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Loss of Chromosome 17q

MedGen UID:
274701
Concept ID:
C1517966
Cell or Molecular Dysfunction
Synonym: del(17q)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 17 (17q). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 17q

Professional guidelines

PubMed

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Ribeiro IP, Marques F, Caramelo F, Pereira J, Patrício M, Prazeres H, Ferrão J, Julião MJ, Castelo-Branco M, de Melo JB, Baptista IP, Carreira IM
Cell Oncol (Dordr) 2014 Feb;37(1):29-39. Epub 2013 Dec 19 doi: 10.1007/s13402-013-0161-5. PMID: 24353162
Grosfeld JL
J Am Coll Surg 1999 Oct;189(4):407-25. doi: 10.1016/s1072-7515(99)00167-2. PMID: 10509467

Recent clinical studies

Etiology

Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin-Guerrero I, García-Ariza M, Navajas A, Masliah-Planchon J, Bourdeaut F, Dufour C, Ayrault O, Goschzik T, Pietsch T, Sill M, Pfister SM, Rutkowski S, Richardson S, Hill RM, Williamson D, Bailey S, Schwalbe EC, Clifford SC, Hicks D
Acta Neuropathol 2023 May;145(5):651-666. Epub 2023 Apr 4 doi: 10.1007/s00401-023-02566-0. PMID: 37014508Free PMC Article
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Kanagal-Shamanna R, Orazi A, Hasserjian RP, Arber DA, Reichard K, Hsi ED, Bagg A, Rogers HJ, Geyer J, Darbaniyan F, Do KA, Devins KM, Pozdnyakova O, George TI, Cin PD, Greipp PT, Routbort MJ, Patel K, Garcia-Manero G, Verstovsek S, Medeiros LJ, Wang SA, Bueso-Ramos C
Mod Pathol 2022 Apr;35(4):470-479. Epub 2021 Nov 13 doi: 10.1038/s41379-021-00961-0. PMID: 34775472Free PMC Article
Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
Dewald GW, Noel P, Dahl RJ, Spurbeck JL
Mayo Clin Proc 1985 Oct;60(10):675-89. doi: 10.1016/s0025-6196(12)60744-7. PMID: 3897733

Diagnosis

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Kanagal-Shamanna R, Orazi A, Hasserjian RP, Arber DA, Reichard K, Hsi ED, Bagg A, Rogers HJ, Geyer J, Darbaniyan F, Do KA, Devins KM, Pozdnyakova O, George TI, Cin PD, Greipp PT, Routbort MJ, Patel K, Garcia-Manero G, Verstovsek S, Medeiros LJ, Wang SA, Bueso-Ramos C
Mod Pathol 2022 Apr;35(4):470-479. Epub 2021 Nov 13 doi: 10.1038/s41379-021-00961-0. PMID: 34775472Free PMC Article
Zalatimo O, Zoccoli CM, Patel A, Weston CL, Glantz M
Adv Exp Med Biol 2013;779:267-89. doi: 10.1007/978-1-4614-6176-0_12. PMID: 23288644
Biegel JA
J Pediatr Hematol Oncol 1997 Nov-Dec;19(6):492-501. doi: 10.1097/00043426-199711000-00002. PMID: 9407934
Bast RC Jr
Clin Chem 1993 Nov;39(11 Pt 2):2444-51. PMID: 8222257

Therapy

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Poluben L, Puligandla M, Neuberg D, Bryke CR, Hsu Y, Shumeiko O, Yuan X, Voznesensky O, Pihan G, Adam M, Fraenkel E, Rasnic R, Linial M, Klymenko S, Balk SP, Fraenkel PG
Am J Hematol 2019 Jan;94(1):62-73. Epub 2018 Oct 31 doi: 10.1002/ajh.25307. PMID: 30295334Free PMC Article
Fellay CN, Frappaz D, Sunyach MP, Franceschi E, Brandes AA, Stupp R
Curr Opin Neurol 2011 Dec;24(6):626-32. doi: 10.1097/WCO.0b013e32834cd4b1. PMID: 22027544
De Schutter H, Barbé B, Spaepen M, Begg AC, Balm A, Gregoire V, Haustermans K, Mahy P, Vander Poorten V, Nuyts S
Radiother Oncol 2006 Aug;80(2):143-50. Epub 2006 Aug 17 doi: 10.1016/j.radonc.2006.07.018. PMID: 16916559
Larson PS, de las Morenas A, Cerda SR, Bennett SR, Cupples LA, Rosenberg CL
J Pathol 2006 Jul;209(3):307-16. doi: 10.1002/path.1973. PMID: 16604511

Prognosis

Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin-Guerrero I, García-Ariza M, Navajas A, Masliah-Planchon J, Bourdeaut F, Dufour C, Ayrault O, Goschzik T, Pietsch T, Sill M, Pfister SM, Rutkowski S, Richardson S, Hill RM, Williamson D, Bailey S, Schwalbe EC, Clifford SC, Hicks D
Acta Neuropathol 2023 May;145(5):651-666. Epub 2023 Apr 4 doi: 10.1007/s00401-023-02566-0. PMID: 37014508Free PMC Article
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Fanoni D, Corti L, Alberti-Violetti S, Tensen CP, Venegoni L, Vermeer M, Willemze R, Berti E
Genes Chromosomes Cancer 2018 Dec;57(12):622-629. Epub 2018 Oct 11 doi: 10.1002/gcc.22673. PMID: 30307677
Xiang DB, Wei B, Abraham SC, Huo L, Albarracin CT, Zhang H, Babiera G, Caudle AS, Akay CL, Rao P, Zhao YJ, Lu X, Wu Y
Hum Pathol 2014 Sep;45(9):1951-6. Epub 2014 Jun 18 doi: 10.1016/j.humpath.2014.06.002. PMID: 25074542
Rickert CH
J Neuropathol Exp Neurol 2004 Dec;63(12):1211-24. doi: 10.1093/jnen/63.12.1211. PMID: 15624758

Clinical prediction guides

Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Zalatimo O, Zoccoli CM, Patel A, Weston CL, Glantz M
Adv Exp Med Biol 2013;779:267-89. doi: 10.1007/978-1-4614-6176-0_12. PMID: 23288644
Rickert CH
J Neuropathol Exp Neurol 2004 Dec;63(12):1211-24. doi: 10.1093/jnen/63.12.1211. PMID: 15624758
Frohman LA, Eguchi K
Growth Horm IGF Res 2004 Jun;14 Suppl A:S90-6. doi: 10.1016/j.ghir.2004.03.021. PMID: 15135786
Dewald GW, Noel P, Dahl RJ, Spurbeck JL
Mayo Clin Proc 1985 Oct;60(10):675-89. doi: 10.1016/s0025-6196(12)60744-7. PMID: 3897733

Recent systematic reviews

Mao X, Lillington DM, Czepulkowski B, Russell-Jones R, Young BD, Whittaker S
Genes Chromosomes Cancer 2003 Mar;36(3):250-60. doi: 10.1002/gcc.10152. PMID: 12557225

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