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Mediastinal malignant germ cell tumor

MedGen UID:
277334
Concept ID:
C1334597
Neoplastic Process
Synonyms: Malignant germ cell neoplasm of mediastinum; Malignant Germ Cell Neoplasm of Mediastinum; malignant germ cell neoplasm of mediastinum; Malignant Germ Cell Neoplasm of the Mediastinum; malignant germ cell neoplasm of the mediastinum; Malignant Germ Cell Tumor of Mediastinum; malignant germ cell tumor of mediastinum; Malignant Germ Cell Tumor of the Mediastinum; malignant germ cell tumor of the mediastinum; malignant germ cell tumour of mediastinum; malignant germ cell tumour of the mediastinum; Malignant Mediastinal Germ Cell Neoplasm; malignant mediastinal germ cell neoplasm; Malignant Mediastinal Germ Cell Tumor; malignant mediastinal germ cell tumor; malignant mediastinal germ cell tumour; mediastinal germ cell tumor, malignant; Mediastinal Malignant Germ Cell Tumor; mediastinal malignant germ cell tumor; Thymic Malignant Germ Cell Tumor; thymic malignant germ cell tumor; thymic malignant germ cell tumour
SNOMED CT: Malignant germ cell neoplasm of mediastinum (713293002)
 
Monarch Initiative: MONDO:0006298

Definition

An extragonadal malignant germ cell tumor that arises from the mediastinum. This category includes seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, mixed germ cell tumors, and immature malignant teratoma. [from NCI]

Professional guidelines

PubMed

Biswas B, Dabkara D, Sengupta M, Ganguly S, Ghosh J, Arunsingh S M, Sen S
Cancer Rep (Hoboken) 2021 Feb;4(1):e1306. Epub 2020 Oct 8 doi: 10.1002/cnr2.1306. PMID: 33029924Free PMC Article
Liu Y, Wang Z, Peng ZM, Yu Y
Diagn Pathol 2014 Feb 19;9:33. doi: 10.1186/1746-1596-9-33. PMID: 24552239Free PMC Article

Recent clinical studies

Etiology

Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
Feldman DR, Sheinfeld J, Bajorin DF, Fischer P, Turkula S, Ishill N, Patil S, Bains M, Reich LM, Bosl GJ, Motzer RJ
J Clin Oncol 2010 Apr 1;28(10):1706-13. Epub 2010 Mar 1 doi: 10.1200/JCO.2009.25.1561. PMID: 20194867Free PMC Article
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Diagnosis

Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P
J Thorac Oncol 2022 Feb;17(2):200-213. Epub 2021 Oct 22 doi: 10.1016/j.jtho.2021.10.010. PMID: 34695605
Fichtner A, Richter A, Filmar S, Kircher S, Rosenwald A, Küffer S, Nettersheim D, Oing C, Marx A, Ströbel P, Bremmer F
Histopathology 2022 Jan;80(2):381-396. Epub 2021 Nov 16 doi: 10.1111/his.14560. PMID: 34506648
Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Stram AR, Kesler KA
Surg Oncol Clin N Am 2020 Oct;29(4):571-579. Epub 2020 Jul 20 doi: 10.1016/j.soc.2020.06.005. PMID: 32883459

Therapy

Oing C, Seidel C, von Amsberg G, Oechsle K, Bokemeyer C
Expert Opin Pharmacother 2016;17(4):545-60. Epub 2015 Dec 31 doi: 10.1517/14656566.2016.1127357. PMID: 26630452
Albany C, Einhorn LH
Curr Opin Oncol 2013 May;25(3):261-5. doi: 10.1097/CCO.0b013e32835f085d. PMID: 23422328
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550
Feldman DR, Sheinfeld J, Bajorin DF, Fischer P, Turkula S, Ishill N, Patil S, Bains M, Reich LM, Bosl GJ, Motzer RJ
J Clin Oncol 2010 Apr 1;28(10):1706-13. Epub 2010 Mar 1 doi: 10.1200/JCO.2009.25.1561. PMID: 20194867Free PMC Article
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Prognosis

Stram AR, Kesler KA
Surg Oncol Clin N Am 2020 Oct;29(4):571-579. Epub 2020 Jul 20 doi: 10.1016/j.soc.2020.06.005. PMID: 32883459
Reynolds JP, Liu S
Semin Diagn Pathol 2020 Jul;37(4):174-178. Epub 2020 May 13 doi: 10.1053/j.semdp.2020.04.008. PMID: 32444243
Rosti G, Secondino S, Necchi A, Fornarini G, Pedrazzoli P
Semin Oncol 2019 Apr;46(2):107-111. Epub 2019 Apr 24 doi: 10.1053/j.seminoncol.2019.04.001. PMID: 31076171
Mukherjee S, Ibrahimi S, John S, Adnan MM, Scordino T, Khalil MO, Cherry M
Ann Hematol 2017 Sep;96(9):1435-1439. Epub 2017 Jun 3 doi: 10.1007/s00277-017-3037-3. PMID: 28578457
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Clinical prediction guides

Stram AR, Kesler KA
Surg Oncol Clin N Am 2020 Oct;29(4):571-579. Epub 2020 Jul 20 doi: 10.1016/j.soc.2020.06.005. PMID: 32883459
Feldman DR, Sheinfeld J, Bajorin DF, Fischer P, Turkula S, Ishill N, Patil S, Bains M, Reich LM, Bosl GJ, Motzer RJ
J Clin Oncol 2010 Apr 1;28(10):1706-13. Epub 2010 Mar 1 doi: 10.1200/JCO.2009.25.1561. PMID: 20194867Free PMC Article
Detterbeck FC
Ann Thorac Surg 2010 Mar;89(3):998-1005. doi: 10.1016/j.athoracsur.2009.07.097. PMID: 20172187
Thomas CR Jr, Bonomi PD
Curr Opin Oncol 1991 Apr;3(2):335-43. doi: 10.1097/00001622-199104000-00015. PMID: 1648973
LeGolvan DP, Abell MR
Cancer 1977 May;39(5):2142-57. doi: 10.1002/1097-0142(197705)39:5<2142::aid-cncr2820390531>3.0.co;2-q. PMID: 558046

Recent systematic reviews

Winter C, Zengerling F, Busch J, Heinzelbecker J, Pfister D, Ruf C, Lackner J, Albers P, Kliesch S, Schmidt S, Bokemeyer C
World J Urol 2022 Dec;40(12):2863-2878. Epub 2022 May 12 doi: 10.1007/s00345-022-04009-z. PMID: 35554637Free PMC Article
Gao ZY, Liu XB, Pandey S, Gao B, Liu P, Zhang QH, Gao YJ, Li SB
Int J Clin Oncol 2021 Feb;26(2):284-295. Epub 2020 Nov 20 doi: 10.1007/s10147-020-01809-4. PMID: 33216242
Kirchweger P, Wundsam HV, Fischer I, Rösch CS, Böhm G, Tsybrovskyy O, Alibegovic V, Függer R
World J Surg Oncol 2020 Sep 18;18(1):248. doi: 10.1186/s12957-020-02016-1. PMID: 32948207Free PMC Article
Rubio-Rivas M, Moreira C, Marcoval J
Autoimmun Rev 2020 Aug;19(8):102587. Epub 2020 Jun 14 doi: 10.1016/j.autrev.2020.102587. PMID: 32553612
Wang T, Liu L, Luo J, Liu T, Wei A
Urol J 2015 Apr 29;12(2):2057-64. PMID: 25923148

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