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Cellular Stress

MedGen UID:
275701
•Concept ID:
C1516373
•
Cell or Molecular Dysfunction

Definition

Cellular or subcellular processes involved with significant disturbance from a homeostatic condition. (NCI) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular Stress

Professional guidelines

PubMed

Etiopathogenesis and Emerging Methods for Treatment of Vitiligo.
Iwanowski T, Kołkowski K, Nowicki RJ, Sokołowska-Wojdyło M
Int J Mol Sci 2023 Jun 5;24(11) doi: 10.3390/ijms24119749. PMID: 37298700Free PMC Article
Diabetic nephropathy: Focusing on pathological signals, clinical treatment, and dietary regulation.
Hu Q, Chen Y, Deng X, Li Y, Ma X, Zeng J, Zhao Y
Biomed Pharmacother 2023 Mar;159:114252. Epub 2023 Jan 13 doi: 10.1016/j.biopha.2023.114252. PMID: 36641921
RNA methylation and cancer treatment.
Yang B, Wang JQ, Tan Y, Yuan R, Chen ZS, Zou C
Pharmacol Res 2021 Dec;174:105937. Epub 2021 Oct 12 doi: 10.1016/j.phrs.2021.105937. PMID: 34648969

Recent clinical studies

Etiology

Effects of Intermittent Fasting on Brain Metabolism.
Brocchi A, Rebelos E, Dardano A, Mantuano M, Daniele G
Nutrients 2022 Mar 17;14(6) doi: 10.3390/nu14061275. PMID: 35334932Free PMC Article
Hypertension-induced cognitive impairment: from pathophysiology to public health.
Ungvari Z, Toth P, Tarantini S, Prodan CI, Sorond F, Merkely B, Csiszar A
Nat Rev Nephrol 2021 Oct;17(10):639-654. Epub 2021 Jun 14 doi: 10.1038/s41581-021-00430-6. PMID: 34127835Free PMC Article
Principles of the Molecular and Cellular Mechanisms of Aging.
da Silva PFL, Schumacher B
J Invest Dermatol 2021 Apr;141(4S):951-960. Epub 2021 Jan 29 doi: 10.1016/j.jid.2020.11.018. PMID: 33518357
Senescent cells: an emerging target for diseases of ageing.
Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, van Deursen JM
Nat Rev Drug Discov 2017 Oct;16(10):718-735. Epub 2017 Jul 21 doi: 10.1038/nrd.2017.116. PMID: 28729727Free PMC Article
Obesity, insulin resistance and free fatty acids.
Boden G
Curr Opin Endocrinol Diabetes Obes 2011 Apr;18(2):139-43. doi: 10.1097/MED.0b013e3283444b09. PMID: 21297467Free PMC Article

Diagnosis

Defining Acute Kidney Injury.
Verma S, Kellum JA
Crit Care Clin 2021 Apr;37(2):251-266. doi: 10.1016/j.ccc.2020.11.001. PMID: 33752854
Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology.
Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA
Lancet Infect Dis 2021 Aug;21(8):e246-e257. Epub 2021 Feb 16 doi: 10.1016/S1473-3099(20)30784-2. PMID: 33606997
The Metabolic Underpinnings of Ferroptosis.
Zheng J, Conrad M
Cell Metab 2020 Dec 1;32(6):920-937. Epub 2020 Nov 19 doi: 10.1016/j.cmet.2020.10.011. PMID: 33217331
HMGB1 in health and disease.
Kang R, Chen R, Zhang Q, Hou W, Wu S, Cao L, Huang J, Yu Y, Fan XG, Yan Z, Sun X, Wang H, Wang Q, Tsung A, Billiar TR, Zeh HJ 3rd, Lotze MT, Tang D
Mol Aspects Med 2014 Dec;40:1-116. Epub 2014 Jul 8 doi: 10.1016/j.mam.2014.05.001. PMID: 25010388Free PMC Article
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network.
Salminen A, Kaarniranta K
Ageing Res Rev 2012 Apr;11(2):230-41. Epub 2011 Dec 15 doi: 10.1016/j.arr.2011.12.005. PMID: 22186033

Therapy

Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, Wu J, Wei X, Qu Q, Yu Y, Long S, Feng JW, Li C, Zhang C, Xie C, Wu Y, Xu Z, Chen J, Yu Y, Huang X, He Y, Yao L, Zhang L, Zhu M, Wang W, Wang ZC, Zhang M, Bao Y, Jia W, Lin SY, Ye Z, Piao HL, Deng X, Zhang CS, Lin SC
Nature 2022 Mar;603(7899):159-165. Epub 2022 Feb 23 doi: 10.1038/s41586-022-04431-8. PMID: 35197629Free PMC Article
Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures.
Hallek M, Al-Sawaf O
Am J Hematol 2021 Dec 1;96(12):1679-1705. doi: 10.1002/ajh.26367. PMID: 34625994
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease.
Lebeaupin C, Vallée D, Hazari Y, Hetz C, Chevet E, Bailly-Maitre B
J Hepatol 2018 Oct;69(4):927-947. Epub 2018 Jun 27 doi: 10.1016/j.jhep.2018.06.008. PMID: 29940269
Impact of intermittent fasting on health and disease processes.
Mattson MP, Longo VD, Harvie M
Ageing Res Rev 2017 Oct;39:46-58. Epub 2016 Oct 31 doi: 10.1016/j.arr.2016.10.005. PMID: 27810402Free PMC Article

Prognosis

Chronic lymphocytic leukemia: 2022 update on diagnostic and therapeutic procedures.
Hallek M, Al-Sawaf O
Am J Hematol 2021 Dec 1;96(12):1679-1705. doi: 10.1002/ajh.26367. PMID: 34625994
Pathobiology of Japanese encephalitis virus infection.
Sharma KB, Vrati S, Kalia M
Mol Aspects Med 2021 Oct;81:100994. Epub 2021 Jul 15 doi: 10.1016/j.mam.2021.100994. PMID: 34274157
Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting.
Hernández Borrero LJ, El-Deiry WS
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188556. Epub 2021 Apr 29 doi: 10.1016/j.bbcan.2021.188556. PMID: 33932560Free PMC Article
Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology.
Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA
Lancet Infect Dis 2021 Aug;21(8):e246-e257. Epub 2021 Feb 16 doi: 10.1016/S1473-3099(20)30784-2. PMID: 33606997
Invasive Fungal Infection.
von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O
Dtsch Arztebl Int 2019 Apr 19;116(16):271-278. doi: 10.3238/arztebl.2019.0271. PMID: 31159914Free PMC Article

Clinical prediction guides

Habitual daily intake of a sweet and fatty snack modulates reward processing in humans.
Edwin Thanarajah S, DiFeliceantonio AG, Albus K, Kuzmanovic B, Rigoux L, Iglesias S, Hanßen R, Schlamann M, Cornely OA, Brüning JC, Tittgemeyer M, Small DM
Cell Metab 2023 Apr 4;35(4):571-584.e6. Epub 2023 Mar 22 doi: 10.1016/j.cmet.2023.02.015. PMID: 36958330
β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.
Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang TY, Zheng Q, Xu H, Wang X
Cell 2023 Mar 2;186(5):1026-1038.e20. doi: 10.1016/j.cell.2023.01.021. PMID: 36868208
SGLT2 inhibitors: role in protective reprogramming of cardiac nutrient transport and metabolism.
Packer M
Nat Rev Cardiol 2023 Jul;20(7):443-462. Epub 2023 Jan 6 doi: 10.1038/s41569-022-00824-4. PMID: 36609604
GDF15 and Cardiac Cells: Current Concepts and New Insights.
Rochette L, Dogon G, Zeller M, Cottin Y, Vergely C
Int J Mol Sci 2021 Aug 18;22(16) doi: 10.3390/ijms22168889. PMID: 34445593Free PMC Article
Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions.
Fischer K, Al-Sawaf O, Bahlo J, Fink AM, Tandon M, Dixon M, Robrecht S, Warburton S, Humphrey K, Samoylova O, Liberati AM, Pinilla-Ibarz J, Opat S, Sivcheva L, Le Dû K, Fogliatto LM, Niemann CU, Weinkove R, Robinson S, Kipps TJ, Boettcher S, Tausch E, Humerickhouse R, Eichhorst B, Wendtner CM, Langerak AW, Kreuzer KA, Ritgen M, Goede V, Stilgenbauer S, Mobasher M, Hallek M
N Engl J Med 2019 Jun 6;380(23):2225-2236. Epub 2019 Jun 4 doi: 10.1056/NEJMoa1815281. PMID: 31166681

Recent systematic reviews

Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review.
Akinyemi AO, Simpson KE, Oyelere SF, Nur M, Ngule CM, Owoyemi BCD, Ayarick VA, Oyelami FF, Obaleye O, Esoe DP, Liu X, Li Z
Mol Med 2023 Aug 21;29(1):112. doi: 10.1186/s10020-023-00706-6. PMID: 37605113Free PMC Article
European consensus for the diagnosis of MCI and mild dementia: Preparatory phase.
Festari C, Massa F, Cotta Ramusino M, Gandolfo F, Nicolosi V, Orini S, Aarsland D, Agosta F, Babiloni C, Boada M, Borroni B, Cappa S, Dubois B, Frederiksen KS, Froelich L, Garibotto V, Georges J, Haliassos A, Hansson O, Jessen F, Kamondi A, Kessels RPC, Morbelli S, O'Brien JT, Otto M, Perret-Liaudet A, Pizzini FB, Ritchie CW, Scheltens P, Vandenbulcke M, Vanninen R, Verhey F, Vernooij MW, Yousry T, Van Der Flier WM, Nobili F, Frisoni GB
Alzheimers Dement 2023 May;19(5):1729-1741. Epub 2022 Oct 9 doi: 10.1002/alz.12798. PMID: 36209379
Antifungal prophylaxis in adult patients with acute myeloid leukaemia treated with novel targeted therapies: a systematic review and expert consensus recommendation from the European Hematology Association.
Stemler J, de Jonge N, Skoetz N, Sinkó J, Brüggemann RJ, Busca A, Ben-Ami R, Ráčil Z, Piechotta V, Lewis R, Cornely OA
Lancet Haematol 2022 May;9(5):e361-e373. doi: 10.1016/S2352-3026(22)00073-4. PMID: 35483397
Prevention from radiation damage by natural products.
Fischer N, Seo EJ, Efferth T
Phytomedicine 2018 Aug 1;47:192-200. Epub 2017 Nov 13 doi: 10.1016/j.phymed.2017.11.005. PMID: 30166104
A systematic review of p53 regulation of oxidative stress in skeletal muscle.
Beyfuss K, Hood DA
Redox Rep 2018 Dec;23(1):100-117. Epub 2018 Jan 3 doi: 10.1080/13510002.2017.1416773. PMID: 29298131Free PMC Article

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