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Clonal T-Cell Receptor Beta Chain Gene Rearrangement

MedGen UID:
275772
•Concept ID:
C1516678
•
Cell or Molecular Dysfunction
Synonym: Monoclonal T-Cell Receptor Beta Chain Gene Rearrangement

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClonal T-Cell Receptor Beta Chain Gene Rearrangement

Professional guidelines

PubMed

Molecular Screening in Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor Immunoprofiling.
Kalinova M, Mrhalova M, Kabickova E, Svaton M, Skotnicova A, Prouzova Z, Krenova Z, Kolenova A, Divoka M, Fronkova E, Kodet R
Mod Pathol 2024 Mar;37(3):100428. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100428. PMID: 38266918
High Incidence of Clonal CD8+ T-cell Proliferation in Non-malignant Conditions May Reduce the Significance of T-cell Clonality Assay for Differential Diagnosis in Oncohematology.
Sidorova YV, Sychevskaya KA, Chernova NG, Julhakyan HL, Smirnova SJ, Ryzhikova NV, Gorodetskiy VR, Naumova EV, Sudarikov AB
Clin Lymphoma Myeloma Leuk 2020 Apr;20(4):203-208. Epub 2020 Jan 8 doi: 10.1016/j.clml.2019.12.021. PMID: 32046930
Resolving T-cell receptor clonality in two and genotype in four multiplex polymerase chain reactions.
Dictor M, Warenholt J, Isinger A
Haematologica 2005 Nov;90(11):1524-32. PMID: 16266900

Recent clinical studies

Etiology

Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms.
Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H
Cytometry B Clin Cytom 2021 May;100(3):361-369. Epub 2020 Apr 25 doi: 10.1002/cyto.b.21881. PMID: 32333725
Distinct immune characteristics distinguish hereditary and idiopathic chronic pancreatitis.
Lee B, Adamska JZ, Namkoong H, Bellin MD, Wilhelm J, Szot GL, Louis DM, Davis MM, Pandol SJ, Habtezion A
J Clin Invest 2020 May 1;130(5):2705-2711. doi: 10.1172/JCI134066. PMID: 32053120Free PMC Article
High Incidence of Clonal CD8+ T-cell Proliferation in Non-malignant Conditions May Reduce the Significance of T-cell Clonality Assay for Differential Diagnosis in Oncohematology.
Sidorova YV, Sychevskaya KA, Chernova NG, Julhakyan HL, Smirnova SJ, Ryzhikova NV, Gorodetskiy VR, Naumova EV, Sudarikov AB
Clin Lymphoma Myeloma Leuk 2020 Apr;20(4):203-208. Epub 2020 Jan 8 doi: 10.1016/j.clml.2019.12.021. PMID: 32046930
T-cell repertoires in refractory coeliac disease.
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M
Gut 2018 Apr;67(4):644-653. Epub 2017 Feb 10 doi: 10.1136/gutjnl-2016-311816. PMID: 28188172Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Diagnosis

Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms.
Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H
Cytometry B Clin Cytom 2021 May;100(3):361-369. Epub 2020 Apr 25 doi: 10.1002/cyto.b.21881. PMID: 32333725
Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis.
Werner L, Nunberg MY, Rechavi E, Lev A, Braun T, Haberman Y, Lahad A, Shteyer E, Schvimer M, Somech R, Weiss B, Lee YN, Shouval DS
Clin Exp Immunol 2019 Apr;196(1):1-11. Epub 2019 Jan 27 doi: 10.1111/cei.13247. PMID: 30556140Free PMC Article
CapTCR-seq: hybrid capture for T-cell receptor repertoire profiling.
Mulder DT, Mahé ER, Dowar M, Hanna Y, Li T, Nguyen LT, Butler MO, Hirano N, Delabie J, Ohashi PS, Pugh TJ
Blood Adv 2018 Dec 11;2(23):3506-3514. doi: 10.1182/bloodadvances.2017014639. PMID: 30530777Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.
van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, García-Sanz R, van Krieken JH, Droese J, González D, Bastard C, White HE, Spaargaren M, González M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA
Leukemia 2003 Dec;17(12):2257-317. doi: 10.1038/sj.leu.2403202. PMID: 14671650

Therapy

Flow cytometric evaluation of TRBC1 expression in tissue specimens and body fluids is a novel and specific method for assessment of T-cell clonality and diagnosis of T-cell neoplasms.
Berg H, Otteson GE, Corley H, Shi M, Horna P, Jevremovic D, Olteanu H
Cytometry B Clin Cytom 2021 May;100(3):361-369. Epub 2020 Apr 25 doi: 10.1002/cyto.b.21881. PMID: 32333725
Copy-number variations in adult patients with chronic immune thrombocytopenia.
Yucesan E, Hatirnaz Ng O, Yalniz FF, Yilmaz H, Salihoglu A, Sudutan T, Eskazan AE, Ongoren S, Baslar Z, Soysal T, Ozbek U, Sayitoglu M, Ar MC
Expert Rev Hematol 2020 Nov;13(11):1277-1287. Epub 2020 Sep 23 doi: 10.1080/17474086.2020.1819786. PMID: 32885695
Skewing of the T-cell receptor repertoire in patients receiving rituximab after allogeneic hematopoietic cell transplantation: what lies beneath?
Papalexandri A, Karypidou M, Stalika E, Kotta K, Touloumenidou T, Zerva P, Paleta A, Mallouri D, Batsis I, Sakellari I, Kotsianidis I, Anagnostopoulos A, Hadzidimitriou A, Margaritis D, Stamatopoulos K
Leuk Lymphoma 2019 Jul;60(7):1685-1692. Epub 2019 Jan 17 doi: 10.1080/10428194.2018.1543881. PMID: 30652530
T-cell repertoires in refractory coeliac disease.
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M
Gut 2018 Apr;67(4):644-653. Epub 2017 Feb 10 doi: 10.1136/gutjnl-2016-311816. PMID: 28188172Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Prognosis

T-Cell Receptor Profiling and Prognosis After Stereotactic Body Radiation Therapy For Stage I Non-Small-Cell Lung Cancer.
Wu L, Zhu J, Rudqvist NP, Welsh J, Lee P, Liao Z, Xu T, Jiang M, Zhu X, Pan X, Li P, Zhou Z, He X, Yin R, Feng J
Front Immunol 2021;12:719285. Epub 2021 Oct 18 doi: 10.3389/fimmu.2021.719285. PMID: 34733273Free PMC Article
Preselection TCR repertoire predicts CD4(+) and CD8(+) T-cell differentiation state.
Hou X, Chen W, Zhang X, Wang G, Chen J, Zeng P, Fu X, Zhang Q, Liu X, Diao H
Immunology 2020 Dec;161(4):354-363. Epub 2020 Oct 7 doi: 10.1111/imm.13256. PMID: 32875554Free PMC Article
T-cell repertoires in refractory coeliac disease.
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M
Gut 2018 Apr;67(4):644-653. Epub 2017 Feb 10 doi: 10.1136/gutjnl-2016-311816. PMID: 28188172Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Molecular genetics of the T cell-receptor beta chain.
Davis MM
Annu Rev Immunol 1985;3:537-60. doi: 10.1146/annurev.iy.03.040185.002541. PMID: 3933533

Clinical prediction guides

Preselection TCR repertoire predicts CD4(+) and CD8(+) T-cell differentiation state.
Hou X, Chen W, Zhang X, Wang G, Chen J, Zeng P, Fu X, Zhang Q, Liu X, Diao H
Immunology 2020 Dec;161(4):354-363. Epub 2020 Oct 7 doi: 10.1111/imm.13256. PMID: 32875554Free PMC Article
High Incidence of Clonal CD8+ T-cell Proliferation in Non-malignant Conditions May Reduce the Significance of T-cell Clonality Assay for Differential Diagnosis in Oncohematology.
Sidorova YV, Sychevskaya KA, Chernova NG, Julhakyan HL, Smirnova SJ, Ryzhikova NV, Gorodetskiy VR, Naumova EV, Sudarikov AB
Clin Lymphoma Myeloma Leuk 2020 Apr;20(4):203-208. Epub 2020 Jan 8 doi: 10.1016/j.clml.2019.12.021. PMID: 32046930
Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis.
Werner L, Nunberg MY, Rechavi E, Lev A, Braun T, Haberman Y, Lahad A, Shteyer E, Schvimer M, Somech R, Weiss B, Lee YN, Shouval DS
Clin Exp Immunol 2019 Apr;196(1):1-11. Epub 2019 Jan 27 doi: 10.1111/cei.13247. PMID: 30556140Free PMC Article
T-cell repertoires in refractory coeliac disease.
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M
Gut 2018 Apr;67(4):644-653. Epub 2017 Feb 10 doi: 10.1136/gutjnl-2016-311816. PMID: 28188172Free PMC Article
Molecular genetics of the T cell-receptor beta chain.
Davis MM
Annu Rev Immunol 1985;3:537-60. doi: 10.1146/annurev.iy.03.040185.002541. PMID: 3933533

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