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Mediastinum seminoma

MedGen UID:
277355
Concept ID:
C1334680
Neoplastic Process
Synonyms: Mediastinal Seminoma; mediastinal seminoma; mediastinum seminoma; Seminoma of Mediastinum; seminoma of mediastinum; Seminoma of the Mediastinum; seminoma of the mediastinum
 
Monarch Initiative: MONDO:0003826

Definition

An extragonadal malignant germ cell tumor that arises from the mediastinum. It is characterized by the presence of uniform cells with clear or eosinophilic cytoplasm, round nucleus with one or more nucleoli, and distinct cellular borders. It usually arises from the anterior mediastinum. It may present with respiratory distress, chest pain, or superior vena cava syndrome or it may be asymptomatic, with the tumor detected on routine chest x-ray. The prognosis of mediastinal pure seminomas is favorable compared to the mediastinal non-seminomatous malignant germ cell tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMediastinum seminoma

Professional guidelines

PubMed

Makino T, Konaka H, Namiki M
Anticancer Res 2016 Jan;36(1):313-7. PMID: 26722059
Jyothirmayi R, Ramadas K, Jacob R, Gangadharan VP, Nair MK
Acta Oncol 1997;36(3):317-21. doi: 10.3109/02841869709001270. PMID: 9208904
Kantoff P
Chest 1993 Apr;103(4 Suppl):331S-333S. doi: 10.1378/chest.103.4_supplement.331s. PMID: 8384966

Recent clinical studies

Etiology

Looijenga LH, Gillis AJ, Stoop HJ, Hersmus R, Oosterhuis JW
Ann N Y Acad Sci 2007 Dec;1120:187-214. Epub 2007 Oct 2 doi: 10.1196/annals.1411.000. PMID: 17911410
Schmidberger H, Bamberg M, Meisner C, Classen J, Winkler C, Hartmann M, Templin R, Wiegel T, Dornoff W, Ross D, Thiel HJ, Martini C, Haase W
Int J Radiat Oncol Biol Phys 1997 Sep 1;39(2):321-6. doi: 10.1016/s0360-3016(97)00155-7. PMID: 9308934
Jyothirmayi R, Ramadas K, Jacob R, Gangadharan VP, Nair MK
Acta Oncol 1997;36(3):317-21. doi: 10.3109/02841869709001270. PMID: 9208904
Aygun C, Slawson RG, Bajaj K, Salazar OM
Urology 1984 Feb;23(2):109-17. PMID: 6364524
Buskirk SJ, Evans RG, Farrow GM, Earle JD
Cancer 1982 May 1;49(9):1934-6. doi: 10.1002/1097-0142(19820501)49:9<1934::aid-cncr2820490930>3.0.co;2-t. PMID: 7074590

Diagnosis

Aguiar Bujanda D, Pérez Cabrera D, Croissier Sánchez L
Am J Clin Oncol 2022 Dec 1;45(12):493-500. Epub 2022 Nov 17 doi: 10.1097/COC.0000000000000959. PMID: 36394133
Fichtner A, Richter A, Filmar S, Kircher S, Rosenwald A, Küffer S, Nettersheim D, Oing C, Marx A, Ströbel P, Bremmer F
Histopathology 2022 Jan;80(2):381-396. Epub 2021 Nov 16 doi: 10.1111/his.14560. PMID: 34506648
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Reynolds JP, Liu S
Semin Diagn Pathol 2020 Jul;37(4):174-178. Epub 2020 May 13 doi: 10.1053/j.semdp.2020.04.008. PMID: 32444243
Buskirk SJ, Evans RG, Farrow GM, Earle JD
Cancer 1982 May 1;49(9):1934-6. doi: 10.1002/1097-0142(19820501)49:9<1934::aid-cncr2820490930>3.0.co;2-t. PMID: 7074590

Therapy

Taza F, Abonour R, Zaid MA, Althouse SK, Anouti B, Akel R, Hanna NH, Adra N, Einhorn LH
Clin Genitourin Cancer 2023 Apr;21(2):213-220. Epub 2023 Jan 18 doi: 10.1016/j.clgc.2023.01.004. PMID: 36737276
Busch J, Seidel C, Zengerling F
Oncol Res Treat 2016;39(3):140-4. Epub 2016 Feb 23 doi: 10.1159/000444271. PMID: 27032104
Warde P, Gospodarowicz M, Panzarella T, Catton C, Sturgeon J, Moore M, Jewett M
J Clin Oncol 1998 Jan;16(1):290-4. doi: 10.1200/JCO.1998.16.1.290. PMID: 9440755
Schmidberger H, Bamberg M, Meisner C, Classen J, Winkler C, Hartmann M, Templin R, Wiegel T, Dornoff W, Ross D, Thiel HJ, Martini C, Haase W
Int J Radiat Oncol Biol Phys 1997 Sep 1;39(2):321-6. doi: 10.1016/s0360-3016(97)00155-7. PMID: 9308934
Jyothirmayi R, Ramadas K, Jacob R, Gangadharan VP, Nair MK
Acta Oncol 1997;36(3):317-21. doi: 10.3109/02841869709001270. PMID: 9208904

Prognosis

Aguiar Bujanda D, Pérez Cabrera D, Croissier Sánchez L
Am J Clin Oncol 2022 Dec 1;45(12):493-500. Epub 2022 Nov 17 doi: 10.1097/COC.0000000000000959. PMID: 36394133
Reynolds JP, Liu S
Semin Diagn Pathol 2020 Jul;37(4):174-178. Epub 2020 May 13 doi: 10.1053/j.semdp.2020.04.008. PMID: 32444243
Aygun C, Slawson RG, Bajaj K, Salazar OM
Urology 1984 Feb;23(2):109-17. PMID: 6364524
Buskirk SJ, Evans RG, Farrow GM, Earle JD
Cancer 1982 May 1;49(9):1934-6. doi: 10.1002/1097-0142(19820501)49:9<1934::aid-cncr2820490930>3.0.co;2-t. PMID: 7074590
Raghavan D, Barrett A
Cancer 1980 Sep 1;46(5):1187-91. doi: 10.1002/1097-0142(19800901)46:5<1187::aid-cncr2820460518>3.0.co;2-2. PMID: 7214301

Clinical prediction guides

Aguiar Bujanda D, Pérez Cabrera D, Croissier Sánchez L
Am J Clin Oncol 2022 Dec 1;45(12):493-500. Epub 2022 Nov 17 doi: 10.1097/COC.0000000000000959. PMID: 36394133
Looijenga LH, Gillis AJ, Stoop HJ, Hersmus R, Oosterhuis JW
Ann N Y Acad Sci 2007 Dec;1120:187-214. Epub 2007 Oct 2 doi: 10.1196/annals.1411.000. PMID: 17911410
McKenney JK, Heerema-McKenney A, Rouse RV
Adv Anat Pathol 2007 Mar;14(2):69-92. doi: 10.1097/PAP.0b013e31803240e6. PMID: 17471115
Ueno T, Tanaka YO, Nagata M, Tsunoda H, Anno I, Ishikawa S, Kawai K, Itai Y
Radiographics 2004 Mar-Apr;24(2):387-404. doi: 10.1148/rg.242035082. PMID: 15026588
Schmidberger H, Bamberg M, Meisner C, Classen J, Winkler C, Hartmann M, Templin R, Wiegel T, Dornoff W, Ross D, Thiel HJ, Martini C, Haase W
Int J Radiat Oncol Biol Phys 1997 Sep 1;39(2):321-6. doi: 10.1016/s0360-3016(97)00155-7. PMID: 9308934

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