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Sarcomatoid basal cell carcinoma

MedGen UID:
275402
•Concept ID:
C1519182
•
Neoplastic Process
Synonyms: sarcomatoid basal cell carcinoma; Skin Basal Cell Carcinoma with Sarcomatoid Differentiation; Skin Sarcomatoid Basal Cell Carcinoma; skin sarcomatoid basal cell carcinoma
 
Monarch Initiative: MONDO:0002957

Definition

A basal cell carcinoma of the skin characterized by the presence of sarcomatoid features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSarcomatoid basal cell carcinoma

Professional guidelines

PubMed

Sarcomatoid transformation of a basal cell carcinoma following treatment with hedgehog inhibitors.
Barrabés-Torrella C, Arandes-Marcocci J, Armillas-Lliteras L, Posada-Caez RA, Koptseva I, Fumagalli C, Piñol-Ballús D, Salleras-Redonnet M
Br J Dermatol 2023 Sep 15;189(4):470-472. doi: 10.1093/bjd/ljad206. PMID: 37378960
Best practices recommendations in the application of immunohistochemistry in the prostate: report from the International Society of Urologic Pathology consensus conference.
Epstein JI, Egevad L, Humphrey PA, Montironi R; Members of the ISUP Immunohistochemistry in Diagnostic Urologic Pathology Group
Am J Surg Pathol 2014 Aug;38(8):e6-e19. doi: 10.1097/PAS.0000000000000238. PMID: 25029122

Recent clinical studies

Etiology

Basal cell carcinoma with sarcomatoid features (sarcomatoid carcinoma): report of a case and review of the literature.
Gómez-Espejo C, Herrera-Sabal A, Ríos-Martín JJ, Camacho-Martínez F
J Dermatol 2003 Jul;30(7):543-9. doi: 10.1111/j.1346-8138.2003.tb00430.x. PMID: 12928545

Diagnosis

Reply to "Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation. Is it a new variant of sarcomatoid basal cell carcinoma or a collision tumor composed of a myoepithelial carcinoma and an incidental basal cell carcinoma?".
Mestre-Alagarda C, Monteagudo C
J Cutan Pathol 2020 Jun;47(6):578-580. Epub 2020 Apr 8 doi: 10.1111/cup.13685. PMID: 32181509
"Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation": Is it a new variant of sarcomatoid basal cell carcinoma or a collision tumor composed of a myoepithelial carcinoma and an incidental basal cell carcinoma?
Tran TAN
J Cutan Pathol 2020 Jun;47(6):576-578. doi: 10.1111/cup.13651. PMID: 31995232
Study of D2-40 immunoexpression of the spindle cell areas of a metaplastic basal cell carcinoma (sarcomatoid basal cell carcinoma).
Fernandez-Flores A
Appl Immunohistochem Mol Morphol 2012 Oct;20(5):518-22. doi: 10.1097/PAI.0b013e31821acdf5. PMID: 21602664

Prognosis

Study of D2-40 immunoexpression of the spindle cell areas of a metaplastic basal cell carcinoma (sarcomatoid basal cell carcinoma).
Fernandez-Flores A
Appl Immunohistochem Mol Morphol 2012 Oct;20(5):518-22. doi: 10.1097/PAI.0b013e31821acdf5. PMID: 21602664
Sarcomatoid basal cell carcinoma--predilection for osteosarcomatous differentiation: a series of 11 cases.
Mc Menamin ME, Goh SG, Poblet E, Gostelow BE, Robson A, Calonje E
Am J Surg Pathol 2006 Oct;30(10):1299-308. doi: 10.1097/01.pas.0000208900.23483.ba. PMID: 17001162
Basal cell carcinoma with sarcomatoid features (sarcomatoid carcinoma): report of a case and review of the literature.
Gómez-Espejo C, Herrera-Sabal A, Ríos-Martín JJ, Camacho-Martínez F
J Dermatol 2003 Jul;30(7):543-9. doi: 10.1111/j.1346-8138.2003.tb00430.x. PMID: 12928545

Clinical prediction guides

Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation: A new variant.
Mestre-Alagarda C, Nieto G, Terrádez L, Monteagudo C
J Cutan Pathol 2019 Dec;46(12):949-953. Epub 2019 Aug 1 doi: 10.1111/cup.13543. PMID: 31278765
Biphasic sarcomatoid basal cell carcinoma (carcinosarcoma): four cases with immunohistochemistry and review of the literature.
Bigby SM, Charlton A, Miller MV, Zwi LJ, Oliver GF
J Cutan Pathol 2005 Feb;32(2):141-7. doi: 10.1111/j.0303-6987.2005.00276.x. PMID: 15606673

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