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Clonal T-Cell Receptor Beta Chain Gene Rearrangement

MedGen UID:
275772
•Concept ID:
C1516678
•
Cell or Molecular Dysfunction
Synonym: Monoclonal T-Cell Receptor Beta Chain Gene Rearrangement

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClonal T-Cell Receptor Beta Chain Gene Rearrangement

Professional guidelines

PubMed

Resolving T-cell receptor clonality in two and genotype in four multiplex polymerase chain reactions.
Dictor M, Warenholt J, Isinger A
Haematologica 2005 Nov;90(11):1524-32. PMID: 16266900
Dual genotype in cutaneous T cell lymphoma: immunoglobulin gene rearrangement in clonal T cell malignancy.
Berger CL, Eisenberg A, Soper L, Chow J, Simone J, Gapas Y, Cacciapaglia B, Bennett L, Edelson RL, Warburton D
J Invest Dermatol 1988 Jan;90(1):73-7. doi: 10.1111/1523-1747.ep12462574. PMID: 2961816
Immunoglobulin and T-cell receptor beta-chain gene rearrangement analysis of Hodgkin's disease: implications for lineage determination and differential diagnosis.
Knowles DM 2nd, Neri A, Pelicci PG, Burke JS, Wu A, Winberg CD, Sheibani K, Dalla-Favera R
Proc Natl Acad Sci U S A 1986 Oct;83(20):7942-6. doi: 10.1073/pnas.83.20.7942. PMID: 3464009Free PMC Article

Recent clinical studies

Etiology

Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms.
Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H
Cytometry B Clin Cytom 2021 May;100(3):361-369. Epub 2020 Apr 25 doi: 10.1002/cyto.b.21881. PMID: 32333725
Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis.
Lee B, Adamska JZ, Namkoong H, Bellin MD, Wilhelm J, Szot GL, Louis DM, Davis MM, Pandol SJ, Habtezion A
J Clin Invest 2020 May 1;130(5):2705-2711. doi: 10.1172/JCI134066. PMID: 32053120Free PMC Article
Skewing of the T-cell receptor repertoire in patients receiving rituximab after allogeneic hematopoietic cell transplantation: what lies beneath?
Papalexandri A, Karypidou M, Stalika E, Kotta K, Touloumenidou T, Zerva P, Paleta A, Mallouri D, Batsis I, Sakellari I, Kotsianidis I, Anagnostopoulos A, Hadzidimitriou A, Margaritis D, Stamatopoulos K
Leuk Lymphoma 2019 Jul;60(7):1685-1692. Epub 2019 Jan 17 doi: 10.1080/10428194.2018.1543881. PMID: 30652530
T-cell repertoires in refractory coeliac disease.
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M
Gut 2018 Apr;67(4):644-653. Epub 2017 Feb 10 doi: 10.1136/gutjnl-2016-311816. PMID: 28188172Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Diagnosis

Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms.
Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H
Cytometry B Clin Cytom 2021 May;100(3):361-369. Epub 2020 Apr 25 doi: 10.1002/cyto.b.21881. PMID: 32333725
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.
van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, García-Sanz R, van Krieken JH, Droese J, González D, Bastard C, White HE, Spaargaren M, González M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA
Leukemia 2003 Dec;17(12):2257-317. doi: 10.1038/sj.leu.2403202. PMID: 14671650
T-cell receptor gene rearrangements and the diagnosis of human T-cell neoplasms.
Cossman J, Uppenkamp M, Andrade R, Medeiros LJ
Crit Rev Oncol Hematol 1990;10(3):267-81. doi: 10.1016/1040-8428(90)90035-q. PMID: 2257088
Immunophenotypic and antigen receptor gene rearrangement analysis in T cell neoplasia.
Knowles DM
Am J Pathol 1989 Apr;134(4):761-85. PMID: 2495724Free PMC Article

Therapy

Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms.
Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H
Cytometry B Clin Cytom 2021 May;100(3):361-369. Epub 2020 Apr 25 doi: 10.1002/cyto.b.21881. PMID: 32333725
Skewing of the T-cell receptor repertoire in patients receiving rituximab after allogeneic hematopoietic cell transplantation: what lies beneath?
Papalexandri A, Karypidou M, Stalika E, Kotta K, Touloumenidou T, Zerva P, Paleta A, Mallouri D, Batsis I, Sakellari I, Kotsianidis I, Anagnostopoulos A, Hadzidimitriou A, Margaritis D, Stamatopoulos K
Leuk Lymphoma 2019 Jul;60(7):1685-1692. Epub 2019 Jan 17 doi: 10.1080/10428194.2018.1543881. PMID: 30652530
T-cell repertoires in refractory coeliac disease.
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M
Gut 2018 Apr;67(4):644-653. Epub 2017 Feb 10 doi: 10.1136/gutjnl-2016-311816. PMID: 28188172Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Immunosuppressive treatments for myelodysplastic syndromes.
Shimamoto T, Ohyashiki K
Leuk Lymphoma 2003 Apr;44(4):593-604. doi: 10.1080/1042819021000055345. PMID: 12769335

Prognosis

T-Cell Receptor Profiling and Prognosis After Stereotactic Body Radiation Therapy For Stage I Non-Small-Cell Lung Cancer.
Wu L, Zhu J, Rudqvist NP, Welsh J, Lee P, Liao Z, Xu T, Jiang M, Zhu X, Pan X, Li P, Zhou Z, He X, Yin R, Feng J
Front Immunol 2021;12:719285. Epub 2021 Oct 18 doi: 10.3389/fimmu.2021.719285. PMID: 34733273Free PMC Article
Preselection TCR repertoire predicts CD4(+) and CD8(+) T-cell differentiation state.
Hou X, Chen W, Zhang X, Wang G, Chen J, Zeng P, Fu X, Zhang Q, Liu X, Diao H
Immunology 2020 Dec;161(4):354-363. Epub 2020 Oct 7 doi: 10.1111/imm.13256. PMID: 32875554Free PMC Article
T-cell repertoires in refractory coeliac disease.
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M
Gut 2018 Apr;67(4):644-653. Epub 2017 Feb 10 doi: 10.1136/gutjnl-2016-311816. PMID: 28188172Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Molecular genetics of the T cell-receptor beta chain.
Davis MM
Annu Rev Immunol 1985;3:537-60. doi: 10.1146/annurev.iy.03.040185.002541. PMID: 3933533

Clinical prediction guides

Preselection TCR repertoire predicts CD4(+) and CD8(+) T-cell differentiation state.
Hou X, Chen W, Zhang X, Wang G, Chen J, Zeng P, Fu X, Zhang Q, Liu X, Diao H
Immunology 2020 Dec;161(4):354-363. Epub 2020 Oct 7 doi: 10.1111/imm.13256. PMID: 32875554Free PMC Article
Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis.
Werner L, Nunberg MY, Rechavi E, Lev A, Braun T, Haberman Y, Lahad A, Shteyer E, Schvimer M, Somech R, Weiss B, Lee YN, Shouval DS
Clin Exp Immunol 2019 Apr;196(1):1-11. Epub 2019 Jan 27 doi: 10.1111/cei.13247. PMID: 30556140Free PMC Article
T-cell repertoires in refractory coeliac disease.
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M
Gut 2018 Apr;67(4):644-653. Epub 2017 Feb 10 doi: 10.1136/gutjnl-2016-311816. PMID: 28188172Free PMC Article
The structure of the T cell antigen receptor genes in normal and malignant T cells.
Minden MD, Mak TW
Blood 1986 Aug;68(2):327-36. PMID: 3089348
Molecular genetics of the T cell-receptor beta chain.
Davis MM
Annu Rev Immunol 1985;3:537-60. doi: 10.1146/annurev.iy.03.040185.002541. PMID: 3933533

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