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Metastatic carcinoma in the adrenal medulla

MedGen UID:
277362
•Concept ID:
C1334717
•
Neoplastic Process
Synonyms: Metastatic Carcinoma in the Adrenal Medulla; metastatic carcinoma in the adrenal medulla; Metastatic Carcinoma to the Adrenal Medulla; metastatic carcinoma to the adrenal medulla
 
Monarch Initiative: MONDO:0024868

Definition

A carcinoma that has spread to the adrenal medulla from an adjacent or distant anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic carcinoma in the adrenal medulla

Professional guidelines

PubMed

Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495
Adrenal incidentalomas: surgical treatment in 28 patients and update of the literature.
Porcaro AB, Novella G, Ficarra V, Curti P, Antoniolli SZ, Suangwoua HS, Malossini G
Int Urol Nephrol 2001;32(3):295-302. doi: 10.1023/a:1017587312369. PMID: 11583337
Immunocytochemical differential diagnosis of adrenocortical neoplasms using the monoclonal antibody D11.
Schröder S, Niendorf A, Achilles E, Dietel M, Padberg BC, Beisiegel U, Dralle H, Bressel M, Klöppel G
Virchows Arch A Pathol Anat Histopathol 1990;417(2):89-96. doi: 10.1007/BF02190525. PMID: 2114700

Recent clinical studies

Etiology

PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas.
Cubiella T, Celada L, San-Juan-Guardado J, Rodríguez-Aguilar R, Suárez-Priede Á, Poch M, Dominguez F, Fernández-Vega I, Montero-Pavón P, Fraga MF, Nakatani Y, Takata S, Yachida S, Valdés N, Chiara MD
J Pathol 2024 Aug;263(4-5):418-428. Epub 2024 May 25 doi: 10.1002/path.6291. PMID: 38795318
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Vagus nerve regulates breast cancer metastasis to the adrenal gland.
Erin N, Barkan GA, Clawson GA
Anticancer Res 2013 Sep;33(9):3675-82. PMID: 24023295
Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495
Adrenal incidentalomas: surgical treatment in 28 patients and update of the literature.
Porcaro AB, Novella G, Ficarra V, Curti P, Antoniolli SZ, Suangwoua HS, Malossini G
Int Urol Nephrol 2001;32(3):295-302. doi: 10.1023/a:1017587312369. PMID: 11583337

Diagnosis

Hand2 Immunohistochemistry in the Diagnosis of Paragangliomas and Other Neuroendocrine Neoplasms.
Soukup J, Manethova M, Stejskal V, Novakova M, Duskova J, Hornychova H, Hacova M, Staniczkova-Zambo I, Zelinka T, Kosak M, Cesak T, Netuka D, Ryska A, Gabalec F
Endocr Pathol 2024 Mar;35(1):14-24. Epub 2024 Feb 28 doi: 10.1007/s12022-024-09803-6. PMID: 38416360
Inflammation in the neoplasms of the adrenal gland: Is there a prognostic role? An immunohistochemical study.
Guadagno E, Russo D, Pignatiello S, Del Basso De Caro M
Pathol Res Pract 2020 Sep;216(9):153070. Epub 2020 Jun 20 doi: 10.1016/j.prp.2020.153070. PMID: 32825943
The role of PET in the surgical approach to adrenal disease.
Gross MD, Gauger PG, Djekidel M, Rubello D
Eur J Surg Oncol 2009 Nov;35(11):1137-45. Epub 2009 Feb 25 doi: 10.1016/j.ejso.2009.01.010. PMID: 19243910
Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495
Adrenal incidentalomas: surgical treatment in 28 patients and update of the literature.
Porcaro AB, Novella G, Ficarra V, Curti P, Antoniolli SZ, Suangwoua HS, Malossini G
Int Urol Nephrol 2001;32(3):295-302. doi: 10.1023/a:1017587312369. PMID: 11583337

Therapy

Laparoscopic radiofrequency thermal ablation of adrenal tumors: technical details.
Berber E, Siperstein A
Surg Laparosc Endosc Percutan Tech 2010 Feb;20(1):58-62. doi: 10.1097/SLE.0b013e3181cd44fc. PMID: 20173624
Breast metastasis by medullary thyroid carcinoma detected by FDG positron emission tomography.
Nofech-Mozes S, Mackenzie R, Kahn HJ, Ehrlich L, Raphael SJ
Ann Diagn Pathol 2008 Feb;12(1):67-71. Epub 2007 Jul 24 doi: 10.1016/j.anndiagpath.2006.08.004. PMID: 18164420
Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495

Prognosis

PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas.
Cubiella T, Celada L, San-Juan-Guardado J, Rodríguez-Aguilar R, Suárez-Priede Á, Poch M, Dominguez F, Fernández-Vega I, Montero-Pavón P, Fraga MF, Nakatani Y, Takata S, Yachida S, Valdés N, Chiara MD
J Pathol 2024 Aug;263(4-5):418-428. Epub 2024 May 25 doi: 10.1002/path.6291. PMID: 38795318
Inflammation in the neoplasms of the adrenal gland: Is there a prognostic role? An immunohistochemical study.
Guadagno E, Russo D, Pignatiello S, Del Basso De Caro M
Pathol Res Pract 2020 Sep;216(9):153070. Epub 2020 Jun 20 doi: 10.1016/j.prp.2020.153070. PMID: 32825943
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.
Berthon A, Sahut-Barnola I, Lambert-Langlais S, de Joussineau C, Damon-Soubeyrand C, Louiset E, Taketo MM, Tissier F, Bertherat J, Lefrançois-Martinez AM, Martinez A, Val P
Hum Mol Genet 2010 Apr 15;19(8):1561-76. Epub 2010 Jan 27 doi: 10.1093/hmg/ddq029. PMID: 20106872
Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495

Clinical prediction guides

PCDHGC3 hypermethylation as a potential biomarker of intestinal neuroendocrine carcinomas.
Cubiella T, Celada L, San-Juan-Guardado J, Rodríguez-Aguilar R, Suárez-Priede Á, Poch M, Dominguez F, Fernández-Vega I, Montero-Pavón P, Fraga MF, Nakatani Y, Takata S, Yachida S, Valdés N, Chiara MD
J Pathol 2024 Aug;263(4-5):418-428. Epub 2024 May 25 doi: 10.1002/path.6291. PMID: 38795318
Hand2 Immunohistochemistry in the Diagnosis of Paragangliomas and Other Neuroendocrine Neoplasms.
Soukup J, Manethova M, Stejskal V, Novakova M, Duskova J, Hornychova H, Hacova M, Staniczkova-Zambo I, Zelinka T, Kosak M, Cesak T, Netuka D, Ryska A, Gabalec F
Endocr Pathol 2024 Mar;35(1):14-24. Epub 2024 Feb 28 doi: 10.1007/s12022-024-09803-6. PMID: 38416360
Inflammation in the neoplasms of the adrenal gland: Is there a prognostic role? An immunohistochemical study.
Guadagno E, Russo D, Pignatiello S, Del Basso De Caro M
Pathol Res Pract 2020 Sep;216(9):153070. Epub 2020 Jun 20 doi: 10.1016/j.prp.2020.153070. PMID: 32825943
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.
Lam AK
Endocr Pathol 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5. PMID: 28477311
Constitutive beta-catenin activation induces adrenal hyperplasia and promotes adrenal cancer development.
Berthon A, Sahut-Barnola I, Lambert-Langlais S, de Joussineau C, Damon-Soubeyrand C, Louiset E, Taketo MM, Tissier F, Bertherat J, Lefrançois-Martinez AM, Martinez A, Val P
Hum Mol Genet 2010 Apr 15;19(8):1561-76. Epub 2010 Jan 27 doi: 10.1093/hmg/ddq029. PMID: 20106872

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