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Neurotropism

MedGen UID:
276560
•Concept ID:
C1518304
•
Pathologic Function

Definition

Processes by which certain microorganisms and toxins are attracted to nervous tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurotropism

Professional guidelines

PubMed

A Comprehensive Review of Neurologic Manifestations of COVID-19 and Management of Pre-existing Neurologic Disorders in Children.
Kim Y, Walser SA, Asghar SJ, Jain R, Mainali G, Kumar A
J Child Neurol 2021 Mar;36(4):324-330. Epub 2020 Oct 28 doi: 10.1177/0883073820968995. PMID: 33112694Free PMC Article
Management of brain metastases in non-small cell lung cancer in the era of tyrosine kinase inhibitors.
Wrona A, Dziadziuszko R, Jassem J
Cancer Treat Rev 2018 Dec;71:59-67. Epub 2018 Oct 21 doi: 10.1016/j.ctrv.2018.10.011. PMID: 30366200
Is psychosocial and cognitive dysfunction misattributed to the virus in hepatitis C infection? Select psychosocial contributors identified.
Lowry D, Burke T, Galvin Z, Ryan JD, Russell J, Murphy A, Hegarty J, Stewart S, Crowe J
J Viral Hepat 2016 Aug;23(8):584-95. Epub 2016 May 11 doi: 10.1111/jvh.12544. PMID: 27167497

Recent clinical studies

Etiology

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids.
Samudyata, Oliveira AO, Malwade S, Rufino de Sousa N, Goparaju SK, Gracias J, Orhan F, Steponaviciute L, Schalling M, Sheridan SD, Perlis RH, Rothfuchs AG, Sellgren CM
Mol Psychiatry 2022 Oct;27(10):3939-3950. Epub 2022 Oct 5 doi: 10.1038/s41380-022-01786-2. PMID: 36198765Free PMC Article
(18)F-FDG brain PET hypometabolism in patients with long COVID.
Guedj E, Campion JY, Dudouet P, Kaphan E, Bregeon F, Tissot-Dupont H, Guis S, Barthelemy F, Habert P, Ceccaldi M, Million M, Raoult D, Cammilleri S, Eldin C
Eur J Nucl Med Mol Imaging 2021 Aug;48(9):2823-2833. Epub 2021 Jan 26 doi: 10.1007/s00259-021-05215-4. PMID: 33501506Free PMC Article
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.
Wang C, Zhang M, Garcia G Jr, Tian E, Cui Q, Chen X, Sun G, Wang J, Arumugaswami V, Shi Y
Cell Stem Cell 2021 Feb 4;28(2):331-342.e5. Epub 2021 Jan 4 doi: 10.1016/j.stem.2020.12.018. PMID: 33450186Free PMC Article
Infectious Myelopathies.
Grill MF
Continuum (Minneap Minn) 2018 Apr;24(2, Spinal Cord Disorders):441-473. doi: 10.1212/CON.0000000000000597. PMID: 29613895
Desmoplastic melanoma, neurotropism, and neurotrophin receptors--what we know and what we do not.
Frydenlund N, Mahalingam M
Adv Anat Pathol 2015 Jul;22(4):227-41. doi: 10.1097/PAP.0000000000000076. PMID: 26050260

Diagnosis

Monkeypox virus neurological manifestations in comparison to other orthopoxviruses.
Shafaati M, Zandi M
Travel Med Infect Dis 2022 Sep-Oct;49:102414. Epub 2022 Aug 2 doi: 10.1016/j.tmaid.2022.102414. PMID: 35926767Free PMC Article
Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222).
Román GC, Gracia F, Torres A, Palacios A, Gracia K, Harris D
Front Immunol 2021;12:653786. Epub 2021 Apr 26 doi: 10.3389/fimmu.2021.653786. PMID: 33981305Free PMC Article
(18)F-FDG brain PET hypometabolism in patients with long COVID.
Guedj E, Campion JY, Dudouet P, Kaphan E, Bregeon F, Tissot-Dupont H, Guis S, Barthelemy F, Habert P, Ceccaldi M, Million M, Raoult D, Cammilleri S, Eldin C
Eur J Nucl Med Mol Imaging 2021 Aug;48(9):2823-2833. Epub 2021 Jan 26 doi: 10.1007/s00259-021-05215-4. PMID: 33501506Free PMC Article
Neurological and Neuropsychiatric Impacts of COVID-19 Pandemic.
Roy D, Ghosh R, Dubey S, Dubey MJ, Benito-León J, Kanti Ray B
Can J Neurol Sci 2021 Jan;48(1):9-24. Epub 2020 Aug 5 doi: 10.1017/cjn.2020.173. PMID: 32753076Free PMC Article
Infectious Myelopathies.
Grill MF
Continuum (Minneap Minn) 2018 Apr;24(2, Spinal Cord Disorders):441-473. doi: 10.1212/CON.0000000000000597. PMID: 29613895

Therapy

Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222).
Román GC, Gracia F, Torres A, Palacios A, Gracia K, Harris D
Front Immunol 2021;12:653786. Epub 2021 Apr 26 doi: 10.3389/fimmu.2021.653786. PMID: 33981305Free PMC Article
COVID in obstetrics: labor analgesia and cesarean section.
Guasch E, Brogly N, Gilsanz F
Curr Opin Anaesthesiol 2021 Feb 1;34(1):62-68. doi: 10.1097/ACO.0000000000000949. PMID: 33315638
Effects of COVID-19 on the Nervous System.
Iadecola C, Anrather J, Kamel H
Cell 2020 Oct 1;183(1):16-27.e1. Epub 2020 Aug 19 doi: 10.1016/j.cell.2020.08.028. PMID: 32882182Free PMC Article
Vaccines against botulism.
Karalewitz AP, Barbieri JT
Curr Opin Microbiol 2012 Jun;15(3):317-24. Epub 2012 Jun 12 doi: 10.1016/j.mib.2012.05.009. PMID: 22694934
Cerebral phaeohyphomycosis.
Palaoglu S, Sav A, Basak T, Yalcinlar Y, Scheithauer BW
Neurosurgery 1993 Nov;33(5):894-7. doi: 10.1227/00006123-199311000-00018. PMID: 8264889

Prognosis

Olfactory and taste dysfunctions in COVID-19.
Rouadi PW, Idriss SA, Bousquet J
Curr Opin Allergy Clin Immunol 2021 Jun 1;21(3):229-244. doi: 10.1097/ACI.0000000000000735. PMID: 33560742
Nerve fibers in the tumor microenvironment in neurotropic cancer-pancreatic cancer and cholangiocarcinoma.
Tan X, Sivakumar S, Bednarsch J, Wiltberger G, Kather JN, Niehues J, de Vos-Geelen J, Valkenburg-van Iersel L, Kintsler S, Roeth A, Hao G, Lang S, Coolsen ME, den Dulk M, Aberle MR, Koolen J, Gaisa NT, Olde Damink SWM, Neumann UP, Heij LR
Oncogene 2021 Feb;40(5):899-908. Epub 2020 Dec 7 doi: 10.1038/s41388-020-01578-4. PMID: 33288884Free PMC Article
Psychiatric face of COVID-19.
Steardo L Jr, Steardo L, Verkhratsky A
Transl Psychiatry 2020 Jul 30;10(1):261. doi: 10.1038/s41398-020-00949-5. PMID: 32732883Free PMC Article
Melanoma pathology reporting and staging.
Scolyer RA, Rawson RV, Gershenwald JE, Ferguson PM, Prieto VG
Mod Pathol 2020 Jan;33(Suppl 1):15-24. Epub 2019 Nov 22 doi: 10.1038/s41379-019-0402-x. PMID: 31758078
Desmoplastic melanoma, neurotropism, and neurotrophin receptors--what we know and what we do not.
Frydenlund N, Mahalingam M
Adv Anat Pathol 2015 Jul;22(4):227-41. doi: 10.1097/PAP.0000000000000076. PMID: 26050260

Clinical prediction guides

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids.
Samudyata, Oliveira AO, Malwade S, Rufino de Sousa N, Goparaju SK, Gracias J, Orhan F, Steponaviciute L, Schalling M, Sheridan SD, Perlis RH, Rothfuchs AG, Sellgren CM
Mol Psychiatry 2022 Oct;27(10):3939-3950. Epub 2022 Oct 5 doi: 10.1038/s41380-022-01786-2. PMID: 36198765Free PMC Article
Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse.
Seehusen F, Clark JJ, Sharma P, Bentley EG, Kirby A, Subramaniam K, Wunderlin-Giuliani S, Hughes GL, Patterson EI, Michael BD, Owen A, Hiscox JA, Stewart JP, Kipar A
Viruses 2022 May 11;14(5) doi: 10.3390/v14051020. PMID: 35632761Free PMC Article
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response.
Wang C, Zhang M, Garcia G Jr, Tian E, Cui Q, Chen X, Sun G, Wang J, Arumugaswami V, Shi Y
Cell Stem Cell 2021 Feb 4;28(2):331-342.e5. Epub 2021 Jan 4 doi: 10.1016/j.stem.2020.12.018. PMID: 33450186Free PMC Article
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
Meinhardt J, Radke J, Dittmayer C, Franz J, Thomas C, Mothes R, Laue M, Schneider J, Brünink S, Greuel S, Lehmann M, Hassan O, Aschman T, Schumann E, Chua RL, Conrad C, Eils R, Stenzel W, Windgassen M, Rößler L, Goebel HH, Gelderblom HR, Martin H, Nitsche A, Schulz-Schaeffer WJ, Hakroush S, Winkler MS, Tampe B, Scheibe F, Körtvélyessy P, Reinhold D, Siegmund B, Kühl AA, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, Ingold-Heppner B, Stadelmann C, Drosten C, Corman VM, Radbruch H, Heppner FL
Nat Neurosci 2021 Feb;24(2):168-175. Epub 2020 Nov 30 doi: 10.1038/s41593-020-00758-5. PMID: 33257876
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids.
Pellegrini L, Albecka A, Mallery DL, Kellner MJ, Paul D, Carter AP, James LC, Lancaster MA
Cell Stem Cell 2020 Dec 3;27(6):951-961.e5. Epub 2020 Oct 13 doi: 10.1016/j.stem.2020.10.001. PMID: 33113348Free PMC Article

Recent systematic reviews

Local Recurrence Rates After Excision of Desmoplastic Melanoma: A Systematic Review and Meta-Analysis.
Ran NA, Veerabagu S, Miller CJ, Elenitsas R, Chu EY, Krausz AE
Dermatol Surg 2023 Apr 1;49(4):330-337. Epub 2023 Mar 1 doi: 10.1097/DSS.0000000000003699. PMID: 36857167
Olfactory system measurements in COVID-19: a systematic review and meta-analysis.
Mohammadi S, Gouravani M, Salehi MA, Harandi H, Moosaie F, Dehghani Firouzabadi F, Yousem DM
Neuroradiology 2023 Jan;65(1):25-39. Epub 2022 Jul 18 doi: 10.1007/s00234-022-03014-8. PMID: 35843987Free PMC Article
SARS-CoV-2 and the brain: A review of the current knowledge on neuropathology in COVID-19.
Maiese A, Manetti AC, Bosetti C, Del Duca F, La Russa R, Frati P, Di Paolo M, Turillazzi E, Fineschi V
Brain Pathol 2021 Nov;31(6):e13013. Epub 2021 Aug 13 doi: 10.1111/bpa.13013. PMID: 34390282Free PMC Article
Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222).
Román GC, Gracia F, Torres A, Palacios A, Gracia K, Harris D
Front Immunol 2021;12:653786. Epub 2021 Apr 26 doi: 10.3389/fimmu.2021.653786. PMID: 33981305Free PMC Article
Does coronaviruses induce neurodegenerative diseases? A systematic review on the neurotropism and neuroinvasion of SARS-CoV-2.
ElBini Dhouib I
Drug Discov Ther 2021 Jan 23;14(6):262-272. Epub 2020 Dec 31 doi: 10.5582/ddt.2020.03106. PMID: 33390561

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