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Gain of Chromosome 12q13

MedGen UID:
275934
•Concept ID:
C1517385
•
Cell or Molecular Dysfunction
Synonym: Gain in Chromosome 12(q13)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 12q13

Recent clinical studies

Etiology

Selective genomic copy number imbalances and probability of recurrence in early-stage breast cancer.
Thompson PA, Brewster AM, Kim-Anh D, Baladandayuthapani V, Broom BM, Edgerton ME, Hahn KM, Murray JL, Sahin A, Tsavachidis S, Wang Y, Zhang L, Hortobagyi GN, Mills GB, Bondy ML
PLoS One 2011;6(8):e23543. Epub 2011 Aug 12 doi: 10.1371/journal.pone.0023543. PMID: 21858162Free PMC Article
Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways.
Booman M, Szuhai K, Rosenwald A, Hartmann E, Kluin-Nelemans H, de Jong D, Schuuring E, Kluin P
J Pathol 2008 Oct;216(2):209-17. doi: 10.1002/path.2399. PMID: 18729069
Loss of chromosome 13q is a frequently acquired event in genetic progression of soft tissue sarcomas in the abdominal cavity.
Weng WH, Lerner M, Grandér D, Ahlén J, Villablanca A, Pang ST, Wejde J, Lui WO, Larsson C
Int J Oncol 2005 Jan;26(1):5-16. PMID: 15586219
Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.
Warr T, Ward S, Burrows J, Harding B, Wilkins P, Harkness W, Hayward R, Darling J, Thomas D
Genes Chromosomes Cancer 2001 May;31(1):15-22. doi: 10.1002/gcc.1113. PMID: 11284031
Cytogenetic evolution patterns in non-Hodgkin's lymphoma.
Johansson B, Mertens F, Mitelman F
Blood 1995 Nov 15;86(10):3905-14. PMID: 7579360

Diagnosis

Early G₁ cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma.
Ismail A, Bandla S, Reveiller M, Toia L, Zhou Z, Gooding WE, Kalatskaya I, Stein L, D'Souza M, Litle VR, Peters JH, Pennathur A, Luketich JD, Godfrey TE
Clin Cancer Res 2011 Jul 1;17(13):4513-22. Epub 2011 May 18 doi: 10.1158/1078-0432.CCR-11-0244. PMID: 21593195Free PMC Article
Similarity in genetic alterations between paired well-differentiated and dedifferentiated components of dedifferentiated liposarcoma.
Horvai AE, DeVries S, Roy R, O'Donnell RJ, Waldman F
Mod Pathol 2009 Nov;22(11):1477-88. Epub 2009 Sep 4 doi: 10.1038/modpathol.2009.119. PMID: 19734852
Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization.
Vranová V, Necesalová E, Kuglík P, Cejpek P, Pesáková M, Budínská E, Relichová J, Veselská R
Oncol Rep 2007 Feb;17(2):457-64. PMID: 17203188
Characterization of large chromosome markers in a malignant fibrous histiocytoma by spectral karyotyping, comparative genomic hybridization (CGH), and array CGH.
Weng WH, Wejde J, Ahlén J, Pang ST, Lui WO, Larsson C
Cancer Genet Cytogenet 2004 Apr 1;150(1):27-32. doi: 10.1016/j.cancergencyto.2003.08.009. PMID: 15041220
Regional cancer cytogenetics: a report on 1,143 diagnostic cases.
Perkins D, Brennan S, Carstairs K, Bailey D, Pantalony D, Poon A, Fernandes B, Dubé I
Cancer Genet Cytogenet 1997 Jul 1;96(1):64-80. doi: 10.1016/s0165-4608(96)00363-9. PMID: 9209473

Therapy

Intratumoral patterns of genomic imbalance in glioblastomas.
Nobusawa S, Lachuer J, Wierinckx A, Kim YH, Huang J, Legras C, Kleihues P, Ohgaki H
Brain Pathol 2010 Sep;20(5):936-44. Epub 2010 Mar 18 doi: 10.1111/j.1750-3639.2010.00395.x. PMID: 20406234Free PMC Article
Similar chromosomal changes in cisplatin and oxaliplatin-resistant sublines of the H69 SCLC cell line are not associated with platinum resistance.
Stordal B, Peters G, Davey R
Genes Chromosomes Cancer 2006 Dec;45(12):1094-105. doi: 10.1002/gcc.20373. PMID: 16967470
Regional cancer cytogenetics: a report on 1,143 diagnostic cases.
Perkins D, Brennan S, Carstairs K, Bailey D, Pantalony D, Poon A, Fernandes B, Dubé I
Cancer Genet Cytogenet 1997 Jul 1;96(1):64-80. doi: 10.1016/s0165-4608(96)00363-9. PMID: 9209473
Benign salivary gland tumors: a cytogenetic study of 21 cases.
Martins C, Fonseca I, Félix A, Roque L, Soares J
J Surg Oncol 1995 Dec;60(4):232-7. doi: 10.1002/jso.2930600404. PMID: 8551731

Prognosis

MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway.
Wu ZH, Lin C, Liu CC, Jiang WW, Huang MZ, Liu X, Guo WJ
Biochem Biophys Res Commun 2018 Jul 2;501(4):1068-1073. Epub 2018 May 21 doi: 10.1016/j.bbrc.2018.05.109. PMID: 29777710
Selective genomic copy number imbalances and probability of recurrence in early-stage breast cancer.
Thompson PA, Brewster AM, Kim-Anh D, Baladandayuthapani V, Broom BM, Edgerton ME, Hahn KM, Murray JL, Sahin A, Tsavachidis S, Wang Y, Zhang L, Hortobagyi GN, Mills GB, Bondy ML
PLoS One 2011;6(8):e23543. Epub 2011 Aug 12 doi: 10.1371/journal.pone.0023543. PMID: 21858162Free PMC Article
Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways.
Booman M, Szuhai K, Rosenwald A, Hartmann E, Kluin-Nelemans H, de Jong D, Schuuring E, Kluin P
J Pathol 2008 Oct;216(2):209-17. doi: 10.1002/path.2399. PMID: 18729069
Microarray-based comparative genomic hybridisation of breast cancer patients receiving neoadjuvant chemotherapy.
Pierga JY, Reis-Filho JS, Cleator SJ, Dexter T, Mackay A, Simpson P, Fenwick K, Iravani M, Salter J, Hills M, Jones C, Ashworth A, Smith IE, Powles T, Dowsett M
Br J Cancer 2007 Jan 29;96(2):341-51. Epub 2006 Nov 28 doi: 10.1038/sj.bjc.6603483. PMID: 17133270Free PMC Article
Conserved properties of HP1(Hsalpha).
Norwood LE, Grade SK, Cryderman DE, Hines KA, Furiasse N, Toro R, Li Y, Dhasarathy A, Kladde MP, Hendrix MJ, Kirschmann DA, Wallrath LL
Gene 2004 Jul 7;336(1):37-46. doi: 10.1016/j.gene.2004.04.003. PMID: 15225874

Clinical prediction guides

MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway.
Wu ZH, Lin C, Liu CC, Jiang WW, Huang MZ, Liu X, Guo WJ
Biochem Biophys Res Commun 2018 Jul 2;501(4):1068-1073. Epub 2018 May 21 doi: 10.1016/j.bbrc.2018.05.109. PMID: 29777710
Loss of chromosome 13q is a frequently acquired event in genetic progression of soft tissue sarcomas in the abdominal cavity.
Weng WH, Lerner M, Grandér D, Ahlén J, Villablanca A, Pang ST, Wejde J, Lui WO, Larsson C
Int J Oncol 2005 Jan;26(1):5-16. PMID: 15586219
Conserved properties of HP1(Hsalpha).
Norwood LE, Grade SK, Cryderman DE, Hines KA, Furiasse N, Toro R, Li Y, Dhasarathy A, Kladde MP, Hendrix MJ, Kirschmann DA, Wallrath LL
Gene 2004 Jul 7;336(1):37-46. doi: 10.1016/j.gene.2004.04.003. PMID: 15225874
Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.
Warr T, Ward S, Burrows J, Harding B, Wilkins P, Harkness W, Hayward R, Darling J, Thomas D
Genes Chromosomes Cancer 2001 May;31(1):15-22. doi: 10.1002/gcc.1113. PMID: 11284031
Comparative genomic and in situ hybridization of germ cell tumors of the infantile testis.
Mostert M, Rosenberg C, Stoop H, Schuyer M, Timmer A, Oosterhuis W, Looijenga L
Lab Invest 2000 Jul;80(7):1055-64. doi: 10.1038/labinvest.3780110. PMID: 10908150

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