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Apocrine sweat gland cancer

MedGen UID:
277327
•Concept ID:
C1334561
•
Neoplastic Process
Synonyms: apocrine sweat gland cancer; cancer of apocrine sweat gland; Malignant Apocrine Neoplasm; malignant apocrine neoplasm; Malignant Apocrine Neoplasm of Skin; malignant apocrine neoplasm of skin; Malignant Apocrine Neoplasm of the Skin; malignant apocrine neoplasm of the skin; Malignant Apocrine Skin Neoplasm; malignant apocrine skin neoplasm; Malignant Apocrine Skin Tumor; malignant apocrine skin tumor; malignant apocrine skin tumour; malignant apocrine sweat gland neoplasm; Malignant Apocrine Tumor; malignant apocrine tumor; Malignant Apocrine Tumor of Skin; malignant apocrine tumor of skin; Malignant Apocrine Tumor of the Skin; malignant apocrine tumor of the skin; malignant apocrine tumour; malignant apocrine tumour of skin; malignant apocrine tumour of the skin; malignant neoplasm of apocrine sweat gland
 
Monarch Initiative: MONDO:0003215

Definition

A malignant neoplasm involving the apocrine gland. [from NCI]

Professional guidelines

PubMed

Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Apocrine and Eccrine Differentiation.
Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 May 11;22(10) doi: 10.3390/ijms22105077. PMID: 34064849Free PMC Article
Cutaneous Sweat Gland Carcinomas with Basaloid Differentiation: An Update with Emphasis on Differential Diagnoses.
Flux K, Brenn T
Clin Lab Med 2017 Sep;37(3):587-601. Epub 2017 Jun 9 doi: 10.1016/j.cll.2017.05.006. PMID: 28802502
Treatment strategy for cutaneous apocrine carcinoma.
Ogata D, Kiyohara Y, Yoshikawa S, Kasami M
Int J Clin Oncol 2014 Aug;19(4):712-5. Epub 2013 Jul 31 doi: 10.1007/s10147-013-0594-x. PMID: 23900624

Recent clinical studies

Etiology

Sweat Gland Carcinoma of the Head and Neck: Case Report and Literature Review.
Zhang Z, Yin S, Xu Z, Wang S
Ear Nose Throat J 2023 Oct;102(10):NP522-NP526. Epub 2021 Jun 16 doi: 10.1177/01455613211016717. PMID: 34134535
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Squamoid Eccrine Ductal Carcinoma.
Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321
Alternative Clinical Indications of Botulinum Toxin.
Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806
Skin of color: biology, structure, function, and implications for dermatologic disease.
Taylor SC
J Am Acad Dermatol 2002 Feb;46(2 Suppl Understanding):S41-62. doi: 10.1067/mjd.2002.120790. PMID: 11807469

Diagnosis

Squamoid Eccrine Ductal Carcinoma.
Svoboda SA, Rush PS, Garofola CJ, Grider DJ, Prickett KA, Phillips MA
Cutis 2021 Jun;107(6):E5-E9. doi: 10.12788/cutis.0280. PMID: 34314321
Apocrine and eccrine hidrocystomas: a clinicopathological study.
Koumaki D, Papadakis M, Lagoudaki E, Manios GA, Kassotakis D, Doxastaki A, Krasagakis K, Manios A
Acta Dermatovenerol Alp Pannonica Adriat 2021 Jun;30(2):53-56. PMID: 34169699
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Ceruminous Neoplasms of the Ear.
Nagarajan P
Head Neck Pathol 2018 Sep;12(3):350-361. Epub 2018 Aug 1 doi: 10.1007/s12105-018-0909-3. PMID: 30069843Free PMC Article
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768

Therapy

Alternative Clinical Indications of Botulinum Toxin.
Alster TS, Harrison IS
Am J Clin Dermatol 2020 Dec;21(6):855-880. doi: 10.1007/s40257-020-00532-0. PMID: 32651806
SOX10 immunohistochemistry in sweat ductal/glandular neoplasms.
Cassarino DS, Su A, Robbins BA, Altree-Tacha D, Ra S
J Cutan Pathol 2017 Jun;44(6):544-547. Epub 2017 Apr 20 doi: 10.1111/cup.12939. PMID: 28343365
Apocrine carcinoma of the breast: A brief update on the molecular features and targetable biomarkers.
Vranic S, Feldman R, Gatalica Z
Bosn J Basic Med Sci 2017 Feb 21;17(1):9-11. doi: 10.17305/bjbms.2016.1811. PMID: 28027454Free PMC Article
Angioadnexocentric nevus.
Hashimoto K, Amano M, Setoyama M
J Dermatol 2012 Nov;39(11):909-15. Epub 2012 Jul 4 doi: 10.1111/j.1346-8138.2012.01599.x. PMID: 22762690
Drug targeting through pilosebaceous route.
Chourasia R, Jain SK
Curr Drug Targets 2009 Oct;10(10):950-67. doi: 10.2174/138945009789577918. PMID: 19663765

Prognosis

Adnexal and Sebaceous Carcinomas.
Seger EW, Neill BC, Tolkachjov SN
Dermatol Clin 2023 Jan;41(1):117-132. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.010. PMID: 36410972
Sweat Gland Tumor Microenvironment.
Yuda Handaya A, Anwar SL, Fauzi AR, Werdana VAP
Adv Exp Med Biol 2020;1296:259-274. doi: 10.1007/978-3-030-59038-3_16. PMID: 34185298
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Malignant adnexal neoplasms.
Crowson AN, Magro CM, Mihm MC
Mod Pathol 2006 Feb;19 Suppl 2:S93-S126. doi: 10.1038/modpathol.3800511. PMID: 16446719
Skin of color: biology, structure, function, and implications for dermatologic disease.
Taylor SC
J Am Acad Dermatol 2002 Feb;46(2 Suppl Understanding):S41-62. doi: 10.1067/mjd.2002.120790. PMID: 11807469

Clinical prediction guides

NECTIN4 expression in sebaceous and sweat gland carcinoma.
Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Oda Y, Kaku-Ito Y
Eur J Dermatol 2022 Apr 1;32(2):181-186. doi: 10.1684/ejd.2022.4241. PMID: 35866909
Molecular pathology of skin adnexal tumours.
Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Skin of color: biology, structure, function, and implications for dermatologic disease.
Taylor SC
J Am Acad Dermatol 2002 Feb;46(2 Suppl Understanding):S41-62. doi: 10.1067/mjd.2002.120790. PMID: 11807469
Eccrine porocarcinoma.
Akiyoshi E, Nogita T, Yamaguchi R, Toyoda H, Kawashima M, Hidano A
Dermatologica 1991;182(4):239-42. doi: 10.1159/000247804. PMID: 1653154

Recent systematic reviews

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.
Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Photodynamic therapy for extramammary Paget's disease: A systematic review of the literature.
Shim PJ, Zeitouni NC
Photodiagnosis Photodyn Ther 2020 Sep;31:101911. Epub 2020 Jul 6 doi: 10.1016/j.pdpdt.2020.101911. PMID: 32645437

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