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Midgut Neuroendocrine Tumor G1

MedGen UID:
277371
Concept ID:
C1334763
Neoplastic Process
Synonym: Midgut Carcinoid Tumor

Definition

A well-differentiated, low grade neoplasm with neuroendocrine differentiation that arises from the jejunum, ileum, proximal colon, or appendix. The mitotic count is less than 2 per 10 HPF and/or the Ki67 index is equal to or less than 2 percent. [from NCI]

Professional guidelines

PubMed

Skoura E, Michopoulou S, Mohmaduvesh M, Panagiotidis E, Al Harbi M, Toumpanakis C, Almukhailed O, Kayani I, Syed R, Navalkissoor S, Ell PJ, Caplin ME, Bomanji J
J Nucl Med 2016 Jan;57(1):34-40. Epub 2015 Oct 15 doi: 10.2967/jnumed.115.166017. PMID: 26471695
Maschmeyer G, Mügge LO, Kämpfe D, Kreibich U, Wilhelm S, Aßmann M, Schwarz M, Kahl C, Köhler S, Grobe N, Niederwieser D
J Cancer Res Clin Oncol 2015 Sep;141(9):1639-44. Epub 2015 Mar 15 doi: 10.1007/s00432-015-1954-x. PMID: 25773126
Oberg K
Digestion 2000;62 Suppl 1:92-7. doi: 10.1159/000051862. PMID: 10940694

Recent clinical studies

Etiology

Jacques V, Dierickx L, Texier JS, Brillouet S, Courbon F, Guimbaud R, Vija L, Savagner F
Front Endocrinol (Lausanne) 2024;15:1385079. Epub 2024 Jun 14 doi: 10.3389/fendo.2024.1385079. PMID: 38948517Free PMC Article
Borbon LC, Tran CG, Sherman SK, Ear PH, Chandrasekharan C, Bellizzi AM, Dillon JS, O'Dorisio TM, Howe JR
Ann Surg Oncol 2022 Oct;29(11):6936-6946. Epub 2022 Jul 8 doi: 10.1245/s10434-022-12100-3. PMID: 35802214Free PMC Article
Gut P, Czarnywojtek A, Sawicka-Gutaj N, Woliński K, Maciejewski A, Komarnicki P, Ruchała M
Endokrynol Pol 2021;72(4):308-318. Epub 2021 Jul 22 doi: 10.5603/EP.a2021.0060. PMID: 34292567
Maughan NM, Kim H, Hao Y, Unangst S, Roach MC Jr, Garcia-Ramirez JL, Amurao M, Luechtefeld D, Abdin K, Altman MB, Banks A, Riepe M, Bovard E, Jenkins S, Zoberi JE
Brachytherapy 2021 Jan-Feb;20(1):237-247. Epub 2020 Aug 17 doi: 10.1016/j.brachy.2020.07.004. PMID: 32819853
Sabet A, Dautzenberg K, Haslerud T, Aouf A, Sabet A, Simon B, Mayer K, Biersack HJ, Ezziddin S
Eur J Nucl Med Mol Imaging 2015 Jul;42(8):1238-46. Epub 2015 Mar 26 doi: 10.1007/s00259-015-3041-6. PMID: 25808630

Diagnosis

Borbon LC, Tran CG, Sherman SK, Ear PH, Chandrasekharan C, Bellizzi AM, Dillon JS, O'Dorisio TM, Howe JR
Ann Surg Oncol 2022 Oct;29(11):6936-6946. Epub 2022 Jul 8 doi: 10.1245/s10434-022-12100-3. PMID: 35802214Free PMC Article
Gut P, Czarnywojtek A, Sawicka-Gutaj N, Woliński K, Maciejewski A, Komarnicki P, Ruchała M
Endokrynol Pol 2021;72(4):308-318. Epub 2021 Jul 22 doi: 10.5603/EP.a2021.0060. PMID: 34292567
Childs A, Vesely C, Ensell L, Lowe H, Luong TV, Caplin ME, Toumpanakis C, Thirlwell C, Hartley JA, Meyer T
Br J Cancer 2016 Dec 6;115(12):1540-1547. Epub 2016 Nov 22 doi: 10.1038/bjc.2016.377. PMID: 27875519Free PMC Article
Skoura E, Michopoulou S, Mohmaduvesh M, Panagiotidis E, Al Harbi M, Toumpanakis C, Almukhailed O, Kayani I, Syed R, Navalkissoor S, Ell PJ, Caplin ME, Bomanji J
J Nucl Med 2016 Jan;57(1):34-40. Epub 2015 Oct 15 doi: 10.2967/jnumed.115.166017. PMID: 26471695
Maschmeyer G, Mügge LO, Kämpfe D, Kreibich U, Wilhelm S, Aßmann M, Schwarz M, Kahl C, Köhler S, Grobe N, Niederwieser D
J Cancer Res Clin Oncol 2015 Sep;141(9):1639-44. Epub 2015 Mar 15 doi: 10.1007/s00432-015-1954-x. PMID: 25773126

Therapy

Gut P, Czarnywojtek A, Sawicka-Gutaj N, Woliński K, Maciejewski A, Komarnicki P, Ruchała M
Endokrynol Pol 2021;72(4):308-318. Epub 2021 Jul 22 doi: 10.5603/EP.a2021.0060. PMID: 34292567
Maughan NM, Kim H, Hao Y, Unangst S, Roach MC Jr, Garcia-Ramirez JL, Amurao M, Luechtefeld D, Abdin K, Altman MB, Banks A, Riepe M, Bovard E, Jenkins S, Zoberi JE
Brachytherapy 2021 Jan-Feb;20(1):237-247. Epub 2020 Aug 17 doi: 10.1016/j.brachy.2020.07.004. PMID: 32819853
Goetz TI, Lang EW, Prante O, Maier A, Cordes M, Kuwert T, Ritt P, Schmidkonz C
Ann Nucl Med 2020 Apr;34(4):244-253. Epub 2020 Feb 29 doi: 10.1007/s12149-020-01440-3. PMID: 32114682Free PMC Article
Childs A, Vesely C, Ensell L, Lowe H, Luong TV, Caplin ME, Toumpanakis C, Thirlwell C, Hartley JA, Meyer T
Br J Cancer 2016 Dec 6;115(12):1540-1547. Epub 2016 Nov 22 doi: 10.1038/bjc.2016.377. PMID: 27875519Free PMC Article
Oberg K
Digestion 2000;62 Suppl 1:92-7. doi: 10.1159/000051862. PMID: 10940694

Prognosis

Jacques V, Dierickx L, Texier JS, Brillouet S, Courbon F, Guimbaud R, Vija L, Savagner F
Front Endocrinol (Lausanne) 2024;15:1385079. Epub 2024 Jun 14 doi: 10.3389/fendo.2024.1385079. PMID: 38948517Free PMC Article
Borbon LC, Tran CG, Sherman SK, Ear PH, Chandrasekharan C, Bellizzi AM, Dillon JS, O'Dorisio TM, Howe JR
Ann Surg Oncol 2022 Oct;29(11):6936-6946. Epub 2022 Jul 8 doi: 10.1245/s10434-022-12100-3. PMID: 35802214Free PMC Article
Skoura E, Michopoulou S, Mohmaduvesh M, Panagiotidis E, Al Harbi M, Toumpanakis C, Almukhailed O, Kayani I, Syed R, Navalkissoor S, Ell PJ, Caplin ME, Bomanji J
J Nucl Med 2016 Jan;57(1):34-40. Epub 2015 Oct 15 doi: 10.2967/jnumed.115.166017. PMID: 26471695
Sabet A, Dautzenberg K, Haslerud T, Aouf A, Sabet A, Simon B, Mayer K, Biersack HJ, Ezziddin S
Eur J Nucl Med Mol Imaging 2015 Jul;42(8):1238-46. Epub 2015 Mar 26 doi: 10.1007/s00259-015-3041-6. PMID: 25808630
Khan MS, Luong TV, Watkins J, Toumpanakis C, Caplin ME, Meyer T
Br J Cancer 2013 May 14;108(9):1838-45. Epub 2013 Apr 11 doi: 10.1038/bjc.2013.156. PMID: 23579216Free PMC Article

Clinical prediction guides

Jacques V, Dierickx L, Texier JS, Brillouet S, Courbon F, Guimbaud R, Vija L, Savagner F
Front Endocrinol (Lausanne) 2024;15:1385079. Epub 2024 Jun 14 doi: 10.3389/fendo.2024.1385079. PMID: 38948517Free PMC Article
Gut P, Czarnywojtek A, Sawicka-Gutaj N, Woliński K, Maciejewski A, Komarnicki P, Ruchała M
Endokrynol Pol 2021;72(4):308-318. Epub 2021 Jul 22 doi: 10.5603/EP.a2021.0060. PMID: 34292567
Maughan NM, Kim H, Hao Y, Unangst S, Roach MC Jr, Garcia-Ramirez JL, Amurao M, Luechtefeld D, Abdin K, Altman MB, Banks A, Riepe M, Bovard E, Jenkins S, Zoberi JE
Brachytherapy 2021 Jan-Feb;20(1):237-247. Epub 2020 Aug 17 doi: 10.1016/j.brachy.2020.07.004. PMID: 32819853
Ida H, Honma Y, Hirano H, Shoji H, Iwasa S, Okita N, Takashima A, Kato K, Fukuda T, Boku N
Invest New Drugs 2019 Jun;37(3):573-578. Epub 2018 Sep 28 doi: 10.1007/s10637-018-0669-7. PMID: 30267338
Sabet A, Dautzenberg K, Haslerud T, Aouf A, Sabet A, Simon B, Mayer K, Biersack HJ, Ezziddin S
Eur J Nucl Med Mol Imaging 2015 Jul;42(8):1238-46. Epub 2015 Mar 26 doi: 10.1007/s00259-015-3041-6. PMID: 25808630

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