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Gain of Chromosome 3q

MedGen UID:
275944
•Concept ID:
C1517410
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGain of Chromosome 3q

Professional guidelines

PubMed

New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases.
Bensen R, Brognard J
Int J Mol Sci 2021 Mar 11;22(6) doi: 10.3390/ijms22062831. PMID: 33799513Free PMC Article
Opportunities to improve the prevention and treatment of cervical cancer.
Roden RB, Monie A, Wu TC
Curr Mol Med 2007 Aug;7(5):490-503. doi: 10.2174/156652407781387127. PMID: 17691964
Molecular cytogenetic analysis of prostatic adenocarcinomas from screening studies : early cancers may contain aggressive genetic features.
Alers JC, Krijtenburg PJ, Vis AN, Hoedemaeker RF, Wildhagen MF, Hop WC, van Der Kwast TT, Schröder FH, Tanke HJ, van Dekken H
Am J Pathol 2001 Feb;158(2):399-406. doi: 10.1016/s0002-9440(10)63983-1. PMID: 11159178Free PMC Article

Recent clinical studies

Etiology

Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
Dehner CA, Bell RC, Cao Y, He K, Chrisinger JSA, Armstrong AE, Yohe M, Shern J, Hirbe AC
JCO Precis Oncol 2023 Sep;7:e2300037. doi: 10.1200/PO.23.00037. PMID: 37738543Free PMC Article
Is there a gain in chromosome 3q in the pathway to anal cancer?
Ricciardi R, Burks E, Schoetz DJ, Verma Y, Kershnar E, Kilpatrick MW, Tsipouras P, Walat RJ
Dis Colon Rectum 2014 Oct;57(10):1183-7. doi: 10.1097/DCR.0000000000000198. PMID: 25203374
Opportunities to improve the prevention and treatment of cervical cancer.
Roden RB, Monie A, Wu TC
Curr Mol Med 2007 Aug;7(5):490-503. doi: 10.2174/156652407781387127. PMID: 17691964
HPV-mediated transformation of the anogenital tract.
Steenbergen RD, de Wilde J, Wilting SM, Brink AA, Snijders PJ, Meijer CJ
J Clin Virol 2005 Mar;32 Suppl 1:S25-33. doi: 10.1016/j.jcv.2004.11.019. PMID: 15753009
Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects.
Kuroda N, Toi M, Hiroi M, Enzan H
Histol Histopathol 2003 Apr;18(2):487-94. doi: 10.14670/HH-18.487. PMID: 12647800

Diagnosis

Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
Dehner CA, Bell RC, Cao Y, He K, Chrisinger JSA, Armstrong AE, Yohe M, Shern J, Hirbe AC
JCO Precis Oncol 2023 Sep;7:e2300037. doi: 10.1200/PO.23.00037. PMID: 37738543Free PMC Article
Gene-level dissection of chromosome 3q locus amplification in squamous cell carcinoma of the lung using the nCounter assay.
Jeon T, Oh UJ, Min J, Kim C
Thorac Cancer 2023 Sep;14(26):2635-2641. Epub 2023 Jul 19 doi: 10.1111/1759-7714.15045. PMID: 37469197Free PMC Article
Gain of Chromosomal Region 3q26 as a Prognostic Biomarker for High-Grade Cervical Intraepithelial Neoplasia: Literature Overview and Pilot Study.
Koeneman MM, Ovestad IT, Janssen EAM, Ummelen M, Kruitwagen RFPM, Hopman AH, Kruse AJ
Pathol Oncol Res 2019 Apr;25(2):549-557. Epub 2018 Oct 25 doi: 10.1007/s12253-018-0480-y. PMID: 30361910Free PMC Article
Cytogenetics of melanoma and nonmelanoma skin cancer.
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365
Role of chromosome 3q amplification in lung cancer.
Qian J, Massion PP
J Thorac Oncol 2008 Mar;3(3):212-5. doi: 10.1097/JTO.0b013e3181663544. PMID: 18317062

Therapy

New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases.
Bensen R, Brognard J
Int J Mol Sci 2021 Mar 11;22(6) doi: 10.3390/ijms22062831. PMID: 33799513Free PMC Article
Chromosome 3q arm gain linked to immunotherapy response in advanced cutaneous squamous cell carcinoma.
Kacew AJ, Harris EJ, Lorch JH, Haddad RI, Chau NG, Rabinowits G, LeBoeuf NR, Schmults CD, Thakuria M, MacConaill LE, Hanna GJ
Eur J Cancer 2019 May;113:1-9. Epub 2019 Apr 4 doi: 10.1016/j.ejca.2019.03.004. PMID: 30954880
Copy number variations could predict the outcome of bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Kim M, Lee SH, Kim J, Lee SE, Kim YJ, Min CK
Genes Chromosomes Cancer 2015 Jan;54(1):20-7. Epub 2014 Aug 21 doi: 10.1002/gcc.22213. PMID: 25145975
Patients with Fanconi anemia and AML have different cytogenetic clones than de novo cases of AML.
Rochowski A, Olson SB, Alonzo TA, Gerbing RB, Lange BJ, Alter BP
Pediatr Blood Cancer 2012 Nov;59(5):922-4. Epub 2012 Apr 19 doi: 10.1002/pbc.24168. PMID: 22517793Free PMC Article
Regional cancer cytogenetics: a report on 1,143 diagnostic cases.
Perkins D, Brennan S, Carstairs K, Bailey D, Pantalony D, Poon A, Fernandes B, Dubé I
Cancer Genet Cytogenet 1997 Jul 1;96(1):64-80. doi: 10.1016/s0165-4608(96)00363-9. PMID: 9209473

Prognosis

Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma.
Dehner CA, Bell RC, Cao Y, He K, Chrisinger JSA, Armstrong AE, Yohe M, Shern J, Hirbe AC
JCO Precis Oncol 2023 Sep;7:e2300037. doi: 10.1200/PO.23.00037. PMID: 37738543Free PMC Article
Gene-level dissection of chromosome 3q locus amplification in squamous cell carcinoma of the lung using the nCounter assay.
Jeon T, Oh UJ, Min J, Kim C
Thorac Cancer 2023 Sep;14(26):2635-2641. Epub 2023 Jul 19 doi: 10.1111/1759-7714.15045. PMID: 37469197Free PMC Article
Gain of Chromosomal Region 3q26 as a Prognostic Biomarker for High-Grade Cervical Intraepithelial Neoplasia: Literature Overview and Pilot Study.
Koeneman MM, Ovestad IT, Janssen EAM, Ummelen M, Kruitwagen RFPM, Hopman AH, Kruse AJ
Pathol Oncol Res 2019 Apr;25(2):549-557. Epub 2018 Oct 25 doi: 10.1007/s12253-018-0480-y. PMID: 30361910Free PMC Article
Is there a gain in chromosome 3q in the pathway to anal cancer?
Ricciardi R, Burks E, Schoetz DJ, Verma Y, Kershnar E, Kilpatrick MW, Tsipouras P, Walat RJ
Dis Colon Rectum 2014 Oct;57(10):1183-7. doi: 10.1097/DCR.0000000000000198. PMID: 25203374
Role of chromosome 3q amplification in lung cancer.
Qian J, Massion PP
J Thorac Oncol 2008 Mar;3(3):212-5. doi: 10.1097/JTO.0b013e3181663544. PMID: 18317062

Clinical prediction guides

Gene-level dissection of chromosome 3q locus amplification in squamous cell carcinoma of the lung using the nCounter assay.
Jeon T, Oh UJ, Min J, Kim C
Thorac Cancer 2023 Sep;14(26):2635-2641. Epub 2023 Jul 19 doi: 10.1111/1759-7714.15045. PMID: 37469197Free PMC Article
Chromosome 3q arm gain linked to immunotherapy response in advanced cutaneous squamous cell carcinoma.
Kacew AJ, Harris EJ, Lorch JH, Haddad RI, Chau NG, Rabinowits G, LeBoeuf NR, Schmults CD, Thakuria M, MacConaill LE, Hanna GJ
Eur J Cancer 2019 May;113:1-9. Epub 2019 Apr 4 doi: 10.1016/j.ejca.2019.03.004. PMID: 30954880
Gain of Chromosomal Region 3q26 as a Prognostic Biomarker for High-Grade Cervical Intraepithelial Neoplasia: Literature Overview and Pilot Study.
Koeneman MM, Ovestad IT, Janssen EAM, Ummelen M, Kruitwagen RFPM, Hopman AH, Kruse AJ
Pathol Oncol Res 2019 Apr;25(2):549-557. Epub 2018 Oct 25 doi: 10.1007/s12253-018-0480-y. PMID: 30361910Free PMC Article
Is there a gain in chromosome 3q in the pathway to anal cancer?
Ricciardi R, Burks E, Schoetz DJ, Verma Y, Kershnar E, Kilpatrick MW, Tsipouras P, Walat RJ
Dis Colon Rectum 2014 Oct;57(10):1183-7. doi: 10.1097/DCR.0000000000000198. PMID: 25203374
Role of chromosome 3q amplification in lung cancer.
Qian J, Massion PP
J Thorac Oncol 2008 Mar;3(3):212-5. doi: 10.1097/JTO.0b013e3181663544. PMID: 18317062

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