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Chromosomal Loss

MedGen UID:
275732
•Concept ID:
C1516519
•
Cell or Molecular Dysfunction

Definition

Loss of an entire chromosome or chromosome arm. [from NCI]

Professional guidelines

PubMed

The in vitro micronucleus assay and kinetochore staining: methodology and criteria for the accurate assessment of genotoxicity and cytotoxicity.
Manshian BB, Singh N, Doak SH
Methods Mol Biol 2013;1044:269-89. doi: 10.1007/978-1-62703-529-3_14. PMID: 23896882
Risk-based management: current concepts of treating malignant solid tumors of childhood.
Grosfeld JL
J Am Coll Surg 1999 Oct;189(4):407-25. doi: 10.1016/s1072-7515(99)00167-2. PMID: 10509467
Small cell lung cancer: etiology, biology, clinical features, staging, and treatment.
Cook RM, Miller YE, Bunn PA Jr
Curr Probl Cancer 1993 Mar-Apr;17(2):69-141. doi: 10.1016/0147-0272(93)90010-y. PMID: 8395998

Recent clinical studies

Etiology

Genomic and Therapeutic Landscape of Non-muscle-invasive Bladder Cancer.
Cooley LF, McLaughlin KA, Meeks JJ
Urol Clin North Am 2020 Feb;47(1):35-46. doi: 10.1016/j.ucl.2019.09.006. PMID: 31757298
Managing Patients With TP53-Deficient Chronic Lymphocytic Leukemia.
Edelmann J, Gribben JG
J Oncol Pract 2017 Jun;13(6):371-377. doi: 10.1200/JOP.2017.023291. PMID: 28605616
Proteogenomics connects somatic mutations to signalling in breast cancer.
Mertins P, Mani DR, Ruggles KV, Gillette MA, Clauser KR, Wang P, Wang X, Qiao JW, Cao S, Petralia F, Kawaler E, Mundt F, Krug K, Tu Z, Lei JT, Gatza ML, Wilkerson M, Perou CM, Yellapantula V, Huang KL, Lin C, McLellan MD, Yan P, Davies SR, Townsend RR, Skates SJ, Wang J, Zhang B, Kinsinger CR, Mesri M, Rodriguez H, Ding L, Paulovich AG, Fenyö D, Ellis MJ, Carr SA; NCI CPTAC
Nature 2016 Jun 2;534(7605):55-62. Epub 2016 May 25 doi: 10.1038/nature18003. PMID: 27251275Free PMC Article
Alcohol and hepatocellular carcinoma.
Morgan TR, Mandayam S, Jamal MM
Gastroenterology 2004 Nov;127(5 Suppl 1):S87-96. doi: 10.1053/j.gastro.2004.09.020. PMID: 15508108
Chromosomal deletions in myelodysplasia.
Boultwood J, Fidler C
Leuk Lymphoma 1995 Mar;17(1-2):71-8. doi: 10.3109/10428199509051705. PMID: 7773164

Diagnosis

Genomic and Therapeutic Landscape of Non-muscle-invasive Bladder Cancer.
Cooley LF, McLaughlin KA, Meeks JJ
Urol Clin North Am 2020 Feb;47(1):35-46. doi: 10.1016/j.ucl.2019.09.006. PMID: 31757298
Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas.
Hernandez AL, Wang Y, Somerset HL, Keysar SB, Aisner DL, Marshall C, Bowles DW, Karam SD, Raben D, Jimeno A, Varella-Garcia M, Wang XJ
Mol Carcinog 2019 May;58(5):666-673. Epub 2019 Jan 16 doi: 10.1002/mc.22958. PMID: 30575147Free PMC Article
The correlation of clinical and chromosomal alterations of benign meningiomas and their recurrences.
Och W, Szmuda T, Kulbacki K, Witek K, Sikorska B, Zakrzewska M, Springer J, Reszeć J, Parda A, Liberski PP
Neurol Neurochir Pol 2016 Nov-Dec;50(6):395-402. Epub 2016 Jul 26 doi: 10.1016/j.pjnns.2016.07.001. PMID: 27480481
From the archives of the AFIP: Oligodendroglioma and its variants: radiologic-pathologic correlation.
Koeller KK, Rushing EJ
Radiographics 2005 Nov-Dec;25(6):1669-88. doi: 10.1148/rg.256055137. PMID: 16284142
Molecular diagnosis of haematological neoplasms.
Fey MF, Wainscoat JS
Blood Rev 1988 Jun;2(2):78-87. doi: 10.1016/0268-960x(88)90028-8. PMID: 3042060

Therapy

Genomic and Therapeutic Landscape of Non-muscle-invasive Bladder Cancer.
Cooley LF, McLaughlin KA, Meeks JJ
Urol Clin North Am 2020 Feb;47(1):35-46. doi: 10.1016/j.ucl.2019.09.006. PMID: 31757298
MicroRNAs Associated with Von Hippel-Lindau Pathway in Renal Cell Carcinoma: A Comprehensive Review.
Schanza LM, Seles M, Stotz M, Fosselteder J, Hutterer GC, Pichler M, Stiegelbauer V
Int J Mol Sci 2017 Nov 22;18(11) doi: 10.3390/ijms18112495. PMID: 29165391Free PMC Article
Managing Patients With TP53-Deficient Chronic Lymphocytic Leukemia.
Edelmann J, Gribben JG
J Oncol Pract 2017 Jun;13(6):371-377. doi: 10.1200/JOP.2017.023291. PMID: 28605616
Alcohol and hepatocellular carcinoma.
Morgan TR, Mandayam S, Jamal MM
Gastroenterology 2004 Nov;127(5 Suppl 1):S87-96. doi: 10.1053/j.gastro.2004.09.020. PMID: 15508108
Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.
Virmani AK, Fong KM, Kodagoda D, McIntire D, Hung J, Tonk V, Minna JD, Gazdar AF
Genes Chromosomes Cancer 1998 Apr;21(4):308-19. doi: 10.1002/(sici)1098-2264(199804)21:4<308::aid-gcc4>3.0.co;2-2. PMID: 9559342

Prognosis

Inter- and intra-tumor heterogeneity of SMAD4 loss in head and neck squamous cell carcinomas.
Hernandez AL, Wang Y, Somerset HL, Keysar SB, Aisner DL, Marshall C, Bowles DW, Karam SD, Raben D, Jimeno A, Varella-Garcia M, Wang XJ
Mol Carcinog 2019 May;58(5):666-673. Epub 2019 Jan 16 doi: 10.1002/mc.22958. PMID: 30575147Free PMC Article
Managing Patients With TP53-Deficient Chronic Lymphocytic Leukemia.
Edelmann J, Gribben JG
J Oncol Pract 2017 Jun;13(6):371-377. doi: 10.1200/JOP.2017.023291. PMID: 28605616
The correlation of clinical and chromosomal alterations of benign meningiomas and their recurrences.
Och W, Szmuda T, Kulbacki K, Witek K, Sikorska B, Zakrzewska M, Springer J, Reszeć J, Parda A, Liberski PP
Neurol Neurochir Pol 2016 Nov-Dec;50(6):395-402. Epub 2016 Jul 26 doi: 10.1016/j.pjnns.2016.07.001. PMID: 27480481
Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer.
Lando M, Fjeldbo CS, Wilting SM, C Snoek B, Aarnes EK, Forsberg MF, Kristensen GB, Steenbergen RD, Lyng H
Epigenetics 2015;10(10):970-80. doi: 10.1080/15592294.2015.1085140. PMID: 26291246Free PMC Article
Alcohol and hepatocellular carcinoma.
Morgan TR, Mandayam S, Jamal MM
Gastroenterology 2004 Nov;127(5 Suppl 1):S87-96. doi: 10.1053/j.gastro.2004.09.020. PMID: 15508108

Clinical prediction guides

CDKN2A loss and PIK3CA mutation in myoepithelial-like metaplastic breast cancer.
Bartels S, van Luttikhuizen JL, Christgen M, Mägel L, Luft A, Hänzelmann S, Lehmann U, Schlegelberger B, Leo F, Steinemann D, Kreipe H
J Pathol 2018 Jul;245(3):373-383. Epub 2018 May 28 doi: 10.1002/path.5091. PMID: 29708279
The correlation of clinical and chromosomal alterations of benign meningiomas and their recurrences.
Och W, Szmuda T, Kulbacki K, Witek K, Sikorska B, Zakrzewska M, Springer J, Reszeć J, Parda A, Liberski PP
Neurol Neurochir Pol 2016 Nov-Dec;50(6):395-402. Epub 2016 Jul 26 doi: 10.1016/j.pjnns.2016.07.001. PMID: 27480481
Genetic and epigenetic changes in lung carcinoma and their clinical implications.
Wen J, Fu J, Zhang W, Guo M
Mod Pathol 2011 Jul;24(7):932-43. Epub 2011 Mar 18 doi: 10.1038/modpathol.2011.46. PMID: 21423157
Molecular biology of neuroblastoma.
Maris JM, Matthay KK
J Clin Oncol 1999 Jul;17(7):2264-79. doi: 10.1200/JCO.1999.17.7.2264. PMID: 10561284
Chromosomal deletions in myelodysplasia.
Boultwood J, Fidler C
Leuk Lymphoma 1995 Mar;17(1-2):71-8. doi: 10.3109/10428199509051705. PMID: 7773164

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