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Uterine corpus endometrial stromal sarcoma

MedGen UID:
275553
•Concept ID:
C1519849
•
Neoplastic Process
Synonyms: body of uterus endometrial stromal sarcoma; body of uterus endometrioid stromal sarcoma; endometrioid stromal sarcoma of body of uterus; Uterine Corpus Endometrial Stromal Sarcoma; uterine corpus endometrial stromal sarcoma; uterine corpus endometrial stromal tumor; uterine corpus endometrial stromal tumour; Uterine Corpus ESS; uterine corpus ess
 
Monarch Initiative: MONDO:0002923

Definition

A uterine corpus sarcoma originating from the endometrial stroma. It is further subdivided into low grade and high grade endometrial stromal sarcoma. [from NCI]

Professional guidelines

PubMed

Results of postoperative radiotherapy in the treatment of sarcoma of the corpus uteri.
Knocke TH, Kucera H, Dörfler D, Pokrajac B, Pötter R
Cancer 1998 Nov 1;83(9):1972-9. doi: 10.1002/(sici)1097-0142(19981101)83:9<1972::aid-cncr13>3.0.co;2-m. PMID: 9806656
Treatment, results and prognostic factors in stage I and II sarcomas of the corpus uteri.
Vongtama V, Karlen JR, Piver SM, Tsukada Y, Moore RH
AJR Am J Roentgenol 1976 Jan;126(1):139-47. doi: 10.2214/ajr.126.1.139. PMID: 175673

Recent clinical studies

Etiology

High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities.
Zou Y, Turashvili G, Soslow RA, Park KJ, Croce S, McCluggage WG, Stewart CJR, Oda Y, Oliva E, Young RH, Da Cruz Paula A, Dessources K, Ashley CW, Hensley ML, Yip S, Weigelt B, Benayed R, Antonescu CR, Lee CH, Chiang S
Mod Pathol 2020 Sep;33(9):1861-1870. Epub 2020 Apr 21 doi: 10.1038/s41379-020-0535-y. PMID: 32317704Free PMC Article
Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739
A multi-institutional review of outcomes of endometrial stromal sarcoma.
Leath CA 3rd, Huh WK, Hyde J Jr, Cohn DE, Resnick KE, Taylor NP, Powell MA, Mutch DG, Bradley WH, Geller MA, Argenta PA, Gold MA
Gynecol Oncol 2007 Jun;105(3):630-4. Epub 2007 Feb 23 doi: 10.1016/j.ygyno.2007.01.031. PMID: 17320937
Malignant lesions of the female genital tract and peritoneum that may be underdiagnosed.
Young RH, Clement PB
Semin Diagn Pathol 1995 Feb;12(1):14-29. PMID: 7770671

Diagnosis

Low-grade endometrial stromal sarcoma-like tumors in male with JAZF1 gene fusions.
Dermawan JK, Zhang L, Singer S, Chi P, Antonescu CR
Genes Chromosomes Cancer 2022 Feb;61(2):63-70. Epub 2021 Oct 23 doi: 10.1002/gcc.23003. PMID: 34651371Free PMC Article
High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities.
Zou Y, Turashvili G, Soslow RA, Park KJ, Croce S, McCluggage WG, Stewart CJR, Oda Y, Oliva E, Young RH, Da Cruz Paula A, Dessources K, Ashley CW, Hensley ML, Yip S, Weigelt B, Benayed R, Antonescu CR, Lee CH, Chiang S
Mod Pathol 2020 Sep;33(9):1861-1870. Epub 2020 Apr 21 doi: 10.1038/s41379-020-0535-y. PMID: 32317704Free PMC Article
Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Problematic issues in the staging of endometrial, cervical and vulval carcinomas.
Hirschowitz L, Nucci M, Zaino RJ
Histopathology 2013 Jan;62(1):176-202. doi: 10.1111/his.12058. PMID: 23240675
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739

Therapy

Endometrial stromal sarcoma of twenty cases.
Huang KT, Chen CA, Tseng GC, Chen TM, Cheng WF, Hsieh CY
Acta Obstet Gynecol Scand 1996 Jul;75(6):551-5. doi: 10.3109/00016349609054670. PMID: 8693932
Different types and different prognosis-study of 310 uterine sarcomas.
Nickie-Psikuta M, Gawrychowski K
Eur J Gynaecol Oncol 1993;14 Suppl:105-13. PMID: 8200360

Prognosis

High-grade transformation of low-grade endometrial stromal sarcomas lacking YWHAE and BCOR genetic abnormalities.
Zou Y, Turashvili G, Soslow RA, Park KJ, Croce S, McCluggage WG, Stewart CJR, Oda Y, Oliva E, Young RH, Da Cruz Paula A, Dessources K, Ashley CW, Hensley ML, Yip S, Weigelt B, Benayed R, Antonescu CR, Lee CH, Chiang S
Mod Pathol 2020 Sep;33(9):1861-1870. Epub 2020 Apr 21 doi: 10.1038/s41379-020-0535-y. PMID: 32317704Free PMC Article
Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739
Mullerian adenosarcoma of the female genital tract.
McCluggage WG
Adv Anat Pathol 2010 Mar;17(2):122-9. doi: 10.1097/PAP.0b013e3181cfe732. PMID: 20179434
Endometrial stromal sarcoma of twenty cases.
Huang KT, Chen CA, Tseng GC, Chen TM, Cheng WF, Hsieh CY
Acta Obstet Gynecol Scand 1996 Jul;75(6):551-5. doi: 10.3109/00016349609054670. PMID: 8693932

Clinical prediction guides

Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Incidence and survival trends of uncommon corpus uteri malignancies in the Netherlands, 1989-2008.
Boll D, Verhoeven RH, van der Aa MA, Pauwels P, Karim-Kos HE, Coebergh JW, van Doorn HC
Int J Gynecol Cancer 2012 May;22(4):599-606. doi: 10.1097/IGC.0b013e318244cedc. PMID: 22398706
Endometrial stromal sarcoma: clinicopathological and immunophenotype study of 18 cases.
Vera AA, Guadarrama MB
Ann Diagn Pathol 2011 Oct;15(5):312-7. Epub 2011 Jun 8 doi: 10.1016/j.anndiagpath.2011.01.008. PMID: 21652246
Heterologous and rare homologous sarcomas of the uterine corpus: a clinicopathologic review.
Fadare O
Adv Anat Pathol 2011 Jan;18(1):60-74. doi: 10.1097/PAP.0b013e3182026be7. PMID: 21169739
Uterine stromal sarcoma cell line. A cytogenetic and electron microscopic study.
Fresia AE, Currie JL, Farrington JE, Laxman R, Griffin CA
Cancer Genet Cytogenet 1992 May;60(1):60-6. doi: 10.1016/0165-4608(92)90234-y. PMID: 1591708

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