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Loss of Chromosome 11q

MedGen UID:
274696
•Concept ID:
C1517952
•
Cell or Molecular Dysfunction
Synonyms: 11q Deletion; del(11q)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 11 (11q). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 11q

Professional guidelines

PubMed

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management.
Ribeiro IP, Marques F, Caramelo F, Pereira J, Patrício M, Prazeres H, Ferrão J, Julião MJ, Castelo-Branco M, de Melo JB, Baptista IP, Carreira IM
Cell Oncol (Dordr) 2014 Feb;37(1):29-39. Epub 2013 Dec 19 doi: 10.1007/s13402-013-0161-5. PMID: 24353162
Genetic stratification of neuroblastoma for treatment tailoring.
Jeison M, Yaniv I, Ash S
Future Oncol 2011 Sep;7(9):1087-99. doi: 10.2217/fon.11.87. PMID: 21919696

Recent clinical studies

Etiology

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Takagi M, Yoshida M, Nemoto Y, Tamaichi H, Tsuchida R, Seki M, Uryu K, Nishii R, Miyamoto S, Saito M, Hanada R, Kaneko H, Miyano S, Kataoka K, Yoshida K, Ohira M, Hayashi Y, Nakagawara A, Ogawa S, Mizutani S, Takita J
J Natl Cancer Inst 2017 Nov 1;109(11) doi: 10.1093/jnci/djx062. PMID: 29059438
Profiling of ileal carcinoids.
Nilsson O
Neuroendocrinology 2013;97(1):7-18. Epub 2012 Nov 2 doi: 10.1159/000343232. PMID: 22986706
Neuroblastoma: biology and staging.
Mueller S, Matthay KK
Curr Oncol Rep 2009 Nov;11(6):431-8. doi: 10.1007/s11912-009-0059-6. PMID: 19840520
Inherited peripheral neuropathy.
Keller MP, Chance PF
Semin Neurol 1999;19(4):353-62. doi: 10.1055/s-2008-1040850. PMID: 10716658

Diagnosis

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Takagi M, Yoshida M, Nemoto Y, Tamaichi H, Tsuchida R, Seki M, Uryu K, Nishii R, Miyamoto S, Saito M, Hanada R, Kaneko H, Miyano S, Kataoka K, Yoshida K, Ohira M, Hayashi Y, Nakagawara A, Ogawa S, Mizutani S, Takita J
J Natl Cancer Inst 2017 Nov 1;109(11) doi: 10.1093/jnci/djx062. PMID: 29059438
The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.
Stankovic T, Skowronska A
Leuk Lymphoma 2014 Jun;55(6):1227-39. Epub 2013 Sep 12 doi: 10.3109/10428194.2013.829919. PMID: 23906020
Neuroblastoma: biology and staging.
Mueller S, Matthay KK
Curr Oncol Rep 2009 Nov;11(6):431-8. doi: 10.1007/s11912-009-0059-6. PMID: 19840520
Natural killer cell neoplasms.
Liang X, Graham DK
Cancer 2008 Apr 1;112(7):1425-36. doi: 10.1002/cncr.23316. PMID: 18286525

Therapy

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Takagi M, Yoshida M, Nemoto Y, Tamaichi H, Tsuchida R, Seki M, Uryu K, Nishii R, Miyamoto S, Saito M, Hanada R, Kaneko H, Miyano S, Kataoka K, Yoshida K, Ohira M, Hayashi Y, Nakagawara A, Ogawa S, Mizutani S, Takita J
J Natl Cancer Inst 2017 Nov 1;109(11) doi: 10.1093/jnci/djx062. PMID: 29059438
Allele loss in Wilms tumors of chromosome arms 11q, 16q, and 22q correlate with clinicopathological parameters.
Klamt B, Schulze M, Thäte C, Mares J, Goetz P, Kodet R, Scheulen W, Weirich A, Graf N, Gessler M
Genes Chromosomes Cancer 1998 Aug;22(4):287-94. doi: 10.1002/(sici)1098-2264(199808)22:4<287::aid-gcc4>3.0.co;2-r. PMID: 9669666
Neuroblastoma: the result of multistep transformation?
Tonini GP
Stem Cells 1993 Jul;11(4):276-82. doi: 10.1002/stem.5530110404. PMID: 8401251

Prognosis

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Takagi M, Yoshida M, Nemoto Y, Tamaichi H, Tsuchida R, Seki M, Uryu K, Nishii R, Miyamoto S, Saito M, Hanada R, Kaneko H, Miyano S, Kataoka K, Yoshida K, Ohira M, Hayashi Y, Nakagawara A, Ogawa S, Mizutani S, Takita J
J Natl Cancer Inst 2017 Nov 1;109(11) doi: 10.1093/jnci/djx062. PMID: 29059438
The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.
Stankovic T, Skowronska A
Leuk Lymphoma 2014 Jun;55(6):1227-39. Epub 2013 Sep 12 doi: 10.3109/10428194.2013.829919. PMID: 23906020
Neuroblastoma: biology and staging.
Mueller S, Matthay KK
Curr Oncol Rep 2009 Nov;11(6):431-8. doi: 10.1007/s11912-009-0059-6. PMID: 19840520

Clinical prediction guides

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Takagi M, Yoshida M, Nemoto Y, Tamaichi H, Tsuchida R, Seki M, Uryu K, Nishii R, Miyamoto S, Saito M, Hanada R, Kaneko H, Miyano S, Kataoka K, Yoshida K, Ohira M, Hayashi Y, Nakagawara A, Ogawa S, Mizutani S, Takita J
J Natl Cancer Inst 2017 Nov 1;109(11) doi: 10.1093/jnci/djx062. PMID: 29059438
Histologic and Molecular Profile of Pediatric Insulinomas: Evidence of a Paternal Parent-of-Origin Effect.
Bhatti TR, Ganapathy K, Huppmann AR, Conlin L, Boodhansingh KE, MacMullen C, Becker S, Ernst LM, Adzick NS, Ruchelli ED, Ganguly A, Stanley CA
J Clin Endocrinol Metab 2016 Mar;101(3):914-22. Epub 2016 Jan 12 doi: 10.1210/jc.2015-2914. PMID: 26756113Free PMC Article
Genetics of bladder cancer.
Saran KK, Gould D, Godec CJ, Verma RS
J Mol Med (Berl) 1996 Aug;74(8):441-5. doi: 10.1007/BF00217519. PMID: 8872857

Recent systematic reviews

Genetic variation frequencies in Wilms' tumor: A meta-analysis and systematic review.
Deng C, Dai R, Li X, Liu F
Cancer Sci 2016 May;107(5):690-9. Epub 2016 Mar 18 doi: 10.1111/cas.12910. PMID: 26892980Free PMC Article

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