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KRAS Gene Amplification

MedGen UID:
276001
•Concept ID:
C1517648
•
Cell or Molecular Dysfunction
Synonyms: c-K-ras Gene Amplification; KRAS Gene Activation; KRAS-2 Gene Amplification; KRAS2 Gene Amplification; v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the KRAS gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVKRAS Gene Amplification

Professional guidelines

PubMed

Principles in the Management of Glioblastoma.
Roda D, Veiga P, Melo JB, Carreira IM, Ribeiro IP
Genes (Basel) 2024 Apr 17;15(4) doi: 10.3390/genes15040501. PMID: 38674436Free PMC Article
Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer.
Harrold E, Keane F, Walch H, Chou JF, Sinopoli J, Palladino S, Al-Rawi DH, Chadalavada K, Manca P, Chalasani S, Yang J, Cercek A, Shia J, Capanu M, Bakhoum SF, Schultz N, Chatila WK, Yaeger R
Clin Cancer Res 2024 Jun 14;30(12):2672-2683. doi: 10.1158/1078-0432.CCR-23-4005. PMID: 38502113Free PMC Article
Molecular Subtypes and the Evolution of Treatment Decisions in Metastatic Colorectal Cancer.
Dienstmann R, Salazar R, Tabernero J
Am Soc Clin Oncol Educ Book 2018 May 23;38:231-238. doi: 10.1200/EDBK_200929. PMID: 30231342

Recent clinical studies

Etiology

Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.
Qian Z, Zhu G, Tang L, Wang M, Zhang L, Fu J, Huang C, Fan S, Sun Y, Lv J, Dong H, Gao B, Su X, Yu D, Zang J, Zhang X, Ji J, Ji Q
Genes Chromosomes Cancer 2014 Nov;53(11):883-94. Epub 2014 Jun 17 doi: 10.1002/gcc.22196. PMID: 24935174
KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy.
Valtorta E, Misale S, Sartore-Bianchi A, Nagtegaal ID, Paraf F, Lauricella C, Dimartino V, Hobor S, Jacobs B, Ercolani C, Lamba S, Scala E, Veronese S, Laurent-Puig P, Siena S, Tejpar S, Mottolese M, Punt CJ, Gambacorta M, Bardelli A, Di Nicolantonio F
Int J Cancer 2013 Sep 1;133(5):1259-65. Epub 2013 Mar 16 doi: 10.1002/ijc.28106. PMID: 23404247

Diagnosis

Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.
Qian Z, Zhu G, Tang L, Wang M, Zhang L, Fu J, Huang C, Fan S, Sun Y, Lv J, Dong H, Gao B, Su X, Yu D, Zang J, Zhang X, Ji J, Ji Q
Genes Chromosomes Cancer 2014 Nov;53(11):883-94. Epub 2014 Jun 17 doi: 10.1002/gcc.22196. PMID: 24935174
Circulating tumor cells: exploring intratumor heterogeneity of colorectal cancer.
Raimondi C, Nicolazzo C, Gradilone A, Giannini G, De Falco E, Chimenti I, Varriale E, Hauch S, Plappert L, Cortesi E, Gazzaniga P
Cancer Biol Ther 2014 May;15(5):496-503. Epub 2014 Feb 12 doi: 10.4161/cbt.28020. PMID: 24521660Free PMC Article
KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy.
Valtorta E, Misale S, Sartore-Bianchi A, Nagtegaal ID, Paraf F, Lauricella C, Dimartino V, Hobor S, Jacobs B, Ercolani C, Lamba S, Scala E, Veronese S, Laurent-Puig P, Siena S, Tejpar S, Mottolese M, Punt CJ, Gambacorta M, Bardelli A, Di Nicolantonio F
Int J Cancer 2013 Sep 1;133(5):1259-65. Epub 2013 Mar 16 doi: 10.1002/ijc.28106. PMID: 23404247
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer.
Birkeland E, Wik E, Mjøs S, Hoivik EA, Trovik J, Werner HM, Kusonmano K, Petersen K, Raeder MB, Holst F, Øyan AM, Kalland KH, Akslen LA, Simon R, Krakstad C, Salvesen HB
Br J Cancer 2012 Dec 4;107(12):1997-2004. Epub 2012 Oct 25 doi: 10.1038/bjc.2012.477. PMID: 23099803Free PMC Article
A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.
Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
BMC Cancer 2009 Jun 23;9:198. doi: 10.1186/1471-2407-9-198. PMID: 19545448Free PMC Article

Therapy

Clinical Benefit of Sorafenib Combined with Paclitaxel and Carboplatin to a Patient with Metastatic Chemotherapy-Refractory Testicular Tumors.
Lian B, Zhang W, Wang T, Yang Q, Jia Z, Chen H, Wang L, Xu J, Wang W, Cao K, Gao X, Sun Y, Shao C, Liu Z, Li J
Oncologist 2019 Dec;24(12):e1437-e1442. Epub 2019 Sep 6 doi: 10.1634/theoncologist.2019-0295. PMID: 31492770Free PMC Article

Prognosis

Clinical Benefit of Sorafenib Combined with Paclitaxel and Carboplatin to a Patient with Metastatic Chemotherapy-Refractory Testicular Tumors.
Lian B, Zhang W, Wang T, Yang Q, Jia Z, Chen H, Wang L, Xu J, Wang W, Cao K, Gao X, Sun Y, Shao C, Liu Z, Li J
Oncologist 2019 Dec;24(12):e1437-e1442. Epub 2019 Sep 6 doi: 10.1634/theoncologist.2019-0295. PMID: 31492770Free PMC Article
Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.
Qian Z, Zhu G, Tang L, Wang M, Zhang L, Fu J, Huang C, Fan S, Sun Y, Lv J, Dong H, Gao B, Su X, Yu D, Zang J, Zhang X, Ji J, Ji Q
Genes Chromosomes Cancer 2014 Nov;53(11):883-94. Epub 2014 Jun 17 doi: 10.1002/gcc.22196. PMID: 24935174
Circulating tumor cells: exploring intratumor heterogeneity of colorectal cancer.
Raimondi C, Nicolazzo C, Gradilone A, Giannini G, De Falco E, Chimenti I, Varriale E, Hauch S, Plappert L, Cortesi E, Gazzaniga P
Cancer Biol Ther 2014 May;15(5):496-503. Epub 2014 Feb 12 doi: 10.4161/cbt.28020. PMID: 24521660Free PMC Article
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer.
Birkeland E, Wik E, Mjøs S, Hoivik EA, Trovik J, Werner HM, Kusonmano K, Petersen K, Raeder MB, Holst F, Øyan AM, Kalland KH, Akslen LA, Simon R, Krakstad C, Salvesen HB
Br J Cancer 2012 Dec 4;107(12):1997-2004. Epub 2012 Oct 25 doi: 10.1038/bjc.2012.477. PMID: 23099803Free PMC Article
MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors.
Cepero V, Sierra JR, Corso S, Ghiso E, Casorzo L, Perera T, Comoglio PM, Giordano S
Cancer Res 2010 Oct 1;70(19):7580-90. Epub 2010 Sep 14 doi: 10.1158/0008-5472.CAN-10-0436. PMID: 20841479

Clinical prediction guides

Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.
Qian Z, Zhu G, Tang L, Wang M, Zhang L, Fu J, Huang C, Fan S, Sun Y, Lv J, Dong H, Gao B, Su X, Yu D, Zang J, Zhang X, Ji J, Ji Q
Genes Chromosomes Cancer 2014 Nov;53(11):883-94. Epub 2014 Jun 17 doi: 10.1002/gcc.22196. PMID: 24935174
KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer.
Birkeland E, Wik E, Mjøs S, Hoivik EA, Trovik J, Werner HM, Kusonmano K, Petersen K, Raeder MB, Holst F, Øyan AM, Kalland KH, Akslen LA, Simon R, Krakstad C, Salvesen HB
Br J Cancer 2012 Dec 4;107(12):1997-2004. Epub 2012 Oct 25 doi: 10.1038/bjc.2012.477. PMID: 23099803Free PMC Article
MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors.
Cepero V, Sierra JR, Corso S, Ghiso E, Casorzo L, Perera T, Comoglio PM, Giordano S
Cancer Res 2010 Oct 1;70(19):7580-90. Epub 2010 Sep 14 doi: 10.1158/0008-5472.CAN-10-0436. PMID: 20841479

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