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PDGFRalpha Protein Overexpression

MedGen UID:
274100
•Concept ID:
C1518783
•
Cell or Molecular Dysfunction
Synonyms: PDGFRA Protein Overexpression; Platelet-Derived Growth Factor Receptor Alpha Protein Overexpression

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPDGFRalpha Protein Overexpression

Professional guidelines

PubMed

Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure-Activity Relationship (SAR).
Godesi S, Lee J, Nada H, Quan G, Elkamhawy A, Choi Y, Lee K
Int J Mol Sci 2023 May 29;24(11) doi: 10.3390/ijms24119450. PMID: 37298401Free PMC Article
Appendix-derived Pseudomyxoma Peritonei (PMP): Molecular Profiling Toward Treatment of a Rare Malignancy.
Gleeson EM, Feldman R, Mapow BL, Mackovick LT, Ward KM, Morano WF, Rubin RR, Bowne WB
Am J Clin Oncol 2018 Aug;41(8):777-783. doi: 10.1097/COC.0000000000000376. PMID: 28263231
Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS).
Saponara M, Urbini M, Astolfi A, Indio V, Ercolani G, Del Gaudio M, Santini D, Pirini MG, Fiorentino M, Nannini M, Lolli C, Mandrioli A, Gatto L, Brandi G, Biasco G, Pinna AD, Pantaleo MA
Oncotarget 2015 Dec 8;6(39):42243-57. doi: 10.18632/oncotarget.6278. PMID: 26544626Free PMC Article

Recent clinical studies

Etiology

Anaplastic lymphoma kinase expression in PDGFRA-mutated gastrointestinal stromal tumors probably correlates with poor prognosis.
Wu Y, Gao B, Xia Q, Zhu Y, Wang N, Chang X, Huang B, Luo D, Zhang J, Zhang P, Shi H, Fan J, Nie X
World J Surg Oncol 2023 Apr 29;21(1):138. doi: 10.1186/s12957-023-03019-4. PMID: 37120571Free PMC Article
Appendix-derived Pseudomyxoma Peritonei (PMP): Molecular Profiling Toward Treatment of a Rare Malignancy.
Gleeson EM, Feldman R, Mapow BL, Mackovick LT, Ward KM, Morano WF, Rubin RR, Bowne WB
Am J Clin Oncol 2018 Aug;41(8):777-783. doi: 10.1097/COC.0000000000000376. PMID: 28263231
Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas.
Cassol CA, Winer D, Liu W, Guo M, Ezzat S, Asa SL
Mod Pathol 2014 Aug;27(8):1050-62. Epub 2014 Jan 3 doi: 10.1038/modpathol.2013.233. PMID: 24390213Free PMC Article
Targeting signaling pathways in acute lymphoblastic leukemia: new insights.
Harrison CJ
Hematology Am Soc Hematol Educ Program 2013;2013:118-25. doi: 10.1182/asheducation-2013.1.118. PMID: 24319172
Colorectal gastrointestinal stromal tumor.
Amato A
Tech Coloproctol 2010 Nov;14 Suppl 1:S91-5. doi: 10.1007/s10151-010-0631-y. PMID: 20967481

Diagnosis

Tenascin-C, a Prognostic Determinant of Esophageal Squamous Cell Carcinoma.
Yang ZT, Yeo SY, Yin YX, Lin ZH, Lee HM, Xuan YH, Cui Y, Kim SH
PLoS One 2016;11(1):e0145807. Epub 2016 Jan 5 doi: 10.1371/journal.pone.0145807. PMID: 26731558Free PMC Article
A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma.
Wang F, Remke M, Bhat K, Wong ET, Zhou S, Ramaswamy V, Dubuc A, Fonkem E, Salem S, Zhang H, Hsieh TC, O'Rourke ST, Wu L, Li DW, Hawkins C, Kohane IS, Wu JM, Wu M, Taylor MD, Wu E
Oncotarget 2015 Feb 20;6(5):2709-24. doi: 10.18632/oncotarget.2779. PMID: 25576913Free PMC Article
Platelet-derived growth factor receptor alpha in glioma: a bad seed.
Liu KW, Hu B, Cheng SY
Chin J Cancer 2011 Sep;30(9):590-602. doi: 10.5732/cjc.011.10236. PMID: 21880180Free PMC Article
Nilotinib: a novel, selective tyrosine kinase inhibitor.
Blay JY, von Mehren M
Semin Oncol 2011 Apr;38 Suppl 1(0 1):S3-9. doi: 10.1053/j.seminoncol.2011.01.016. PMID: 21419934Free PMC Article
FIP1L1/PDGFR alpha-associated systemic mastocytosis.
Yamada Y, Cancelas JA
Int Arch Allergy Immunol 2010;152 Suppl 1(Suppl 1):101-5. Epub 2010 Jun 4 doi: 10.1159/000312134. PMID: 20523072Free PMC Article

Therapy

The HIF1α-PDGFD-PDGFRα axis controls glioblastoma growth at normoxia/mild-hypoxia and confers sensitivity to targeted therapy by echinomycin.
Peng G, Wang Y, Ge P, Bailey C, Zhang P, Zhang D, Meng Z, Qi C, Chen Q, Chen J, Niu J, Zheng P, Liu Y, Liu Y
J Exp Clin Cancer Res 2021 Sep 1;40(1):278. doi: 10.1186/s13046-021-02082-7. PMID: 34470658Free PMC Article
Succinate dehydrogenase-deficient gastrointestinal stromal tumors.
Wang YM, Gu ML, Ji F
World J Gastroenterol 2015 Feb 28;21(8):2303-14. doi: 10.3748/wjg.v21.i8.2303. PMID: 25741136Free PMC Article
Therapeutic angiogenesis for revascularization in peripheral artery disease.
Grochot-Przeczek A, Dulak J, Jozkowicz A
Gene 2013 Aug 10;525(2):220-8. Epub 2013 Apr 5 doi: 10.1016/j.gene.2013.03.097. PMID: 23566831
Platelet-derived growth factor receptor alpha in glioma: a bad seed.
Liu KW, Hu B, Cheng SY
Chin J Cancer 2011 Sep;30(9):590-602. doi: 10.5732/cjc.011.10236. PMID: 21880180Free PMC Article
Nilotinib: a novel, selective tyrosine kinase inhibitor.
Blay JY, von Mehren M
Semin Oncol 2011 Apr;38 Suppl 1(0 1):S3-9. doi: 10.1053/j.seminoncol.2011.01.016. PMID: 21419934Free PMC Article

Prognosis

Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm.
Wen Y, Liu Y, Li Q, Tan J, Fu X, Liang Y, Tuo Y, Liu L, Zhou X, LiuFu D, Fan X, Chen C, Chen Z, Wang Z, Fan S, Liu R, Pan L, Zhang Y, Tang WH
Circ Res 2024 May 24;134(11):1495-1511. Epub 2024 Apr 30 doi: 10.1161/CIRCRESAHA.124.324323. PMID: 38686580
CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma.
Zeng S, Chen XI, Yi Q, Thakur A, Yang H, Yan Y, Liu S
Oncol Res 2023;32(2):261-272. Epub 2023 Dec 28 doi: 10.32604/or.2023.042345. PMID: 38186580Free PMC Article
Depletion of slow-cycling PDGFRα(+)ADAM12(+) mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis.
Di Carlo SE, Raffenne J, Varet H, Ode A, Granados DC, Stein M, Legendre R, Tuckermann J, Bousquet C, Peduto L
Nat Immunol 2023 Nov;24(11):1867-1878. Epub 2023 Oct 5 doi: 10.1038/s41590-023-01642-7. PMID: 37798557Free PMC Article
MiR-24-3p regulates the differentiation of adipose-derived stem cells toward pericytes and promotes fat grafting vascularization.
Cai Z, Li Z, Wei Q, Yang F, Li T, Ke C, He Y, Wang J, Ni B, Lin M, Li L
FASEB J 2023 May;37(5):e22935. doi: 10.1096/fj.202202037RR. PMID: 37086094
Succinate dehydrogenase-deficient gastrointestinal stromal tumors.
Wang YM, Gu ML, Ji F
World J Gastroenterol 2015 Feb 28;21(8):2303-14. doi: 10.3748/wjg.v21.i8.2303. PMID: 25741136Free PMC Article

Clinical prediction guides

CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma.
Zeng S, Chen XI, Yi Q, Thakur A, Yang H, Yan Y, Liu S
Oncol Res 2023;32(2):261-272. Epub 2023 Dec 28 doi: 10.32604/or.2023.042345. PMID: 38186580Free PMC Article
MiR-24-3p regulates the differentiation of adipose-derived stem cells toward pericytes and promotes fat grafting vascularization.
Cai Z, Li Z, Wei Q, Yang F, Li T, Ke C, He Y, Wang J, Ni B, Lin M, Li L
FASEB J 2023 May;37(5):e22935. doi: 10.1096/fj.202202037RR. PMID: 37086094
ATG5 promotes eosinopoiesis but inhibits eosinophil effector functions.
Germic N, Hosseini A, Stojkov D, Oberson K, Claus M, Benarafa C, Calzavarini S, Angelillo-Scherrer A, Arnold IC, Müller A, Riether C, Yousefi S, Simon HU
Blood 2021 May 27;137(21):2958-2969. doi: 10.1182/blood.2020010208. PMID: 33598715Free PMC Article
Sirt2 epigenetically down-regulates PDGFRα expression and promotes CG4 cell differentiation.
Fang N, Cheng J, Zhang C, Chen K, Zhang C, Hu Z, Bi R, Furber KL, Thangaraj M, Nazarali AJ, Ji S
Cell Cycle 2019 May;18(10):1095-1109. Epub 2019 May 10 doi: 10.1080/15384101.2019.1609818. PMID: 31020898Free PMC Article
Spinal myxopapillary ependymomas: a retrospective clinical and immunohistochemical study.
Chen X, Li C, Che X, Chen H, Liu Z
Acta Neurochir (Wien) 2016 Jan;158(1):101-7. Epub 2015 Nov 17 doi: 10.1007/s00701-015-2637-8. PMID: 26577638

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