Gain of Chromosome 1p31

MedGen UID:: 274555
•Concept ID:: C1517400
•: Cell or Molecular Dysfunction

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGain of Chromosome 1p31

Molecular Abnormality
- Cytogenetic Abnormality
  - Numerical Chromosomal Abnormality
    - Chromosomal Gain
      - Gain of Chromosome 1p31

Recent clinical studies

Etiology

Gain of 17q in malignant fibrous histiocytoma is associated with a longer disease-free survival and a low risk of developing distant metastasis.

Weng WH, Ahlén J, Lui WO, Brosjö O, Pang ST, Von Rosen A, Auer G, Larsson O, Larsson C
Br J Cancer 2003 Aug 18;89(4):720-6. doi: 10.1038/sj.bjc.6601069. PMID: 12915885 Free PMC Article

Cytogenetic evolution patterns in non-Hodgkin's lymphoma.

Johansson B, Mertens F, Mitelman F
Blood 1995 Nov 15;86(10):3905-14. PMID: 7579360

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Diagnosis

The hypermethylation of the O6-methylguanine-DNA methyltransferase gene promoter in gliomas--correlation with array comparative genome hybridization results and IDH1 mutation.

Tuononen K, Tynninen O, Sarhadi VK, Tyybäkinoja A, Lindlöf M, Antikainen M, Näpänkangas J, Hirvonen A, Mäenpää H, Paetau A, Knuutila S
Genes Chromosomes Cancer 2012 Jan;51(1):20-9. Epub 2011 Sep 15 doi: 10.1002/gcc.20927. PMID: 21922591

DNA copy number changes in human malignant fibrous histiocytomas by array comparative genomic hybridisation.

Kresse SH, Ohnstad HO, Bjerkehagen B, Myklebost O, Meza-Zepeda LA
PLoS One 2010 Nov 9;5(11):e15378. doi: 10.1371/journal.pone.0015378. PMID: 21085701 Free PMC Article

Malignant myoepithelioma of soft tissue: a case report with cytogenetic findings.

Balogh Z, Deák L, Sápi Z
Cancer Genet Cytogenet 2008 Jun;183(2):121-4. doi: 10.1016/j.cancergencyto.2008.02.013. PMID: 18503832

Chromosomal and genetic imbalances in synovial sarcoma detected by conventional and microarray comparative genomic hybridization.

Nakagawa Y, Numoto K, Yoshida A, Kunisada T, Ohata H, Takeda K, Wai D, Poremba C, Ozaki T
J Cancer Res Clin Oncol 2006 Jul;132(7):444-50. Epub 2006 Mar 24 doi: 10.1007/s00432-006-0089-5. PMID: 16557383

Characterization of a highly aberrant plasma cell leukemia karyotype: a case report.

Heller A, Fricke HJ, Starke H, Loncarevic IF, Claussen U, Liehr T
Oncol Rep 2004 Jan;11(1):89-92. PMID: 14654908

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Prognosis

Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma.

Takita J, Chen Y, Okubo J, Sanada M, Adachi M, Ohki K, Nishimura R, Hanada R, Igarashi T, Hayashi Y, Ogawa S
Cancer Sci 2011 Sep;102(9):1645-50. Epub 2011 Jul 3 doi: 10.1111/j.1349-7006.2011.01995.x. PMID: 21624008

Chromosomal and genetic imbalances in synovial sarcoma detected by conventional and microarray comparative genomic hybridization.

Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma.

Rao PH, Arias-Pulido H, Lu XY, Harris CP, Vargas H, Zhang FF, Narayan G, Schneider A, Terry MB, Murty VV
BMC Cancer 2004 Feb 6;4:5. doi: 10.1186/1471-2407-4-5. PMID: 15018632 Free PMC Article

Gain of 17q in malignant fibrous histiocytoma is associated with a longer disease-free survival and a low risk of developing distant metastasis.

Weng WH, Ahlén J, Lui WO, Brosjö O, Pang ST, Von Rosen A, Auer G, Larsson O, Larsson C
Br J Cancer 2003 Aug 18;89(4):720-6. doi: 10.1038/sj.bjc.6601069. PMID: 12915885 Free PMC Article

Comparative genomic hybridization of malignant fibrous histiocytoma reveals a novel prognostic marker.

Larramendy ML, Tarkkanen M, Blomqvist C, Virolainen M, Wiklund T, Asko-Seljavaara S, Elomaa I, Knuutila S
Am J Pathol 1997 Oct;151(4):1153-61. PMID: 9327749 Free PMC Article

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Clinical prediction guides

The hypermethylation of the O6-methylguanine-DNA methyltransferase gene promoter in gliomas--correlation with array comparative genome hybridization results and IDH1 mutation.

Quantitative microsatellite analysis to delineate the commonly deleted region 1p22.3 in mantle cell lymphomas.

Balakrishnan A, von Neuhoff N, Rudolph C, Kamphues K, Schraders M, Groenen P, van Krieken JH, Callet-Bauchu E, Schlegelberger B, Steinemann D
Genes Chromosomes Cancer 2006 Oct;45(10):883-92. doi: 10.1002/gcc.20352. PMID: 16830336

Chromosomal and genetic imbalances in synovial sarcoma detected by conventional and microarray comparative genomic hybridization.

Molecular and cytogenetic analysis of glioblastoma multiforme.

Mao X, Hamoudi RA
Cancer Genet Cytogenet 2000 Oct 15;122(2):87-92. doi: 10.1016/s0165-4608(00)00278-8. PMID: 11106817

The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.

Wong WT, Kraus MH, Carlomagno F, Zelano A, Druck T, Croce CM, Huebner K, Di Fiore PP
Oncogene 1994 Jun;9(6):1591-7. PMID: 8183552

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