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Loss of Chromosome 17

MedGen UID:
274700
•Concept ID:
C1517964
•
Cell or Molecular Dysfunction
Synonym: del(17)

Definition

A cytogenic abnormality that refers to loss of all or part of chromosome 17. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 17

Professional guidelines

PubMed

Current strategies for the treatment of Alzheimer's disease and other tauopathies.
Dickey CA, Petrucelli L
Expert Opin Ther Targets 2006 Oct;10(5):665-76. doi: 10.1517/14728222.10.5.665. PMID: 16981824
Loss of heterozygosity and microsatellite instability as predictive markers for neoadjuvant treatment in gastric carcinoma.
Grundei T, Vogelsang H, Ott K, Mueller J, Scholz M, Becker K, Fink U, Siewert JR, Höfler H, Keller G
Clin Cancer Res 2000 Dec;6(12):4782-8. PMID: 11156235
Biology and treatment of malignant glioma.
Shapiro WR, Shapiro JR
Oncology (Williston Park) 1998 Feb;12(2):233-40; discussion 240, 246. PMID: 9507524

Recent clinical studies

Etiology

The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups.
Vriend J, Marzban H
Cell Mol Life Sci 2017 Feb;74(3):449-467. Epub 2016 Sep 3 doi: 10.1007/s00018-016-2354-3. PMID: 27592301
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Wilms tumor: an update.
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Inherited peripheral neuropathy.
Keller MP, Chance PF
Semin Neurol 1999;19(4):353-62. doi: 10.1055/s-2008-1040850. PMID: 10716658
Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies.
Spillantini MG, Bird TD, Ghetti B
Brain Pathol 1998 Apr;8(2):387-402. doi: 10.1111/j.1750-3639.1998.tb00162.x. PMID: 9546295Free PMC Article

Diagnosis

Biological and Genetic Features of Neuroblastoma and Their Clinical Importance.
Aygun N
Curr Pediatr Rev 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. PMID: 29380702
Update on frontotemporal dementia.
Arvanitakis Z
Neurologist 2010 Jan;16(1):16-22. doi: 10.1097/NRL.0b013e3181b1d5c6. PMID: 20065792Free PMC Article
Frontotemporal dementia and tauopathy.
Yoshiyama Y, Lee VM, Trojanowski JQ
Curr Neurol Neurosci Rep 2001 Sep;1(5):413-21. doi: 10.1007/s11910-001-0100-0. PMID: 11898551
Gliomas.
Collins VP
Cancer Surv 1998;32:37-51. PMID: 10489622
Chromosome 17 abnormalities and inactivation of the p53 gene in chronic myeloid leukemia and their prognostic significance.
Nakai H, Misawa S
Leuk Lymphoma 1995 Oct;19(3-4):213-21. doi: 10.3109/10428199509107891. PMID: 8535212

Therapy

Molecular Biomarkers of Response to Eribulin in Patients with Leiomyosarcoma.
Wozniak A, Boeckx B, Modave E, Weaver A, Lambrechts D, Littlefield BA, Schöffski P
Clin Cancer Res 2021 Jun 1;27(11):3106-3115. Epub 2021 Apr 1 doi: 10.1158/1078-0432.CCR-20-4315. PMID: 33795257
Monosomal karyotype and chromosome 17p loss or TP53 mutations in decitabine-treated patients with acute myeloid leukemia.
Becker H, Pfeifer D, Ihorst G, Pantic M, Wehrle J, Rüter BH, Bullinger L, Hackanson B, Germing U, Kuendgen A, Platzbecker U, Döhner K, Ganser A, Hagemeijer A, Wijermans PW, Döhner H, Duyster J, Lübbert M
Ann Hematol 2020 Jul;99(7):1551-1560. Epub 2020 Jun 6 doi: 10.1007/s00277-020-04082-7. PMID: 32504186Free PMC Article
Managing Patients With TP53-Deficient Chronic Lymphocytic Leukemia.
Edelmann J, Gribben JG
J Oncol Pract 2017 Jun;13(6):371-377. doi: 10.1200/JOP.2017.023291. PMID: 28605616
Update on frontotemporal dementia.
Arvanitakis Z
Neurologist 2010 Jan;16(1):16-22. doi: 10.1097/NRL.0b013e3181b1d5c6. PMID: 20065792Free PMC Article
Variety and complexity of chromosome 17 translocations in neuroblastoma.
Schleiermacher G, Raynal V, Janoueix-Lerosey I, Combaret V, Aurias A, Delattre O
Genes Chromosomes Cancer 2004 Feb;39(2):143-50. doi: 10.1002/gcc.10313. PMID: 14695994

Prognosis

Biological and Genetic Features of Neuroblastoma and Their Clinical Importance.
Aygun N
Curr Pediatr Rev 2018;14(2):73-90. doi: 10.2174/1573396314666180129101627. PMID: 29380702
The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups.
Vriend J, Marzban H
Cell Mol Life Sci 2017 Feb;74(3):449-467. Epub 2016 Sep 3 doi: 10.1007/s00018-016-2354-3. PMID: 27592301
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Wilms tumor: an update.
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic response.
Reinholz MM, Bruzek AK, Visscher DW, Lingle WL, Schroeder MJ, Perez EA, Jenkins RB
Lancet Oncol 2009 Mar;10(3):267-77. doi: 10.1016/S1470-2045(09)70063-4. PMID: 19261255Free PMC Article

Clinical prediction guides

TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics.
Campo E, Cymbalista F, Ghia P, Jäger U, Pospisilova S, Rosenquist R, Schuh A, Stilgenbauer S
Haematologica 2018 Dec;103(12):1956-1968. Epub 2018 Nov 15 doi: 10.3324/haematol.2018.187583. PMID: 30442727Free PMC Article
The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups.
Vriend J, Marzban H
Cell Mol Life Sci 2017 Feb;74(3):449-467. Epub 2016 Sep 3 doi: 10.1007/s00018-016-2354-3. PMID: 27592301
Suppressors of hedgehog signaling: Linking aberrant development of neural progenitors and tumorigenesis.
Di Marcotullio L, Ferretti E, De Smaele E, Screpanti I, Gulino A
Mol Neurobiol 2006 Dec;34(3):193-204. doi: 10.1385/MN:34:3:193. PMID: 17308352
Familial acromegaly.
Frohman LA, Eguchi K
Growth Horm IGF Res 2004 Jun;14 Suppl A:S90-6. doi: 10.1016/j.ghir.2004.03.021. PMID: 15135786
Oncogenes and tumor-suppressor genes.
Lehman TA, Reddel R, Peiifer AM, Spillare E, Kaighn ME, Weston A, Gerwin BI, Harris CC
Environ Health Perspect 1991 Jun;93:133-44. doi: 10.1289/ehp.9193133. PMID: 1685442Free PMC Article

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