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Lymphohistiocytic Variant Anaplastic Large Cell Lymphoma

MedGen UID:
277305
Concept ID:
C1334463
Neoplastic Process

Definition

A histologic variant of anaplastic large cell lymphoma characterized by the presence of a large number of histiocytes admixed with the anaplastic lymphoma cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphohistiocytic Variant Anaplastic Large Cell Lymphoma

Recent clinical studies

Etiology

Bittencourt AL, de Oliveira RF, Santos JB
J Cutan Med Surg 2011 May-Jun;15(3):172-6. doi: 10.2310/7750.2011.09071. PMID: 21561587
Klapper W, Böhm M, Siebert R, Lennert K
Virchows Arch 2008 Jun;452(6):599-605. Epub 2008 May 14 doi: 10.1007/s00428-008-0616-7. PMID: 18478258
Lin CN, Hou CC, Hwang WS, Chuang SS
Leuk Lymphoma 2003 Oct;44(10):1727-31. doi: 10.1080/1042819031000103999. PMID: 14692525
Ponzoni M, Terreni MR, Ciceri F, Ferreri AJ, Gerevini S, Anzalone N, Valle M, Pizzolito S, Arrigoni G
Ann Oncol 2002 Nov;13(11):1827-32. doi: 10.1093/annonc/mdf300. PMID: 12419758
Stein H, Foss HD, Dürkop H, Marafioti T, Delsol G, Pulford K, Pileri S, Falini B
Blood 2000 Dec 1;96(12):3681-95. PMID: 11090048

Diagnosis

Chuang SS, Hsieh YC, Ye H, Hwang WS
Pathol Res Pract 2009;205(4):283-7. Epub 2008 Dec 16 doi: 10.1016/j.prp.2008.10.009. PMID: 19091487
Klapper W, Böhm M, Siebert R, Lennert K
Virchows Arch 2008 Jun;452(6):599-605. Epub 2008 May 14 doi: 10.1007/s00428-008-0616-7. PMID: 18478258
Yang CS, Chou G, Jan YJ, Wang J, Yeh DC, Teng CL
J Chin Med Assoc 2007 Feb;70(2):71-5. doi: 10.1016/S1726-4901(09)70305-3. PMID: 17339148
Jaffe ES
Mod Pathol 2001 Mar;14(3):219-28. doi: 10.1038/modpathol.3880289. PMID: 11266530
Stein H, Foss HD, Dürkop H, Marafioti T, Delsol G, Pulford K, Pileri S, Falini B
Blood 2000 Dec 1;96(12):3681-95. PMID: 11090048

Therapy

Williams D, Mori T, Reiter A, Woessman W, Rosolen A, Wrobel G, Zsiros J, Uyttebroeck A, Marky I, Le Deley MC, Brugières L; European Intergroup for Childhood Non-Hodgkin Lymphoma, the Japanese Pediatric Leukemia/Lymphoma Study Group
Pediatr Blood Cancer 2013 Oct;60(10):E118-21. Epub 2013 May 29 doi: 10.1002/pbc.24591. PMID: 23720354
Lamant L, McCarthy K, d'Amore E, Klapper W, Nakagawa A, Fraga M, Maldyk J, Simonitsch-Klupp I, Oschlies I, Delsol G, Mauguen A, Brugières L, Le Deley MC
J Clin Oncol 2011 Dec 10;29(35):4669-76. Epub 2011 Nov 14 doi: 10.1200/JCO.2011.36.5411. PMID: 22084369
Ponzoni M, Terreni MR, Ciceri F, Ferreri AJ, Gerevini S, Anzalone N, Valle M, Pizzolito S, Arrigoni G
Ann Oncol 2002 Nov;13(11):1827-32. doi: 10.1093/annonc/mdf300. PMID: 12419758

Prognosis

Khanlari M, Li S, Miranda RN, Iyer S, Konoplev S, Lin P, Yin CC, Tang G, Qiu L, Vega F, Medeiros LJ, Xu J
Mod Pathol 2022 Mar;35(3):412-418. Epub 2021 Oct 9 doi: 10.1038/s41379-021-00944-1. PMID: 34628481
Magro CM, Momtahen S, Kiuru M
Am J Dermatopathol 2017 Dec;39(12):877-889. doi: 10.1097/DAD.0000000000000908. PMID: 28570392
Ponzoni M, Terreni MR, Ciceri F, Ferreri AJ, Gerevini S, Anzalone N, Valle M, Pizzolito S, Arrigoni G
Ann Oncol 2002 Nov;13(11):1827-32. doi: 10.1093/annonc/mdf300. PMID: 12419758
Jaffe ES
Mod Pathol 2001 Mar;14(3):219-28. doi: 10.1038/modpathol.3880289. PMID: 11266530
Stein H, Foss HD, Dürkop H, Marafioti T, Delsol G, Pulford K, Pileri S, Falini B
Blood 2000 Dec 1;96(12):3681-95. PMID: 11090048

Clinical prediction guides

Khanlari M, Li S, Miranda RN, Iyer S, Konoplev S, Lin P, Yin CC, Tang G, Qiu L, Vega F, Medeiros LJ, Xu J
Mod Pathol 2022 Mar;35(3):412-418. Epub 2021 Oct 9 doi: 10.1038/s41379-021-00944-1. PMID: 34628481
Magro CM, Momtahen S, Kiuru M
Am J Dermatopathol 2017 Dec;39(12):877-889. doi: 10.1097/DAD.0000000000000908. PMID: 28570392
Ponzoni M, Terreni MR, Ciceri F, Ferreri AJ, Gerevini S, Anzalone N, Valle M, Pizzolito S, Arrigoni G
Ann Oncol 2002 Nov;13(11):1827-32. doi: 10.1093/annonc/mdf300. PMID: 12419758
Stein H, Foss HD, Dürkop H, Marafioti T, Delsol G, Pulford K, Pileri S, Falini B
Blood 2000 Dec 1;96(12):3681-95. PMID: 11090048
Ott G, Bastian BC, Katzenberger T, Decoteau JF, Kalla J, Rosenwald A, Weissinger F, Ott MM, Kadin ME, Müller-Hermelink HK
Br J Haematol 1998 Jan;100(1):187-90. doi: 10.1046/j.1365-2141.1998.00531.x. PMID: 9450809

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