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Apocrine sweat gland cancer

MedGen UID:: 277327
•Concept ID:: C1334561
•: Neoplastic Process

Synonyms:	apocrine sweat gland cancer; cancer of apocrine sweat gland; Malignant Apocrine Neoplasm; malignant apocrine neoplasm; Malignant Apocrine Neoplasm of Skin; malignant apocrine neoplasm of skin; Malignant Apocrine Neoplasm of the Skin; malignant apocrine neoplasm of the skin; Malignant Apocrine Skin Neoplasm; malignant apocrine skin neoplasm; Malignant Apocrine Skin Tumor; malignant apocrine skin tumor; malignant apocrine skin tumour; malignant apocrine sweat gland neoplasm; Malignant Apocrine Tumor; malignant apocrine tumor; Malignant Apocrine Tumor of Skin; malignant apocrine tumor of skin; Malignant Apocrine Tumor of the Skin; malignant apocrine tumor of the skin; malignant apocrine tumour; malignant apocrine tumour of skin; malignant apocrine tumour of the skin; malignant neoplasm of apocrine sweat gland

Monarch Initiative:	MONDO:0003215

Definition

A malignant neoplasm involving the apocrine gland. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVApocrine sweat gland cancer

Disease
- Disorder by Site
  - Skin disorder
    - Disorder of sweat gland
      - Sweat gland neoplasm
        Apocrine sweat gland neoplasm
        Apocrine sweat gland cancer
        Apocrine adenocarcinoma
        Breast apocrine carcinoma
        Breast apocrine carcinoma in situ
        Invasive Breast Apocrine Carcinoma
        Ceruminous carcinoma
        Vulvar apocrine adenocarcinoma

Professional guidelines

PubMed

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation.

Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 May 11;22(10) doi: 10.3390/ijms22105077. PMID: 34064849 Free PMC Article

Aggressive Digital Papillary Adenocarcinoma: Population-Based Analysis of Incidence, Demographics, Treatment, and Outcomes.

Rismiller K, Knackstedt TJ
Dermatol Surg 2018 Jul;44(7):911-917. doi: 10.1097/DSS.0000000000001483. PMID: 29578881

Cutaneous Sweat Gland Carcinomas with Basaloid Differentiation: An Update with Emphasis on Differential Diagnoses.

Flux K, Brenn T
Clin Lab Med 2017 Sep;37(3):587-601. Epub 2017 Jun 9 doi: 10.1016/j.cll.2017.05.006. PMID: 28802502

See all (20)

Recent clinical studies

Etiology

Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.

Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546 Free PMC Article

Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.

Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875

Squamoid Eccrine Ductal Carcinoma.

Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321

Alternative Clinical Indications of Botulinum Toxin.

Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806

Skin of color: biology, structure, function, and implications for dermatologic disease.

Taylor SC
J Am Acad Dermatol 2002 Feb;46(2 Suppl Understanding):S41-62. doi: 10.1067/mjd.2002.120790. PMID: 11807469

See all (263)

Diagnosis

Squamoid Eccrine Ductal Carcinoma.

Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321

Apocrine and eccrine hidrocystomas: a clinicopathological study.

Koumaki D, Papadakis M, Lagoudaki E, Manios GA, Kassotakis D, Doxastaki A, Krasagakis K, Manios A
Acta Dermatovenerol Alp Pannonica Adriat 2021 Jun;30(2):53-56. PMID: 34169699

Dermoscopy of Adnexal Tumors.

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Ceruminous Neoplasms of the Ear.

Nagarajan P
Head Neck Pathol 2018 Sep;12(3):350-361. Epub 2018 Aug 1 doi: 10.1007/s12105-018-0909-3. PMID: 30069843 Free PMC Article

Topics in histopathology of sweat gland and sebaceous neoplasms.

Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768

See all (829)

Therapy

Alternative Clinical Indications of Botulinum Toxin.

Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806

Apocrine carcinoma of the breast: A brief update on the molecular features and targetable biomarkers.

Vranic S, Feldman R, Gatalica Z
Bosn J Basic Med Sci 2017 Feb 21;17(1):9-11. doi: 10.17305/bjbms.2016.1811. PMID: 28027454 Free PMC Article

Angioadnexocentric nevus.

Hashimoto K, Amano M, Setoyama M
J Dermatol 2012 Nov;39(11):909-15. Epub 2012 Jul 4 doi: 10.1111/j.1346-8138.2012.01599.x. PMID: 22762690

Benign and malignant apocrine lesions of the breast.

Gerhard R, Costa JL, Schmitt F
Expert Rev Anticancer Ther 2012 Feb;12(2):215-21. doi: 10.1586/era.11.213. PMID: 22316369

Drug targeting through pilosebaceous route.

Chourasia R, Jain SK
Curr Drug Targets 2009 Oct;10(10):950-67. doi: 10.2174/138945009789577918. PMID: 19663765

See all (105)

Prognosis

Adnexal and Sebaceous Carcinomas.

Seger EW, Neill BC, Tolkachjov SN
Dermatol Clin 2023 Jan;41(1):117-132. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.010. PMID: 36410972

Sweat Gland Tumor Microenvironment.

Yuda Handaya A, Anwar SL, Fauzi AR, Werdana VAP
Adv Exp Med Biol 2020;1296:259-274. doi: 10.1007/978-3-030-59038-3_16. PMID: 34185298

Topics in histopathology of sweat gland and sebaceous neoplasms.

Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768

Malignant adnexal neoplasms.

Crowson AN, Magro CM, Mihm MC
Mod Pathol 2006 Feb;19 Suppl 2:S93-S126. doi: 10.1038/modpathol.3800511. PMID: 16446719

Skin of color: biology, structure, function, and implications for dermatologic disease.

Taylor SC
J Am Acad Dermatol 2002 Feb;46(2 Suppl Understanding):S41-62. doi: 10.1067/mjd.2002.120790. PMID: 11807469

See all (235)

Clinical prediction guides

NECTIN4 expression in sebaceous and sweat gland carcinoma.

Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Oda Y, Kaku-Ito Y
Eur J Dermatol 2022 Apr 1;32(2):181-186. doi: 10.1684/ejd.2022.4241. PMID: 35866909

Molecular pathology of skin adnexal tumours.

Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659

Apocrine and eccrine hidrocystomas: a clinicopathological study.

Koumaki D, Papadakis M, Lagoudaki E, Manios GA, Kassotakis D, Doxastaki A, Krasagakis K, Manios A
Acta Dermatovenerol Alp Pannonica Adriat 2021 Jun;30(2):53-56. PMID: 34169699

Dermoscopy of Adnexal Tumors.

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Skin of color: biology, structure, function, and implications for dermatologic disease.

Taylor SC
J Am Acad Dermatol 2002 Feb;46(2 Suppl Understanding):S41-62. doi: 10.1067/mjd.2002.120790. PMID: 11807469

See all (273)