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Metastasizing Pleomorphic Adenoma of the Salivary Gland

MedGen UID:
277361
Concept ID:
C1334711
Neoplastic Process
Synonyms: Metastasizing Mixed Tumor of Salivary Gland; Metastasizing Mixed Tumor of the Salivary Gland

Definition

A very rare pleomorphic adenoma of the salivary glands that metastasizes inexplicably, despite the benign histopathologic features. The most common sites of metastasis are bone, lung, and head and neck. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastasizing Pleomorphic Adenoma of the Salivary Gland

Professional guidelines

PubMed

Choi SY, Lee E, Kim E, Chung MK, Son YI, Baek CH, Jeong HS
BMC Cancer 2021 Feb 18;21(1):178. doi: 10.1186/s12885-021-07902-9. PMID: 33602169Free PMC Article
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866

Recent clinical studies

Etiology

Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344
Xu B, Mneimneh W, Torrence DE, Higgins K, Klimstra D, Ghossein R, Katabi N
Am J Surg Pathol 2019 May;43(5):601-609. doi: 10.1097/PAS.0000000000001218. PMID: 30789358Free PMC Article
Seethala RR
Adv Anat Pathol 2011 Jan;18(1):29-45. doi: 10.1097/PAP.0b013e318202645a. PMID: 21169736
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859
Lee YY, Wong KT, King AD, Ahuja AT
Eur J Radiol 2008 Jun;66(3):419-36. Epub 2008 Mar 11 doi: 10.1016/j.ejrad.2008.01.027. PMID: 18337041

Diagnosis

Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859
Lee YY, Wong KT, King AD, Ahuja AT
Eur J Radiol 2008 Jun;66(3):419-36. Epub 2008 Mar 11 doi: 10.1016/j.ejrad.2008.01.027. PMID: 18337041
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Therapy

Stodulski D, Mikaszewski B, Majewska H, Kuczkowski J
Eur Arch Otorhinolaryngol 2019 Jul;276(7):2031-2038. Epub 2019 May 6 doi: 10.1007/s00405-019-05454-0. PMID: 31062093Free PMC Article
Prigent M, Teissier N, Peuchmaur M, El Maleh-Berges M, Philippe-Chomette P, Cardin P, Orbach D
Int J Pediatr Otorhinolaryngol 2010 Aug;74(8):942-5. doi: 10.1016/j.ijporl.2010.01.026. PMID: 20554035
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Henriksson G, Westrin KM, Carlsöö B, Silfverswärd C
Cancer 1998 Feb 15;82(4):617-20. doi: 10.1002/(sici)1097-0142(19980215)82:4<617::aid-cncr1>3.0.co;2-i. PMID: 9477091

Prognosis

Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Seethala RR
Adv Anat Pathol 2011 Jan;18(1):29-45. doi: 10.1097/PAP.0b013e318202645a. PMID: 21169736
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859

Clinical prediction guides

Xu B, Mneimneh W, Torrence DE, Higgins K, Klimstra D, Ghossein R, Katabi N
Am J Surg Pathol 2019 May;43(5):601-609. doi: 10.1097/PAS.0000000000001218. PMID: 30789358Free PMC Article
Seethala RR
Adv Anat Pathol 2011 Jan;18(1):29-45. doi: 10.1097/PAP.0b013e318202645a. PMID: 21169736
Manucha V, Ioffe OB
Arch Pathol Lab Med 2008 Sep;132(9):1445-7. doi: 10.5858/2008-132-1445-MPAOTS. PMID: 18788859
Nouraei SA, Ferguson MS, Clarke PM, Sandison A, Sandhu GS, Michaels L, Rhys-Evans P
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):788-93. doi: 10.1001/archotol.132.7.788. PMID: 16847191
Diaz NM, McDivitt RW, Wick MR
Hum Pathol 1991 Dec;22(12):1206-14. doi: 10.1016/0046-8177(91)90102-u. PMID: 1660850

Recent systematic reviews

Thompson C, Nolli T, Bannister M
J Laryngol Otol 2021 Sep;135(9):765-769. Epub 2021 Jul 26 doi: 10.1017/S0022215121002036. PMID: 34308809
Louredo BVR, Santos-Silva AR, Vargas PA, Ajudarte Lopes M, Martins MD, Guerra ENDS, Prado Ribeiro AC, Brandão TB, de Mendonça RMH, Kowalski LP, Speight PM, Khurram SA, Pérez-de-Oliveira ME
J Oral Pathol Med 2021 May;50(5):435-443. Epub 2021 Jan 8 doi: 10.1111/jop.13151. PMID: 33314344
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

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