investigating the AC079305/DUSP1 Axis as Oxidative Stress-Related Signatures and Immune Infiltration Characteristics in Ischemic Stroke.
Fan J, Cao S, Chen M, Yao Q, Zhang X, Du S, Qu H, Cheng Y, Ma S, Zhang M, Huang Y, Zhang N, Shi K, Zhan S
Oxid Med Cell Longev 2022;2022:8432352. Epub 2022 Jun 14 doi: 10.1155/2022/8432352. PMID: 35746962Free PMC Article
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z
Mol Cell 2021 Jun 3;81(11):2303-2316.e8. Epub 2021 May 14 doi: 10.1016/j.molcel.2021.04.002. PMID: 33991485
Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy.
Hu J, Li Y, Li H, Shi F, Xie L, Zhao L, Tang M, Luo X, Jia W, Fan J, Zhou J, Gao Q, Qiu S, Wu W, Zhang X, Liao W, Bode AM, Cao Y
Theranostics 2020;10(26):11921-11937. Epub 2020 Oct 25 doi: 10.7150/thno.46006. PMID: 33204320Free PMC Article
Mitochondrial biogenesis: pharmacological approaches.
Valero T
Curr Pharm Des 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. PMID: 24606795
Genetic mouse models of brain ageing and Alzheimer's disease.
Bilkei-Gorzo A
Pharmacol Ther 2014 May;142(2):244-57. Epub 2013 Dec 19 doi: 10.1016/j.pharmthera.2013.12.009. PMID: 24362083

Therapy

Panax ginseng and aging related disorders: A systematic review.
de Oliveira Zanuso B, de Oliveira Dos Santos AR, Miola VFB, Guissoni Campos LM, Spilla CSG, Barbalho SM
Exp Gerontol 2022 May;161:111731. Epub 2022 Feb 7 doi: 10.1016/j.exger.2022.111731. PMID: 35143871
Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship.
Ruiz-Ojeda FJ, Anguita-Ruiz A, Leis R, Aguilera CM
Ann Nutr Metab 2018;73(2):89-99. Epub 2018 Jul 6 doi: 10.1159/000490669. PMID: 29982250
l-Carnitine Supplementation in Recovery after Exercise.
Fielding R, Riede L, Lugo JP, Bellamine A
Nutrients 2018 Mar 13;10(3) doi: 10.3390/nu10030349. PMID: 29534031Free PMC Article
Vitamin C, Aging and Alzheimer's Disease.
Monacelli F, Acquarone E, Giannotti C, Borghi R, Nencioni A
Nutrients 2017 Jun 27;9(7) doi: 10.3390/nu9070670. PMID: 28654021Free PMC Article
Mitochondrial biogenesis: pharmacological approaches.
Valero T
Curr Pharm Des 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. PMID: 24606795

Prognosis

Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway.
Li X, Xu B, Wu J, Pu Y, Wan S, Zeng Y, Wang M, Luo L, Zhang F, Jiang Z, Xu Y
Oxid Med Cell Longev 2022;2022:7177889. Epub 2022 Apr 19 doi: 10.1155/2022/7177889. PMID: 35498124Free PMC Article
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z
Mol Cell 2021 Jun 3;81(11):2303-2316.e8. Epub 2021 May 14 doi: 10.1016/j.molcel.2021.04.002. PMID: 33991485
Food, Nutrition, Physical Activity and Microbiota: Which Impact on Lung Cancer?
Nigro E, Perrotta F, Scialò F, D'Agnano V, Mallardo M, Bianco A, Daniele A
Int J Environ Res Public Health 2021 Mar 1;18(5) doi: 10.3390/ijerph18052399. PMID: 33804536Free PMC Article
Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy.
Hu J, Li Y, Li H, Shi F, Xie L, Zhao L, Tang M, Luo X, Jia W, Fan J, Zhou J, Gao Q, Qiu S, Wu W, Zhang X, Liao W, Bode AM, Cao Y
Theranostics 2020;10(26):11921-11937. Epub 2020 Oct 25 doi: 10.7150/thno.46006. PMID: 33204320Free PMC Article
Mitochondrial biogenesis: pharmacological approaches.
Valero T
Curr Pharm Des 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. PMID: 24606795

Clinical prediction guides

Maresin 1 Alleviates Diabetic Kidney Disease via LGR6-Mediated cAMP-SOD2-ROS Pathway.
Li X, Xu B, Wu J, Pu Y, Wan S, Zeng Y, Wang M, Luo L, Zhang F, Jiang Z, Xu Y
Oxid Med Cell Longev 2022;2022:7177889. Epub 2022 Apr 19 doi: 10.1155/2022/7177889. PMID: 35498124Free PMC Article
Factors inducing transdifferentiation of myoblasts into adipocytes.
Wang L, Shan T
J Cell Physiol 2021 Apr;236(4):2276-2289. Epub 2020 Sep 28 doi: 10.1002/jcp.30074. PMID: 32989814
Immunity and longevity.
Csaba G
Acta Microbiol Immunol Hung 2019 Mar 1;66(1):1-17. Epub 2018 Jul 3 doi: 10.1556/030.65.2018.029. PMID: 29968490
Regulatory crosstalk between the oxidative stress-related transcription factor Nfe2l2/Nrf2 and mitochondria.
Ryoo IG, Kwak MK
Toxicol Appl Pharmacol 2018 Nov 15;359:24-33. Epub 2018 Sep 18 doi: 10.1016/j.taap.2018.09.014. PMID: 30236989
Mitochondrial biogenesis: pharmacological approaches.
Valero T
Curr Pharm Des 2014;20(35):5507-9. doi: 10.2174/138161282035140911142118. PMID: 24606795

Recent systematic reviews

Mass Spectrometry as a Quantitative Proteomic Analysis Tool for the Search for Temporal Lobe Epilepsy Biomarkers: A Systematic Review.
Timechko EE, Yakimov AM, Paramonova AI, Usoltseva AA, Utyashev NP, Ivin NO, Utyasheva AA, Yakunina AV, Kalinin VA, Dmitrenko DV
Int J Mol Sci 2023 Jul 5;24(13) doi: 10.3390/ijms241311130. PMID: 37446307Free PMC Article
Panax ginseng and aging related disorders: A systematic review.
de Oliveira Zanuso B, de Oliveira Dos Santos AR, Miola VFB, Guissoni Campos LM, Spilla CSG, Barbalho SM
Exp Gerontol 2022 May;161:111731. Epub 2022 Feb 7 doi: 10.1016/j.exger.2022.111731. PMID: 35143871

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