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Gain of Chromosome 3q

MedGen UID:
275944
•Concept ID:
C1517410
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 3q

Professional guidelines

PubMed

New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases.
Bensen R, Brognard J
Int J Mol Sci 2021 Mar 11;22(6) doi: 10.3390/ijms22062831. PMID: 33799513Free PMC Article
Copy number variations could predict the outcome of bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Kim M, Lee SH, Kim J, Lee SE, Kim YJ, Min CK
Genes Chromosomes Cancer 2015 Jan;54(1):20-7. Epub 2014 Aug 21 doi: 10.1002/gcc.22213. PMID: 25145975
Opportunities to improve the prevention and treatment of cervical cancer.
Roden RB, Monie A, Wu TC
Curr Mol Med 2007 Aug;7(5):490-503. doi: 10.2174/156652407781387127. PMID: 17691964

Recent clinical studies

Etiology

Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
Dehner CA, Bell RC, Cao Y, He K, Chrisinger JSA, Armstrong AE, Yohe M, Shern J, Hirbe AC
JCO Precis Oncol 2023 Sep;7:e2300037. doi: 10.1200/PO.23.00037. PMID: 37738543Free PMC Article
The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis.
Teng L, Feng YC, Guo ST, Wang PL, Qi TF, Yue YM, Wang SX, Zhang SN, Tang CX, La T, Zhang YY, Zhao XH, Gao JN, Wei LY, Zhang D, Wang JY, Shi Y, Liu XY, Li JM, Cao H, Liu T, Thorne RF, Jin L, Shao FM, Zhang XD
Nat Commun 2021 Jun 18;12(1):3734. doi: 10.1038/s41467-021-24099-4. PMID: 34145290Free PMC Article
Is there a gain in chromosome 3q in the pathway to anal cancer?
Ricciardi R, Burks E, Schoetz DJ, Verma Y, Kershnar E, Kilpatrick MW, Tsipouras P, Walat RJ
Dis Colon Rectum 2014 Oct;57(10):1183-7. doi: 10.1097/DCR.0000000000000198. PMID: 25203374
Opportunities to improve the prevention and treatment of cervical cancer.
Roden RB, Monie A, Wu TC
Curr Mol Med 2007 Aug;7(5):490-503. doi: 10.2174/156652407781387127. PMID: 17691964
HPV-mediated transformation of the anogenital tract.
Steenbergen RD, de Wilde J, Wilting SM, Brink AA, Snijders PJ, Meijer CJ
J Clin Virol 2005 Mar;32 Suppl 1:S25-33. doi: 10.1016/j.jcv.2004.11.019. PMID: 15753009

Diagnosis

Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
Dehner CA, Bell RC, Cao Y, He K, Chrisinger JSA, Armstrong AE, Yohe M, Shern J, Hirbe AC
JCO Precis Oncol 2023 Sep;7:e2300037. doi: 10.1200/PO.23.00037. PMID: 37738543Free PMC Article
Gene-level dissection of chromosome 3q locus amplification in squamous cell carcinoma of the lung using the nCounter assay.
Jeon T, Oh UJ, Min J, Kim C
Thorac Cancer 2023 Sep;14(26):2635-2641. Epub 2023 Jul 19 doi: 10.1111/1759-7714.15045. PMID: 37469197Free PMC Article
Gain of Chromosomal Region 3q26 as a Prognostic Biomarker for High-Grade Cervical Intraepithelial Neoplasia: Literature Overview and Pilot Study.
Koeneman MM, Ovestad IT, Janssen EAM, Ummelen M, Kruitwagen RFPM, Hopman AH, Kruse AJ
Pathol Oncol Res 2019 Apr;25(2):549-557. Epub 2018 Oct 25 doi: 10.1007/s12253-018-0480-y. PMID: 30361910Free PMC Article
Cytogenetics of melanoma and nonmelanoma skin cancer.
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365
Role of chromosome 3q amplification in lung cancer.
Qian J, Massion PP
J Thorac Oncol 2008 Mar;3(3):212-5. doi: 10.1097/JTO.0b013e3181663544. PMID: 18317062

Therapy

New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases.
Bensen R, Brognard J
Int J Mol Sci 2021 Mar 11;22(6) doi: 10.3390/ijms22062831. PMID: 33799513Free PMC Article
Chromosome 3q arm gain linked to immunotherapy response in advanced cutaneous squamous cell carcinoma.
Kacew AJ, Harris EJ, Lorch JH, Haddad RI, Chau NG, Rabinowits G, LeBoeuf NR, Schmults CD, Thakuria M, MacConaill LE, Hanna GJ
Eur J Cancer 2019 May;113:1-9. Epub 2019 Apr 4 doi: 10.1016/j.ejca.2019.03.004. PMID: 30954880
Copy number variations could predict the outcome of bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Kim M, Lee SH, Kim J, Lee SE, Kim YJ, Min CK
Genes Chromosomes Cancer 2015 Jan;54(1):20-7. Epub 2014 Aug 21 doi: 10.1002/gcc.22213. PMID: 25145975
Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML.
Rochowski A, Olson SB, Alonzo TA, Gerbing RB, Lange BJ, Alter BP
Pediatr Blood Cancer 2012 Nov;59(5):922-4. Epub 2012 Apr 19 doi: 10.1002/pbc.24168. PMID: 22517793Free PMC Article
Cytogenetic studies in prostate cancer: are we making progress?
Brothman AR
Cancer Genet Cytogenet 1997 May;95(1):116-21. doi: 10.1016/s0165-4608(96)00302-0. PMID: 9140461

Prognosis

Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
Dehner CA, Bell RC, Cao Y, He K, Chrisinger JSA, Armstrong AE, Yohe M, Shern J, Hirbe AC
JCO Precis Oncol 2023 Sep;7:e2300037. doi: 10.1200/PO.23.00037. PMID: 37738543Free PMC Article
Gene-level dissection of chromosome 3q locus amplification in squamous cell carcinoma of the lung using the nCounter assay.
Jeon T, Oh UJ, Min J, Kim C
Thorac Cancer 2023 Sep;14(26):2635-2641. Epub 2023 Jul 19 doi: 10.1111/1759-7714.15045. PMID: 37469197Free PMC Article
Chromosome 3q arm gain linked to immunotherapy response in advanced cutaneous squamous cell carcinoma.
Kacew AJ, Harris EJ, Lorch JH, Haddad RI, Chau NG, Rabinowits G, LeBoeuf NR, Schmults CD, Thakuria M, MacConaill LE, Hanna GJ
Eur J Cancer 2019 May;113:1-9. Epub 2019 Apr 4 doi: 10.1016/j.ejca.2019.03.004. PMID: 30954880
Gain of Chromosomal Region 3q26 as a Prognostic Biomarker for High-Grade Cervical Intraepithelial Neoplasia: Literature Overview and Pilot Study.
Koeneman MM, Ovestad IT, Janssen EAM, Ummelen M, Kruitwagen RFPM, Hopman AH, Kruse AJ
Pathol Oncol Res 2019 Apr;25(2):549-557. Epub 2018 Oct 25 doi: 10.1007/s12253-018-0480-y. PMID: 30361910Free PMC Article
Role of chromosome 3q amplification in lung cancer.
Qian J, Massion PP
J Thorac Oncol 2008 Mar;3(3):212-5. doi: 10.1097/JTO.0b013e3181663544. PMID: 18317062

Clinical prediction guides

Gene-level dissection of chromosome 3q locus amplification in squamous cell carcinoma of the lung using the nCounter assay.
Jeon T, Oh UJ, Min J, Kim C
Thorac Cancer 2023 Sep;14(26):2635-2641. Epub 2023 Jul 19 doi: 10.1111/1759-7714.15045. PMID: 37469197Free PMC Article
Chromosome 3q arm gain linked to immunotherapy response in advanced cutaneous squamous cell carcinoma.
Kacew AJ, Harris EJ, Lorch JH, Haddad RI, Chau NG, Rabinowits G, LeBoeuf NR, Schmults CD, Thakuria M, MacConaill LE, Hanna GJ
Eur J Cancer 2019 May;113:1-9. Epub 2019 Apr 4 doi: 10.1016/j.ejca.2019.03.004. PMID: 30954880
Gain of Chromosomal Region 3q26 as a Prognostic Biomarker for High-Grade Cervical Intraepithelial Neoplasia: Literature Overview and Pilot Study.
Koeneman MM, Ovestad IT, Janssen EAM, Ummelen M, Kruitwagen RFPM, Hopman AH, Kruse AJ
Pathol Oncol Res 2019 Apr;25(2):549-557. Epub 2018 Oct 25 doi: 10.1007/s12253-018-0480-y. PMID: 30361910Free PMC Article
Role of chromosome 3q amplification in lung cancer.
Qian J, Massion PP
J Thorac Oncol 2008 Mar;3(3):212-5. doi: 10.1097/JTO.0b013e3181663544. PMID: 18317062
Gain of chromosome 3q defines the transition from severe dysplasia to invasive carcinoma of the uterine cervix.
Heselmeyer K, Schröck E, du Manoir S, Blegen H, Shah K, Steinbeck R, Auer G, Ried T
Proc Natl Acad Sci U S A 1996 Jan 9;93(1):479-84. doi: 10.1073/pnas.93.1.479. PMID: 8552665Free PMC Article

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