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Juvenile Bilateral Ovarian Granulosa Cell Tumor

MedGen UID:
274609
•Concept ID:
C1517627
•
Neoplastic Process
Synonym: Juvenile Type Bilateral Ovarian Granulosa Cell Tumor

Definition

A juvenile granulosa cell tumor that involves both ovaries. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuvenile Bilateral Ovarian Granulosa Cell Tumor

Recent clinical studies

Etiology

Granulosa cell tumor of the ovary: a series of 6 cases.
da Costa REAR, Silva MCA, Cavalcante ECX, Branco ROC, Dos Reis CA, Vieira SC
Pan Afr Med J 2024;47:58. Epub 2024 Feb 11 doi: 10.11604/pamj.2024.47.58.38324. PMID: 38646138Free PMC Article
Ovarian juvenile granulosa cell tumors with Ollier's disease in children with IDH1 gene somatic mutation.
Zhang J, Hua R, Ma L, Liu C, Zhang Y, Lü X, Wang T, Wan N
Front Endocrinol (Lausanne) 2023;14:1093273. Epub 2023 May 30 doi: 10.3389/fendo.2023.1093273. PMID: 37324278Free PMC Article
Retrospective analysis of clinicopathological characteristics of 19 ovarian juvenile granulosa cell tumor cases.
Ndhlovu E, Liu L, Dai J, Dong X, Zhang W, Chen B
J Obstet Gynaecol Res 2021 Jul;47(7):2492-2499. Epub 2021 Apr 27 doi: 10.1111/jog.14805. PMID: 33904645
Juvenile granulosa cell tumor of the ovary: A comprehensive clinicopathologic analysis of 15 cases.
Parikshaa G, Ariba Z, Pranab D, Nalini G, Manish R, Vanita S, Bhavana R, Devi D, Ram S, Prema M, Arvind R, Radhika S
Ann Diagn Pathol 2021 Jun;52:151721. Epub 2021 Feb 10 doi: 10.1016/j.anndiagpath.2021.151721. PMID: 33725665
Hyperreactio Luteinalis (Multiple Luteinized Follicle Cysts): A Report of 10 Cases.
Watkins JC, Lebok P, Young RH
Int J Gynecol Pathol 2021 Sep 1;40(5):427-434. doi: 10.1097/PGP.0000000000000746. PMID: 33323862

Diagnosis

Bilateral Ovarian Juvenile Granulosa Cell Tumor with Extensive Extracellular Mucin Deposition in an Adolescent: Report of a Rare Presentation with a Comprehensive Review of the Literature.
Ahuja N, Gupta P, Gupta N, Sikka P
J Adolesc Young Adult Oncol 2022 Dec;11(6):621-631. Epub 2022 Jan 19 doi: 10.1089/jayao.2021.0166. PMID: 35049372
Retrospective analysis of clinicopathological characteristics of 19 ovarian juvenile granulosa cell tumor cases.
Ndhlovu E, Liu L, Dai J, Dong X, Zhang W, Chen B
J Obstet Gynaecol Res 2021 Jul;47(7):2492-2499. Epub 2021 Apr 27 doi: 10.1111/jog.14805. PMID: 33904645
Juvenile granulosa cell tumor of the ovary: A comprehensive clinicopathologic analysis of 15 cases.
Parikshaa G, Ariba Z, Pranab D, Nalini G, Manish R, Vanita S, Bhavana R, Devi D, Ram S, Prema M, Arvind R, Radhika S
Ann Diagn Pathol 2021 Jun;52:151721. Epub 2021 Feb 10 doi: 10.1016/j.anndiagpath.2021.151721. PMID: 33725665
Natural history of Ollier disease and Maffucci syndrome: Patient survey and review of clinical literature.
El Abiad JM, Robbins SM, Cohen B, Levin AS, Valle DL, Morris CD, de Macena Sobreira NL
Am J Med Genet A 2020 May;182(5):1093-1103. Epub 2020 Mar 7 doi: 10.1002/ajmg.a.61530. PMID: 32144835Free PMC Article
Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature.
Inada Y, Nakai G, Yamamoto K, Yamada T, Hirose Y, Terai Y, Ohmichi M, Narumi Y
J Ovarian Res 2018 Dec 14;11(1):100. doi: 10.1186/s13048-018-0474-0. PMID: 30547828Free PMC Article

Prognosis

Granulosa cell tumor of the ovary: a series of 6 cases.
da Costa REAR, Silva MCA, Cavalcante ECX, Branco ROC, Dos Reis CA, Vieira SC
Pan Afr Med J 2024;47:58. Epub 2024 Feb 11 doi: 10.11604/pamj.2024.47.58.38324. PMID: 38646138Free PMC Article
Mixed sex cord-stromal tumor (gynandroblastoma) with malignant morphology involving both ovaries: a case report.
Maraqa B, Al-Ashhab M, Kamal N, Sughayer M, Barakat F
J Int Med Res 2023 Jul;51(7):3000605231187796. doi: 10.1177/03000605231187796. PMID: 37493465Free PMC Article
Juvenile granulosa cell tumor of the ovary: A comprehensive clinicopathologic analysis of 15 cases.
Parikshaa G, Ariba Z, Pranab D, Nalini G, Manish R, Vanita S, Bhavana R, Devi D, Ram S, Prema M, Arvind R, Radhika S
Ann Diagn Pathol 2021 Jun;52:151721. Epub 2021 Feb 10 doi: 10.1016/j.anndiagpath.2021.151721. PMID: 33725665
Natural history of Ollier disease and Maffucci syndrome: Patient survey and review of clinical literature.
El Abiad JM, Robbins SM, Cohen B, Levin AS, Valle DL, Morris CD, de Macena Sobreira NL
Am J Med Genet A 2020 May;182(5):1093-1103. Epub 2020 Mar 7 doi: 10.1002/ajmg.a.61530. PMID: 32144835Free PMC Article
Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems.
Young RH
Mod Pathol 2005 Feb;18 Suppl 2:S81-98. doi: 10.1038/modpathol.3800311. PMID: 15502809

Clinical prediction guides

Precocious Pseudo-puberty in a Two-year-old Girl, Presenting with Bilateral Ovarian Enlargement and Progressing to Unilateral Juvenile Granulosa Cell Tumour.
Barakizou H, Gannouni S, Kamoun T, Mehdi M, Amary F, Huma Z, Todeschini AL, Veitia R, Donaldson M
J Clin Res Pediatr Endocrinol 2022 Mar 3;14(1):107-113. Epub 2021 Apr 14 doi: 10.4274/jcrpe.galenos.2021.2021.0039. PMID: 33849266Free PMC Article
Bilateral juvenile granulosa cell tumours associated with skeletal enchondromas.
Pounder DJ, Iyer PV, Davy ML
Aust N Z J Obstet Gynaecol 1985 May;25(2):123-6. doi: 10.1111/j.1479-828x.1985.tb00624.x. PMID: 3863589

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