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Loss of Chromosome 17

MedGen UID:
274700
Concept ID:
C1517964
Cell or Molecular Dysfunction
Synonym: del(17)

Definition

A cytogenic abnormality that refers to loss of all or part of chromosome 17. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 17

Professional guidelines

PubMed

Dickey CA, Petrucelli L
Expert Opin Ther Targets 2006 Oct;10(5):665-76. doi: 10.1517/14728222.10.5.665. PMID: 16981824
Clark J, Edwards S, Feber A, Flohr P, John M, Giddings I, Crossland S, Stratton MR, Wooster R, Campbell C, Cooper CS
Oncogene 2003 Feb 27;22(8):1247-52. doi: 10.1038/sj.onc.1206247. PMID: 12606952
Shapiro WR, Shapiro JR
Oncology (Williston Park) 1998 Feb;12(2):233-40; discussion 240, 246. PMID: 9507524

Recent clinical studies

Etiology

Edelmann J, Gribben JG
J Oncol Pract 2017 Jun;13(6):371-377. doi: 10.1200/JOP.2017.023291. PMID: 28605616
Vriend J, Marzban H
Cell Mol Life Sci 2017 Feb;74(3):449-467. Epub 2016 Sep 3 doi: 10.1007/s00018-016-2354-3. PMID: 27592301
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Keller MP, Chance PF
Semin Neurol 1999;19(4):353-62. doi: 10.1055/s-2008-1040850. PMID: 10716658

Diagnosis

Aygun N
Curr Pediatr Rev 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. PMID: 29380702
Schmidt LS, Linehan WM
Nat Rev Urol 2015 Oct;12(10):558-69. Epub 2015 Sep 1 doi: 10.1038/nrurol.2015.206. PMID: 26334087Free PMC Article
Arvanitakis Z
Neurologist 2010 Jan;16(1):16-22. doi: 10.1097/NRL.0b013e3181b1d5c6. PMID: 20065792Free PMC Article
Yoshiyama Y, Lee VM, Trojanowski JQ
Curr Neurol Neurosci Rep 2001 Sep;1(5):413-21. doi: 10.1007/s11910-001-0100-0. PMID: 11898551
Collins VP
Cancer Surv 1998;32:37-51. PMID: 10489622

Therapy

Wozniak A, Boeckx B, Modave E, Weaver A, Lambrechts D, Littlefield BA, Schöffski P
Clin Cancer Res 2021 Jun 1;27(11):3106-3115. Epub 2021 Apr 1 doi: 10.1158/1078-0432.CCR-20-4315. PMID: 33795257
Becker H, Pfeifer D, Ihorst G, Pantic M, Wehrle J, Rüter BH, Bullinger L, Hackanson B, Germing U, Kuendgen A, Platzbecker U, Döhner K, Ganser A, Hagemeijer A, Wijermans PW, Döhner H, Duyster J, Lübbert M
Ann Hematol 2020 Jul;99(7):1551-1560. Epub 2020 Jun 6 doi: 10.1007/s00277-020-04082-7. PMID: 32504186Free PMC Article
Edelmann J, Gribben JG
J Oncol Pract 2017 Jun;13(6):371-377. doi: 10.1200/JOP.2017.023291. PMID: 28605616
Arvanitakis Z
Neurologist 2010 Jan;16(1):16-22. doi: 10.1097/NRL.0b013e3181b1d5c6. PMID: 20065792Free PMC Article
Schleiermacher G, Raynal V, Janoueix-Lerosey I, Combaret V, Aurias A, Delattre O
Genes Chromosomes Cancer 2004 Feb;39(2):143-50. doi: 10.1002/gcc.10313. PMID: 14695994

Prognosis

Aygun N
Curr Pediatr Rev 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. PMID: 29380702
Vriend J, Marzban H
Cell Mol Life Sci 2017 Feb;74(3):449-467. Epub 2016 Sep 3 doi: 10.1007/s00018-016-2354-3. PMID: 27592301
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Hervé AL, Florence M, Philippe M, Michel A, Thierry F, Kenneth A, Jean-Luc H, Nikhil M, Stéphane M
J Clin Oncol 2011 May 10;29(14):1893-7. Epub 2011 Apr 11 doi: 10.1200/JCO.2010.32.8435. PMID: 21482986

Clinical prediction guides

Campo E, Cymbalista F, Ghia P, Jäger U, Pospisilova S, Rosenquist R, Schuh A, Stilgenbauer S
Haematologica 2018 Dec;103(12):1956-1968. Epub 2018 Nov 15 doi: 10.3324/haematol.2018.187583. PMID: 30442727Free PMC Article
Vriend J, Marzban H
Cell Mol Life Sci 2017 Feb;74(3):449-467. Epub 2016 Sep 3 doi: 10.1007/s00018-016-2354-3. PMID: 27592301
Di Marcotullio L, Ferretti E, De Smaele E, Screpanti I, Gulino A
Mol Neurobiol 2006 Dec;34(3):193-204. doi: 10.1385/MN:34:3:193. PMID: 17308352
Frohman LA, Eguchi K
Growth Horm IGF Res 2004 Jun;14 Suppl A:S90-6. doi: 10.1016/j.ghir.2004.03.021. PMID: 15135786
Lehman TA, Reddel R, Peiifer AM, Spillare E, Kaighn ME, Weston A, Gerwin BI, Harris CC
Environ Health Perspect 1991 Jun;93:133-44. doi: 10.1289/ehp.9193133. PMID: 1685442Free PMC Article

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