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Gain of Chromosome 12q13

MedGen UID:
275934
•Concept ID:
C1517385
•
Cell or Molecular Dysfunction
Synonym: Gain in Chromosome 12(q13)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 12q13

Recent clinical studies

Etiology

Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways.
Booman M, Szuhai K, Rosenwald A, Hartmann E, Kluin-Nelemans H, de Jong D, Schuuring E, Kluin P
J Pathol 2008 Oct;216(2):209-17. doi: 10.1002/path.2399. PMID: 18729069
Loss of chromosome 13q is a frequently acquired event in genetic progression of soft tissue sarcomas in the abdominal cavity.
Weng WH, Lerner M, Grandér D, Ahlén J, Villablanca A, Pang ST, Wejde J, Lui WO, Larsson C
Int J Oncol 2005 Jan;26(1):5-16. PMID: 15586219
Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity.
Coindre JM, Hostein I, Maire G, Derré J, Guillou L, Leroux A, Ghnassia JP, Collin F, Pedeutour F, Aurias A
J Pathol 2004 Jul;203(3):822-30. doi: 10.1002/path.1579. PMID: 15221942
Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.
Warr T, Ward S, Burrows J, Harding B, Wilkins P, Harkness W, Hayward R, Darling J, Thomas D
Genes Chromosomes Cancer 2001 May;31(1):15-22. doi: 10.1002/gcc.1113. PMID: 11284031
Cytogenetic evolution patterns in non-Hodgkin's lymphoma.
Johansson B, Mertens F, Mitelman F
Blood 1995 Nov 15;86(10):3905-14. PMID: 7579360

Diagnosis

Early G₁ cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma.
Ismail A, Bandla S, Reveiller M, Toia L, Zhou Z, Gooding WE, Kalatskaya I, Stein L, D'Souza M, Litle VR, Peters JH, Pennathur A, Luketich JD, Godfrey TE
Clin Cancer Res 2011 Jul 1;17(13):4513-22. Epub 2011 May 18 doi: 10.1158/1078-0432.CCR-11-0244. PMID: 21593195Free PMC Article
Similarity in genetic alterations between paired well-differentiated and dedifferentiated components of dedifferentiated liposarcoma.
Horvai AE, DeVries S, Roy R, O'Donnell RJ, Waldman F
Mod Pathol 2009 Nov;22(11):1477-88. Epub 2009 Sep 4 doi: 10.1038/modpathol.2009.119. PMID: 19734852
Characterization of large chromosome markers in a malignant fibrous histiocytoma by spectral karyotyping, comparative genomic hybridization (CGH), and array CGH.
Weng WH, Wejde J, Ahlén J, Pang ST, Lui WO, Larsson C
Cancer Genet Cytogenet 2004 Apr 1;150(1):27-32. doi: 10.1016/j.cancergencyto.2003.08.009. PMID: 15041220
Regional cancer cytogenetics: a report on 1,143 diagnostic cases.
Perkins D, Brennan S, Carstairs K, Bailey D, Pantalony D, Poon A, Fernandes B, Dubé I
Cancer Genet Cytogenet 1997 Jul 1;96(1):64-80. doi: 10.1016/s0165-4608(96)00363-9. PMID: 9209473
Gains, losses, and amplification of genomic material in rhabdomyosarcoma analyzed by comparative genomic hybridization.
Weber-Hall S, Anderson J, McManus A, Abe S, Nojima T, Pinkerton R, Pritchard-Jones K, Shipley J
Cancer Res 1996 Jul 15;56(14):3220-4. PMID: 8764111

Therapy

Intratumoral patterns of genomic imbalance in glioblastomas.
Nobusawa S, Lachuer J, Wierinckx A, Kim YH, Huang J, Legras C, Kleihues P, Ohgaki H
Brain Pathol 2010 Sep;20(5):936-44. Epub 2010 Mar 18 doi: 10.1111/j.1750-3639.2010.00395.x. PMID: 20406234Free PMC Article
Similar chromosomal changes in cisplatin and oxaliplatin-resistant sublines of the H69 SCLC cell line are not associated with platinum resistance.
Stordal B, Peters G, Davey R
Genes Chromosomes Cancer 2006 Dec;45(12):1094-105. doi: 10.1002/gcc.20373. PMID: 16967470
Regional cancer cytogenetics: a report on 1,143 diagnostic cases.
Perkins D, Brennan S, Carstairs K, Bailey D, Pantalony D, Poon A, Fernandes B, Dubé I
Cancer Genet Cytogenet 1997 Jul 1;96(1):64-80. doi: 10.1016/s0165-4608(96)00363-9. PMID: 9209473
Benign salivary gland tumors: a cytogenetic study of 21 cases.
Martins C, Fonseca I, Félix A, Roque L, Soares J
J Surg Oncol 1995 Dec;60(4):232-7. doi: 10.1002/jso.2930600404. PMID: 8551731

Prognosis

MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway.
Wu ZH, Lin C, Liu CC, Jiang WW, Huang MZ, Liu X, Guo WJ
Biochem Biophys Res Commun 2018 Jul 2;501(4):1068-1073. Epub 2018 May 21 doi: 10.1016/j.bbrc.2018.05.109. PMID: 29777710
Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways.
Booman M, Szuhai K, Rosenwald A, Hartmann E, Kluin-Nelemans H, de Jong D, Schuuring E, Kluin P
J Pathol 2008 Oct;216(2):209-17. doi: 10.1002/path.2399. PMID: 18729069
Array-comparative genomic hybridization of central chondrosarcoma: identification of ribosomal protein S6 and cyclin-dependent kinase 4 as candidate target genes for genomic aberrations.
Rozeman LB, Szuhai K, Schrage YM, Rosenberg C, Tanke HJ, Taminiau AH, Cleton-Jansen AM, Bovée JV, Hogendoorn PC
Cancer 2006 Jul 15;107(2):380-8. doi: 10.1002/cncr.22001. PMID: 16779802
G-banding and molecular cytogenetic analyses of marginal zone lymphoma.
Aamot HV, Micci F, Holte H, Delabie J, Heim S
Br J Haematol 2005 Sep;130(6):890-901. doi: 10.1111/j.1365-2141.2005.05706.x. PMID: 16156859
Conserved properties of HP1(Hsalpha).
Norwood LE, Grade SK, Cryderman DE, Hines KA, Furiasse N, Toro R, Li Y, Dhasarathy A, Kladde MP, Hendrix MJ, Kirschmann DA, Wallrath LL
Gene 2004 Jul 7;336(1):37-46. doi: 10.1016/j.gene.2004.04.003. PMID: 15225874

Clinical prediction guides

MiR-616-3p promotes angiogenesis and EMT in gastric cancer via the PTEN/AKT/mTOR pathway.
Wu ZH, Lin C, Liu CC, Jiang WW, Huang MZ, Liu X, Guo WJ
Biochem Biophys Res Commun 2018 Jul 2;501(4):1068-1073. Epub 2018 May 21 doi: 10.1016/j.bbrc.2018.05.109. PMID: 29777710
Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways.
Booman M, Szuhai K, Rosenwald A, Hartmann E, Kluin-Nelemans H, de Jong D, Schuuring E, Kluin P
J Pathol 2008 Oct;216(2):209-17. doi: 10.1002/path.2399. PMID: 18729069
Loss of chromosome 13q is a frequently acquired event in genetic progression of soft tissue sarcomas in the abdominal cavity.
Weng WH, Lerner M, Grandér D, Ahlén J, Villablanca A, Pang ST, Wejde J, Lui WO, Larsson C
Int J Oncol 2005 Jan;26(1):5-16. PMID: 15586219
Identification of extensive genomic loss and gain by comparative genomic hybridisation in malignant astrocytoma in children and young adults.
Warr T, Ward S, Burrows J, Harding B, Wilkins P, Harkness W, Hayward R, Darling J, Thomas D
Genes Chromosomes Cancer 2001 May;31(1):15-22. doi: 10.1002/gcc.1113. PMID: 11284031
Comparative genomic and in situ hybridization of germ cell tumors of the infantile testis.
Mostert M, Rosenberg C, Stoop H, Schuyer M, Timmer A, Oosterhuis W, Looijenga L
Lab Invest 2000 Jul;80(7):1055-64. doi: 10.1038/labinvest.3780110. PMID: 10908150

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