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Tumor Immunity

MedGen UID:
274319
•Concept ID:
C1519680
•
Disease or Syndrome

Definition

Mechanisms that prevent immune detection and elimination of tumor cells [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTumor Immunity

Professional guidelines

PubMed

Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy.
Long H, Jia Q, Wang L, Fang W, Wang Z, Jiang T, Zhou F, Jin Z, Huang J, Zhou L, Hu C, Wang X, Zhang J, Ba Y, Gong Y, Zeng X, Zeng D, Su X, Alexander PB, Wang L, Wang L, Wan YY, Wang XF, Zhang L, Li QJ, Zhu B
Cancer Cell 2022 Jun 13;40(6):674-693.e7. Epub 2022 May 19 doi: 10.1016/j.ccell.2022.04.018. PMID: 35594863
Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment.
Saab S, Zalzale H, Rahal Z, Khalifeh Y, Sinjab A, Kadara H
Front Immunol 2020;11:159. Epub 2020 Feb 11 doi: 10.3389/fimmu.2020.00159. PMID: 32117295Free PMC Article
Potential targeting of B7-H4 for the treatment of cancer.
Podojil JR, Miller SD
Immunol Rev 2017 Mar;276(1):40-51. doi: 10.1111/imr.12530. PMID: 28258701Free PMC Article

Recent clinical studies

Etiology

Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway.
Constanzo J, Faget J, Ursino C, Badie C, Pouget JP
Front Immunol 2021;12:680503. Epub 2021 May 17 doi: 10.3389/fimmu.2021.680503. PMID: 34079557Free PMC Article
Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8(+) T cell exclusion.
Fang W, Zhou T, Shi H, Yao M, Zhang D, Qian H, Zeng Q, Wang Y, Jin F, Chai C, Chen T
J Exp Clin Cancer Res 2021 Jan 4;40(1):4. doi: 10.1186/s13046-020-01786-6. PMID: 33390170Free PMC Article
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC
Cell 2020 Dec 23;183(7):1848-1866.e26. Epub 2020 Dec 9 doi: 10.1016/j.cell.2020.11.009. PMID: 33301708Free PMC Article
Circulating tumor cells in hepatocellular carcinoma: single-cell based analysis, preclinical models, and clinical applications.
Zhang Q, Rong Y, Yi K, Huang L, Chen M, Wang F
Theranostics 2020;10(26):12060-12071. Epub 2020 Oct 26 doi: 10.7150/thno.48918. PMID: 33204329Free PMC Article
Cancer-associated adipocytes: key players in breast cancer progression.
Wu Q, Li B, Li Z, Li J, Sun S, Sun S
J Hematol Oncol 2019 Sep 10;12(1):95. doi: 10.1186/s13045-019-0778-6. PMID: 31500658Free PMC Article

Diagnosis

GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer.
Chen G, Luo D, Zhong N, Li D, Zheng J, Liao H, Li Z, Lin X, Chen Q, Zhang C, Lu Y, Chan YT, Ren Q, Wang N, Feng Y
Front Immunol 2022;13:857308. Epub 2022 Mar 8 doi: 10.3389/fimmu.2022.857308. PMID: 35345673Free PMC Article
Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies.
Giraud J, Chalopin D, Blanc JF, Saleh M
Front Immunol 2021;12:655697. Epub 2021 Mar 18 doi: 10.3389/fimmu.2021.655697. PMID: 33815418Free PMC Article
Exosomes in cancer development, metastasis, and immunity.
Zhang L, Yu D
Biochim Biophys Acta Rev Cancer 2019 Apr;1871(2):455-468. Epub 2019 Apr 30 doi: 10.1016/j.bbcan.2019.04.004. PMID: 31047959Free PMC Article
Effect of exosomal miRNA on cancer biology and clinical applications.
Sun Z, Shi K, Yang S, Liu J, Zhou Q, Wang G, Song J, Li Z, Zhang Z, Yuan W
Mol Cancer 2018 Oct 11;17(1):147. doi: 10.1186/s12943-018-0897-7. PMID: 30309355Free PMC Article
Targeting adenosine for cancer immunotherapy.
Leone RD, Emens LA
J Immunother Cancer 2018 Jun 18;6(1):57. doi: 10.1186/s40425-018-0360-8. PMID: 29914571Free PMC Article

Therapy

Immune checkpoint therapy-current perspectives and future directions.
Sharma P, Goswami S, Raychaudhuri D, Siddiqui BA, Singh P, Nagarajan A, Liu J, Subudhi SK, Poon C, Gant KL, Herbrich SM, Anandhan S, Islam S, Amit M, Anandappa G, Allison JP
Cell 2023 Apr 13;186(8):1652-1669. doi: 10.1016/j.cell.2023.03.006. PMID: 37059068
Immunotherapy: Reshape the Tumor Immune Microenvironment.
Lv B, Wang Y, Ma D, Cheng W, Liu J, Yong T, Chen H, Wang C
Front Immunol 2022;13:844142. Epub 2022 Jul 6 doi: 10.3389/fimmu.2022.844142. PMID: 35874717Free PMC Article
Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy.
Luoma AM, Suo S, Wang Y, Gunasti L, Porter CBM, Nabilsi N, Tadros J, Ferretti AP, Liao S, Gurer C, Chen YH, Criscitiello S, Ricker CA, Dionne D, Rozenblatt-Rosen O, Uppaluri R, Haddad RI, Ashenberg O, Regev A, Van Allen EM, MacBeath G, Schoenfeld JD, Wucherpfennig KW
Cell 2022 Aug 4;185(16):2918-2935.e29. Epub 2022 Jul 7 doi: 10.1016/j.cell.2022.06.018. PMID: 35803260Free PMC Article
B7-H3: An Attractive Target for Antibody-based Immunotherapy.
Kontos F, Michelakos T, Kurokawa T, Sadagopan A, Schwab JH, Ferrone CR, Ferrone S
Clin Cancer Res 2021 Mar 1;27(5):1227-1235. Epub 2020 Oct 13 doi: 10.1158/1078-0432.CCR-20-2584. PMID: 33051306Free PMC Article
Fibrosis and cancer: A strained relationship.
Piersma B, Hayward MK, Weaver VM
Biochim Biophys Acta Rev Cancer 2020 Apr;1873(2):188356. Epub 2020 Mar 5 doi: 10.1016/j.bbcan.2020.188356. PMID: 32147542Free PMC Article

Prognosis

Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer.
Sha S, Si L, Wu X, Chen Y, Xiong H, Xu Y, Liu W, Mei H, Wang T, Li M
Front Immunol 2022;13:922780. Epub 2022 Aug 1 doi: 10.3389/fimmu.2022.922780. PMID: 35979353Free PMC Article
Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy.
Long H, Jia Q, Wang L, Fang W, Wang Z, Jiang T, Zhou F, Jin Z, Huang J, Zhou L, Hu C, Wang X, Zhang J, Ba Y, Gong Y, Zeng X, Zeng D, Su X, Alexander PB, Wang L, Wang L, Wan YY, Wang XF, Zhang L, Li QJ, Zhu B
Cancer Cell 2022 Jun 13;40(6):674-693.e7. Epub 2022 May 19 doi: 10.1016/j.ccell.2022.04.018. PMID: 35594863
GPC2 Is a Potential Diagnostic, Immunological, and Prognostic Biomarker in Pan-Cancer.
Chen G, Luo D, Zhong N, Li D, Zheng J, Liao H, Li Z, Lin X, Chen Q, Zhang C, Lu Y, Chan YT, Ren Q, Wang N, Feng Y
Front Immunol 2022;13:857308. Epub 2022 Mar 8 doi: 10.3389/fimmu.2022.857308. PMID: 35345673Free PMC Article
B7-H3: An Attractive Target for Antibody-based Immunotherapy.
Kontos F, Michelakos T, Kurokawa T, Sadagopan A, Schwab JH, Ferrone CR, Ferrone S
Clin Cancer Res 2021 Mar 1;27(5):1227-1235. Epub 2020 Oct 13 doi: 10.1158/1078-0432.CCR-20-2584. PMID: 33051306Free PMC Article
Targeting Treg cells in cancer immunotherapy.
Tanaka A, Sakaguchi S
Eur J Immunol 2019 Aug;49(8):1140-1146. Epub 2019 Jul 5 doi: 10.1002/eji.201847659. PMID: 31257581

Clinical prediction guides

Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer.
Sha S, Si L, Wu X, Chen Y, Xiong H, Xu Y, Liu W, Mei H, Wang T, Li M
Front Immunol 2022;13:922780. Epub 2022 Aug 1 doi: 10.3389/fimmu.2022.922780. PMID: 35979353Free PMC Article
The theory of tumor ecosystem.
Chen X, Song E
Cancer Commun (Lond) 2022 Jul;42(7):587-608. Epub 2022 Jun 1 doi: 10.1002/cac2.12316. PMID: 35642770Free PMC Article
Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy.
Long H, Jia Q, Wang L, Fang W, Wang Z, Jiang T, Zhou F, Jin Z, Huang J, Zhou L, Hu C, Wang X, Zhang J, Ba Y, Gong Y, Zeng X, Zeng D, Su X, Alexander PB, Wang L, Wang L, Wan YY, Wang XF, Zhang L, Li QJ, Zhu B
Cancer Cell 2022 Jun 13;40(6):674-693.e7. Epub 2022 May 19 doi: 10.1016/j.ccell.2022.04.018. PMID: 35594863
Insights Gained from Single-Cell Analysis of Immune Cells in the Tumor Microenvironment.
Ren X, Zhang L, Zhang Y, Li Z, Siemers N, Zhang Z
Annu Rev Immunol 2021 Apr 26;39:583-609. Epub 2021 Feb 26 doi: 10.1146/annurev-immunol-110519-071134. PMID: 33637019
Pembrolizumab (Keytruda).
Kwok G, Yau TC, Chiu JW, Tse E, Kwong YL
Hum Vaccin Immunother 2016 Nov;12(11):2777-2789. Epub 2016 Jul 11 doi: 10.1080/21645515.2016.1199310. PMID: 27398650Free PMC Article

Recent systematic reviews

New trends in brain tumor immunity with the opportunities of lymph nodes targeted drug delivery.
Qi Y, Xiong W, Chen Q, Ye Z, Jiang C, He Y, Ye Q
J Nanobiotechnology 2023 Aug 4;21(1):254. doi: 10.1186/s12951-023-02011-0. PMID: 37542241Free PMC Article
The molecular basis of immuno-radiotherapy.
Koukourakis IM, Tiniakos D, Kouloulias V, Zygogianni A
Int J Radiat Biol 2023;99(5):715-736. Epub 2022 Nov 16 doi: 10.1080/09553002.2023.2144960. PMID: 36383201
Bridging Radiotherapy to Immunotherapy: The IFN-JAK-STAT Axis.
Shi LZ, Bonner JA
Int J Mol Sci 2021 Nov 14;22(22) doi: 10.3390/ijms222212295. PMID: 34830176Free PMC Article
Crosstalk Between Trophoblasts and Decidual Immune Cells: The Cornerstone of Maternal-Fetal Immunotolerance.
Xu L, Li Y, Sang Y, Li DJ, Du M
Front Immunol 2021;12:642392. Epub 2021 Feb 25 doi: 10.3389/fimmu.2021.642392. PMID: 33717198Free PMC Article
The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer: a critical review of the literature.
deLeeuw RJ, Kost SE, Kakal JA, Nelson BH
Clin Cancer Res 2012 Jun 1;18(11):3022-9. Epub 2012 Apr 17 doi: 10.1158/1078-0432.CCR-11-3216. PMID: 22510350

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