U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Loss of Chromosome 13

MedGen UID:
276072
•Concept ID:
C1517957
•
Cell or Molecular Dysfunction
Synonym: del(13)

Definition

A cytogenic abnormality that refers to loss of all or part of chromosome 13. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 13

Professional guidelines

PubMed

Multiple myeloma: an update on biology and treatment.
Ludwig H, Meran J, Zojer N
Ann Oncol 1999;10 Suppl 6:31-43. PMID: 10676551

Recent clinical studies

Etiology

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
The implications of non-invasive prenatal testing failures: a review of an under-discussed phenomenon.
Yaron Y
Prenat Diagn 2016 May;36(5):391-6. Epub 2016 Apr 2 doi: 10.1002/pd.4804. PMID: 26941176
Development of patients with 47,XX,+13/45,X mosaics: case report and review of the literature.
Tang HW, Liao SF, Li JS
Eur J Pediatr 2014 Feb;173(2):251-5. Epub 2013 May 12 doi: 10.1007/s00431-013-2001-z. PMID: 23666113
Prognostic and therapeutic significance of myeloma genetics and gene expression profiling.
Stewart AK, Fonseca R
J Clin Oncol 2005 Sep 10;23(26):6339-44. doi: 10.1200/JCO.2005.05.023. PMID: 16155017
Diagnosis and management of retinoblastoma.
Shields CL, Shields JA
Cancer Control 2004 Sep-Oct;11(5):317-27. doi: 10.1177/107327480401100506. PMID: 15377991

Diagnosis

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
High-grade glioma with pleomorphic and pseudopapillary features (HPAP): a proposed type of circumscribed glioma in adults harboring frequent TP53 mutations and recurrent monosomy 13.
Pratt D, Abdullaev Z, Papanicolau-Sengos A, Ketchum C, Panneer Selvam P, Chung HJ, Lee I, Raffeld M, Gilbert MR, Armstrong TS, Pytel P, Borys E, Klonoski JM, McCord M, Horbinski C, Brat D, Perry A, Solomon D, Eberhart C, Giannini C, Quezado M, Aldape K
Acta Neuropathol 2022 Mar;143(3):403-414. Epub 2022 Feb 1 doi: 10.1007/s00401-022-02404-9. PMID: 35103816Free PMC Article
Molecular biology of rhabdomyosarcoma.
Gallego Melcón S, Sánchez de Toledo Codina J
Clin Transl Oncol 2007 Jul;9(7):415-9. doi: 10.1007/s12094-007-0079-3. PMID: 17652054
Diagnosis and management of retinoblastoma.
Shields CL, Shields JA
Cancer Control 2004 Sep-Oct;11(5):317-27. doi: 10.1177/107327480401100506. PMID: 15377991
Wilson disease.
Brewer GJ, Yuzbasiyan-Gurkan V
Medicine (Baltimore) 1992 May;71(3):139-64. doi: 10.1097/00005792-199205000-00004. PMID: 1635439

Therapy

BCL2 and miR-15/16: from gene discovery to treatment.
Pekarsky Y, Balatti V, Croce CM
Cell Death Differ 2018 Jan;25(1):21-26. Epub 2017 Oct 6 doi: 10.1038/cdd.2017.159. PMID: 28984869Free PMC Article
Loss of retinoblastoma in pleomorphic fibroma: An immunohistochemical and genomic analysis.
Hinds B, Agulló Pérez AD, LeBoit PE, McCalmont TH, North JP
J Cutan Pathol 2017 Aug;44(8):665-671. Epub 2017 Jun 13 doi: 10.1111/cup.12965. PMID: 28543636
Diagnosis and management of retinoblastoma.
Shields CL, Shields JA
Cancer Control 2004 Sep-Oct;11(5):317-27. doi: 10.1177/107327480401100506. PMID: 15377991
Therapy related leukemias: susceptibility, prevention and treatment.
Leone G, Voso MT, Sica S, Morosetti R, Pagano L
Leuk Lymphoma 2001 Apr;41(3-4):255-76. doi: 10.3109/10428190109057981. PMID: 11378539
Cytogenetic and molecular abnormalities in chronic lymphocytic leukaemia.
Oscier DG
Blood Rev 1994 Jun;8(2):88-97. doi: 10.1016/s0268-960x(05)80013-x. PMID: 7950479

Prognosis

Two Cases with Ring Chromosome 13 at either End of the Phenotypic Spectrum.
Çakmaklı S, Çankaya T, Gürsoy S, Koç A, Kırbıyık Ö, Kılıçarslan ÖA, Özer E, Erçal D, Bozkaya ÖG
Cytogenet Genome Res 2017;153(4):175-180. Epub 2018 Mar 9 doi: 10.1159/000486775. PMID: 29518772
The implications of non-invasive prenatal testing failures: a review of an under-discussed phenomenon.
Yaron Y
Prenat Diagn 2016 May;36(5):391-6. Epub 2016 Apr 2 doi: 10.1002/pd.4804. PMID: 26941176
Development of patients with 47,XX,+13/45,X mosaics: case report and review of the literature.
Tang HW, Liao SF, Li JS
Eur J Pediatr 2014 Feb;173(2):251-5. Epub 2013 May 12 doi: 10.1007/s00431-013-2001-z. PMID: 23666113
Prognostic and therapeutic significance of myeloma genetics and gene expression profiling.
Stewart AK, Fonseca R
J Clin Oncol 2005 Sep 10;23(26):6339-44. doi: 10.1200/JCO.2005.05.023. PMID: 16155017
The genetics of retinoblastoma.
Stahl A, Levy N, Wadzynska T, Sussan JM, Jourdan-Fonta D, Saracco JB
Ann Genet 1994;37(4):172-8. PMID: 7710251

Clinical prediction guides

Myxoid pleomorphic liposarcoma-a clinicopathologic, immunohistochemical, molecular genetic and epigenetic study of 12 cases, suggesting a possible relationship with conventional pleomorphic liposarcoma.
Creytens D, Folpe AL, Koelsche C, Mentzel T, Ferdinande L, van Gorp JM, Van der Linden M, Raman L, Menten B, Fritchie K, von Deimling A, Van Dorpe J, Flucke U
Mod Pathol 2021 Nov;34(11):2043-2049. Epub 2021 Jun 24 doi: 10.1038/s41379-021-00862-2. PMID: 34168281
Monosomic loss of MIR15A/MIR16-1 is a driver of multiple myeloma proliferation and disease progression.
Chesi M, Stein CK, Garbitt VM, Sharik ME, Asmann YW, Bergsagel M, Riggs DL, Welsh SJ, Meermeier EW, Kumar SK, Braggio E, Bergsagel PL
Blood Cancer Discov 2020 Jul;1(1):68-81. doi: 10.1158/0008-5472.BCD-19-0068. PMID: 32954360Free PMC Article
Development of patients with 47,XX,+13/45,X mosaics: case report and review of the literature.
Tang HW, Liao SF, Li JS
Eur J Pediatr 2014 Feb;173(2):251-5. Epub 2013 May 12 doi: 10.1007/s00431-013-2001-z. PMID: 23666113
Loss of chromosome 13 in cultured human vascular endothelial cells.
Zhang L, Aviv H, Gardner JP, Okuda K, Patel S, Kimura M, Bardeguez A, Aviv A
Exp Cell Res 2000 Nov 1;260(2):357-64. doi: 10.1006/excr.2000.4997. PMID: 11035931
The genetics of retinoblastoma.
Stahl A, Levy N, Wadzynska T, Sussan JM, Jourdan-Fonta D, Saracco JB
Ann Genet 1994;37(4):172-8. PMID: 7710251

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...