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Gain of Chromosome 5p

MedGen UID:
274558
•Concept ID:
C1517412
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that refers to allelic gain of all or part of the chromosomal arm 5q. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 5p

Professional guidelines

PubMed

Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Copy number variations could predict the outcome of bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Kim M, Lee SH, Kim J, Lee SE, Kim YJ, Min CK
Genes Chromosomes Cancer 2015 Jan;54(1):20-7. Epub 2014 Aug 21 doi: 10.1002/gcc.22213. PMID: 25145975
Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes.
De Angelis PM, Clausen OP, Schjølberg A, Stokke T
Br J Cancer 1999 May;80(3-4):526-35. doi: 10.1038/sj.bjc.6690388. PMID: 10408863Free PMC Article

Recent clinical studies

Etiology

Integrated proteogenomic characterization of urothelial carcinoma of the bladder.
Xu N, Yao Z, Shang G, Ye D, Wang H, Zhang H, Qu Y, Xu F, Wang Y, Qin Z, Zhu J, Zhang F, Feng J, Tian S, Liu Y, Zhao J, Hou J, Guo J, Hou Y, Ding C
J Hematol Oncol 2022 Jun 3;15(1):76. doi: 10.1186/s13045-022-01291-7. PMID: 35659036Free PMC Article
Phospholipase C Beta 2 Protein Overexpression Is a Favorable Prognostic Indicator in Newly Diagnosed Normal Karyotype Acute Myeloid Leukemia.
Park MS, Lee YE, Kim HR, Shin JH, Cho HW, Lee JH, Shin MG
Ann Lab Med 2021 Jul 1;41(4):409-413. doi: 10.3343/alm.2021.41.4.409. PMID: 33536360Free PMC Article
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Perturbation of DROSHA and DICER expression by human papillomavirus 16 oncoproteins.
Harden ME, Munger K
Virology 2017 Jul;507:192-198. Epub 2017 Apr 24 doi: 10.1016/j.virol.2017.04.022. PMID: 28448850Free PMC Article
Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes.
Dowen SE, Neutze DM, Pett MR, Cottage A, Stern P, Coleman N, Stanley MA
Oncogene 2003 Apr 24;22(16):2531-40. doi: 10.1038/sj.onc.1206296. PMID: 12717429

Diagnosis

microRNA-99a-5p induces cellular senescence in gemcitabine-resistant bladder cancer by targeting SMARCD1.
Tamai M, Tatarano S, Okamura S, Fukumoto W, Kawakami I, Osako Y, Sakaguchi T, Sugita S, Yonemori M, Yamada Y, Nakagawa M, Enokida H, Yoshino H
Mol Oncol 2022 Mar;16(6):1329-1346. Epub 2022 Feb 28 doi: 10.1002/1878-0261.13192. PMID: 35148461Free PMC Article
Genomic and transcriptomic characterization of desmoplastic small round cell tumors.
Sydow S, Versleijen-Jonkers YMH, Hansson M, van Erp AEM, Hillebrandt-Roeffen MHS, van der Graaf WTA, Piccinelli P, Rissler P, Flucke UE, Mertens F
Genes Chromosomes Cancer 2021 Sep;60(9):595-603. Epub 2021 May 17 doi: 10.1002/gcc.22955. PMID: 33928700
Phospholipase C Beta 2 Protein Overexpression Is a Favorable Prognostic Indicator in Newly Diagnosed Normal Karyotype Acute Myeloid Leukemia.
Park MS, Lee YE, Kim HR, Shin JH, Cho HW, Lee JH, Shin MG
Ann Lab Med 2021 Jul 1;41(4):409-413. doi: 10.3343/alm.2021.41.4.409. PMID: 33536360Free PMC Article
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article
Ring chromosome 5 in acute myeloid leukemia defined by whole-genome single nucleotide polymorphism array.
Huh J, Mun YC, Chung WS, Seong CM
Ann Lab Med 2012 Jul;32(4):307-11. Epub 2012 Jun 20 doi: 10.3343/alm.2012.32.4.307. PMID: 22779075Free PMC Article

Therapy

The Importance of FISH Signal Cut-off Value and Copy Number Variation for 1q21 in Newly Diagnosed Multiple Myeloma: Is it Underestimated?
Gao L, Liu Y, Li Y, Feng L, Wang Z, Wen L, Wang F, Huang X, Lu J, Lai Y
Clin Lymphoma Myeloma Leuk 2022 Jul;22(7):535-544. Epub 2022 Jan 31 doi: 10.1016/j.clml.2022.01.013. PMID: 35292207
Oncogenic miR-96-5p inhibits apoptosis by targeting the caspase-9 gene in hepatocellular carcinoma.
Iwai N, Yasui K, Tomie A, Gen Y, Terasaki K, Kitaichi T, Soda T, Yamada N, Dohi O, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y
Int J Oncol 2018 Jul;53(1):237-245. Epub 2018 Apr 12 doi: 10.3892/ijo.2018.4369. PMID: 29658604
Copy number variations could predict the outcome of bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Kim M, Lee SH, Kim J, Lee SE, Kim YJ, Min CK
Genes Chromosomes Cancer 2015 Jan;54(1):20-7. Epub 2014 Aug 21 doi: 10.1002/gcc.22213. PMID: 25145975
Oncostatin M receptor is a novel therapeutic target in cervical squamous cell carcinoma.
Caffarel MM, Coleman N
J Pathol 2014 Mar;232(4):386-90. doi: 10.1002/path.4305. PMID: 24659184Free PMC Article
Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer.
Nymark P, Guled M, Borze I, Faisal A, Lahti L, Salmenkivi K, Kettunen E, Anttila S, Knuutila S
Genes Chromosomes Cancer 2011 Aug;50(8):585-97. Epub 2011 May 11 doi: 10.1002/gcc.20880. PMID: 21563230

Prognosis

Distinct patterns of copy number alterations may predict poor outcome in central nervous system germ cell tumors.
Takami H, Satomi K, Fukuoka K, Nakamura T, Tanaka S, Mukasa A, Saito N, Suzuki T, Yanagisawa T, Sugiyama K, Kanamori M, Kumabe T, Tominaga T, Tamura K, Maehara T, Nonaka M, Asai A, Yokogami K, Takeshima H, Iuchi T, Kobayashi K, Yoshimoto K, Sakai K, Nakazato Y, Matsutani M, Nagane M, Nishikawa R, Ichimura K
Sci Rep 2023 Sep 21;13(1):15760. doi: 10.1038/s41598-023-42842-3. PMID: 37735187Free PMC Article
Integrated proteogenomic characterization of urothelial carcinoma of the bladder.
Xu N, Yao Z, Shang G, Ye D, Wang H, Zhang H, Qu Y, Xu F, Wang Y, Qin Z, Zhu J, Zhang F, Feng J, Tian S, Liu Y, Zhao J, Hou J, Guo J, Hou Y, Ding C
J Hematol Oncol 2022 Jun 3;15(1):76. doi: 10.1186/s13045-022-01291-7. PMID: 35659036Free PMC Article
The Importance of FISH Signal Cut-off Value and Copy Number Variation for 1q21 in Newly Diagnosed Multiple Myeloma: Is it Underestimated?
Gao L, Liu Y, Li Y, Feng L, Wang Z, Wen L, Wang F, Huang X, Lu J, Lai Y
Clin Lymphoma Myeloma Leuk 2022 Jul;22(7):535-544. Epub 2022 Jan 31 doi: 10.1016/j.clml.2022.01.013. PMID: 35292207
Phospholipase C Beta 2 Protein Overexpression Is a Favorable Prognostic Indicator in Newly Diagnosed Normal Karyotype Acute Myeloid Leukemia.
Park MS, Lee YE, Kim HR, Shin JH, Cho HW, Lee JH, Shin MG
Ann Lab Med 2021 Jul 1;41(4):409-413. doi: 10.3343/alm.2021.41.4.409. PMID: 33536360Free PMC Article
Clinical characteristics and treatment outcomes of newly diagnosed multiple myeloma with chromosome 1q abnormalities.
Abdallah N, Greipp P, Kapoor P, Gertz MA, Dispenzieri A, Baughn LB, Lacy MQ, Hayman SR, Buadi FK, Dingli D, Go RS, Hwa YL, Fonder A, Hobbs M, Lin Y, Leung N, Kourelis T, Warsame R, Siddiqui M, Lust J, Kyle RA, Bergsagel L, Ketterling R, Rajkumar SV, Kumar SK
Blood Adv 2020 Aug 11;4(15):3509-3519. doi: 10.1182/bloodadvances.2020002218. PMID: 32750129Free PMC Article

Clinical prediction guides

Distinct patterns of copy number alterations may predict poor outcome in central nervous system germ cell tumors.
Takami H, Satomi K, Fukuoka K, Nakamura T, Tanaka S, Mukasa A, Saito N, Suzuki T, Yanagisawa T, Sugiyama K, Kanamori M, Kumabe T, Tominaga T, Tamura K, Maehara T, Nonaka M, Asai A, Yokogami K, Takeshima H, Iuchi T, Kobayashi K, Yoshimoto K, Sakai K, Nakazato Y, Matsutani M, Nagane M, Nishikawa R, Ichimura K
Sci Rep 2023 Sep 21;13(1):15760. doi: 10.1038/s41598-023-42842-3. PMID: 37735187Free PMC Article
Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo.
Winsel S, Mäki-Jouppila J, Tambe M, Aure MR, Pruikkonen S, Salmela AL, Halonen T, Leivonen SK, Kallio L, Børresen-Dale AL, Kallio MJ
Br J Cancer 2014 Nov 25;111(11):2142-51. Epub 2014 Sep 30 doi: 10.1038/bjc.2014.524. PMID: 25268374Free PMC Article
ALK gene copy number gain and its clinical significance in hepatocellular carcinoma.
Jia SW, Fu S, Wang F, Shao Q, Huang HB, Shao JY
World J Gastroenterol 2014 Jan 7;20(1):183-92. doi: 10.3748/wjg.v20.i1.183. PMID: 24415871Free PMC Article
Cytogenetic characterization of tumors of the vulva and vagina.
Micci F, Teixeira MR, Scheistrøen M, Abeler VM, Heim S
Genes Chromosomes Cancer 2003 Oct;38(2):137-48. doi: 10.1002/gcc.10263. PMID: 12939741
Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes.
Dowen SE, Neutze DM, Pett MR, Cottage A, Stern P, Coleman N, Stanley MA
Oncogene 2003 Apr 24;22(16):2531-40. doi: 10.1038/sj.onc.1206296. PMID: 12717429

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