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Loss of Chromosome 12q

MedGen UID:
276071
Concept ID:
C1517956
Cell or Molecular Dysfunction
Synonym: del(12q)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 12 (12q). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 12q

Professional guidelines

PubMed

Skotheim RI, Kraggerud SM, Fosså SD, Stenwig AE, Gedde-Dahl T Jr, Danielsen HE, Jakobsen KS, Lothe RA
Neoplasia 2001 May-Jun;3(3):196-203. doi: 10.1038/sj.neo.7900153. PMID: 11494113Free PMC Article

Recent clinical studies

Etiology

Miyai K, Ito K, Nakanishi K, Tsuda H
Hum Pathol 2019 Feb;84:71-80. Epub 2018 Sep 25 doi: 10.1016/j.humpath.2018.09.007. PMID: 30266250
Lourenço N, Hélias-Rodzewicz Z, Bachet JB, Brahimi-Adouane S, Jardin F, Tran van Nhieu J, Peschaud F, Martin E, Beauchet A, Chibon F, Emile JF
Mol Cancer 2014 Nov 6;13:246. doi: 10.1186/1476-4598-13-246. PMID: 25373456Free PMC Article
van Dieren JM, Wink JC, Vissers KJ, van Marion R, Hoogmans MM, Dinjens WN, Schouten WR, Tanke HJ, Szuhai K, Kuipers EJ, van der Woude CJ, van Dekken H
Diagn Mol Pathol 2006 Dec;15(4):216-22. doi: 10.1097/01.pdm.0000213470.92925.18. PMID: 17122649
Kuroda N, Toi M, Hiroi M, Enzan H
Histol Histopathol 2003 Apr;18(2):487-94. doi: 10.14670/HH-18.487. PMID: 12647800
Cryns VL, Yi SM, Tahara H, Gaz RD, Arnold A
Genes Chromosomes Cancer 1995 May;13(1):9-17. doi: 10.1002/gcc.2870130103. PMID: 7541648

Diagnosis

Recalcati MP, Catusi I, Garzo M, Redaelli S, Massimello M, Maitz SB, Gentile M, Ponzi E, Orsini P, Zilio A, Montaldi A, Calò A, Capra AP, Briuglia S, La Rosa MA, Grillo L, Romano C, Bianca S, Malacarne M, Busè M, Piccione M, Larizza L
Genes (Basel) 2022 Apr 27;13(5) doi: 10.3390/genes13050780. PMID: 35627165Free PMC Article
Rosenberg RE, Egan M, Rodgers S, Harter D, Burnside RD, Milla S, Pappas J
Pediatrics 2013 Jun;131(6):e1996-2001. Epub 2013 May 27 doi: 10.1542/peds.2012-0749. PMID: 23713105
Antony J, Gopalan V, Smith RA, Lam AK
Head Neck Pathol 2012 Mar;6(1):1-9. Epub 2011 Jul 9 doi: 10.1007/s12105-011-0281-z. PMID: 21744105Free PMC Article
Furukawa T, Sunamura M, Horii A
Cancer Sci 2006 Jan;97(1):1-7. doi: 10.1111/j.1349-7006.2005.00134.x. PMID: 16367914
Kuroda N, Toi M, Hiroi M, Enzan H
Histol Histopathol 2003 Apr;18(2):487-94. doi: 10.14670/HH-18.487. PMID: 12647800

Therapy

Chen QR, Bilke S, Wei JS, Whiteford CC, Cenacchi N, Krasnoselsky AL, Greer BT, Son CG, Westermann F, Berthold F, Schwab M, Catchpoole D, Khan J
BMC Genomics 2004 Sep 20;5:70. doi: 10.1186/1471-2164-5-70. PMID: 15380028Free PMC Article
Sunamura M, Oonuma M, Motoi F, Abe H, Saitoh Y, Hoshida T, Ottomo S, Horii A, Matsuno S
Hum Cell 2002 Sep;15(3):138-50. doi: 10.1111/j.1749-0774.2002.tb00108.x. PMID: 12703544
van Grieken NC, Weiss MM, Meijer GA, Hermsen MA, Scholte GH, Lindeman J, Craanen ME, Bloemena E, Meuwissen SG, Baak JP, Kuipers EJ
J Pathol 2000 Nov;192(3):301-6. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH697>3.0.CO;2-F. PMID: 11054712
Murty VV, Bosl GJ, Houldsworth J, Meyers M, Mukherjee AB, Reuter V, Chaganti RS
Oncogene 1994 Aug;9(8):2245-51. PMID: 7518576

Prognosis

Antony J, Gopalan V, Smith RA, Lam AK
Head Neck Pathol 2012 Mar;6(1):1-9. Epub 2011 Jul 9 doi: 10.1007/s12105-011-0281-z. PMID: 21744105Free PMC Article
van Dieren JM, Wink JC, Vissers KJ, van Marion R, Hoogmans MM, Dinjens WN, Schouten WR, Tanke HJ, Szuhai K, Kuipers EJ, van der Woude CJ, van Dekken H
Diagn Mol Pathol 2006 Dec;15(4):216-22. doi: 10.1097/01.pdm.0000213470.92925.18. PMID: 17122649
Schneider BG, Rha SY, Chung HC, Bravo JC, Mera R, Torres JC, Plaisance KT Jr, Schlegel R, McBride CM, Reveles XT, Leach RJ
Mol Pathol 2003 Jun;56(3):141-9. doi: 10.1136/mp.56.3.141. PMID: 12782760Free PMC Article
Kuroda N, Toi M, Hiroi M, Enzan H
Histol Histopathol 2003 Apr;18(2):487-94. doi: 10.14670/HH-18.487. PMID: 12647800
Cryns VL, Yi SM, Tahara H, Gaz RD, Arnold A
Genes Chromosomes Cancer 1995 May;13(1):9-17. doi: 10.1002/gcc.2870130103. PMID: 7541648

Clinical prediction guides

Jurmeister P, Wrede N, Hoffmann I, Vollbrecht C, Heim D, Hummel M, Wolkenstein P, Koch I, Heynol V, Schmitt WD, Thieme A, Teichmann D, Sers C, von Deimling A, Thierauf JC, von Laffert M, Klauschen F, Capper D
J Pathol 2022 Jan;256(1):61-70. Epub 2021 Oct 25 doi: 10.1002/path.5808. PMID: 34564861
Ueda T, Komiya A, Suzuki H, Shimbo M, Sakamoto S, Imamoto T, Akakura K, Shiraishi T, Ichikawa T
Prostate 2005 Aug 1;64(3):265-71. doi: 10.1002/pros.20228. PMID: 15717310
Choi C, Kim MH, Juhng SW, Oh BR
Int J Cancer 2000 May 15;86(4):501-5. doi: 10.1002/(sici)1097-0215(20000515)86:4<501::aid-ijc9>3.0.co;2-#. PMID: 10797262
Sehgal A
Semin Surg Oncol 1998 Jan-Feb;14(1):3-12. doi: 10.1002/(sici)1098-2388(199801/02)14:1<3::aid-ssu2>3.0.co;2-f. PMID: 9407626
Cryns VL, Yi SM, Tahara H, Gaz RD, Arnold A
Genes Chromosomes Cancer 1995 May;13(1):9-17. doi: 10.1002/gcc.2870130103. PMID: 7541648

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