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Gestational ovarian choriocarcinoma

MedGen UID:
274586
•Concept ID:
C1517538
•
Neoplastic Process
Synonyms: Gestational Ovarian Choriocarcinoma; gestational ovarian choriocarcinoma; Ovarian Gestational Choriocarcinoma
 
Monarch Initiative: MONDO:0004294

Definition

A rare malignant trophoblastic tumor that arises from the ovary as a result of ectopic ovarian pregnancy. There is no germ cell component present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGestational ovarian choriocarcinoma

Professional guidelines

PubMed

Challenging gestational trophoblastic disease cases and mimics: An exemplar for the management of rare tumours.
Hamid M, Joyce CM, Carroll HK, Kenneally C, Mulcahy S, O'Neill MK, Coulter J, O'Reilly S
Eur J Obstet Gynecol Reprod Biol 2023 Jul;286:76-84. Epub 2023 May 13 doi: 10.1016/j.ejogrb.2023.05.016. PMID: 37224702
Management of ovarian masses in pregnancy: patient selection for interventional treatment.
Testa AC, Mascilini F, Quagliozzi L, Moro F, Bolomini G, Mirandola MT, Moruzzi MC, Scambia G, Fagotti A
Int J Gynecol Cancer 2021 Jun;31(6):899-906. Epub 2020 Nov 10 doi: 10.1136/ijgc-2020-001996. PMID: 33172924
Management and outcome of ovarian malignancy complicating pregnancy: an analysis of 41 cases and review of the literature.
Gui T, Cao D, Shen K, Yang J, Fu C, Lang J, Liu X
Clin Transl Oncol 2013 Jul;15(7):548-54. Epub 2012 Nov 13 doi: 10.1007/s12094-012-0965-1. PMID: 23150218

Recent clinical studies

Etiology

Imaging in gynecological disease (22): clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors.
Moro F, Castellano LM, Franchi D, Epstein E, Fischerova D, Froyman W, Timmerman D, Zannoni GF, Scambia G, Valentin L, Testa AC, Mascilini F
Ultrasound Obstet Gynecol 2021 Jun;57(6):987-994. doi: 10.1002/uog.23529. PMID: 33142349
Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma.
Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P
Arch Gynecol Obstet 2020 Apr;301(4):901-912. Epub 2020 Mar 17 doi: 10.1007/s00404-020-05502-9. PMID: 32185550

Diagnosis

A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy.
Sakurai S, Asano R, Furugori M, Shigeta H
Taiwan J Obstet Gynecol 2022 Jul;61(4):708-712. doi: 10.1016/j.tjog.2021.09.036. PMID: 35779927
Imaging in gynecological disease (22): clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors.
Moro F, Castellano LM, Franchi D, Epstein E, Fischerova D, Froyman W, Timmerman D, Zannoni GF, Scambia G, Valentin L, Testa AC, Mascilini F
Ultrasound Obstet Gynecol 2021 Jun;57(6):987-994. doi: 10.1002/uog.23529. PMID: 33142349
Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma.
Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P
Arch Gynecol Obstet 2020 Apr;301(4):901-912. Epub 2020 Mar 17 doi: 10.1007/s00404-020-05502-9. PMID: 32185550
Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite.
Hu T, Yang M, Zhu H, Shi G, Wang H
J Obstet Gynaecol Res 2011 Dec;37(12):1900-5. Epub 2011 Nov 9 doi: 10.1111/j.1447-0756.2011.01693.x. PMID: 22070612

Therapy

Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083

Prognosis

A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy.
Sakurai S, Asano R, Furugori M, Shigeta H
Taiwan J Obstet Gynecol 2022 Jul;61(4):708-712. doi: 10.1016/j.tjog.2021.09.036. PMID: 35779927
Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma.
Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P
Arch Gynecol Obstet 2020 Apr;301(4):901-912. Epub 2020 Mar 17 doi: 10.1007/s00404-020-05502-9. PMID: 32185550
A positive urine pregnancy test (UPT) with adnexal mass; ectopic pregnancy is not the ultimate diagnosis.
Ahmad MF, Abu MA, Chew KT, Sheng KL, Zakaria MA
Horm Mol Biol Clin Investig 2018 Mar 20;34(2) doi: 10.1515/hmbci-2018-0004. PMID: 29558344
Pure non-gestational choriocarcinoma arising in the ovary.
Ahn SH, Roh HJ, Cho HJ, You SG, Lee SH, Kwon YS
Eur J Gynaecol Oncol 2016 Aug;37(4):549-553. PMID: 29894083
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite.
Hu T, Yang M, Zhu H, Shi G, Wang H
J Obstet Gynaecol Res 2011 Dec;37(12):1900-5. Epub 2011 Nov 9 doi: 10.1111/j.1447-0756.2011.01693.x. PMID: 22070612

Clinical prediction guides

A rare case of gestational ovarian choriocarcinoma coexistent with intrauterine pregnancy.
Sakurai S, Asano R, Furugori M, Shigeta H
Taiwan J Obstet Gynecol 2022 Jul;61(4):708-712. doi: 10.1016/j.tjog.2021.09.036. PMID: 35779927

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