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Ovarian Signet Ring Stromal Tumor

MedGen UID:
275293
Concept ID:
C1518735
Neoplastic Process
Synonym: Ovarian Signet-Ring Stromal Tumor

Definition

A rare, benign sex cord-stromal tumor that arises from the ovary. It is characterized by the presence of round cells with a single cytoplasmic vacuole and an eccentric nucleus resembling signet ring cells. Mucin stains are negative. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Signet Ring Stromal Tumor

Professional guidelines

PubMed

Tchrakian N, Oliva E, Chong AS, Rivera-Polo B, Bennett JA, Nucci MR, Sah S, Schoolmeester JK, van der Griend RA, Foulkes WD, Clarke BA, Young RH, McCluggage WG
Am J Surg Pathol 2022 Dec 1;46(12):1599-1610. Epub 2022 Aug 29 doi: 10.1097/PAS.0000000000001954. PMID: 36040033

Recent clinical studies

Etiology

Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
Terada T
Arch Gynecol Obstet 2011 Jun;283(6):1403-6. Epub 2010 Jul 23 doi: 10.1007/s00404-010-1591-1. PMID: 20652287
Kuo CY, Wen MC, Wang J, Jan YJ
Hum Pathol 2009 Apr;40(4):584-7. Epub 2008 Oct 5 doi: 10.1016/j.humpath.2008.07.012. PMID: 18835626
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813

Diagnosis

Tchrakian N, Oliva E, Chong AS, Rivera-Polo B, Bennett JA, Nucci MR, Sah S, Schoolmeester JK, van der Griend RA, Foulkes WD, Clarke BA, Young RH, McCluggage WG
Am J Surg Pathol 2022 Dec 1;46(12):1599-1610. Epub 2022 Aug 29 doi: 10.1097/PAS.0000000000001954. PMID: 36040033
DeCoste R, Offman SL
Arch Pathol Lab Med 2018 Oct;142(10):1289-1291. doi: 10.5858/arpa.2017-0272-RS. PMID: 30281366
Roth LM, Ramzy I
Adv Anat Pathol 2014 Nov;21(6):443-9. doi: 10.1097/PAP.0000000000000042. PMID: 25299313
Hardisson D, Regojo RM, Mariño-Enríquez A, Martínez-García M
Pathol Oncol Res 2008 Sep;14(3):333-6. Epub 2008 Aug 29 doi: 10.1007/s12253-008-9080-6. PMID: 18758997
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Therapy

Terada T
Arch Gynecol Obstet 2011 Jun;283(6):1403-6. Epub 2010 Jul 23 doi: 10.1007/s00404-010-1591-1. PMID: 20652287
Verschraegen CF, Kumagai S, Davidson R, Feig B, Mansfield P, Lee SJ, Maclean DS, Hu W, Khokhar AR, Siddik ZH
J Cancer Res Clin Oncol 2003 Oct;129(10):549-55. Epub 2003 Aug 29 doi: 10.1007/s00432-003-0481-3. PMID: 14513369
Matias-Guiu X, Lerma E, Prat J
Semin Diagn Pathol 1997 Nov;14(4):233-9. PMID: 9383823

Prognosis

Chuang AY, Watkins JC, Young RH, Lerwill MF
Am J Surg Pathol 2022 Feb 1;46(2):179-189. doi: 10.1097/PAS.0000000000001812. PMID: 34931622
Roth LM, Ramzy I
Adv Anat Pathol 2014 Nov;21(6):443-9. doi: 10.1097/PAP.0000000000000042. PMID: 25299313
Terada T
Arch Gynecol Obstet 2011 Jun;283(6):1403-6. Epub 2010 Jul 23 doi: 10.1007/s00404-010-1591-1. PMID: 20652287
Kuo CY, Wen MC, Wang J, Jan YJ
Hum Pathol 2009 Apr;40(4):584-7. Epub 2008 Oct 5 doi: 10.1016/j.humpath.2008.07.012. PMID: 18835626
Prat J
Mod Pathol 2005 Feb;18 Suppl 2:S99-111. doi: 10.1038/modpathol.3800312. PMID: 15492758

Clinical prediction guides

Parra-Herran C, McCluggage WG
Histopathology 2022 May;80(6):898-904. Epub 2022 Feb 28 doi: 10.1111/his.14616. PMID: 35020947
Chuang AY, Watkins JC, Young RH, Lerwill MF
Am J Surg Pathol 2022 Feb 1;46(2):179-189. doi: 10.1097/PAS.0000000000001812. PMID: 34931622
Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
Roth LM, Ramzy I
Adv Anat Pathol 2014 Nov;21(6):443-9. doi: 10.1097/PAP.0000000000000042. PMID: 25299313
Kuo CY, Wen MC, Wang J, Jan YJ
Hum Pathol 2009 Apr;40(4):584-7. Epub 2008 Oct 5 doi: 10.1016/j.humpath.2008.07.012. PMID: 18835626

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