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Loss of Chromosome 7

MedGen UID:
276488
•Concept ID:
C1517989
•
Cell or Molecular Dysfunction
Synonyms: -7; del(7)

Definition

A cytogenic abnormality that refers to loss of all or part of chromosome 7. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 7

Professional guidelines

PubMed

The role of neuropathology in the management of newly diagnosed glioblastoma: a systematic review and evidence-based clinical practice guideline.
Velázquez Vega JE, Brat DJ, Ryken TC, Olson JJ
J Neurooncol 2020 Nov;150(2):143-164. Epub 2020 Nov 19 doi: 10.1007/s11060-020-03616-3. PMID: 33215342
Advances in the treatment of acute myeloid leukemia: from chromosomal aberrations to biologically targeted therapy.
Lübbert M, Müller-Tidow C, Hofmann WK, Koeffler HP
J Cell Biochem 2008 Aug 15;104(6):2059-70. doi: 10.1002/jcb.21770. PMID: 18613031
Cytogenetic studies in patients with secondary leukemia/dysmyelopoietic syndrome after different treatment modalities.
Whang-Peng J, Young RC, Lee EC, Longo DL, Schechter GP, DeVita VT Jr
Blood 1988 Feb;71(2):403-14. PMID: 3337904

Recent clinical studies

Etiology

GPNMB confers risk for Parkinson's disease through interaction with α-synuclein.
Diaz-Ortiz ME, Seo Y, Posavi M, Carceles Cordon M, Clark E, Jain N, Charan R, Gallagher MD, Unger TL, Amari N, Skrinak RT, Davila-Rivera R, Brody EM, Han N, Zack R, Van Deerlin VM, Tropea TF, Luk KC, Lee EB, Weintraub D, Chen-Plotkin AS
Science 2022 Aug 19;377(6608):eabk0637. doi: 10.1126/science.abk0637. PMID: 35981040Free PMC Article
Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System.
Komori T
Lab Invest 2022 Feb;102(2):126-133. Epub 2021 Sep 9 doi: 10.1038/s41374-021-00667-6. PMID: 34504304
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
Stichel D, Ebrahimi A, Reuss D, Schrimpf D, Ono T, Shirahata M, Reifenberger G, Weller M, Hänggi D, Wick W, Herold-Mende C, Westphal M, Brandner S, Pfister SM, Capper D, Sahm F, von Deimling A
Acta Neuropathol 2018 Nov;136(5):793-803. Epub 2018 Sep 5 doi: 10.1007/s00401-018-1905-0. PMID: 30187121
The enigma of monosomy 7.
Inaba T, Honda H, Matsui H
Blood 2018 Jun 28;131(26):2891-2898. Epub 2018 Apr 3 doi: 10.1182/blood-2017-12-822262. PMID: 29615405

Diagnosis

Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies.
Stubbins RJ, Korotev S, Godley LA
Curr Hematol Malig Rep 2022 Aug;17(4):94-104. Epub 2022 Jun 8 doi: 10.1007/s11899-022-00663-7. PMID: 35674998
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System.
Komori T
Lab Invest 2022 Feb;102(2):126-133. Epub 2021 Sep 9 doi: 10.1038/s41374-021-00667-6. PMID: 34504304
Prognostic and Predictive Biomarkers in Gliomas.
Śledzińska P, Bebyn MG, Furtak J, Kowalewski J, Lewandowska MA
Int J Mol Sci 2021 Sep 26;22(19) doi: 10.3390/ijms221910373. PMID: 34638714Free PMC Article
Molecular Pathology of Gliomas.
Galbraith K, Snuderl M
Surg Pathol Clin 2021 Sep;14(3):379-386. Epub 2021 Jul 8 doi: 10.1016/j.path.2021.05.003. PMID: 34373090
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
Stichel D, Ebrahimi A, Reuss D, Schrimpf D, Ono T, Shirahata M, Reifenberger G, Weller M, Hänggi D, Wick W, Herold-Mende C, Westphal M, Brandner S, Pfister SM, Capper D, Sahm F, von Deimling A
Acta Neuropathol 2018 Nov;136(5):793-803. Epub 2018 Sep 5 doi: 10.1007/s00401-018-1905-0. PMID: 30187121

Therapy

Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial.
Tesileanu CMS, Sanson M, Wick W, Brandes AA, Clement PM, Erridge SC, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, van Linde ME, Aldape K, Jenkins RB, Kros JM, Wesseling P, von Deimling A, Hoogstrate Y, de Heer I, Atmodimedjo PN, Dubbink HJ, Brouwer RWW, van IJcken WFJ, Cheung KJ, Golfinopoulos V, Baumert BG, Gorlia T, French PJ, van den Bent MJ
Clin Cancer Res 2022 Jun 13;28(12):2527-2535. doi: 10.1158/1078-0432.CCR-21-4283. PMID: 35275197Free PMC Article
Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy.
Abbas HA, Hao D, Tomczak K, Barrodia P, Im JS, Reville PK, Alaniz Z, Wang W, Wang R, Wang F, Al-Atrash G, Takahashi K, Ning J, Ding M, Beird HC, Mathews JT, Little L, Zhang J, Basu S, Konopleva M, Marques-Piubelli ML, Solis LM, Parra ER, Lu W, Tamegnon A, Garcia-Manero G, Green MR, Sharma P, Allison JP, Kornblau SM, Rai K, Wang L, Daver N, Futreal A
Nat Commun 2021 Oct 18;12(1):6071. doi: 10.1038/s41467-021-26282-z. PMID: 34663807Free PMC Article
Prognostic and Predictive Biomarkers in Gliomas.
Śledzińska P, Bebyn MG, Furtak J, Kowalewski J, Lewandowska MA
Int J Mol Sci 2021 Sep 26;22(19) doi: 10.3390/ijms221910373. PMID: 34638714Free PMC Article
-7/7q- syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity.
Honda H, Nagamachi A, Inaba T
Oncogene 2015 May 7;34(19):2413-25. Epub 2014 Jul 7 doi: 10.1038/onc.2014.196. PMID: 24998854
Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug.
Desmond R, Townsley DM, Dumitriu B, Olnes MJ, Scheinberg P, Bevans M, Parikh AR, Broder K, Calvo KR, Wu CO, Young NS, Dunbar CE
Blood 2014 Mar 20;123(12):1818-25. Epub 2013 Dec 17 doi: 10.1182/blood-2013-10-534743. PMID: 24345753Free PMC Article

Prognosis

Molecular landscape of IDH-wild type, pTERT-wild type adult glioblastomas.
Liu EM, Shi ZF, Li KK, Malta TM, Chung NY, Chen H, Chan JY, Poon MF, Kwan JS, Chan DT, Noushmehr H, Mao Y, Ng HK
Brain Pathol 2022 Nov;32(6):e13107. Epub 2022 Jul 11 doi: 10.1111/bpa.13107. PMID: 35815721Free PMC Article
Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial.
Tesileanu CMS, Sanson M, Wick W, Brandes AA, Clement PM, Erridge SC, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, van Linde ME, Aldape K, Jenkins RB, Kros JM, Wesseling P, von Deimling A, Hoogstrate Y, de Heer I, Atmodimedjo PN, Dubbink HJ, Brouwer RWW, van IJcken WFJ, Cheung KJ, Golfinopoulos V, Baumert BG, Gorlia T, French PJ, van den Bent MJ
Clin Cancer Res 2022 Jun 13;28(12):2527-2535. doi: 10.1158/1078-0432.CCR-21-4283. PMID: 35275197Free PMC Article
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System.
Komori T
Lab Invest 2022 Feb;102(2):126-133. Epub 2021 Sep 9 doi: 10.1038/s41374-021-00667-6. PMID: 34504304
Prognostic and Predictive Biomarkers in Gliomas.
Śledzińska P, Bebyn MG, Furtak J, Kowalewski J, Lewandowska MA
Int J Mol Sci 2021 Sep 26;22(19) doi: 10.3390/ijms221910373. PMID: 34638714Free PMC Article
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
Stichel D, Ebrahimi A, Reuss D, Schrimpf D, Ono T, Shirahata M, Reifenberger G, Weller M, Hänggi D, Wick W, Herold-Mende C, Westphal M, Brandner S, Pfister SM, Capper D, Sahm F, von Deimling A
Acta Neuropathol 2018 Nov;136(5):793-803. Epub 2018 Sep 5 doi: 10.1007/s00401-018-1905-0. PMID: 30187121

Clinical prediction guides

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
López-Rivera JA, Leu C, Macnee M, Khoury J, Hoffmann L, Coras R, Kobow K, Bhattarai N, Pérez-Palma E, Hamer H, Brandner S, Rössler K, Bien CG, Kalbhenn T, Pieper T, Hartlieb T, Butler E, Genovese G, Becker K, Altmüller J, Niestroj LM, Ferguson L, Busch RM, Nürnberg P, Najm I, Blümcke I, Lal D
Brain 2023 Apr 19;146(4):1342-1356. doi: 10.1093/brain/awac376. PMID: 36226386Free PMC Article
Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial.
Tesileanu CMS, Sanson M, Wick W, Brandes AA, Clement PM, Erridge SC, Vogelbaum MA, Nowak AK, Baurain JF, Mason WP, Wheeler H, Chinot OL, Gill S, Griffin M, Rogers L, Taal W, Rudà R, Weller M, McBain C, van Linde ME, Aldape K, Jenkins RB, Kros JM, Wesseling P, von Deimling A, Hoogstrate Y, de Heer I, Atmodimedjo PN, Dubbink HJ, Brouwer RWW, van IJcken WFJ, Cheung KJ, Golfinopoulos V, Baumert BG, Gorlia T, French PJ, van den Bent MJ
Clin Cancer Res 2022 Jun 13;28(12):2527-2535. doi: 10.1158/1078-0432.CCR-21-4283. PMID: 35275197Free PMC Article
Grading of adult diffuse gliomas according to the 2021 WHO Classification of Tumors of the Central Nervous System.
Komori T
Lab Invest 2022 Feb;102(2):126-133. Epub 2021 Sep 9 doi: 10.1038/s41374-021-00667-6. PMID: 34504304
Prognostic and Predictive Biomarkers in Gliomas.
Śledzińska P, Bebyn MG, Furtak J, Kowalewski J, Lewandowska MA
Int J Mol Sci 2021 Sep 26;22(19) doi: 10.3390/ijms221910373. PMID: 34638714Free PMC Article
Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma.
Stichel D, Ebrahimi A, Reuss D, Schrimpf D, Ono T, Shirahata M, Reifenberger G, Weller M, Hänggi D, Wick W, Herold-Mende C, Westphal M, Brandner S, Pfister SM, Capper D, Sahm F, von Deimling A
Acta Neuropathol 2018 Nov;136(5):793-803. Epub 2018 Sep 5 doi: 10.1007/s00401-018-1905-0. PMID: 30187121

Recent systematic reviews

The role of neuropathology in the management of newly diagnosed glioblastoma: a systematic review and evidence-based clinical practice guideline.
Velázquez Vega JE, Brat DJ, Ryken TC, Olson JJ
J Neurooncol 2020 Nov;150(2):143-164. Epub 2020 Nov 19 doi: 10.1007/s11060-020-03616-3. PMID: 33215342

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