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Loss of Chromosome 9p

MedGen UID:
276490
•Concept ID:
C1517994
•
Cell or Molecular Dysfunction
Synonym: del(9p)

Definition

A cytogenetic abnormality that refers to the loss of all or part of the short arm of chromosome 9 (9p). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 9p

Professional guidelines

PubMed

Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264

Recent clinical studies

Etiology

Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study.
Szymanski JJ, Sundby RT, Jones PA, Srihari D, Earland N, Harris PK, Feng W, Qaium F, Lei H, Roberts D, Landeau M, Bell J, Huang Y, Hoffman L, Spencer M, Spraker MB, Ding L, Widemann BC, Shern JF, Hirbe AC, Chaudhuri AA
PLoS Med 2021 Aug;18(8):e1003734. Epub 2021 Aug 31 doi: 10.1371/journal.pmed.1003734. PMID: 34464388Free PMC Article
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.
Turajlic S, Xu H, Litchfield K, Rowan A, Chambers T, Lopez JI, Nicol D, O'Brien T, Larkin J, Horswell S, Stares M, Au L, Jamal-Hanjani M, Challacombe B, Chandra A, Hazell S, Eichler-Jonsson C, Soultati A, Chowdhury S, Rudman S, Lynch J, Fernando A, Stamp G, Nye E, Jabbar F, Spain L, Lall S, Guarch R, Falzon M, Proctor I, Pickering L, Gore M, Watkins TBK, Ward S, Stewart A, DiNatale R, Becerra MF, Reznik E, Hsieh JJ, Richmond TA, Mayhew GF, Hill SM, McNally CD, Jones C, Rosenbaum H, Stanislaw S, Burgess DL, Alexander NR, Swanton C; PEACE; TRACERx Renal Consortium
Cell 2018 Apr 19;173(3):581-594.e12. Epub 2018 Apr 12 doi: 10.1016/j.cell.2018.03.057. PMID: 29656895Free PMC Article
Clonality of oligoastrocytomas.
Dong ZQ, Pang JC, Tong CY, Zhou LF, Ng HK
Hum Pathol 2002 May;33(5):528-35. doi: 10.1053/hupa.2002.124784. PMID: 12094379
Hereditary cutaneous melanoma.
Platz A, Ringborg U, Hansson J
Semin Cancer Biol 2000 Aug;10(4):319-26. doi: 10.1006/scbi.2000.0149. PMID: 10966854
Bladder cancer.
Ozen H
Curr Opin Oncol 1998 May;10(3):273-8. PMID: 9619365

Diagnosis

Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study.
Szymanski JJ, Sundby RT, Jones PA, Srihari D, Earland N, Harris PK, Feng W, Qaium F, Lei H, Roberts D, Landeau M, Bell J, Huang Y, Hoffman L, Spencer M, Spraker MB, Ding L, Widemann BC, Shern JF, Hirbe AC, Chaudhuri AA
PLoS Med 2021 Aug;18(8):e1003734. Epub 2021 Aug 31 doi: 10.1371/journal.pmed.1003734. PMID: 34464388Free PMC Article
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Immunologic and immunogenomic aspects of tumor progression.
Ladányi A, Tímár J
Semin Cancer Biol 2020 Feb;60:249-261. Epub 2019 Aug 13 doi: 10.1016/j.semcancer.2019.08.011. PMID: 31419526
A Meta-Analysis Evaluating Clinical Outcomes of Patients with Renal Cell Carcinoma Harboring Chromosome 9P Loss.
Di Nunno V, Mollica V, Brunelli M, Gatto L, Schiavina R, Fiorentino M, Santoni M, Montironi R, Caliò A, Eccher A, Milella M, Martignoni G, Brunocilla E, Massari F
Mol Diagn Ther 2019 Oct;23(5):569-577. doi: 10.1007/s40291-019-00414-0. PMID: 31332726
Cytogenetics of melanoma and nonmelanoma skin cancer.
Carless MA, Griffiths LR
Adv Exp Med Biol 2014;810:160-81. doi: 10.1007/978-1-4939-0437-2_9. PMID: 25207365

Therapy

Lack of association between denture trauma and loss of heterozygosity confronts the proposed pathologic role of chronic mucosal trauma in oral carcinogenesis.
Bernardes VF, Diniz MG, Silva JC, Moraes DC, De Marco L, Gomes CC, Gomez RS
J Oral Pathol Med 2019 May;48(5):421-423. Epub 2019 Mar 21 doi: 10.1111/jop.12846. PMID: 30849196
Loss of Heterozygosity of 9p Is Associated with Poorer Survival in Patients with Gliomas.
Huang T, Li S, Yang Z, Liu J, Han Y
Mol Neurobiol 2016 Nov;53(9):6407-6412. Epub 2015 Nov 19 doi: 10.1007/s12035-015-9523-5. PMID: 26582467
Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264
Asbestos, chromosomal deletions, and tumor suppressor gene alterations in human malignant mesothelioma.
Murthy SS, Testa JR
J Cell Physiol 1999 Aug;180(2):150-7. doi: 10.1002/(SICI)1097-4652(199908)180:2<150::AID-JCP2>3.0.CO;2-H. PMID: 10395284
Bladder cancer.
Ozen H
Curr Opin Oncol 1998 May;10(3):273-8. PMID: 9619365

Prognosis

New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
A Meta-Analysis Evaluating Clinical Outcomes of Patients with Renal Cell Carcinoma Harboring Chromosome 9P Loss.
Di Nunno V, Mollica V, Brunelli M, Gatto L, Schiavina R, Fiorentino M, Santoni M, Montironi R, Caliò A, Eccher A, Milella M, Martignoni G, Brunocilla E, Massari F
Mol Diagn Ther 2019 Oct;23(5):569-577. doi: 10.1007/s40291-019-00414-0. PMID: 31332726
Loss of Heterozygosity of 9p Is Associated with Poorer Survival in Patients with Gliomas.
Huang T, Li S, Yang Z, Liu J, Han Y
Mol Neurobiol 2016 Nov;53(9):6407-6412. Epub 2015 Nov 19 doi: 10.1007/s12035-015-9523-5. PMID: 26582467
Quantitative loss of heterozygosity analysis for urothelial carcinoma detection and prognosis.
Collin-Chavagnac D, Marçais C, Billon S, Descotes F, Piaton E, Decaussin M, Rodriguez-Lafrasse C, Ruffion A
Urology 2010 Aug;76(2):515.e1-7. Epub 2010 Mar 5 doi: 10.1016/j.urology.2009.11.046. PMID: 20206968
Bladder cancer.
Ozen H
Curr Opin Oncol 1998 May;10(3):273-8. PMID: 9619365

Clinical prediction guides

Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study.
Szymanski JJ, Sundby RT, Jones PA, Srihari D, Earland N, Harris PK, Feng W, Qaium F, Lei H, Roberts D, Landeau M, Bell J, Huang Y, Hoffman L, Spencer M, Spraker MB, Ding L, Widemann BC, Shern JF, Hirbe AC, Chaudhuri AA
PLoS Med 2021 Aug;18(8):e1003734. Epub 2021 Aug 31 doi: 10.1371/journal.pmed.1003734. PMID: 34464388Free PMC Article
New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia.
Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
A Meta-Analysis Evaluating Clinical Outcomes of Patients with Renal Cell Carcinoma Harboring Chromosome 9P Loss.
Di Nunno V, Mollica V, Brunelli M, Gatto L, Schiavina R, Fiorentino M, Santoni M, Montironi R, Caliò A, Eccher A, Milella M, Martignoni G, Brunocilla E, Massari F
Mol Diagn Ther 2019 Oct;23(5):569-577. doi: 10.1007/s40291-019-00414-0. PMID: 31332726
Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.
Turajlic S, Xu H, Litchfield K, Rowan A, Chambers T, Lopez JI, Nicol D, O'Brien T, Larkin J, Horswell S, Stares M, Au L, Jamal-Hanjani M, Challacombe B, Chandra A, Hazell S, Eichler-Jonsson C, Soultati A, Chowdhury S, Rudman S, Lynch J, Fernando A, Stamp G, Nye E, Jabbar F, Spain L, Lall S, Guarch R, Falzon M, Proctor I, Pickering L, Gore M, Watkins TBK, Ward S, Stewart A, DiNatale R, Becerra MF, Reznik E, Hsieh JJ, Richmond TA, Mayhew GF, Hill SM, McNally CD, Jones C, Rosenbaum H, Stanislaw S, Burgess DL, Alexander NR, Swanton C; PEACE; TRACERx Renal Consortium
Cell 2018 Apr 19;173(3):581-594.e12. Epub 2018 Apr 12 doi: 10.1016/j.cell.2018.03.057. PMID: 29656895Free PMC Article
Bladder cancer.
Ozen H
Curr Opin Oncol 1998 May;10(3):273-8. PMID: 9619365

Recent systematic reviews

Management of patients with recurrence of diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Nahed BV, Redjal N, Brat DJ, Chi AS, Oh K, Batchelor TT, Ryken TC, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):609-30. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1910-2. PMID: 26530264

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