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Ovarian clear cell adenocarcinoma

MedGen UID:
276659
Concept ID:
C1518693
Neoplastic Process
Synonyms: Clear cell adenocarcinoma of ovary; clear cell adenocarcinoma of ovary; clear cell adenocarcinoma of the ovary; Clear cell adenocarcinoma of the ovary; Ovarian Clear Cell Adenocarcinoma; ovarian clear cell adenocarcinoma; ovary clear cell adenocarcinoma
SNOMED CT: Clear cell adenocarcinoma of ovary (763131005); Ovarian clear cell adenocarcinoma (763131005)
 
Monarch Initiative: MONDO:0006045
Orphanet: ORPHA398971

Definition

A rare, malignant, epithelilal ovarian neoplasm, composed of clear, eosinophilic and hobnail cells displaying variable degrees of tubulocystic, papillary and solid histological patterns, macroscopically appearing as a typically unilateral mass in the ovary which ranges from solid to cystic. Patients are often diagnosed in early stages and usually present with pelvic pain and pressure, an abdominal mass and/or gastrointestinal problems, such as early satiety or bloating. Association with Lynch syndrome has been reported. [from ORDO]

Professional guidelines

PubMed

Wakana K, Yasugi T, Nako Y, Nei T, Ozaki Y, Mizutani K
Int J Clin Oncol 2011 Aug;16(4):447-9. Epub 2010 Dec 4 doi: 10.1007/s10147-010-0149-3. PMID: 21132452
Fujimura M, Katsumata N, Tsuda H, Uchi N, Miyazaki S, Hidaka T, Sakai M, Saito S
Jpn J Cancer Res 2002 Nov;93(11):1250-7. doi: 10.1111/j.1349-7006.2002.tb01231.x. PMID: 12460467Free PMC Article

Recent clinical studies

Etiology

Macrie BD, Strauss JB, Helenowski IB, Rademaker A, Schink JC, Lurain JR, Small W Jr
Int J Gynecol Cancer 2014 Nov;24(9):1597-602. doi: 10.1097/IGC.0000000000000270. PMID: 25275661
Offman SL, Longacre TA
Adv Anat Pathol 2012 Sep;19(5):296-312. doi: 10.1097/PAP.0b013e31826663b1. PMID: 22885379
Ho CM, Lai HC, Huang SH, Chien TY, Lin MC, Chang SF
Eur J Clin Invest 2010 Apr;40(4):310-8. doi: 10.1111/j.1365-2362.2010.02266.x. PMID: 20486992
Kennedy AW, Biscotti CV, Hart WR, Webster KD
Gynecol Oncol 1989 Mar;32(3):342-9. doi: 10.1016/0090-8258(89)90637-9. PMID: 2920955
Jenison EL, Montag AG, Griffiths CT, Welch WR, Lavin PT, Greer J, Knapp RC
Gynecol Oncol 1989 Jan;32(1):65-71. doi: 10.1016/0090-8258(89)90852-4. PMID: 2642454

Diagnosis

Takeda T, Banno K, Okawa R, Yanokura M, Iijima M, Irie-Kunitomi H, Nakamura K, Iida M, Adachi M, Umene K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D
Oncol Rep 2016 Feb;35(2):607-13. Epub 2015 Nov 16 doi: 10.3892/or.2015.4421. PMID: 26572704Free PMC Article
Matsuo Y, Tashiro H, Yanai H, Moriya T, Katabuchi H
Med Mol Morphol 2015 Sep;48(3):146-54. Epub 2014 Nov 15 doi: 10.1007/s00795-014-0090-z. PMID: 25398420
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Offman SL, Longacre TA
Adv Anat Pathol 2012 Sep;19(5):296-312. doi: 10.1097/PAP.0b013e31826663b1. PMID: 22885379
Jenison EL, Montag AG, Griffiths CT, Welch WR, Lavin PT, Greer J, Knapp RC
Gynecol Oncol 1989 Jan;32(1):65-71. doi: 10.1016/0090-8258(89)90852-4. PMID: 2642454

Therapy

Takeda T, Banno K, Okawa R, Yanokura M, Iijima M, Irie-Kunitomi H, Nakamura K, Iida M, Adachi M, Umene K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D
Oncol Rep 2016 Feb;35(2):607-13. Epub 2015 Nov 16 doi: 10.3892/or.2015.4421. PMID: 26572704Free PMC Article
Macrie BD, Strauss JB, Helenowski IB, Rademaker A, Schink JC, Lurain JR, Small W Jr
Int J Gynecol Cancer 2014 Nov;24(9):1597-602. doi: 10.1097/IGC.0000000000000270. PMID: 25275661
Kashiyama T, Oda K, Ikeda Y, Shiose Y, Hirota Y, Inaba K, Makii C, Kurikawa R, Miyasaka A, Koso T, Fukuda T, Tanikawa M, Shoji K, Sone K, Arimoto T, Wada-Hiraike O, Kawana K, Nakagawa S, Matsuda K, McCormick F, Aburatani H, Yano T, Osuga Y, Fujii T
PLoS One 2014;9(2):e87220. Epub 2014 Feb 4 doi: 10.1371/journal.pone.0087220. PMID: 24504419Free PMC Article
Takemoto Y, Yano H, Momosaki S, Ogasawara S, Nishida N, Kojiro S, Kamura T, Kojiro M
Clin Cancer Res 2004 Nov 1;10(21):7418-26. doi: 10.1158/1078-0432.CCR-04-0279. PMID: 15534119
Ohta I, Gorai I, Miyamoto Y, Yang J, Zheng JH, Kawata N, Hirahara F, Shirotake S
Cancer Lett 2001 Jan 10;162(1):39-48. doi: 10.1016/s0304-3835(00)00605-4. PMID: 11121861

Prognosis

Matsuo Y, Tashiro H, Yanai H, Moriya T, Katabuchi H
Med Mol Morphol 2015 Sep;48(3):146-54. Epub 2014 Nov 15 doi: 10.1007/s00795-014-0090-z. PMID: 25398420
Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S
Int J Cancer 2014 Jul 15;135(2):308-18. Epub 2014 Jan 10 doi: 10.1002/ijc.28692. PMID: 24375438
Tan DS, Kaye S
J Clin Pathol 2007 Apr;60(4):355-60. Epub 2006 Oct 3 doi: 10.1136/jcp.2006.040030. PMID: 17018684Free PMC Article
Kennedy AW, Biscotti CV, Hart WR, Webster KD
Gynecol Oncol 1989 Mar;32(3):342-9. doi: 10.1016/0090-8258(89)90637-9. PMID: 2920955
Jenison EL, Montag AG, Griffiths CT, Welch WR, Lavin PT, Greer J, Knapp RC
Gynecol Oncol 1989 Jan;32(1):65-71. doi: 10.1016/0090-8258(89)90852-4. PMID: 2642454

Clinical prediction guides

Azar WJ, Christie EL, Mitchell C, Liu DS, Au-Yeung G, Bowtell DDL
Cancer Res 2020 Nov 15;80(22):4960-4971. Epub 2020 Sep 11 doi: 10.1158/0008-5472.CAN-19-3044. PMID: 32917727
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Maeda D, Ota S, Takazawa Y, Aburatani H, Nakagawa S, Yano T, Taketani Y, Kodama T, Fukayama M
Mod Pathol 2009 Jun;22(6):824-32. Epub 2009 Mar 27 doi: 10.1038/modpathol.2009.40. PMID: 19329941
Ohta I, Gorai I, Miyamoto Y, Yang J, Zheng JH, Kawata N, Hirahara F, Shirotake S
Cancer Lett 2001 Jan 10;162(1):39-48. doi: 10.1016/s0304-3835(00)00605-4. PMID: 11121861
Kennedy AW, Biscotti CV, Hart WR, Webster KD
Gynecol Oncol 1989 Mar;32(3):342-9. doi: 10.1016/0090-8258(89)90637-9. PMID: 2920955

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