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Loss of Chromosome 11q

MedGen UID:
274696
•Concept ID:
C1517952
•
Cell or Molecular Dysfunction
Synonyms: 11q Deletion; del(11q)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 11 (11q). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 11q

Professional guidelines

PubMed

Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses.
Caroselli S, Figliuzzi M, Picchetta L, Cogo F, Zambon P, Pergher I, Girardi L, Patassini C, Poli M, Bakalova D, Cimadomo D, Findikli N, Coban O, Serdarogullari M, Favero F, Bortolato S, Anastasi A, Capodanno F, Gallinelli A, Brancati F, Rienzi L, Ubaldi FM, Jimenez-Almazán J, Blesa-Jarque D, Miravet-Valenciano J, Rubio C, Simòn C, Capalbo A
Hum Reprod 2023 Apr 3;38(4):762-775. doi: 10.1093/humrep/dead033. PMID: 36824049
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Genetic stratification of neuroblastoma for treatment tailoring.
Jeison M, Yaniv I, Ash S
Future Oncol 2011 Sep;7(9):1087-99. doi: 10.2217/fon.11.87. PMID: 21919696

Recent clinical studies

Etiology

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Profiling of ileal carcinoids.
Nilsson O
Neuroendocrinology 2013;97(1):7-18. Epub 2012 Nov 2 doi: 10.1159/000343232. PMID: 22986706
Neuroblastoma: biology and staging.
Mueller S, Matthay KK
Curr Oncol Rep 2009 Nov;11(6):431-8. doi: 10.1007/s11912-009-0059-6. PMID: 19840520
Natural killer cell neoplasms.
Liang X, Graham DK
Cancer 2008 Apr 1;112(7):1425-36. doi: 10.1002/cncr.23316. PMID: 18286525
Inherited peripheral neuropathy.
Keller MP, Chance PF
Semin Neurol 1999;19(4):353-62. doi: 10.1055/s-2008-1040850. PMID: 10716658

Diagnosis

Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch 2023 Sep;483(3):281-298. Epub 2023 Aug 9 doi: 10.1007/s00428-023-03590-x. PMID: 37555980Free PMC Article
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression.
Quijada-Álamo M, Hernández-Sánchez M, Rodríguez-Vicente AE, Pérez-Carretero C, Rodríguez-Sánchez A, Martín-Izquierdo M, Alonso-Pérez V, García-Tuñón I, Bastida JM, Vidal-Manceñido MJ, Galende J, Aguilar C, Queizán JA, González-Gascón Y Marín I, Hernández-Rivas JÁ, Benito R, Ordóñez JL, Hernández-Rivas JM
Blood Cancer J 2021 Jul 9;11(7):127. doi: 10.1038/s41408-021-00520-5. PMID: 34244476Free PMC Article
Neuroblastoma: biology and staging.
Mueller S, Matthay KK
Curr Oncol Rep 2009 Nov;11(6):431-8. doi: 10.1007/s11912-009-0059-6. PMID: 19840520
Natural killer cell neoplasms.
Liang X, Graham DK
Cancer 2008 Apr 1;112(7):1425-36. doi: 10.1002/cncr.23316. PMID: 18286525

Therapy

Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses.
Caroselli S, Figliuzzi M, Picchetta L, Cogo F, Zambon P, Pergher I, Girardi L, Patassini C, Poli M, Bakalova D, Cimadomo D, Findikli N, Coban O, Serdarogullari M, Favero F, Bortolato S, Anastasi A, Capodanno F, Gallinelli A, Brancati F, Rienzi L, Ubaldi FM, Jimenez-Almazán J, Blesa-Jarque D, Miravet-Valenciano J, Rubio C, Simòn C, Capalbo A
Hum Reprod 2023 Apr 3;38(4):762-775. doi: 10.1093/humrep/dead033. PMID: 36824049
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Takagi M, Yoshida M, Nemoto Y, Tamaichi H, Tsuchida R, Seki M, Uryu K, Nishii R, Miyamoto S, Saito M, Hanada R, Kaneko H, Miyano S, Kataoka K, Yoshida K, Ohira M, Hayashi Y, Nakagawara A, Ogawa S, Mizutani S, Takita J
J Natl Cancer Inst 2017 Nov 1;109(11) doi: 10.1093/jnci/djx062. PMID: 29059438
Neuroblastoma: the result of multistep transformation?
Tonini GP
Stem Cells 1993 Jul;11(4):276-82. doi: 10.1002/stem.5530110404. PMID: 8401251

Prognosis

Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch 2023 Sep;483(3):281-298. Epub 2023 Aug 9 doi: 10.1007/s00428-023-03590-x. PMID: 37555980Free PMC Article
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia.
Stankovic T, Skowronska A
Leuk Lymphoma 2014 Jun;55(6):1227-39. Epub 2013 Sep 12 doi: 10.3109/10428194.2013.829919. PMID: 23906020
Neuroblastoma: biology and staging.
Mueller S, Matthay KK
Curr Oncol Rep 2009 Nov;11(6):431-8. doi: 10.1007/s11912-009-0059-6. PMID: 19840520

Clinical prediction guides

Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses.
Caroselli S, Figliuzzi M, Picchetta L, Cogo F, Zambon P, Pergher I, Girardi L, Patassini C, Poli M, Bakalova D, Cimadomo D, Findikli N, Coban O, Serdarogullari M, Favero F, Bortolato S, Anastasi A, Capodanno F, Gallinelli A, Brancati F, Rienzi L, Ubaldi FM, Jimenez-Almazán J, Blesa-Jarque D, Miravet-Valenciano J, Rubio C, Simòn C, Capalbo A
Hum Reprod 2023 Apr 3;38(4):762-775. doi: 10.1093/humrep/dead033. PMID: 36824049
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?
Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Takagi M, Yoshida M, Nemoto Y, Tamaichi H, Tsuchida R, Seki M, Uryu K, Nishii R, Miyamoto S, Saito M, Hanada R, Kaneko H, Miyano S, Kataoka K, Yoshida K, Ohira M, Hayashi Y, Nakagawara A, Ogawa S, Mizutani S, Takita J
J Natl Cancer Inst 2017 Nov 1;109(11) doi: 10.1093/jnci/djx062. PMID: 29059438
Loss of heterozygosity in neuroblastomas--an overview.
Takita J, Hayashi Y, Yokota J
Eur J Cancer 1997 Oct;33(12):1971-3. doi: 10.1016/s0959-8049(97)00292-x. PMID: 9516835

Recent systematic reviews

Genetic variation frequencies in Wilms' tumor: A meta-analysis and systematic review.
Deng C, Dai R, Li X, Liu F
Cancer Sci 2016 May;107(5):690-9. Epub 2016 Mar 18 doi: 10.1111/cas.12910. PMID: 26892980Free PMC Article

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